イナリサーチ List of Products and Services

22nd Inari Research Science Online "In vivo efficacy and safety evaluation of anti-4-1BB antibody drug using Biocytogen's humanized 4-1BB mice" (Live efficacy and safety evaluation of anti-4-1BB antibody drug using a humanized 4-1BB mouse model) Speaker: Min Wang Project Manager Product and Resource Management Dept Biocytogen Pharmaceuticals (Beijing) Co., Ltd *The entire presentation will be in English. *This seminar will use Zoom. The seminar URL and password will be provided to those who register. *Participation from other companies in the same industry may be declined. ★Registration Form★ https://zoom.us/webinar/register/WN_m3tMmxV5Sl2yMAVu47CgVA

• Technical Seminar

Are you having trouble with the safety assessment of pesticides? In addition to the decision to introduce a re-evaluation system for already registered pesticides, the growing awareness of risk assessment has increased the demand for pesticide safety evaluations. Our company offers contract services for "pesticide safety testing." We conduct in vivo/in vitro tests in accordance with regulations related to new pesticide applications and safety evaluations of pesticide formulations, as well as the re-evaluation system and OECD guidelines. We have received high praise from clients who have requested our services for the reliable expertise we have cultivated over many years in pharmaceutical GLP. 【Types of Tests】 ■ General Toxicity Test ■ Genotoxicity Test ■ Reproductive Developmental Toxicity Test ■ Carcinogenicity Test ■ Irritation Test ■ Sensitization Test ■ Safety Testing of Pesticide Formulations (including Acute Oral Toxicity Test) *For more details, please refer to the materials. Feel free to contact us with any inquiries.

• Contract Inspection

Our company, which provides non-clinical trial contract services, focuses on research and development of cutting-edge technologies to meet advanced needs, and we present our findings in academic journals and conferences. We have participated in the Japan Society of Toxicology (JSOT) annual meetings for over 20 years, and this time, we are offering the "poster presentation materials" from the last three years for free. Please take this opportunity to verify our technological capabilities. 【Contents (partial)】 ◎ Application of micro-CT in non-clinical trials ◎ Verification of the detection accuracy of the reinforcing effects of central nervous system depressants in rat self-administration tests using CPP ◎ Verification of the detection accuracy of the reinforcing effects of positive control drugs in intravenous drug self-administration experiments using macaques ◎ Effects of fentanyl citrate on the respiratory system of rats *For more details, please refer to the materials. Feel free to contact us with any inquiries.

• Contract Inspection

At Inari Research, we conduct safety testing for pharmaceuticals, medical devices, chemicals, pesticides, and food. We are also well-regarded for our consulting services, including development consultations and regulatory affairs support. 【Types of Tests】 ◎ General Toxicity Test ◎ Genotoxicity Test ◎ Reproductive and Developmental Toxicity Test ◎ Carcinogenicity Test ◎ Safety Pharmacology Test ◎ Local Irritation Test ◎ Immunotoxicity Test ◎ Dependence Test ◎ Analysis of Test Substances ◎ Drug Concentration Measurement in Biological Samples *For more details, please refer to the materials. Feel free to contact us with any inquiries.

• Contract Inspection

Inari Research, which offers contract services such as safety testing and pharmacological efficacy testing, is currently providing the corporate information magazine "INA NOTES No.6," which features our latest topics, including non-clinical related technical information. The magazine includes a special feature on the recent status and results of the GLP compliance investigation, as well as reports from seminar participation and information on paper presentations. [Contents (excerpt)] ■ SEND Event Report: 5th Hamamatsu Toxicology Testing Forum, 2nd Inari Research SEND Seminar ■ Series: Initiatives in Marmoset Testing Business ■ Special Feature: Inari Research's GLP Compliance ■ TOPICS: A research paper using our MHC monkeys has been published *You can view the "Digest Version" from the download button. If you would like the "Complete Version," please feel free to contact us.

• Contract Inspection

At Inari Research, we conduct specialized pharmacological efficacy evaluation tests primarily focusing on monkeys, related to the central nervous system and ophthalmology. These tests are carried out in a GLP-compliant facility that has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We create various model animals to search for the effects of drugs. We also welcome inquiries regarding various spontaneous disease models. 【Other Tests】 ■ Tests using arthritis model animals (rats, mice) ■ Tests on the uterine and vaginal atrophy suppression effects in ovariectomized rats (rats) ■ Blood coagulation tests ■ Tests using tumor-bearing model animals (tumor-bearing mice) *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

At Inari Research, we conduct specialized pharmacological efficacy evaluation tests related to the central nervous system and ophthalmology, focusing on primates. These tests are carried out at a GLP-compliant facility that has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). 【Nutritional Infusion Related Tests】 ■ Tests on the nutritional effects of TPN (Total Parenteral Nutrition) - Using dogs or primates, we conduct continuous administration (24hr IVH) for up to 3 months to investigate the effects of nutritional solutions on water metabolism, electrolyte metabolism, glucose metabolism, and more. - Testing in a surgical invasion model using dogs is also possible. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

At Inari Research, we conduct specialized pharmacological efficacy evaluation tests primarily focused on monkeys, related to central nervous system and ophthalmology. These tests are carried out at a GLP-compliant facility that has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We search for the effects of drugs using various rat models of nephritis. 【Glomerulonephritis Models】 ■ Anti-Thy-1 Nephritis Model ■ Serum Sickness Type Nephritis Model ■ Type IV Collagen-Induced Glomerulonephritis Model *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

At Inari Research, we conduct specialized pharmacological efficacy evaluation tests related to the central nervous system and ophthalmology, focusing on monkeys. These tests are carried out in a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). 【Antidiabetic Drug Evaluation Tests】 ■ Tests using diabetic model animals (mice, rats) - Searching for the effects of drugs using indicators such as blood glucose, insulin, triglycerides, and free fatty acids - Investigating the effects of drugs on insulin-dependent and non-insulin-dependent diabetes *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

At Inari Research, we conduct specialized pharmacological evaluation tests related to the central nervous system and ophthalmology, focusing on monkeys. These tests are carried out in a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). 【Evaluation Tests for Intraocular Pressure Medications】 ■ Tests related to intraocular pressure measurement (rabbits, cynomolgus monkeys) - Investigating the effects of drugs on intraocular pressure under awake conditions. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

At Inari Research, we conduct specialized pharmacological efficacy evaluation tests primarily focused on monkeys, related to the central nervous system and ophthalmology. These tests are carried out in a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). 【Evaluation Tests for Anti-Osteoporosis Drugs】 ■ Tests using ovariectomized osteoporosis model animals (rats, rabbits) - Searching for the preventive and therapeutic effects of drugs on osteoporosis - Measuring the bone density of the lumbar vertebrae and tibia over time in vivo *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

At Inari Research, we conduct specialized pharmacological efficacy evaluation tests related to the central nervous system and ophthalmology, focusing on monkeys. These tests are carried out at a GLP-compliant facility that has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). 【Antihypertensive Drug Evaluation Tests】 ■ Tests using hypertensive model animals (SHR rats) - Searching for the antihypertensive effects of drugs through non-invasive blood pressure measurement. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

At Inari Research, we conduct specialized pharmacological efficacy evaluation tests primarily focused on monkeys, related to the central nervous system and ophthalmology. These tests are carried out in a GLP-compliant facility that has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). 【Evaluation Tests for Anti-Parkinson's Disease Drugs】 ■ Tests using MPTP-induced Parkinson's model animals (rhesus monkeys) - Searching for the therapeutic effects of drugs - Scoring changes in general condition and measuring spontaneous motor activity as indicators *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

- In vivo tumorigenicity test Using immunodeficient animals (NOG mice), we evaluate the tumorigenicity of the test samples during the observation period. - In vitro tumorigenicity test We culture, amplify, and observe the test samples to directly detect undifferentiated pluripotent liver cells. (Culture amplification method) We are participating in a validation project for testing methods (MEASURE) supported by AMED, conducting experimental studies on testing methods at our facility. We have a track record of long-term breeding of NOG mice and possess background data.

• Contract Inspection

Inari Research supports pharmacological testing from the screening stage to the entry into clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data using standard test systems such as mice, rats, rabbits, dogs, and monkeys. Tests are conducted at facilities certified by AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). 【Test Contents】 ■ Central-related tests: Evaluation tests for anti-Parkinson's disease drugs, evaluation tests for analgesics, tests using pruritus model animals (mice, macaques) ■ Cardiovascular-related tests: Evaluation tests for antihypertensive drugs ■ Osteoporosis-related tests: Evaluation tests for anti-osteoporosis drugs ■ Ophthalmology-related tests: Evaluation tests for intraocular pressure treatment drugs, evaluation tests for corneal epithelial damage, evaluation tests for intraocular inflammation ■ Blood sugar-related tests: Evaluation tests for antidiabetic drugs ■ Nephritis-related tests: Nephrotic model, renal failure model, glomerulonephritis model ■ Nutritional infusion-related tests: Tests on the nutritional effects of TPN (Total Parenteral Nutrition) (dogs, monkeys) and more. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

Our company conducts "safety testing of pharmaceuticals using marmosets," which allows for the efficient acquisition of non-clinical data. Marmosets are small primates weighing between 250 to 500 grams, providing the following advantages for conducting tests, such as requiring smaller amounts of test substances. 【Features】 ◎ Compared to cynomolgus monkeys, valuable test substances are needed in smaller quantities (about 1/10) ◎ Compared to rats and dogs, human-like pharmacological reactivity can be expected ★ Currently, we are compiling and presenting "conference presentation materials" summarizing test data and more. You can view them immediately via the "Download" link.

• Other Testing Contract

Conditioned Place Preference (CPP) test using the small primate common marmoset This is a testing system that can simply evaluate memory and learning abilities, as well as the psychological dependence of central nervous system acting drugs. In Inari Research, we have developed a CPP test using marmosets, which is expected to have higher detection accuracy for the psychological dependence of central nervous system depressants compared to rat CPP tests.

• Contract Inspection

We are pleased to present a report poster summarizing the marmoset testing system developed by Inari Research, which can provide effective non-clinical data early on! Tests using the small primate marmoset require only a small amount of test substance and are expected to have higher cross-reactivity with humans compared to rats in the development of biopharmaceuticals. [Published Catalog] - Safety Pharmacology Marmoset FOB Test - Safety Pharmacology Marmoset Telemetry Test - Marmoset Combination Repeated Dose Toxicity Test

• Other Testing Contract

We are currently offering five volumes of "INA NOTES," which includes technical and academic information based on non-clinical relevance, for free. The content is rich, featuring concepts for pharmaceutical development support alliances, a special section on drug dependence testing, reports from the Japanese Toxicology Society annual meeting, and initiatives related to marmoset testing. It provides useful information on various themes such as responding to increasingly sophisticated development products, speeding up to clinical stages, cost reduction, and animal welfare. 【Information Magazine Lineup】 ■INA NOTES April 2015 No.1 ■INA NOTES December 2015 No.2 ■INA NOTES July 2016 No.3 ■INA NOTES December 2016 No.4 ■INA NOTES June 2017 No.5 *The downloadable version is a "digest edition." If you would like the "full edition," please feel free to contact us.

• Testing Equipment and Devices

At Inari Research Co., Ltd., we provide consulting services by experts on safety evaluations of food additives, cosmetics, food contact materials, nanomaterials, and more, from proposing appropriate evaluation methods to test management. This document introduces the reasons for our reliability, such as being a publicly listed company with stable management and conducting GLP tests that comply with applications in various countries. We can also propose screening tests that achieve low prices and short delivery times, so please feel free to contact us. 【Reasons for Reliability】 ■ Stable management, publicly listed company ■ Animal welfare and high compliance ■ Fully accredited AAALAC International facility ■ GLP tests compliant with applications in various countries ■ Conducting in vivo/in vitro tests compliant with regulations in various countries and regions *For more details, please refer to the catalog or feel free to contact us.

• Contract Inspection

This is a skin irritation test using a human skin model (EPI-200). We have a track record of compliance with GLP. We evaluate the skin irritation of chemical substances, cosmetics/cosmetic ingredients, and pharmaceutical ingredients in vitro. You can utilize this for determining skin irritation categories under EU CLP and UN GHS, GHS classification, SDS creation, REACH registration, and more. It has been validated through confirmatory tests using known substances. 【Features】 ■ Compliance with regulations in various countries ■ Proposal for screening tests that achieve low cost and short delivery times ■ We respond to trust as an internationally certified facility → AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care) certified facility → A GLP-compliant facility with over 40 years of history *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

This is an eye irritation test using a human corneal model (OCL-200). We have a track record of compliance with GLP. We evaluate the eye irritation potential of chemical substances, cosmetics/cosmetic ingredients, and pharmaceutical ingredients in vitro. This can be utilized for determining eye irritation categories under EU CLP and UN GHS, as well as for GHS classification, SDS creation, and REACH registration. It has been validated through confirmation tests using known substances. 【Features】 ■ Compliance with regulations in various countries ■ Proposal for screening tests that achieve low cost and short turnaround time ■ We respond to trust as an internationally certified facility → AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care) certified facility → A GLP-compliant facility with over 40 years of history *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

As of December 17, 2016, the FDA requires the submission of SEND data compliant with CDISC for non-clinical trials starting after this date. Inari Research provides total support from the creation of SEND data packages to FDA submissions. We utilize solutions from Instem, a company known for its high quality and reliability, and which is GLP certified. The biggest risk in SEND submissions is the loss of time and costs due to FDA rejections (refusals to accept). Additionally, there may be burdens related to overall compliance, uncertainty about what to prepare, and the latest trends regarding SEND. If you have any concerns, please feel free to consult with us. 【Service Features】 ■ Comprehensive total support ■ Organizational and comprehensive responses to meet customer needs ■ Creation of reliable datasets by dedicated teams and study directors ■ Support for trials at other facilities is also available ■ Data integration from multiple sites is possible ■ The latest trends and case information on regulatory requirements will be delivered promptly in seminars, etc. *For more details, please refer to the PDF materials or feel free to contact us.

• Other contract services

At Inari Research, we have introduced a virtual slide scanner that converts pathological specimen slides into high-resolution digital data. This allows us to provide pathological specimen slides in digital format. By converting to digital data, the same sample can be observed by multiple people, enhancing convenience for discussions and other activities. Additionally, with network compatibility, specimen data can be shared, enabling faster pathological evaluations. 【Features】 - Multiple people can observe the same sample - Eliminates time lag in specimen delivery - No risk of glass sample damage or loss - Allows observation from whole to magnified images, similar to a microscope - High-resolution images that remain clear even when zoomed in on details We perform rapid work with high-speed scanning. We also support bright field and fluorescence scanning, as well as double-sized slides, improving convenience without compromising the quality of traditional glass samples. *For more details, please refer to the PDF document or feel free to contact us.

• Other contract services

Inari Research has over 40 years of experience as a contract research organization for non-clinical trials of pharmaceuticals and is one of the leading research facilities in Japan, certified by public institutions as a GLP-compliant facility. The safety tests conducted at our facility can be directly utilized for applications for specific health foods. Additionally, our researchers, who have extensive experience, will propose test designs tailored to meet your needs for functionality confirmation. 【Safety Tests】 ■ Single-dose toxicity test ■ 28-day repeated dose toxicity test ■ 90-day repeated dose toxicity test ■ Genotoxicity tests: Ames test, chromosomal aberration test (CHL cells, human lymphocytes), micronucleus test ■ Other tests *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research has over 40 years of experience as a contract research organization for non-clinical trials of pharmaceuticals and is one of the leading research facilities in Japan, certified by public institutions as a GLP-compliant facility. The safety tests conducted at our facility can be directly utilized for applications for specific health foods. Additionally, our researchers, who have extensive experience, will propose test designs tailored to meet your needs for confirming functionality. 【Functional Tests】 ■ Insulin resistance improvement effect test ■ Lipid-lowering effect test in hyperlipidemia models ■ Antihypertensive effect test in hypertension models ■ Arthritis improvement effect test in rheumatoid arthritis models ■ Antitumor effect test *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research has delivered numerous translated documents to our clients over its 40-year history as a non-clinical trial CRO. Our translation department is located within the non-clinical trial contract laboratory. Our staff, trained and educated as GLP system personnel, possess highly specialized knowledge and extensive experience in translation. We have earned a reputation for providing high-quality and stable translation services. If you are considering translation services, please feel free to consult with us. 【Features】 ■ We can also handle translations of reports from trials conducted by other companies. ■ Our in-house translators respond quickly. ■ We provide highly accurate translations through a triple-check system. ■ We have native speakers on staff. ■ Native checks by overseas experts are also available upon request. *For more details, please refer to the PDF materials or feel free to contact us.

• Translation/Interpretation

Inari Research utilizes the method of "Microsampling," which involves blood collection of 50μL or less, in small animal safety testing. This consideration aligns with the 3Rs (Reduction, Replacement, Refinement). We obtain TK Profiles using toxicology test animals (rats and marmosets). Additionally, we can link toxicity evaluations to blood drug concentrations, reduce the amount of test substances, and lower costs. 【Features】 ■ Consideration for the 3Rs (Reduction, Replacement, Refinement) ■ Obtaining TK Profiles using toxicology test animals (rats and marmosets) ■ Conducting TK on the same satellite animals (mice) ■ Ability to link toxicity evaluations to blood drug concentrations ■ Reduction of test substance amounts and cost savings In Plasma Micro-Sampling (PMS): ■ Blood collection volume reduced to 1/15 to 1/10 ■ Measurement sensitivity increased by 20 times *Please feel free to contact us regarding toxicology test design and the development of high-sensitivity measurement methods.

• Other contract services

Inari Research supports toxicity testing from the screening stage until entering clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data in standard test systems such as mice, rats, rabbits, dogs, and of course, monkeys. The tests are conducted in a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). We can complete a series of non-clinical test sets, including genotoxicity tests and safety pharmacology tests necessary to enter clinical trials (Phase I), with the final report preparation finished within six months. 【Main Types of Tests】 ■ Single-dose tests ■ Expanded single-dose toxicity tests ■ Repeated dose tests for 2 weeks, 4 weeks (1 month), 13 weeks (3 months), 26 weeks (6 months), 39 weeks (9 months), and 52 weeks (12 months) ■ Various dose-setting tests ■ General toxicity tests in the drug discovery exploration stage, etc. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening stage until entering clinical trials (clinical studies). We conduct a wide range of tests based on extensive testing experience and accumulated background data in standard test species such as mice, rats, rabbits, dogs, and of course, monkeys. Tests are conducted in a GLP-compliant facility that has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). A series of non-clinical test sets, including genotoxicity tests and safety pharmacology tests necessary to enter clinical trials (Phase I), can be completed with the final report prepared within six months. 【Tests using rodents】 ■Animal species: Mice, rats, hamsters ■Routes of administration: Oral administration, intravenous administration, intraperitoneal administration, subcutaneous administration, transdermal administration, rectal administration ■Tests are also conducted using 24-hour continuous intravenous infusion in rats. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening stage until entering clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data in standard test species such as mice, rats, rabbits, dogs, and of course, monkeys. Tests are conducted in a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). A series of non-clinical test sets, including genotoxicity tests and safety pharmacology tests necessary to enter clinical trials (Phase I), can be completed with the final report prepared within six months. [Tests using dogs] - Animal species: Beagles from domestic and international breeding sites - Routes of administration: Oral, intravenous, subcutaneous, intramuscular, ocular, transdermal, intra-articular, and rectal administration - Tests can also be conducted using continuous intravenous infusion for 24 hours. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening stage until entering clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data in standard test systems such as mice, rats, rabbits, dogs, and of course, monkeys. The tests are conducted in a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). A series of non-clinical test sets, including genotoxicity tests and safety pharmacology tests necessary to enter clinical trials (Phase I), can be completed with the final report prepared within six months. [Test using rabbits] ■ Routes of administration: oral administration, intravenous administration, ocular administration, intramuscular administration, subcutaneous administration, transdermal administration, rectal administration. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening stage until entering clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data in standard test systems such as mice, rats, rabbits, dogs, and of course, monkeys. Tests are conducted at a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). A series of non-clinical test sets, including genotoxicity tests and safety pharmacology tests necessary to enter clinical trials (Phase I), can be completed with the final report prepared within six months. [Test using cynomolgus monkeys] - Routes of administration: oral administration, intravenous administration, intramuscular administration, topical administration, subcutaneous administration, ocular administration, intraperitoneal administration, rectal administration - Tests can also be conducted with continuous intravenous infusion for 24 hours. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening stage until entering clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data in standard test species such as mice, rats, rabbits, dogs, and of course, monkeys. The tests are conducted in a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). A series of non-clinical test sets, including genotoxicity tests and safety pharmacology tests necessary to enter clinical trials (Phase I), can be completed with the final report prepared within six months. [Test using young animals] ■Animal species: Rats, Dogs ■Administration timing: - Young rats can be administered orally, intravenously, or subcutaneously from day 4 of age; transdermal administration is possible from day 23 onwards. - Young dogs can start administration from 3 weeks of age. ■Routes of administration: Oral, intravenous, subcutaneous, transdermal *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening phase to the entry into clinical trials (clinical studies). In addition to application tests in accordance with guidelines, our staff, who have extensive experience and achievements, will also handle screening tests. We conduct our tests at a GLP-compliant facility that has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). A series of non-clinical test sets, including genotoxicity tests and safety pharmacology tests necessary to enter clinical trials (Phase I), can be completed with the final report prepared within six months. 【Genotoxicity Tests】 ■ Reverse mutation test (Ames test) ■ In vitro / in vivo chromosome aberration tests ■ In vitro / in vivo micronucleus tests ■ Phototoxicity tests (3T3 cells) ■ In vivo comet assay *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research's reproductive and developmental toxicity testing boasts top-class achievements in Japan, backed by reliable technology and extensive background data. Even in reproductive tests where stress on the mother animal directly affects the evaluation, we continue to collect stable data through various administration routes such as oral, intravenous, subcutaneous, and transdermal. Certified reproductive and developmental toxicity specialists support the testing from design to evaluation. 【Main Types of Tests】 ■ Tests that encompass all reproductive and developmental processes as outlined in ICH guidelines are possible: - Tests related to fertility and early embryonic development up to implantation (mice, rats) - Tests concerning prenatal and postnatal development as well as the functions of the mother animal (rats) - Tests related to embryonic and fetal development (mice, rats, rabbits) - Single tests (rats) *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening stage to the entry into clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data in standard test systems such as mice, rats, rabbits, dogs, and of course, monkeys. Experienced pathologists in carcinogenicity testing perform tumor diagnoses. The results of tumor diagnoses can undergo peer review by pathologists both domestically and internationally. 【Carcinogenicity Testing】 ■ Long-term carcinogenicity tests using mice and rats (preliminary tests, main tests) - Can be conducted via oral (forced, mixed feed), dermal, subcutaneous, and other routes of administration. ■ Short-term carcinogenicity tests - Short-term carcinogenicity tests using genetically modified mice are also possible. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening phase to the entry into clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data using standard test subjects such as mice, rats, dogs, and of course, monkeys. Safety pharmacology tests are conducted in accordance with guidelines. GLP compliance is available. Our knowledgeable staff ensures stable data delivery. Measurements during intravenous injections are also possible. 【Safety Pharmacology Core Battery Tests】 ■ Central Nervous System - FOB (Rats, Dogs, Monkeys) - Irwin Method (Mice) ■ Cardiovascular System - Telemetry tests using unanesthetized animals (Dogs, Monkeys) - hERG (HEK293, CHO) Other tests, such as measurements with Holter electrocardiograms, can be conducted under various conditions including unrestrained/restrained and unanesthetized/anesthetized, according to your requests. ■ Respiratory System - Measurement of respiratory rate, tidal volume, and minute ventilation (unanesthetized/unrestrained rats) - Blood gas measurements (unanesthetized dogs/monkeys) *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

Inari Research supports safety testing from the screening phase to the entry into clinical trials (clinical studies). In addition to core battery tests based on guidelines, we can propose various follow-up tests and supplementary safety pharmacology tests. With the testing techniques and know-how cultivated over many years, we will suggest appropriate test designs. We also conduct specialized tests such as dependency tests on macaques and rats in the central nervous system. [Central Nervous System Examples] ■ General Condition (Dogs, Cynomolgus Monkeys) - Action search based on the drug's action characteristics ■ Motor Coordination (Mice, Rats) ■ Spontaneous Activity (Mice, Rats) ■ Anesthesia Cooperation/Antagonism (Mice, Rats) - Drug effects under pentobarbital anesthesia ■ Pain Sensation (Mice, Rats) - Tail flick method, pressure stimulation method, etc. ■ Catalepsy Observation (Mice, Rats, Dogs, Macaques) - Searching for catalepsy-inducing effects based on the duration of standing posture, etc. ■ Aversion Effect Tests (Macaques) - Searching for aversion effects through lever-pressing behavior, etc. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports safety testing from the screening phase to the entry into clinical trials (clinical studies). In addition to core battery tests based on guidelines, we can propose various follow-up tests and supplementary safety pharmacology tests. With the testing techniques and know-how we have cultivated over many years, we will propose appropriate test designs. 【Cardiovascular System, Respiratory System】 - Measure action potential duration (APD) using guinea pig papillary muscles or ventricular muscles. - Observe the effects of drugs on the heart using excised atria from guinea pigs. - Measure Enhanced Pause (Penh), an indicator of airway resistance, using unanaesthetized, unrestrained rats. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports safety testing from the screening phase to the entry into clinical trials (clinical studies). In addition to core battery tests based on guidelines, we can propose various follow-up tests and supplementary safety pharmacology tests. With the testing techniques and know-how cultivated over many years, we will propose appropriate test designs. 【Gastrointestinal System Examples】 ■ Effects on gastrointestinal mucosa (rats) - Search for effects on gastrointestinal mucosa through macroscopic observation or pathological examination. ■ Effects on gastric secretion (rats, dogs, monkeys) - Search for effects on gastric secretion using pyloric ligation or gastric lavage methods. ■ Effects on intestinal secretion (rats) - Search for effects on intestinal secretion by measuring the moisture content of the intestines. ■ Effects on bile secretion (rats) ■ Vomiting observation (dogs, monkeys) - Observation of the frequency of vomiting and the contents of vomit. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports safety testing from the screening phase to the entry into clinical trials (clinical studies). In addition to core battery tests based on guidelines, we can propose various follow-up tests and supplementary safety pharmacology studies. With the testing techniques and know-how cultivated over many years, we will propose appropriate test designs. 【Impact Tests on Skeletal Muscle】 ■ Using rat sciatic nerve and gastrocnemius muscle specimens, we investigate the effects of drugs on the neuromuscular junction. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports safety testing from the screening phase to the entry into clinical trials (clinical studies). In addition to core battery tests based on guidelines, we can propose various follow-up tests and supplementary safety pharmacology tests. With years of accumulated testing techniques and know-how, we offer appropriate test designs. 【Kidney/Urological System】 ■ Measure urine volume and Na, K, Cl in urine to investigate the effects of drugs on water and electrolyte metabolism ■ Subjects: Rats, Dogs, Cynomolgus Monkeys *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports safety testing from the screening phase to the entry into clinical trials (clinical studies). In addition to core battery tests based on guidelines, we can propose various follow-up tests and supplementary safety pharmacology tests. With the testing techniques and know-how we have cultivated over many years, we will propose appropriate test designs. 【Tests on Blood Effects】 ■ Search for the effects of drugs on hemolysis and the blood coagulation system ■ Subjects: Rats, Rabbits, Dogs *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing from the screening stage until entering clinical trials (clinical studies). We conduct a wide range of tests based on our extensive testing experience and accumulated background data using standard test species such as mice, rats, rabbits, dogs, and monkeys. Tests are conducted at a GLP-compliant facility that has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). A series of non-clinical test sets, including genotoxicity tests and safety pharmacology tests necessary to enter clinical trials (Phase I), can be completed with the final report prepared within six months. 【Local Irritation Tests】 ■Animal species: Mice, rabbits, guinea pigs, hamsters ■Application sites: Skin, ocular mucosa, blood vessels, muscles, nasal mucosa, oral mucosa, rectal mucosa, knee joint cavity, etc. 【Other Tests】 ■Ocular irritation test during contact lens wear (rabbits) ■Phototoxicity test (mice, guinea pigs) ■In vitro hemolysis test (blood from rabbits, dogs, humans, etc.) *For more details, please refer to the PDF document or feel free to contact us.

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