Cytiva List of Products and Services

The iCELLis® single-use bioreactor is an integrated high-density cell culture bioreactor that combines the advantages of single-use technology and fixed-bed bioreactors to simplify processes. Designed with a focus on rapid setup and ease of use, this compact system allows for a cell adhesion area of 4 square meters in a benchtop system, and commercial production systems can achieve a maximum culture area of 500 square meters with just 3.2 square meters of footprint! It enables cell seeding at lower densities (1000 cells/cm² for Vero cells), significantly reducing manual labor and associated costs by simplifying the process. 【Features】 ■ Simplifies the process from pre-culture to product ■ Integrated single-use bioreactor ■ Rapid process development due to simple structure ■ Linear scalability from research and development to actual production ■ High cell density achieves volume reduction and productivity improvement compared to traditional tank stirred bioreactors *For more details, please refer to the PDF document or feel free to contact us.

Enfron® PFR is a hydrophobic filter with sterilizing grade (0.2μm) that achieves high flow characteristics and long filtration life. It demonstrates excellent durability for the filtration and sterilization of pressurized air, various vent applications, and repeated steam sterilization. 【Main Features】 ■ Validated as a sterilizing grade filter through a bacterial challenge test using B. diminuta (ATCC19146) at a concentration of 1x10^7 cfu/square centimeter or more. ■ Also validated through challenge tests using aerosolized B. diminuta and PP7 bacteriophage (25 nm). ■ Improved reverse pressure strength of the filter cartridge during in-line steam sterilization (SIP) to 0.05 MPa (125°C). ■ Integrity tests that correlate with sterilization performance are possible (forward flow test, pressure hold test, water intrusion test).

The Allegro(TM) STR single-use bioreactor achieves high mixing capabilities and a low overall height of less than 3 meters, even with a capacity of 2,000 L, thanks to its rectangular culture vessel, which surpasses the performance of traditional cylindrical culture vessels. ■ High Mixing Capability The effective baffle effect of the rectangular culture vessel and the elephant ear-shaped mixing blades allow for the desired oxygen transfer rate to be achieved at lower stirring speeds than before. This results in high kLa and P/V values, reducing shear stress on cells during cultivation at lower stirring speeds. ■ Geometric Similarity Across All Scales, Including Mixing Blades Maintains a similar shape across all scales of 50, 200 L, 500 L, 1,000 L, and 2,000 L. ■ Scalable with Constant P/V Due to geometric similarity and the ability to achieve high P/V values, scaling up with constant P/V is possible. ■ Overall Height Below 3 M Even at 2,000 L Significantly reduces the need for high-altitude work, ensuring the safety of operators. ■ Easy Installation of Dedicated Culture Bags After transporting the single-use culture bag into the culture vessel, it can be set up within 30 minutes with minimal operator intervention.