Cytiva List of Products and Services

The "Allegro(TM) 3D Biocontainer" is a single-use bag developed for the storage of large volumes of liquid. It is designed with a focus on high reliability and flexibility, making it very easy to install and handle in the protective tote (receiver container). Additionally, the film used meets the demands of the manufacturing processes for pharmaceuticals, which require high performance. The 3D Biocontainer, which expands the lineup from the 2D Biocontainer, is designed with the latest technology to enhance the robustness of single-use systems, improve operability when handling large volumes of liquid, and increase product recovery rates. 【Features】 ■ Unique design that improves operability ■ Easy and quick installation ■ No need for accessory protection during liquid filling ■ Validation data compliant with regulatory requirements *For more details, please refer to the catalog or feel free to contact us.

The CleanPack(R) Presto Sterile Connector is a sterile connector that does not distinguish between male and female. This sterile connector enables reliable sterile connections between flow paths for all applications in biopharmaceutical manufacturing. 【Applications】 - Preparation and transfer of media and buffers - Cell seeding into culture vessels - Sampling during fermentation/cell culture - Recovery of culture medium from culture vessels - Aseptic fluid transfer between units - Probe insertion into culture vessels, mixers, and 3D biocontainers - Connection of filtration sterilization manifolds *For more details, please refer to the catalog or feel free to contact us.

The "CleanPack® Sterile Connector" is a product that allows for easy sterile connections in a dry state. It consists of a male connector and a female connector, each covered with a strip featuring a venting function. This strip uses a pharmaceutical filtration sterilization filter with membranes from Paul, a company with a long-standing track record. This protects the connection surfaces and maintains the sterility of the flow path. 【Features】 ■ No special capital investment required ■ Can be connected in just a few seconds ■ Autoclave sterilization or gamma radiation sterilization is possible ■ Easy to connect even in narrow environments ■ The connection surfaces are covered with a strip, maintaining sterility until use *For more details, please refer to the PDF materials or feel free to contact us.

The "Allegro(TM) 2D Biocontainer" is made from high-quality film that meets the performance and specifications required in the fields of biotechnology and pharmaceutical manufacturing. As part of a wide range of offerings, capacities are available from 50mL to 50L. It is equipped with various features necessary for single-use systems, including a sample port standard on all sizes, large-diameter ports for sensor installation, and compatibility with a variety of tube sizes to match process flow rates. 【Features】 ■ Shape that allows for efficient fluid discharge ■ Capable of filling to the specified capacity (full) even for applications requiring freezing ■ Inlet and outlet options available in 1/4 to 1/2 inch ■ Sensors can be inserted through the 1/2 inch port ■ Ports designed for connection with cable ties or BarbLock *For more details, please refer to the PDF document or feel free to contact us.

The "CleanPack® Sterile Disconnector" is an easy-to-use product that allows for reliable sterile cutting of flexible tubes even outside of controlled cleaning areas. It maintains the sterility of the flow path not only before cutting but also after cutting. It can be used in all stages of the process, making it particularly suitable for culture processes, liquid preparation processes, and filling processes where ease of use and sterility are essential. 【Features】 ■ Allows tube cutting without compromising the sterility of the flow path even outside of controlled cleaning areas ■ No special environmental maintenance equipment required ■ Can be cut in a short time ■ Easy to cut in tight spaces ■ Sterilization and microbial control via autoclaving or gamma irradiation are possible *For more details, please refer to the PDF document or feel free to contact us.

Paul has contributed to the establishment of many current standards regarding filter validation of critical processes and the use of single-use systems, based on over 40 years of experience in validation support. Moving forward, we will continue to be at the forefront of development to support the adoption of new technologies such as continuous production. We provide professional consulting and testing services while safeguarding our clients' highly confidential information. 【General Testing】 ■ Bacterial Challenge Testing ■ Compatibility Testing ■ Consulting on Extractables ■ Extractables and Leachables Testing ■ Leachables Reduction (Flushing) Testing ■ Integrity Testing Factor Setting with Pharmaceutical Solutions *For more details, please refer to the PDF materials or feel free to contact us.

Are you worried that introducing single-use technology will increase manual operations and lead to more human errors? Even with single-use equipment, full automation can be achieved just like with traditional stainless steel lines, and it's easy to do. In traditional automation systems for stainless steel piping and tanks, SIP and CIP were necessary, resulting in a vast number of valves and pipes, making it impossible to realize an automated process without constructing complex sequences. However, with automation systems for single-use processes, SIP and CIP are eliminated, allowing for automation through simple automatic sequences. With the Allegro MVP single-use automation system, sequences can be developed simply by inputting the parameters of unit processes and stacking them up. This enables customers to easily develop sequences on their own. Multiple sequences can be set up. Operators can select the sequence according to the process they are performing, and by simply pressing the Start button, the automated process begins. This eliminates human errors such as mistakenly opening clamps. *For more details, please download the PDF or feel free to contact us.

Enfron® PFR is a hydrophobic filter with sterilizing grade (0.2μm) that achieves high flow characteristics and long filtration life. It demonstrates excellent durability for the filtration and sterilization of pressurized air, various vent applications, and repeated steam sterilization. 【Main Features】 ■ Validated as a sterilizing grade filter through a bacterial challenge test using B. diminuta (ATCC19146) at a concentration of 1x10^7 cfu/square centimeter or more. ■ Also validated through challenge tests using aerosolized B. diminuta and PP7 bacteriophage (25 nm). ■ Improved reverse pressure strength of the filter cartridge during in-line steam sterilization (SIP) to 0.05 MPa (125°C). ■ Integrity tests that correlate with sterilization performance are possible (forward flow test, pressure hold test, water intrusion test).

The Allegro(TM) STR single-use bioreactor achieves high mixing capabilities and a low overall height of less than 3 meters, even with a capacity of 2,000 L, thanks to its rectangular culture vessel, which surpasses the performance of traditional cylindrical culture vessels. ■ High Mixing Capability The effective baffle effect of the rectangular culture vessel and the elephant ear-shaped mixing blades allow for the desired oxygen transfer rate to be achieved at lower stirring speeds than before. This results in high kLa and P/V values, reducing shear stress on cells during cultivation at lower stirring speeds. ■ Geometric Similarity Across All Scales, Including Mixing Blades Maintains a similar shape across all scales of 50, 200 L, 500 L, 1,000 L, and 2,000 L. ■ Scalable with Constant P/V Due to geometric similarity and the ability to achieve high P/V values, scaling up with constant P/V is possible. ■ Overall Height Below 3 M Even at 2,000 L Significantly reduces the need for high-altitude work, ensuring the safety of operators. ■ Easy Installation of Dedicated Culture Bags After transporting the single-use culture bag into the culture vessel, it can be set up within 30 minutes with minimal operator intervention.

Do you have any of these concerns? With the increase in the number of manufactured items leading to higher operational rates, and the need to accommodate the expansion of manufacturing lines and diversifying modalities, isn't the type and quantity of buffers required on the rise? The labor required to prepare, store, transport to the process room, and supply buffers to tanks can be reduced. "Innovation in Buffer Supply for Biopharmaceutical Manufacturing" By diluting the necessary amount of buffer inline when needed, buffer preparation can achieve labor savings and space reduction (up to 75%). Furthermore, an increase in productivity per area can be expected!