日本ウォーターズ（米国本社 Waters Corporation）　 List of Products and Services

SEC-MALS, which combines size exclusion chromatography and multi-angle static light scattering, is commonly used for the analysis of polymers but is also suitable for molecular weight analysis of low molecular weight (LMW) peptides. Multi-angle light scattering (MALS) detectors such as DAWN and miniDAWN are very useful for online measurement of the molecular weight of peptides under 1,000 daltons. LC-MS allows for detailed characterization analysis, including amino acid sequences and post-translational modifications. By combining LC-MS with SEC-MALS, comprehensive data can be obtained, ranging from detailed analysis to the overall molecular weight and aggregates of peptides. By clicking "Submit," you agree that Waters may use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Light Scattering Photometer
• High Performance Liquid Chromatograph
• Mass Spectrometer

To ensure safe and effective treatment, monitoring of the potency and titer of adeno-associated virus (AAV) vectors, encapsulation, aggregation, genome integrity, and other factors is necessary. By combining SEC (size exclusion chromatography), IEX (ion exchange chromatography), and MALS (multi-angle static light scattering), it is possible to accurately and efficiently evaluate critical quality attributes (CQA) such as the Full/Empty ratio, aggregation, and particle concentration of AAV. RT-MALS allows for real-time measurement of these parameters, which is useful for streamlining the manufacturing process. By combining size separation and light scattering analysis, exosomes can be isolated from other biological components, enabling the detection of new subtypes based on size, composition, charge, and even functional differences, allowing for comprehensive characterization. LC-MS enables the identification and quantification of gene sequences and proteins contained in AAV vectors. By clicking [Submit], you are deemed to have agreed that Waters may use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Light Scattering Photometer
• High Performance Liquid Chromatograph
• Chromatography Consumables

To quickly deliver safe and highly effective vaccines to the market, thorough characterization analysis is necessary. By using light scattering detectors, a wealth of information can be obtained regarding the vaccine's size, aggregation, stability, interactions, composition, and conformation. By combining MALS (Multi-Angle Light Scattering) and DLS (Dynamic Light Scattering), information about the conformation (shape and structure) of molecules can be derived from the ratio of Rh (hydrodynamic radius) to Rg (radius of gyration). Furthermore, by combining separation techniques such as SEC (Size Exclusion Chromatography) and FFF (Field Flow Fractionation), high-resolution size and molecular weight distribution measurements can be achieved. In LC-MS, peptide mapping allows for the confirmation of primary sequences and monitoring of post-translational modifications. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Other separation and analysis equipment
• High Performance Liquid Chromatograph
• Chromatography Consumables

mRNA has been gaining attention as a modality in recent years, but evaluation methods have not yet been established, posing challenges in product development. SEC-MALS (Size Exclusion Chromatography with Multi-Angle Light Scattering detection) serves as a powerful tool for evaluating important biophysical characteristics. By utilizing SEC-MALS, it is possible to measure molecular weight, size, and three-dimensional structure with high precision, obtaining essential information for the development and optimization of mRNA therapeutics. Furthermore, when combined with LC-MS, it enables more comprehensive characterization and biophysical property analysis. The use of LC-MS for the separation and analysis of synthetic nucleic acids is effective, allowing for the simultaneous acquisition of a wide range of information, including purity, impurity content, and sequence confirmation. With the enhancement of dedicated analysis software, anyone can easily perform data analysis, regardless of their experience with LC-MS. By clicking [Submit], you are deemed to have consented to Waters' use and processing of the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Light Scattering Photometer
• High Performance Liquid Chromatograph
• Mass Spectrometer

In the development of antibody drugs and antibody-drug conjugates (ADCs, etc.), it is essential to maximize the efficiency of the development process while ensuring the quality and safety of the products. By using light scattering detectors to evaluate size variants, aggregates, stability, and other factors from the early stages of development, it is possible to identify the characteristics of potential candidate antibodies early on and avoid risks and dropouts in the later stages of development. Combining this with LC-MS allows for even more comprehensive characterization. By clicking "Submit," you are deemed to have agreed to Waters' use and processing of the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Light Scattering Photometer
• High Performance Liquid Chromatograph
• Mass Spectrometer

Eclipse is an advanced system that accurately separates proteins, nanoparticles, and polymers by size using the Field-Flow Fractionation (FFF) method. It works in conjunction with the DAWN multi-angle light scattering detector to measure absolute molecular weight and molecular size, and it can also measure zeta potential using an electric field unit. 【Features】 - High-resolution separation of polymers, fine particles, and emulsions ranging from 1 to 1,000 nm - Sensitivity improved up to 10 times with the Dilution Control Module (DCM) - Zeta potential can also be measured using electric field-based FFF (EAF4) - High reproducibility with a temperature-controlled separation channel - One-touch switching to SEC-MALS - The control and analysis software VISION makes the design and optimization of separation conditions very easy By clicking [Send], you agree that Waters may use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Separation device

The DAWN series measures the molecular weight and size of macromolecules such as proteins with high precision, using multi-angle light scattering (MALS) without the need for calibration curves created from standard substances. It can be connected to HPLC and UPLC, enabling a wide range of applications. 【Features】 - DAWN (18-angle detector) offers high sensitivity and wide-range measurement. - A diverse lineup including DAWN8 (8-angle detector), miniDAWN (3-angle detector), microDAWN (UPLC-compatible model), and UltraDAWN (process-compatible model). - Automated cell cleaning with built-in ultrasonic cleaner COMET. - Equipped with a dynamic light scattering (DLS) module, allowing measurements from a radius of 0.5 nm (optional). - Real-time display of system status, with troubleshooting guidance functionality. By clicking [Send], you agree that the information provided on this site will be used and processed by Waters in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Analytical Equipment and Devices
• High Performance Liquid Chromatograph

The introduction of LC/MS in bioprocessing is progressing overseas. You might be thinking, "I use LC, but MS is difficult..." BioAccord is here to solve that concern. With its simple operability and high reproducibility, it is a recommended system for bioprocess engineers. Do you have any such impressions or questions? ■ Is evaluating aggregates sufficient with just LC? With LC/MS, you can also confirm the intact mass. ■ Is it enough to just confirm major post-translational modifications? With LC/MS, you can perform peptide mapping and post-translational modifications in a single analysis. ■ Is it sufficient to monitor only amino acids? With LC/MS, you can comprehensively detect components* in the culture medium, and integration with JMP is also possible. *Dependent on component concentration. ■ How do you preprocess samples taken from a bioreactor? It's easier than you think. After filtering out particulates, you can simply dilute with water or buffer to measure the intact mass of components and antibodies in the medium. Waters has a walk-up solution to automate this process. *For details, please download the catalog.

• Analytical Equipment
• Protein Analysis Software
• Other Analysis

The DynaPro ZetaStar can measure dynamic light scattering, static light scattering, and electrophoretic light scattering (DLS/SLS/ELS) all in one device, allowing for the acquisition of information on a wide range of molecular sizes, polydispersity, zeta potential, particle concentration, molecular weight, and turbidity/milky degree in up to 1/10 the time compared to conventional methods. It can be used for the analysis and quantification of virus vectors, vesicles, LNPs (lipid nanoparticles), inorganic nanoparticles, nanoemulsions, polymers, peptides, proteins, nucleic acids, and more. With high sensitivity even with very small sample amounts, it is suitable for rare and precious samples. 【Features】 - Supports both manual and automatic measurements - Measurement is completed with just a few clicks, making it easy to operate and reassuring for inexperienced users - Wide temperature setting range (-10 to 120°C) allows for evaluation of thermal degradation and behavior under various storage conditions - High salt concentration compatibility enables reliable measurements under physiological conditions and in formulation buffers - A variety of cell options and disposable cell compatibility eliminate the need for cuvette cleaning and sample carryover

• Light Scattering Photometer

The DynaPro Plate Reader 3 is a commercially available microplate that is a light scattering measurement device capable of measuring the size, molecular weight, concentration, and interactions of proteins, nanoparticles, and other polymers. This plate-based device allows for very high-throughput measurements compared to traditional cuvette-based light scattering devices. Additionally, after dispensing into the plate, there is no need to touch the liquid, minimizing sample carryover. 【Features】 - Compatible with commercially available microplates - Supports high-throughput measurement of multiple samples and automation - Simultaneous measurement of dynamic light scattering (DLS) and static light scattering (SLS) - Saves time and running costs - Non-destructive measurement allows the measured plates to be repurposed for other analytical devices

• Light Scattering Photometer

The DynaPro NanoStar 2 supports both dynamic light scattering (DLS) and static light scattering (SLS) measurements, allowing for the measurement of particle size distribution, particle concentration, interactions (kD, A2), and weight average molecular weight (Mw) of nanoparticles and proteins. It can be used for the analysis of proteins, gene therapy vectors, viruses and virus-like particles, indiscriminate inhibitors, micelles, liposomes, LNPs (lipid nanoparticles), and metal nanoparticles. To accommodate rare and precious samples, the specially designed quartz cuvette provides robust and accurate measurements with just 2 µL of solution. 【Features】 - Supports both dynamic light scattering (DLS) and static light scattering (SLS) measurements - Easy operation with an intuitive touchscreen - Achieves a wide range of temperature settings (-10 to 120°C) and fast temperature gradient settings - Connects with the multi-angle light scattering detector DAWN to support flow DLS measurements - Abundant cell options (2μL capacity quartz cell, 4μL capacity disposable cell, commercially available 4mL quartz cell, disposable cell (using adapter))

• Light Scattering Photometer

Waters offers a comprehensive portfolio of detection technologies for HPLC analysis. This enables the analysis of a wide range of compounds. Each detector comes with several selectable options, such as flow cells and nebulizers, suitable for the separation scale you are using. 【Features】 - A lineup of optional flow cells according to LC scale - Excellent linear range - Low dispersion characteristics, simple operation, high data acquisition speed 【Product Lineup】 - 2489 UV/Visible (UV/Vis) Detector - 2998 Photodiode Array (PDA) Detector - 2424 Evaporative Light Scattering (ELS) Detector - 2414 Differential Refractive Index (RI) Detector - 2475 Fluorescence (FLR) Detector - 2432 Electrical Conductivity Detector for HPLC Systems - 3465 Electrochemical Detector for LC Systems

• Analytical Equipment and Devices

Waters offers a comprehensive portfolio of detection technologies for UPLC/UHPLC analysis. This enables the analysis of a wide range of compounds. Each detector comes with several selectable options, such as flow cells and nebulizers, suitable for the separation scale you are using. 【Features】 - A newly designed dedicated group of detectors to detect sharp peaks obtained from UPLC - Detector cells that minimize diffusion 【Lineup】 - ACQUITY UPLC ELS Detector (ELSD) - ACQUITY UPLC RI Detector - ACQUITY UPLC and ACQUITY Premier FLR Detectors - ACQUITY UPLC PDA Detector - ACQUITY UPLC and ACQUITY Premier PDA eLambda Detectors - ACQUITY UPLC and ACQUITY Premier Tunable UV Detectors

• Analytical Equipment and Devices

Mass spectrometry imaging (MSI) has often utilized MALDI as an ionization method, but it requires specialized knowledge and expertise for matrix selection and application. On the other hand, DESI applies ESI technology, eliminating the need for a matrix and enabling the ionization of a wide range of molecules. DESI XS MSI has been applied in combination with time-of-flight (ToF) mass spectrometers to directly map molecules in tissue sections, making it ideal for non-target exploratory analysis. With the recent possibility of combining it with tandem quadrupole (TQ) mass spectrometers, the sensitivity, speed, and quantitativeness of target molecule measurements using multiple reaction monitoring (MRM) mode have improved, allowing for widespread application in various fields such as drug analysis, biomarker detection, and surface analysis of materials, focusing on the "localization + quantification" of molecules. A remarkable and unique method has become available to quantitatively clarify the localization of previously unseen molecules. 【Features】 - High-sensitivity, rapid, and highly selective visualization of molecular localization - Improved sensitivity and spatial resolution with a new high-performance sprayer - No complicated sample pretreatment required, enabling comprehensive and detailed spatial information acquisition

• Analytical Equipment and Devices

Many people are struggling with systems that are prone to contamination and time-consuming maintenance. The Xevo TQ Absolute, known for its resistance to contamination thanks to the "ZSpray Ion Source," along with a new source shield, minimizes contamination of the ion source from sample matrices and salts in the mobile phase. It also allows for the removal of neutral molecules before the mass separation section (StepWave XS), concentrating ions for introduction into the mass separation section. This helps maintain the system in a "good condition" for a longer period, maximizing uptime. As a latest high-sensitivity model, it achieves higher sensitivity and lower quantitation limits. Additionally, it is more compact compared to conventional products, reducing power and gas consumption by about 50%, and also decreasing heat generation by approximately 50%. 【Features】 - Sensitivity to anionic compounds improved by up to 15 times (compared to previous products) - Ensures consistent robustness and reproducibility, maintaining performance and productivity over a longer period - Reduces electricity and gas consumption by about 50% compared to typical high-performance TQ mass spectrometers, with heat generation also reduced by about 50%

• Mass Spectrometer

Using the state-of-the-art multi-reflecting time-of-flight mass spectrometry (MRT) technology, the SELECT SERIES MRT enables clear compound identification even in very complex samples, regardless of the scan rate, thanks to its high resolution and high specificity. The class-leading ToF mass resolution is achieved through innovative ion beam multi-reflection. This technology allows for high resolution and mass accuracy at sub-ppm levels across a wide m/z range, enabling very detailed structural characterization and overcoming many scientific challenges. 【Features】 - Consistently ppb level mass accuracy (<500ppb) - High mass resolution unaffected by measurement speed (>300,000 FWHM; 30Hz) - High data quality for both MS and MS/MS - Compatible with MS imaging (DESI, MALDI) and LC-MS applications

• Analytical Equipment and Devices

With the SELECT SERIES Cyclic IMS, ions can be selected based on both mass and mobility. By combining ion mobility and mass spectrometry, isomers can be separated based on shape and m/z, allowing for the measurement of ion collision cross-section (CCS) and obtaining very clean mass spectral data. Traditional mobility cells were linear, but by making them circular, the mobility resolution has dramatically improved. Ions can be repeatedly cycled within the cell, and the number of repetitions can be freely set.

• Analytical Equipment and Devices

Mass spectrometers, particularly high-resolution mass spectrometers capable of obtaining precise mass measurements, have traditionally been perceived as complex to operate, requiring deep knowledge and experience to master. However, this product overturns that image, offering a new concept device that anyone, from beginners to experts, can operate easily. With just one click, automatic setup is completed. It features a self-diagnosis function and automation capabilities from data acquisition to result summarization. Analysis is automatically performed upon completion, and reports tailored to the user's objectives are sent immediately. Additionally, despite being a single ToF, it supports CID and can obtain fragment information. Keep this compact single ToF, which can be installed with a 100V power supply, close at hand to enhance the efficiency of your daily operations. **Features:** - Precise mass analysis for screening and structural analysis from low to high molecular weights. - Simple operation allows anyone to easily obtain desired results. - Compact and energy-efficient. - Equipped with numerous functions to support measurement tasks, including automatic setup and self-diagnosis. - DI compatible. - A wide range of dedicated automatic analysis applications for various applications.

• Analytical Equipment and Devices

By using the Xevo G3 QTof, you can maximize the information about the analysis species from samples, enhancing the reliability of results from detailed characterization to accurate quantification. It simplifies and expands the characterization and evaluation of properties, from unstable low molecular weight compounds to complex biopharmaceuticals. By updating the design of the ion optical system and incorporating core technologies that achieve comprehensive quantification capabilities, consistent robustness and performance have been achieved. 【Features】 - Improved permeability of unstable low molecular compounds maximizes coverage of analysis species - Enhanced quantitativeness and expanded dynamic range within and between spectra enable optimal comprehensive quantification/qualitative analysis for screening and target applications - Improvements in the ion optical system lead to a more reliable and robust system - Achieves high levels of accuracy and reproducibility

• Analytical Equipment and Devices

The ACQUITY QDa II - Mass Detector (MS) achieves powerful and reliable separation. With the user-friendly and highly robust ACQUITY QDa II mass detector, the risks of unexpected components and co-elution are minimized, allowing for the reliable detection of trace components. This enhances the quality of analysis and improves productivity. Additionally, the ACQUITY QDa II mass detector has reduced energy consumption and thermal output by up to 70% compared to equivalent devices from other vendors, and it has very low operational costs, minimizing the environmental impact of the lab and maximizing operational efficiency. 【Features】 - Compact size - Easy-to-implement design with a straightforward price - Robust and easy to maintain - Optimized for immediate use without user adjustments - Acquire more information more quickly and easily - Earned the ACT environmental impact coefficient label

• Analytical Equipment and Devices

By using the state-of-the-art Xevo MRT mass spectrometer, which operates at 100 Hz with a mass resolution of 100K FWHM and mass accuracy within ppm, reliable identification and increased productivity can be achieved in the lab. The Multi-Reflection Time-of-Flight (MRT) technology ensures consistent mass resolution across a wide m/z range, regardless of the scan rate, even at the highest acquisition rates. This system guarantees excellent data quality, enabling scientific analysis, making it ideal for large cohort studies in biopharmaceutical research. 【Features】 - Reliable separation of analytes in complex matrices - Improved reliability of compound identification - Reproducible results due to high stability and robustness

• Analytical Equipment and Devices

The Arc Premier system incorporates innovative technology known as MaxPeak High Performance Surfaces (HPS). This allows for the effective reduction of nonspecific adsorption due to interactions with metals, without the need for complex mobile phases or labor-intensive analytical methods. As a result, the peaks of compounds that are susceptible to metal influence become sharper, yielding the following benefits: ■ Ideal for the analysis of organic acids, organophosphates, oligonucleotides, peptides, glycoproteins, phospholipids, veterinary medicines, chelating agents, and more. ■ Improved sensitivity and reduced risk of peak omission. ■ Elimination of column and system passivation and conditioning, saving time and costs. ■ Enhanced reproducibility and reliability of results. We also offer a variety of low-adsorption columns featuring MaxPeak High Performance Surfaces (HPS) technology. When used in combination with the system, more reliable analyses can be achieved. *We also offer online briefings and demonstrations, so please feel free to contact us.

• Analytical Equipment and Devices

Is the time it takes to obtain analysis results a bottleneck in the analysis of cell culture media (CCM), clone selection, process development, and optimization? Waters' bioprocessing walk-up solution eliminates that time lag and accelerates your decision-making. Efficient upstream bioprocessing from cell line development (CLD) to upstream process development (USP) requires a high-sensitivity, robust high-throughput analytical platform. This system is an ideal choice for at-line process analytical technology (PAT) that can overcome cumbersome routine measurements of CPP and CQA, with the capability to integrate with bioreactors such as Sartorius Ambr 15 and Ambr 250, achieving the following: ■ Streamlining the workflow from sample pretreatment to data acquisition through data analysis using samples from the bioreactor ■ Generating quantitative analytical results that guide process development (for both CPP and CQA) ■ Enabling faster and more reliable decision-making through high-quality data from samples taken from the bioreactor

• Analytical Equipment and Devices

This is a low-adsorption column that employs MaxPeak HPS technology, which minimizes the interaction between the analyte and column hardware (column tube) that can cause sample loss, thereby improving the recovery rate, sensitivity, and reproducibility of the analyte. MaxPeak HPS technology is an advanced surface treatment technology rather than a resin coating. It is designed to withstand the rigorous conditions of high-throughput laboratories, providing excellent performance that lasts without compromise. 【Features】 - Reduces the effort and time required for column conditioning and passivation - Improves sensitivity and peak shape - Allows analysis with a simpler mobile phase that does not contain complex additives - Saves time in method development - Reduces risk and enhances reliability in data and decision-making - A lineup compatible with all LC systems including UPLC/UHPLC/HPLC

• Separation device

With RapiZyme trypsin, it is possible to achieve uncompromising speed and clean digestion due to extremely high self-digestion resistance, high purity, and improved activity. It solves issues such as long pre-treatment times, noise from impurities (self-digestion, incompatibility, non-specific cleavage, cleavage errors), and poor reproducibility, resulting in highly reproducible and efficient digestion with minimal artifacts and high coverage. 【Features】 - High self-digestion resistance allows for the use of a high ratio (1:5) of enzyme, enabling efficient digestion in a short time. - Clean baseline without peaks of noise or artifacts. - High sequencing coverage rate. - Achieves reproducibility and predictability with chemically optimized recombinant expressed porcine trypsin. - Improved stability, recovery rate from vials, and activity upon re-dissolution. - Excellent robustness and flexibility to accommodate various protocols.

• Chemicals

The Waters GTxResolve Premier SEC column enables superior and faster separations by minimizing particle size to the extreme. Additionally, the new HO-PEO bonding reduces both ionic and hydrophobic adsorption, and the stable bonding also achieves noise reduction in MALS. The column tube is treated with MaxPeak technology, eliminating concerns about metal adsorption. 【Features】 - High separation capability allows for the detection of low-concentration impurities, accelerating the analysis of aggregates and size variants. - Provides reproducible data with minimal lot-to-lot and column-to-column variation. - Cost reduction through extended column lifespan. - Reduces secondary interactions and decreases noise in multi-angle light scattering detectors (MALS). - Utilizes low-adsorption hardware necessary for improving the recovery rate of biopharmaceuticals.

• Separation device

The OligoWorks solid-phase extraction (SPE) kit is designed to simplify and expedite the extraction of oligonucleotides and metabolites from biological samples, achieving high sensitivity and reproducibility in LC-MS analysis across a variety of oligonucleotide therapeutics, including lipid-binding molecular species. 【Features】 - High recovery rates across a wide range of oligonucleotide therapeutics - Robust protocols that facilitate method development - Streamlined workflow allowing direct injection into LC-MS systems - Improved sensitivity and reproducibility in LC-MS without the use of surfactants - Automation capability to reduce throughput, scalability, and manual handling - Consistent reproducible performance across lots, users, and days

• Chemicals

Waters vials and plates can minimize risks. High-quality products guarantee reliable results and improve data quality. ■ LCMS Quality Assurance Vials Carefully selected materials for optimal LC-MS analysis, with contamination managed during manufacturing and packaging processes. Significantly reduces ion suppression from vials. ■ TruView pH Control LCMS Quality Assurance Vials Prevents degradation of analytes sensitive to pH changes and minimizes adsorption of polar analytes. ■ Ultra High Purity Polypropylene (PP) Vials Ultra high purity vials made from carefully selected materials that minimize leachable components, suitable for high-sensitivity analysis using LC-MS/MS. Ideal for analyzing compounds that easily adsorb to glass. ■ QuanRecovery Vials & Plates Vials and plates that reduce sample loss due to non-specific binding (NSB) and ionic interactions, improving recovery rates, sensitivity, and reproducibility in the quantification of peptides and proteins using LC-MS.

• Other laboratory equipment and containers

PFAS have excellent chemical properties such as water and oil repellency and surfactant characteristics, and are used in a wide range of fields. On the other hand, due to their persistence and bioaccumulation, numerous cases of PFAS detection in water quality, the environment, and food have been reported both domestically and internationally. As a result, countries are advancing regulations and monitoring efforts, and there is a demand for more sensitive and accurate measurement technologies. In Japan, a ministerial ordinance was announced to raise the water quality standards for "PFOS" and "PFOA," which will take effect in April 2026. Waters is focusing on the development of methods for analyzing PFAS in trace amounts in various samples. In addition to providing analytical instruments, we also offer insights on sample preparation and blank contamination prevention, as well as service and support for the instruments, along with consulting services tailored to analytical needs. By clicking [Send], you agree that the information provided on this site will be used and processed by Waters in accordance with the Waters Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Other experimental consumables
• Column Chromatography

1. Centralized management of all measurement data NuGenesis SDMS connects with various measuring instruments present in the laboratory and collects all data generated by these instruments. It can connect regardless of the type or manufacturer of the measuring instruments. 2. Centralized management of all records and reports NuGenesis SDMS also collects reports created in tools like Microsoft Excel. 3. Access to data Data collected in NuGenesis SDMS can be accessed from anywhere according to user permissions. It also features electronic approval functionality. 4. Flexible search functions and data utilization NuGenesis SDMS allows searches using various methods such as text, structural formulas, and spectra. Quickly reaching the necessary information leads to effective data utilization. 5. Complete logging Data is logged (audit trail) with information on when and by whom it was generated, which helps in protecting intellectual property.

• Database

1. Centralized management of all measurement data NuGenesis SDMS connects with various measuring instruments present in laboratories and collects all data generated by these instruments, standardizing it into a machine-readable format. It can connect regardless of the type or manufacturer of the measuring instruments. 2. Extracting desired information from collected data and outputting files When NuGenesis SDMS collects data from measuring instruments, it automatically extracts the desired information based on the settings and outputs a text file. If upper systems like LIMS can automatically read this file, a mechanism can be established to automatically transfer measurement data to the upper system. 3. Data is securely stored Data collected in NuGenesis SDMS has access restricted by user. Logs (audit trails) are recorded, and overwriting or deletion is not permitted. 4. Flexible search functionality and electronic approval feature NuGenesis SDMS is equipped with various search methods, allowing instant access to the necessary information. It also includes an electronic approval feature.

• EAI/ETL/WEB application server

When the person planning the testing operations is different from the one executing them, or when multiple people are involved, managing a series of flows on paper can be cumbersome and time-consuming when dealing with issues. NuGenesis LMS addresses these challenges by integrating and managing information across all phases of the testing operations that proceed through the following flow: 1. Request for Testing Register samples and set necessary tests, responsible personnel, deadlines, etc. Once the settings are complete, sample labels and test instructions are automatically generated. The status of samples and tests can be checked in real-time. ↓ 2. Conducting Tests and Automatic Input of Results The test personnel conduct the tests based on the test instructions. Test results are directly input from measuring instruments via network or electronic media. ↓ 3. Evaluation of Results Individual results are evaluated against pre-set standards. ↓ 4. Approval of Results The scope of operations can be limited based on permissions set for each user, and approvals are also conducted based on these permissions. ↓ 5. Issuance of Reports Once the results are approved, reports are automatically generated. Forwarding to email is also possible.

• Internal Control and Operational Management

General benefits of digitizing experimental records: - Data can be shared within the organization and accessed from anywhere. - The search function significantly reduces the time spent looking for necessary data. - The utilization of data is promoted. Additional benefits with NuGenesis LMS: 1. Microsoft Excel, Word, etc., can be used within NuGenesis LMS. Functions and macros can be used as they are in Excel. Existing records and reports can be utilized. 2. Centralized management of all measurement data. Measurement data is collected and managed by connecting various measuring instruments present in the laboratory. It can connect regardless of the type or manufacturer of the measuring instruments. Data from measuring instruments is linked to experimental records. 3. Complete logging of records. Logs (audit trails) are recorded with the data, managing information such as when and by whom it was generated. This helps in protecting intellectual property. 4. Accumulating experimental records for further utilization. By linking the accumulated data with higher-level systems, it contributes to the promotion of digital transformation (DX).

• Document and Data Management

BioAccord LC-MS System 【Antibodies】 Aiming for the enhancement of antibodies as biopharmaceuticals Professor Ito, Department of Life Chemistry, Graduate School of Science and Engineering, Kagoshima University 【MAM】 Increasing MS users for the rapid launch of MAM Astellas Pharma Inc., Pharmaceutical Technology Division, Physical Research Institute 【Nucleic Acids】 For monitoring intermediates in oligonucleotide synthesis Ajinomoto Bio-Pharma Services, Gene Design Inc. Aiming for a wide range of development from small molecules to medium molecules, nucleic acids, and antibodies Shionogi Pharma Co., Ltd. To bring as many nucleic acid medicines as possible to address unmet medical needs Luxana Biotech Inc. Synthesis of functional artificial nucleic acids based on organic chemistry Associate Professor Tarajima and students from the Laboratory of Biological Organic Chemistry, Graduate School of Medical and Dental Sciences, Tokushima University 【Peptides】 For structural estimation of impurities in peptide synthesis Peptide Star Inc.

• Other protein analysis
• Time-of-flight mass spectrometer

In the quality control (QC) lab, there is a demand for product releases within increasingly strict timelines and budgets while addressing the ever-changing stringent compliance and data quality requirements. Meanwhile, the challenge of securing personnel with skills in LC analysis is becoming more pronounced, exacerbating these issues. The Alliance iS HPLC system provides reliable analytical results from the first run, shortening the product release cycle. Additionally, its software design prevents human errors that could lead to deviations, thereby strengthening the QC lab.

• Analytical Equipment and Devices

PFAS has excellent chemical properties such as water and oil repellency and surfactant characteristics, and is used in a wide range of fields. On the other hand, due to its persistence and bioaccumulation, numerous cases of PFAS detection in water quality, the environment, and food have been reported both domestically and internationally. As a result, countries are advancing regulations and monitoring efforts, and there is a demand for more sensitive and accurate measurement technologies. In Japan, a ministerial ordinance was announced to raise the water quality standards for "PFOS" and "PFOA," which will take effect in April 2026. Waters is focusing on developing methods for trace analysis of PFAS in various samples. In addition to providing analytical instruments, we offer insights on sample preparation and blank contamination prevention, as well as equipment service and support, along with consulting services tailored to analytical needs. By clicking [Send], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with the Waters Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Separation device
• Analytical Equipment and Devices
• Mass Spectrometer

In recent years, "functional ingredients" that add value to food have gained attention, and various foods containing these functional ingredients are being developed, manufactured, and sold as Foods for Specified Health Uses (Tokuho) and Foods with Functional Claims. However, in the analysis of functional ingredients contained in food, achieving excellent separation and high sensitivity detection using liquid chromatography (LC) often poses challenges, making it difficult to objectively evaluate flavor components that affect taste. Waters, as a specialized manufacturer of LC and mass spectrometers, supports reliable analysis of functional claim foods with high-sensitivity mass spectrometers, as well as total solutions including LC systems, columns, and informatics that achieve high separation. ★ Application notes and on-demand webinars are now available We are currently offering application notes and various materials related to reliable routine analysis of functional ingredients and flavor components. Please check them out under "Download."

• Analytical Equipment and Devices
• Mass Spectrometer

The self-inspection regarding the contamination of nitrosamines in pharmaceuticals, notified by the Ministry of Health, Labour and Welfare in October 2021, has a deadline of August 1, 2025. By the deadline, it is necessary to measure the amount of nitrosamines contained in items at risk of contamination, and if the levels exceed the limit, risk reduction measures such as setting standard values must be taken. When setting standard values for nitrosamines, it is essential to use systems and analytical conditions that enable high-sensitivity analysis, and we also want the systems to have the robustness to withstand daily analysis. Waters supports high-sensitivity and robust analysis of nitrosamines with total solutions including high-sensitivity and robust mass spectrometers, LC systems and columns that achieve high separation, and informatics, as a specialized manufacturer of LC and mass spectrometry. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Liquid Chromatograph
• High Performance Liquid Chromatograph
• Mass Spectrometer

The ACQUITY Premier system incorporates the new MaxPeak High Performance Surfaces (HPS) technology, which effectively reduces sample loss due to nonspecific adsorption caused by interactions with metals, while providing the following benefits: ■ Ideal for the analysis of organic acids, organophosphates, oligonucleotides, peptides, glycoproteins, phospholipids, veterinary drugs, chelating agents, and more. ■ Improved sensitivity and reduced risk of peak omission. ■ Elimination of column and system passivation and conditioning, saving time and costs. ■ Enhanced reproducibility and reliability of results. A variety of low-adsorption columns featuring MaxPeak High Performance Surfaces (HPS) technology are also available. When used in combination with the system, they enable more reliable analyses. *We also offer online briefings and demonstrations, so please feel free to contact us.

• Analytical Equipment and Devices

The networking of Chromatography Data Systems (CDS) is progressing, and recently there has been an active shift from on-premises to off-premises solutions, including cloud-based infrastructures. On the other hand, the damage caused by natural disasters and human-made disasters such as cyberattacks is becoming increasingly severe and frequent, necessitating countermeasures. BC LAC/E will address these needs as a new lineup of LAC/E32 within the Empower 3 network system. In cases where communication between the lab and the Empower 3 database server is interrupted for an extended period, BC LAC/E can be switched to a standalone system of Empower 3, allowing for the immediate recovery of chromatography analysis operations even after a disaster. The data necessary for analysis (various methods, user information, etc.) is always synchronized within BC LAC/E, ensuring smooth recovery even in unexpected situations.

• Liquid Chromatograph
• High Performance Liquid Chromatograph

Companies dealing with cosmetics and personal care products must continuously launch innovative products in a very short period to achieve growth and profitability goals in a fiercely competitive market. At the same time, they are required to address many challenges, such as responding to increasing demands from regulatory authorities, analyzing complex samples, ensuring product safety and efficacy, and countering the threat of counterfeit goods.

• Analytical Equipment and Devices
• Separation device

The ACQUITY APC column provides advanced packing technology for the separation of complex synthetic polymers and macromolecular species, delivering superior performance and reliability for high-resolution polymer characterization compared to conventional GPC columns. The ACQUITY APC column further enhances Advanced Polymer Chromatography as follows.

• Analytical Equipment and Devices

We offer the Japanese version of a guidebook that introduces all the basics of solid phase extraction (SPE) and successful techniques gathered from scientists around the world who have been involved with this technology over the past 30 years. Since the launch of the world's first solid phase extraction product, the Sep-Pak cartridge, in 1978, we present the culmination of SPE technology accumulated by Waters to date. Through this book, master the capabilities of SPE and utilize it freely in your lab. ＼ A total of 208 pages, filled with charts and diagrams! ／ ＼＼ Clearly explains the fundamentals of solid phase extraction ／／ * The "Solid Phase Extraction Beginner's Guide" is a paid resource. * It is not available at bookstores or other retailers. Please contact Waters or your local distributor for inquiries.

• Analytical Equipment and Devices
• Other laboratory equipment and containers
• Separation device

RADIAN ASAP is a new dedicated direct analysis system that enables rapid, easy, and low-cost analysis of liquid/solid samples. Developed by combining proven single quadrupole mass spectrometry technology with an atmospheric pressure solid sample analysis probe (ASAP), RADIAN ASAP is compact yet designed for high quality and ease of use. No special training or expertise, complex sample pretreatment, or separation is required! High-quality mass spectral data can be obtained, eliminating the need to wait for analysis results from other departments. The multivariate analysis software "LiveID" allows for real-time classification of samples analyzed using RADIAN ASAP. Information is immediately provided to the user during analysis, enabling informed real-time decision-making without doubts regarding sample identification. [Examples of applications in various fields] ■Pharmaceuticals: Reaction monitoring in exploratory research ■Chemical industry: Quality control of raw materials ■Food/Environment: Authenticity assessment of food ■Forensics: Rapid triage of seized drugs ■Academia: Education/analytical method development

• Analytical Equipment and Devices

The smart LIMS proposed by Waters is a next-generation LIMS that adds important features not found in traditional LIMS, such as raw data management, reagent and equipment management, and the utilization of existing resources. 1. Management of Raw Data It integrates and centrally manages analytical instrument data in various formats and electronic documents. It is also possible to automatically retrieve raw data files from analytical instruments. 2. Reagent Management and Equipment Management Reagent Management - Manages information such as reagent name, lot number, potency, expiration date, manufacturer, usage logs, and links to records that used the reagent. - Supports the issuance of barcode labels. Equipment Management Manages information such as equipment name, manufacturer, serial number, expiration date, calibration date, and regular inspection date, as well as usage logs and links to records that used the equipment. 3. Utilization of Existing Resources - Allows the creation of laboratory notebooks, templating, and data storage using office applications. For example, it can directly import records created in Excel (or through drag & drop). - Existing files can be templated as parts of records, reducing the development time for templates.

• Analytical Equipment and Devices
• Separation device