日本ウォーターズ（米国本社 Waters Corporation）　 List of Products and Services

Smartly perform routine analysis from exploration, development, process, to quality control! Features of the biopharmaceutical LC/MS system solution equipped with the concept of "SmartMS" ■ A compact and robust benchtop system utilizing SmartMS technology maximizes usability and accessibility ■ Optimized for routine biopharmaceutical analysis of proteins, peptides, and free glycans ■ Workflow-driven to expedite automatic data acquisition, analysis, and report generation ■ Compliance-ready, ensuring regulatory requirements are met *If you would like detailed materials or analysis examples, please feel free to contact us.

• Analytical Equipment
• Time-of-flight mass spectrometer

By implementing the Empower server system, it is possible to use Empower from home or while on business trips. • Empower can directly control not only our company's chromatographs (LC/GC) but also those from other manufacturers, enabling centralized management of chromatographic data. • It can be used without installing Empower on each terminal (also on laptops, tablets, and smartphones). • All operations of Empower, including analysis interruptions and re-injections, are possible. • You can carry out your work smoothly using the electronic approval function. * A terminal server with Citrix's XenApp installed is required. If you are interested, please feel free to contact us using the inquiry form below.

• Analytical Equipment and Devices
• Separation device

The Xevo TQ-GC is designed with the aim of ensuring reliable results in the measurement of real samples. This system undergoes rigorous testing to reduce the time spent on regular maintenance, maximize uptime with a maintenance schedule tailored to the lab's workload, and minimize downtime.

• Gas chromatograph
• Mass Spectrometer

The analysis of proteins with high molecular weight and complex structures is accompanied by many difficulties. Waters has developed a new reversed-phase column based on the feedback and requests from researchers and analysts who are actually working on protein analysis. The BioResolve RP mAb Polyphenyl column uses solid core particles with a particle size of 2.7 μm and incorporates novel functional groups, achieving not only improved separation but also significant improvements in carryover compared to low molecular weight compounds. At the same time, it reduces issues commonly associated with high temperatures and ion-pair reagents used in reversed-phase separation of proteins. Additionally, we offer guard columns and standards specifically designed for protein analysis, along with comprehensive support such as user-friendly procedures and analysis examples for those conducting protein analysis for the first time.

• Chromatography

From standard samples and reagents to separation columns, vials, LC, MS, and software for data analysis, Waters provides comprehensive support for our customers' inquiries. Waters' latest innovations in LC and LC/MS, particularly focused on biopharmaceuticals, are designed to address needs related to applications, the challenges posed by a large number of compounds, and regulatory compliance requirements that trouble development labs. Waters' solutions are adopted by leading companies worldwide, helping to obtain faster and more accurate answers regarding the characteristics and quality of biopharmaceuticals.

• Liquid Chromatograph
• Mass Spectrometer

The "Xevo TQ-S cronos" is a tandem quadrupole mass spectrometer developed to meet budgetary requirements while combining reliability and performance, making it suitable for your quantitative workflows. By achieving performance tailored to your objectives, it offers advantages such as targeting more compounds with a single injection and accommodating a wider concentration range. 【Features】 ■ Easily obtain and verify quantitative data to meet analytical and regulatory needs ■ Target more compounds with a single injection and accommodate a wider concentration range ■ Simplify the setup of robust analytical methods and measurement systems *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment and Devices

The "SYNAPT XS" is a drift time ion mobility mass spectrometer that offers excellent flexibility and provides great freedom in the choice of analytical methods to support scientific creativity and technical success across various applications. Our commitment to generating better science through better data is realized through the reproducibility and continuity of this product both daily and across different instruments. By providing the validity of reliable analysis, we facilitate the discovery process and enable confident progress towards innovation. 【Features】 ■ Provides multi-layered, information-rich data ■ Automation of higher-order structure determination is possible ■ Expands the possibilities of MS/MS ■ Supports various applications *For more details, please refer to the PDF materials or feel free to contact us.

• Analytical Equipment and Devices

The Alliance HPLC system, which meets all the functions required for HPLC, is a flexible and reliable high-performance liquid chromatography system. In addition to the performance standards demanded in research and development, it meets the stringent requirements for routine analysis in quality control. The Alliance HPLC system and HPLC columns are manufactured according to strict performance specifications, allowing for method transfer without inter-instrument variability, thereby providing consistent results across units and laboratories.

• Other physicochemical equipment
• Testing Equipment and Devices
• Other inspection equipment and devices

【Features】 ○ Reverse phase solid-phase filler ○ Conditioning and equilibration can be omitted due to water-wettable filler ○ Significantly reduces matrix effects that influence ionization, especially during MS detection ○ High recovery rates and reproducibility for a wide range of analytes ○ Minimal clogging, allowing for use at lower suction pressures and with less applied pressure ○ Maximizes the removal efficiency of lipids and phospholipids

• Other physicochemical equipment

This is the latest high-performance LC column family that maximizes the performance of laboratory LC systems. With high column efficiency, it achieves superior throughput and high separation compared to fully porous particle columns. It offers 1.6μm for UPLC, which realizes the ultimate theoretical plate count, and 2.7μm for HPLC/UHPLC, which is practical with low back pressure, allowing you to choose the optimal column for each analysis from a total of seven types of chemistry. Whether you want to separate complex samples or maintain separation while improving throughput, it delivers results beyond expectations. 【Features】 - Adoption of solid-core (core-shell) particles to maximize column efficiency - Particle size of 1.6μm for UPLC separation and 2.7μm for UHPLC/HPLC separation - A chemistry lineup that broadens selectivity for method development - Seven types of chemistry lineup: C18, C18+, T3, C8, Shield RP18, Phenyl, HILIC - Easy and seamless transfer of methods between 1.6μm and 2.7μm - Excellent reproducibility between batches and columns through comprehensive management of the entire manufacturing process from particle synthesis to final product

• Separation device

By extending the scope of analysis with extremely high sensitivity, we achieve an unprecedented level of reliability, reproducibility, and performance. Through the optimization of each technology, it has been designed with a focus on standardization, allowing a greater number of users to apply top-class sensitivity to a wider range of compounds.

• Separation device

By extending the range of analysis with extremely high sensitivity, we have achieved an unprecedented level of reliability, reproducibility, and performance. Through the optimization of each technology, it has been designed with a focus on standardization, allowing more users to apply class-leading sensitivity to a greater number of compounds.

• Separation device

By extending the range of analysis with extremely high sensitivity, we achieve an unprecedented level of reliability, reproducibility, and performance. Through the optimization of each technology, it has been designed with a focus on standardization, allowing more users to apply class-leading sensitivity to a greater number of compounds.

• Separation device

Extractables and leachables from polymers, monomers, and additives in plastics used in pharmaceutical packaging and single-use systems for biopharmaceuticals must be managed in terms of drug safety and quality. However, the analysis and evaluation of extractables/leachables from plastic products supplied by suppliers often lack clarity regarding the components, presenting numerous challenges. The wide range of technologies offered by Waters can accurately and cost-effectively identify extractables and leachables in a short period.

• Separation device
• Analytical Equipment and Devices

By extending the range of analysis with extremely high sensitivity, we achieve a high level of reliability, reproducibility, and performance. Through the optimization of each technology, it is designed with a focus on standardization, allowing more users to apply class-leading sensitivity to a greater number of compounds.

• Separation device

Empower 3 Chromatography Data Software (CDS) is a system that meets the demands of networking and enables more efficient data acquisition, management, analysis, and reporting. Empower makes it easy to meet requirements for data integrity. Empower provides the highest level of data integrity and traceability for all raw data, metadata, and result data.

• Other physicochemical equipment

Many of the LC columns currently available on the market cannot fully leverage the benefits derived from the performance of the latest UHPLC systems. Waters offers a variety of columns for UHPLC, such as CORTECS columns and eXtended Performance [XP] columns, to assist customers in overcoming challenges in their analyses. This expands the options for column selection and maximizes the potential of analytical laboratories. **Features** - CORTECS 2.7μm columns that utilize solid-core (core-shell) particles to maximize UHPLC separation performance - XP columns that use three types of particle substrates: ethylene-bridged hybrid (BEH), High Strength Silica (HSS), and Charged Surface Hybrid (CSH), providing excellent selectivity and flexibility in method development - Column sizes and particle diameters designed for UHPLC - Seamless method transfer between UPLC, UHPLC, and HPLC - Exceptional reproducibility between batches and columns through comprehensive management of the entire manufacturing process from silica and hybrid synthesis to the final product

• Separation device
• Analytical Equipment and Devices

Waters is developing a business based on chromatography. It is our customers who utilize this chromatography technology in their businesses. The innovative insights in your labs lead to the establishment of analytical/testing methods that contribute to business success. Our customers' "success" can be evaluated by continuously monitoring analytical methods and results, and it is essential that the chosen columns remain available for you to continue achieving "success" in the future. Many customers who fully understand the impact of column performance and innovation on "success" have chosen Waters' cutting-edge reversed-phase and HILIC HPLC column products. 【Features】 - Synthesis of silica and hybrid materials conducted in-house: Latest technology can be applied to particles. - All latest chromatography packing materials are consistently managed from starting monomers to final products. - Manufacturing facilities are certified cGMP, ISO9001, and ISO13485: Establishing analytical reliability through stringent quality control systems. - Most column hardware is also manufactured in-house from raw materials. - As a global company, we provide products of the same quality in countries around the world.

• Separation device
• Analytical Equipment and Devices

To better understand cellular functions and physiology, and to monitor the distribution of drug compounds in tissues or the entire organism, full-spectrum molecular imaging has refined and combined the advantages of several analytical techniques into a single device platform. By integrating MALDI, DESI, ion mobility mass spectrometry, and informatics workflows into a single system, Waters' full-spectrum molecular imaging provides detail and molecular information that surpasses any individual imaging technique.

• Analytical Equipment and Devices

Can we always reach the correct answer in one go with only high-resolution and high-precision mass data? When faced with complex samples containing multiple components, high resolution and precise mass alone may be insufficient to obtain all the information required for comprehensive analysis. The Vion IMS QTof, which opens the door to a new dimension called collision cross-section (CCS), is an innovative mass spectrometer that has never been seen before. There may be important components that have not been discovered yet, buried somewhere.

• Analytical Equipment and Devices

The "Xevo TQ-S micro" is a tandem quadrupole mass spectrometer that achieves excellent performance and flexible analysis in a compact design. It can reproduce high-quality analytical performance even with very complex sample matrices. With reliable operation of the device, it achieves outstanding sensitivity while being compact, maximizing the efficiency of the lab. 【Features】 ■ Detects low-concentration compounds even in complex matrices ■ Achieves excellent efficiency with high precision, accuracy, and robustness at lower injection volumes ■ Flexibility is further enhanced with a wide range of ion source and inlet options *For more details, please refer to the PDF document or feel free to contact us.

• Other physicochemical equipment
• Testing Equipment and Devices
• Analytical Equipment and Devices

Rapid Evaporative Ionization Mass Spectrometry (REIMS) is a novel sampling method that allows for the direct acquisition of molecular profiles from the surface of samples. Researchers involved in cutting-edge studies in areas such as food, microbiology, and histology can quickly and easily discern differences between samples and reliably identify the components responsible for those differences through deep insights into chemical or biological systems.

• Other physicochemical equipment
• Testing Equipment and Devices
• Other inspection equipment and devices

The Arc Multi-flow path technology and unique features such as Gradient SmartStart allow for the correction of differences between systems, enabling the reproduction of analytical methods using your existing HPLC. These innovative characteristics seamlessly reproduce chromatography results that meet your acceptance criteria for the methods you are already using, eliminating the need to change validated gradient tables. You can transfer, adjust, and improve analytical methods on the LC platform seamlessly and efficiently while ensuring the consistency of the methods without altering the already validated gradient tables.

• Other physicochemical equipment
• Testing Equipment and Devices
• Other inspection equipment and devices

Glycosylation of proteins is a very important post-translational modification that regulates both the structure and function of proteins. Changes in glycan profiles can affect drug efficacy and immunogenicity, so glycosylated biopharmaceuticals require thorough characterization. In the characterization of glycoproteins, the wide-pore HILIC amide column (Glycoprotein BEH Amide, 300Å), which provides complementary information with reverse phase columns, allows for the separation of intact glycoproteins, glycoprotein subunits, or at the glycopeptide level based on the number and composition of glycans, enabling the acquisition of unprecedented glycoform information.

• Other laboratory equipment and containers

■Extraction of glycans from glycoproteins, labeling, and purification can be completed in just three steps in 30 minutes. This dramatically improves the throughput of glycan analysis. ■Thanks to a significant increase in sensitivity, reliable glycan analysis is possible even with trace amounts of glycoproteins. Glycan identification is achievable from as little as 0.1 μg of glycoprotein. ■By combining a fluorescence detector with MS, both quantification and mass information of trace glycans can be obtained simultaneously in a single analysis. This enables reliable and rapid glycan analysis. ■The GlycoWorks HILIC μElution plate allows for easy and rapid purification. No more drying down is necessary. ■Everything needed for glycan extraction, labeling, and purification is packaged together. You can start preparing glycans right away.

• Other laboratory equipment and containers

Achieves a level of high sensitivity, chromatography performance, robustness, and operability that cannot be achieved by other MS systems.

• Analytical Equipment and Devices

The structure of glycans is extremely complex, requiring significant time for both separation and analysis. Additionally, sample preparation and reagent preparation can be cumbersome and time-consuming. We have prepared solutions to address these issues, enabling simple and highly reproducible glycan characterization. Our offerings include straightforward and robust sample preparation, excellent 2-AB labeling for glycan separation, and a database to improve and streamline glycan identification and structural elucidation, along with a lineup of analytical standards and reagents. For more details, please contact us or download the catalog.

• Analytical Equipment and Devices

We will demonstrate the advancements in size exclusion separation based on UPLC using data analyzed from polymer protein complexes, comparing it with HPLC data. Additionally, we will analyze monoclonal antibodies containing multivalent aggregates by connecting ACQUITY UPLC BEH SEC columns with pore sizes of 200 Å and 450 Å, showcasing the benefits obtained. 【Application Benefits】 ○ Compared to conventional HPLC-based SEC, improved separation of high molecular weight proteins up to 1.8 MDa. ○ In the analysis of monoclonal antibody aggregates containing dimers and higher-order multimers, the separation range is expanded by connecting the BEH450 SEC column with the BEH200 SEC column. For more details, please contact us or download the catalog.

• Other laboratory equipment and containers

Peptide mapping using formic acid instead of TFA enables more sensitive detection with ESI-MS. The CSH130 C18 shows outstanding performance regardless of the acidic modifier used, making it ideal for LC/MS-based peptide mapping. In LC/MS analysis using a formic acid mobile phase for enolase tryptic digest, the CSH130 C18, 1.7μm column achieved a 30% higher peak capacity compared to common fully porous or superficially porous C18 columns of the same particle size. Furthermore, analysis results of high molecular weight peptides and low molecular weight proteins demonstrated that the CSH130 C18 column with a pore size of 130Å is suitable for the separation of polypeptides up to approximately 10 kDa in molecular weight. 【Application Benefits】 - High peak capacity and unique selectivity compared to other C18 columns - Compatibility with formic acid and ESI-MS - High separation ability for analytes up to approximately 10 kDa - CSH130 C18 has been QC tested with cytochrome c tryptic digest For more details, please contact us or download the catalog.

• Other laboratory equipment and containers

The Glycan Performance Test Standard is labeled with human-type IgG using 2-AB. It has been verified that it contains two important glycans, Man-5 and Man-6, which are not necessarily present in human IgG. Man-5 is particularly important for confirming separation. If these glycans need to be added, it has been verified that the Glycan Performance Test Standard always contains Man-5 and Man-6. 【Features】 ○ Stable freeze-dried product ○ Immediately usable after dissolving in a 50-70% acetonitrile aqueous solution ○ Specially designed considering important criteria for column quality control used in quality management at Waters Corporation's column manufacturing facility For more details, please contact us or download the catalog.

• Other laboratory equipment and containers

To enable systematic analysis of fluorescently labeled N-glycans isolated from recombinant biopharmaceuticals using HILIC-UPLC(R). The data will be analyzed using a robust online glycan database that utilizes standardized retention times. 【Features】 ○ Structures including monosaccharide sequences, stereochemistry, and linkage types displayed in color or black and white diagrams → Linkage types represented in Oxford notation and CFG notation ○ GU retention time values and descriptive quality statistics For more details, please contact us or download the catalog.

• Analytical Equipment and Devices

Many harmful immune responses and diseases are believed to be caused by changes in protein conformation. Until now, X-ray crystallography and NMR-based analyses have primarily been used to measure protein conformation. While these analytical methods are useful, they are not applicable to all proteins and often require high-purity, large quantities of samples. Today, by effectively combining the ACQUITY M-Class HDX system with high-resolution mass spectrometry and rigorously controlling the temperature-sensitive aspects of the HDX sample preparation, we can reliably identify changes in protein conformation. This has made it possible to obtain detailed information about protein conformation. The ACQUITY M-Class HDX system adds a new dimension of separation capability, reproducibility, and durability to chromatography. 【Features】 - Binding of drugs to target molecules of proteins - Development of biopharmaceuticals - Protein-protein interactions - Research in structural biology For more details, please contact us or download the catalog.

• Analytical Equipment and Devices

Glycoprotein analysis requires the identification of complex N-linked and O-linked structures consisting of repetitive similar sugar components. Hydrophilic interaction chromatography (HILIC) utilizing fluorescence detection is a highly reliable analytical method that effectively separates and quantifies glycan chains labeled with fluorescent labeling reagents. The Waters Glycan Separation Technology column is a dedicated QC-tested column developed for the rapid analysis of various glycan structures with excellent UPLC(R) separation capability. By combining the Waters ACQUITY UPLC(R) system with column chemistry, accurate analytical results can be obtained more quickly. 【Features】 ○ Shorter time and higher separation capability compared to conventional HPLC methods ○ Ideal for use with the ACQUITY UPLC fluorescence detection system ○ Stable and reproducible separation of labeled glycan chains Waters BEH particles and functional group bonding technology ○ QC tests using labeled glycan standards are conducted to ensure consistent column performance between batches For more details, please contact us or download the catalog.

• Other laboratory equipment and containers

With UPLC technology, you can invest in the future by having the robustness and reliability to perform existing HPLC analytical methods within a single system, while optimally operating UPLC columns with particle sizes of 2 μm or less. The ACQUITY UPLC(R) system family serves as a platform for LC technology that can be utilized regardless of separation requirements, making it easy to enhance productivity and facilitate method transfer between facilities. 【Features】 - Six types of UPLC particles based on ethylene-bridged hybrid, High Strength Silica, and Charged Surface Hybrid - 22 types of stationary phases - Seven types of application-specific chemistries - Designed to seamlessly deliver performance with the ultra-low dispersion ACQUITY UPLC system - Over 200 options (column sizes and chemistries) available to select the optimal column that balances separation capability and throughput For more details, please contact us or download the catalog. *The catalog will be a digest version. If you need the full version, please contact us.

• Other laboratory equipment and containers

Waters' product development begins with a deep understanding of the challenges related to biomolecules that you are currently facing. We support a wide range of bioseparation with an extensive column lineup to solve various challenges such as sensitivity, separation, selectivity, and load capacity, from reversed phase and HILIC to SEC and ion exchange. Additionally, we provide reliable and high-quality products, from sample preparation products for biomolecules to reagents. For more details, please contact us or download the catalog.

• Other laboratory equipment and containers

ACQUITY UPC2 was born by applying ultra-high-performance liquid chromatography (UPLC) technology to supercritical fluid chromatography (SFC). This allows it to transcend traditional SFC and expand the separation domain of GC and LC chromatography. By using liquefied carbon dioxide (CO2) as the main mobile phase, it achieves high safety, cost reduction, and a lower environmental impact. It can simultaneously analyze mixtures containing compounds with significantly different polarities. Since all compounds that can be dissolved in solvents with lower polarity than alcohols, such as methanol, are targets for analysis, it caters to a wide range of analytical tasks in various fields, including pharmaceuticals, chemical industry, food, environment, and clinical applications. For more details, please contact us or download the catalog.

• Analytical Equipment and Devices

UltraPerformance LC (UPLC) is the result of a total system innovation that has redesigned all aspects of traditional HPLC, including packing material technology, column design, injectors, fluid delivery systems, and detectors. UPLC technology was developed to simultaneously enhance laboratory productivity, efficiency, and throughput for scientists seeking reliable technology. Its success has already been demonstrated through thousands of peer-reviewed papers, application notes, and significant process improvements, making UPLC a standard technology that delivers important scientific and business benefits in leading companies and research institutions around the world. We offer a diverse lineup that allows for effective use of this technology not only in research settings but also in production management. Since the launch of ACQUITY UPLC in 2004, Waters has continued to pursue further innovations, and the new ACQUITY UPLC PLUS series has been introduced, achieving even greater flexibility, performance, and ease of use.

• Analytical Equipment and Devices
• Separation device

To achieve the highest quality in instrument analysis, analytical standards and reagents are essential. Waters Corporation, which has been addressing this issue for some time, has launched a new business for the manufacturing and certification of analytical standards and reagents.

• Analytical Equipment and Devices