日本ウォーターズ（米国本社 Waters Corporation）　 List of Products and Services

PFAS has excellent chemical properties such as water and oil repellency and surfactant characteristics, and is used in a wide range of fields. On the other hand, due to its persistence and bioaccumulation, numerous cases of PFAS detection in water quality, the environment, and food have been reported both domestically and internationally. As a result, countries are advancing regulations and monitoring efforts, and there is a demand for more sensitive and accurate measurement technologies. In Japan, a ministerial ordinance was announced to raise the water quality standards for "PFOS" and "PFOA," which will take effect in April 2026. Waters is focusing on developing methods for trace analysis of PFAS in various samples. In addition to providing analytical instruments, we offer insights on sample preparation and blank contamination prevention, as well as equipment service and support, along with consulting services tailored to analytical needs. By clicking [Send], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with the Waters Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

In the quality control (QC) lab, there is a demand for product releases within increasingly strict timelines and budgets while addressing the ever-changing stringent compliance and data quality requirements. Meanwhile, the challenge of securing personnel with skills in LC analysis is becoming more pronounced, exacerbating these issues. The Alliance iS HPLC system provides reliable analytical results from the first run, shortening the product release cycle. Additionally, its software design prevents human errors that could lead to deviations, thereby strengthening the QC lab.

Waters offers a comprehensive portfolio of detection technologies for HPLC analysis. This enables the analysis of a wide range of compounds. Each detector comes with several selectable options, such as flow cells and nebulizers, suitable for the separation scale you are using. 【Features】 - A lineup of optional flow cells according to LC scale - Excellent linear range - Low dispersion characteristics, simple operation, high data acquisition speed 【Product Lineup】 - 2489 UV/Visible (UV/Vis) Detector - 2998 Photodiode Array (PDA) Detector - 2424 Evaporative Light Scattering (ELS) Detector - 2414 Differential Refractive Index (RI) Detector - 2475 Fluorescence (FLR) Detector - 2432 Electrical Conductivity Detector for HPLC Systems - 3465 Electrochemical Detector for LC Systems

The ACQUITY Premier system incorporates the new MaxPeak High Performance Surfaces (HPS) technology, which effectively reduces sample loss due to nonspecific adsorption caused by interactions with metals, while providing the following benefits: ■ Ideal for the analysis of organic acids, organophosphates, oligonucleotides, peptides, glycoproteins, phospholipids, veterinary drugs, chelating agents, and more. ■ Improved sensitivity and reduced risk of peak omission. ■ Elimination of column and system passivation and conditioning, saving time and costs. ■ Enhanced reproducibility and reliability of results. A variety of low-adsorption columns featuring MaxPeak High Performance Surfaces (HPS) technology are also available. When used in combination with the system, they enable more reliable analyses. *We also offer online briefings and demonstrations, so please feel free to contact us.

UltraPerformance LC (UPLC) is the result of a total system innovation that has redesigned all aspects of traditional HPLC, including packing material technology, column design, injectors, fluid delivery systems, and detectors. UPLC technology was developed to simultaneously enhance laboratory productivity, efficiency, and throughput for scientists seeking reliable technology. Its success has already been demonstrated through thousands of peer-reviewed papers, application notes, and significant process improvements, making UPLC a standard technology that delivers important scientific and business benefits in leading companies and research institutions around the world. We offer a diverse lineup that allows for effective use of this technology not only in research settings but also in production management. Since the launch of ACQUITY UPLC in 2004, Waters has continued to pursue further innovations, and the new ACQUITY UPLC PLUS series has been introduced, achieving even greater flexibility, performance, and ease of use.

Waters offers a comprehensive portfolio of detection technologies for UPLC/UHPLC analysis. This enables the analysis of a wide range of compounds. Each detector comes with several selectable options, such as flow cells and nebulizers, suitable for the separation scale you are using. 【Features】 - A newly designed dedicated group of detectors to detect sharp peaks obtained from UPLC - Detector cells that minimize diffusion 【Lineup】 - ACQUITY UPLC ELS Detector (ELSD) - ACQUITY UPLC RI Detector - ACQUITY UPLC and ACQUITY Premier FLR Detectors - ACQUITY UPLC PDA Detector - ACQUITY UPLC and ACQUITY Premier PDA eLambda Detectors - ACQUITY UPLC and ACQUITY Premier Tunable UV Detectors

Extractables and leachables from polymers, monomers, and additives in plastics used in pharmaceutical packaging and single-use systems for biopharmaceuticals must be managed in terms of drug safety and quality. However, the analysis and evaluation of extractables/leachables from plastic products supplied by suppliers often lack clarity regarding the components, presenting numerous challenges. The wide range of technologies offered by Waters can accurately and cost-effectively identify extractables and leachables in a short period.

The structure of glycans is extremely complex, requiring significant time for both separation and analysis. Additionally, sample preparation and reagent preparation can be cumbersome and time-consuming. We have prepared solutions to address these issues, enabling simple and highly reproducible glycan characterization. Our offerings include straightforward and robust sample preparation, excellent 2-AB labeling for glycan separation, and a database to improve and streamline glycan identification and structural elucidation, along with a lineup of analytical standards and reagents. For more details, please contact us or download the catalog.

The Arc Premier system incorporates innovative technology known as MaxPeak High Performance Surfaces (HPS). This allows for the effective reduction of nonspecific adsorption due to interactions with metals, without the need for complex mobile phases or labor-intensive analytical methods. As a result, the peaks of compounds that are susceptible to metal influence become sharper, yielding the following benefits: ■ Ideal for the analysis of organic acids, organophosphates, oligonucleotides, peptides, glycoproteins, phospholipids, veterinary medicines, chelating agents, and more. ■ Improved sensitivity and reduced risk of peak omission. ■ Elimination of column and system passivation and conditioning, saving time and costs. ■ Enhanced reproducibility and reliability of results. We also offer a variety of low-adsorption columns featuring MaxPeak High Performance Surfaces (HPS) technology. When used in combination with the system, more reliable analyses can be achieved. *We also offer online briefings and demonstrations, so please feel free to contact us.

Many harmful immune responses and diseases are believed to be caused by changes in protein conformation. Until now, X-ray crystallography and NMR-based analyses have primarily been used to measure protein conformation. While these analytical methods are useful, they are not applicable to all proteins and often require high-purity, large quantities of samples. Today, by effectively combining the ACQUITY M-Class HDX system with high-resolution mass spectrometry and rigorously controlling the temperature-sensitive aspects of the HDX sample preparation, we can reliably identify changes in protein conformation. This has made it possible to obtain detailed information about protein conformation. The ACQUITY M-Class HDX system adds a new dimension of separation capability, reproducibility, and durability to chromatography. 【Features】 - Binding of drugs to target molecules of proteins - Development of biopharmaceuticals - Protein-protein interactions - Research in structural biology For more details, please contact us or download the catalog.

With UPLC technology, you can invest in the future by having the robustness and reliability to perform existing HPLC analytical methods within a single system, while optimally operating UPLC columns with particle sizes of 2 μm or less. The ACQUITY UPLC(R) system family serves as a platform for LC technology that can be utilized regardless of separation requirements, making it easy to enhance productivity and facilitate method transfer between facilities. 【Features】 - Six types of UPLC particles based on ethylene-bridged hybrid, High Strength Silica, and Charged Surface Hybrid - 22 types of stationary phases - Seven types of application-specific chemistries - Designed to seamlessly deliver performance with the ultra-low dispersion ACQUITY UPLC system - Over 200 options (column sizes and chemistries) available to select the optimal column that balances separation capability and throughput For more details, please contact us or download the catalog. *The catalog will be a digest version. If you need the full version, please contact us.

ACQUITY UPC2 was born by applying ultra-high-performance liquid chromatography (UPLC) technology to supercritical fluid chromatography (SFC). This allows it to transcend traditional SFC and expand the separation domain of GC and LC chromatography. By using liquefied carbon dioxide (CO2) as the main mobile phase, it achieves high safety, cost reduction, and a lower environmental impact. It can simultaneously analyze mixtures containing compounds with significantly different polarities. Since all compounds that can be dissolved in solvents with lower polarity than alcohols, such as methanol, are targets for analysis, it caters to a wide range of analytical tasks in various fields, including pharmaceuticals, chemical industry, food, environment, and clinical applications. For more details, please contact us or download the catalog.

The Arc Multi-flow path technology and unique features such as Gradient SmartStart allow for the correction of differences between systems, enabling the reproduction of analytical methods using your existing HPLC. These innovative characteristics seamlessly reproduce chromatography results that meet your acceptance criteria for the methods you are already using, eliminating the need to change validated gradient tables. You can transfer, adjust, and improve analytical methods on the LC platform seamlessly and efficiently while ensuring the consistency of the methods without altering the already validated gradient tables.

Smartly perform routine analysis from exploration, development, process, to quality control! Features of the biopharmaceutical LC/MS system solution equipped with the concept of "SmartMS" ■ A compact and robust benchtop system utilizing SmartMS technology maximizes usability and accessibility ■ Optimized for routine biopharmaceutical analysis of proteins, peptides, and free glycans ■ Workflow-driven to expedite automatic data acquisition, analysis, and report generation ■ Compliance-ready, ensuring regulatory requirements are met *If you would like detailed materials or analysis examples, please feel free to contact us.

The Alliance HPLC system, which meets all the functions required for HPLC, is a flexible and reliable high-performance liquid chromatography system. In addition to the performance standards demanded in research and development, it meets the stringent requirements for routine analysis in quality control. The Alliance HPLC system and HPLC columns are manufactured according to strict performance specifications, allowing for method transfer without inter-instrument variability, thereby providing consistent results across units and laboratories.

Empower 3 Chromatography Data Software (CDS) is a system that meets the demands of networking and enables more efficient data acquisition, management, analysis, and reporting. Empower makes it easy to meet requirements for data integrity. Empower provides the highest level of data integrity and traceability for all raw data, metadata, and result data.

From standard samples and reagents to separation columns, vials, LC, MS, and software for data analysis, Waters provides comprehensive support for our customers' inquiries. Waters' latest innovations in LC and LC/MS, particularly focused on biopharmaceuticals, are designed to address needs related to applications, the challenges posed by a large number of compounds, and regulatory compliance requirements that trouble development labs. Waters' solutions are adopted by leading companies worldwide, helping to obtain faster and more accurate answers regarding the characteristics and quality of biopharmaceuticals.

By implementing the Empower server system, it is possible to use Empower from home or while on business trips. • Empower can directly control not only our company's chromatographs (LC/GC) but also those from other manufacturers, enabling centralized management of chromatographic data. • It can be used without installing Empower on each terminal (also on laptops, tablets, and smartphones). • All operations of Empower, including analysis interruptions and re-injections, are possible. • You can carry out your work smoothly using the electronic approval function. * A terminal server with Citrix's XenApp installed is required. If you are interested, please feel free to contact us using the inquiry form below.

ACQUITY APC (Advanced Polymer Chromatography) System ◾ Acquire more polymer information faster than conventional GPC ◾ High separation capability and size separation enabling characterization of high-performance polymers ◾ Rapid daily calibration to improve data integrity and quality ◾ Automation of method development through advanced system technology

For 24 years, the Alliance, the gold standard of HPLC with proven results in laboratories around the world. The new product [Arc HPLC] provides more accurate analytical results along with outstanding ease of use! The [Arc HPLC] excels in carryover performance and injection reproducibility, supporting the acquisition of reliable analytical results. Additionally, for those concerned that "changing the system will alter the separation," this is a must-see! It also has the capability to accurately reproduce existing analytical methods.

The ACQUITY APC column provides advanced packing technology for the separation of complex synthetic polymers and macromolecular species, delivering superior performance and reliability for high-resolution polymer characterization compared to conventional GPC columns. The ACQUITY APC column further enhances Advanced Polymer Chromatography as follows.

Companies dealing with cosmetics and personal care products must continuously launch innovative products in a very short period to achieve growth and profitability goals in a fiercely competitive market. At the same time, they are required to address many challenges, such as responding to increasing demands from regulatory authorities, analyzing complex samples, ensuring product safety and efficacy, and countering the threat of counterfeit goods.

The self-inspection regarding the contamination of nitrosamines in pharmaceuticals, notified by the Ministry of Health, Labour and Welfare in October 2021, has a deadline of August 1, 2025. By the deadline, it is necessary to measure the amount of nitrosamines contained in items at risk of contamination, and if the levels exceed the limit, risk reduction measures such as setting standard values must be taken. When setting standard values for nitrosamines, it is essential to use systems and analytical conditions that enable high-sensitivity analysis, and we also want the systems to have the robustness to withstand daily analysis. Waters supports high-sensitivity and robust analysis of nitrosamines with total solutions including high-sensitivity and robust mass spectrometers, LC systems and columns that achieve high separation, and informatics, as a specialized manufacturer of LC and mass spectrometry. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

In recent years, "functional ingredients" that add value to food have gained attention, and various foods containing these functional ingredients are being developed, manufactured, and sold as Foods for Specified Health Uses (Tokuho) and Foods with Functional Claims. However, in the analysis of functional ingredients contained in food, achieving excellent separation and high sensitivity detection using liquid chromatography (LC) often poses challenges, making it difficult to objectively evaluate flavor components that affect taste. Waters, as a specialized manufacturer of LC and mass spectrometers, supports reliable analysis of functional claim foods with high-sensitivity mass spectrometers, as well as total solutions including LC systems, columns, and informatics that achieve high separation. ★ Application notes and on-demand webinars are now available We are currently offering application notes and various materials related to reliable routine analysis of functional ingredients and flavor components. Please check them out under "Download."

Is the time it takes to obtain analysis results a bottleneck in the analysis of cell culture media (CCM), clone selection, process development, and optimization? Waters' bioprocessing walk-up solution eliminates that time lag and accelerates your decision-making. Efficient upstream bioprocessing from cell line development (CLD) to upstream process development (USP) requires a high-sensitivity, robust high-throughput analytical platform. This system is an ideal choice for at-line process analytical technology (PAT) that can overcome cumbersome routine measurements of CPP and CQA, with the capability to integrate with bioreactors such as Sartorius Ambr 15 and Ambr 250, achieving the following: ■ Streamlining the workflow from sample pretreatment to data acquisition through data analysis using samples from the bioreactor ■ Generating quantitative analytical results that guide process development (for both CPP and CQA) ■ Enabling faster and more reliable decision-making through high-quality data from samples taken from the bioreactor

The introduction of LC/MS in bioprocessing is progressing overseas. You might be thinking, "I use LC, but MS is difficult..." BioAccord is here to solve that concern. With its simple operability and high reproducibility, it is a recommended system for bioprocess engineers. Do you have any such impressions or questions? ■ Is evaluating aggregates sufficient with just LC? With LC/MS, you can also confirm the intact mass. ■ Is it enough to just confirm major post-translational modifications? With LC/MS, you can perform peptide mapping and post-translational modifications in a single analysis. ■ Is it sufficient to monitor only amino acids? With LC/MS, you can comprehensively detect components* in the culture medium, and integration with JMP is also possible. *Dependent on component concentration. ■ How do you preprocess samples taken from a bioreactor? It's easier than you think. After filtering out particulates, you can simply dilute with water or buffer to measure the intact mass of components and antibodies in the medium. Waters has a walk-up solution to automate this process. *For details, please download the catalog.