日本ウォーターズ（米国本社 Waters Corporation）　 List of Products and Services

PFAS has excellent chemical properties such as water and oil repellency and surfactant characteristics, and is used in a wide range of fields. On the other hand, due to its persistence and bioaccumulation, numerous cases of PFAS detection in water quality, the environment, and food have been reported both domestically and internationally. As a result, countries are advancing regulations and monitoring efforts, and there is a demand for more sensitive and accurate measurement technologies. In Japan, a ministerial ordinance was announced to raise the water quality standards for "PFOS" and "PFOA," which will take effect in April 2026. Waters is focusing on developing methods for trace analysis of PFAS in various samples. In addition to providing analytical instruments, we offer insights on sample preparation and blank contamination prevention, as well as equipment service and support, along with consulting services tailored to analytical needs. By clicking [Send], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with the Waters Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

Is the time it takes to obtain analysis results a bottleneck in the analysis of cell culture media (CCM), clone selection, process development, and optimization? Waters' bioprocessing walk-up solution eliminates that time lag and accelerates your decision-making. Efficient upstream bioprocessing from cell line development (CLD) to upstream process development (USP) requires a high-sensitivity, robust high-throughput analytical platform. This system is an ideal choice for at-line process analytical technology (PAT) that can overcome cumbersome routine measurements of CPP and CQA, with the capability to integrate with bioreactors such as Sartorius Ambr 15 and Ambr 250, achieving the following: ■ Streamlining the workflow from sample pretreatment to data acquisition through data analysis using samples from the bioreactor ■ Generating quantitative analytical results that guide process development (for both CPP and CQA) ■ Enabling faster and more reliable decision-making through high-quality data from samples taken from the bioreactor

BioAccord LC-MS System 【Antibodies】 Aiming for the enhancement of antibodies as biopharmaceuticals Professor Ito, Department of Life Chemistry, Graduate School of Science and Engineering, Kagoshima University 【MAM】 Increasing MS users for the rapid launch of MAM Astellas Pharma Inc., Pharmaceutical Technology Division, Physical Research Institute 【Nucleic Acids】 For monitoring intermediates in oligonucleotide synthesis Ajinomoto Bio-Pharma Services, Gene Design Inc. Aiming for a wide range of development from small molecules to medium molecules, nucleic acids, and antibodies Shionogi Pharma Co., Ltd. To bring as many nucleic acid medicines as possible to address unmet medical needs Luxana Biotech Inc. Synthesis of functional artificial nucleic acids based on organic chemistry Associate Professor Tarajima and students from the Laboratory of Biological Organic Chemistry, Graduate School of Medical and Dental Sciences, Tokushima University 【Peptides】 For structural estimation of impurities in peptide synthesis Peptide Star Inc.

Mass spectrometers, particularly high-resolution mass spectrometers capable of obtaining precise mass measurements, have traditionally been perceived as complex to operate, requiring deep knowledge and experience to master. However, this product overturns that image, offering a new concept device that anyone, from beginners to experts, can operate easily. With just one click, automatic setup is completed. It features a self-diagnosis function and automation capabilities from data acquisition to result summarization. Analysis is automatically performed upon completion, and reports tailored to the user's objectives are sent immediately. Additionally, despite being a single ToF, it supports CID and can obtain fragment information. Keep this compact single ToF, which can be installed with a 100V power supply, close at hand to enhance the efficiency of your daily operations. **Features:** - Precise mass analysis for screening and structural analysis from low to high molecular weights. - Simple operation allows anyone to easily obtain desired results. - Compact and energy-efficient. - Equipped with numerous functions to support measurement tasks, including automatic setup and self-diagnosis. - DI compatible. - A wide range of dedicated automatic analysis applications for various applications.

The ACQUITY QDa II - Mass Detector (MS) achieves powerful and reliable separation. With the user-friendly and highly robust ACQUITY QDa II mass detector, the risks of unexpected components and co-elution are minimized, allowing for the reliable detection of trace components. This enhances the quality of analysis and improves productivity. Additionally, the ACQUITY QDa II mass detector has reduced energy consumption and thermal output by up to 70% compared to equivalent devices from other vendors, and it has very low operational costs, minimizing the environmental impact of the lab and maximizing operational efficiency. 【Features】 - Compact size - Easy-to-implement design with a straightforward price - Robust and easy to maintain - Optimized for immediate use without user adjustments - Acquire more information more quickly and easily - Earned the ACT environmental impact coefficient label

APGC (Atmospheric Pressure Gas Chromatography) is a soft ionization technology that features excellent ionization efficiency and high sensitivity. It allows for a quick and easy switch of the MS inlet system from LC to GC without releasing the vacuum. Due to the absence of vacuum constraints, a wider range of GC columns and carrier gas flow rates can be utilized, maximizing the functionality of GC. 【Features】 ■ APGC ion source unaffected by carrier gas ■ Avoids sensitivity loss due to fragmentation ■ Operates stably for long periods without ion burn *For more details, please refer to the PDF document or feel free to contact us.

Many people are struggling with systems that are prone to contamination and time-consuming maintenance. The Xevo TQ Absolute, known for its resistance to contamination thanks to the "ZSpray Ion Source," along with a new source shield, minimizes contamination of the ion source from sample matrices and salts in the mobile phase. It also allows for the removal of neutral molecules before the mass separation section (StepWave XS), concentrating ions for introduction into the mass separation section. This helps maintain the system in a "good condition" for a longer period, maximizing uptime. As a latest high-sensitivity model, it achieves higher sensitivity and lower quantitation limits. Additionally, it is more compact compared to conventional products, reducing power and gas consumption by about 50%, and also decreasing heat generation by approximately 50%. 【Features】 - Sensitivity to anionic compounds improved by up to 15 times (compared to previous products) - Ensures consistent robustness and reproducibility, maintaining performance and productivity over a longer period - Reduces electricity and gas consumption by about 50% compared to typical high-performance TQ mass spectrometers, with heat generation also reduced by about 50%

By using the state-of-the-art Xevo MRT mass spectrometer, which operates at 100 Hz with a mass resolution of 100K FWHM and mass accuracy within ppm, reliable identification and increased productivity can be achieved in the lab. The Multi-Reflection Time-of-Flight (MRT) technology ensures consistent mass resolution across a wide m/z range, regardless of the scan rate, even at the highest acquisition rates. This system guarantees excellent data quality, enabling scientific analysis, making it ideal for large cohort studies in biopharmaceutical research. 【Features】 - Reliable separation of analytes in complex matrices - Improved reliability of compound identification - Reproducible results due to high stability and robustness

By using the Xevo G3 QTof, you can maximize the information about the analysis species from samples, enhancing the reliability of results from detailed characterization to accurate quantification. It simplifies and expands the characterization and evaluation of properties, from unstable low molecular weight compounds to complex biopharmaceuticals. By updating the design of the ion optical system and incorporating core technologies that achieve comprehensive quantification capabilities, consistent robustness and performance have been achieved. 【Features】 - Improved permeability of unstable low molecular compounds maximizes coverage of analysis species - Enhanced quantitativeness and expanded dynamic range within and between spectra enable optimal comprehensive quantification/qualitative analysis for screening and target applications - Improvements in the ion optical system lead to a more reliable and robust system - Achieves high levels of accuracy and reproducibility

With the SELECT SERIES Cyclic IMS, ions can be selected based on both mass and mobility. By combining ion mobility and mass spectrometry, isomers can be separated based on shape and m/z, allowing for the measurement of ion collision cross-section (CCS) and obtaining very clean mass spectral data. Traditional mobility cells were linear, but by making them circular, the mobility resolution has dramatically improved. Ions can be repeatedly cycled within the cell, and the number of repetitions can be freely set.

Using the state-of-the-art multi-reflecting time-of-flight mass spectrometry (MRT) technology, the SELECT SERIES MRT enables clear compound identification even in very complex samples, regardless of the scan rate, thanks to its high resolution and high specificity. The class-leading ToF mass resolution is achieved through innovative ion beam multi-reflection. This technology allows for high resolution and mass accuracy at sub-ppm levels across a wide m/z range, enabling very detailed structural characterization and overcoming many scientific challenges. 【Features】 - Consistently ppb level mass accuracy (<500ppb) - High mass resolution unaffected by measurement speed (>300,000 FWHM; 30Hz) - High data quality for both MS and MS/MS - Compatible with MS imaging (DESI, MALDI) and LC-MS applications

Mass spectrometry imaging (MSI) has often utilized MALDI as an ionization method, but it requires specialized knowledge and expertise for matrix selection and application. On the other hand, DESI applies ESI technology, eliminating the need for a matrix and enabling the ionization of a wide range of molecules. DESI XS MSI has been applied in combination with time-of-flight (ToF) mass spectrometers to directly map molecules in tissue sections, making it ideal for non-target exploratory analysis. With the recent possibility of combining it with tandem quadrupole (TQ) mass spectrometers, the sensitivity, speed, and quantitativeness of target molecule measurements using multiple reaction monitoring (MRM) mode have improved, allowing for widespread application in various fields such as drug analysis, biomarker detection, and surface analysis of materials, focusing on the "localization + quantification" of molecules. A remarkable and unique method has become available to quantitatively clarify the localization of previously unseen molecules. 【Features】 - High-sensitivity, rapid, and highly selective visualization of molecular localization - Improved sensitivity and spatial resolution with a new high-performance sprayer - No complicated sample pretreatment required, enabling comprehensive and detailed spatial information acquisition

Achieves a level of high sensitivity, chromatography performance, robustness, and operability that cannot be achieved by other MS systems.

Extractables and leachables from polymers, monomers, and additives in plastics used in pharmaceutical packaging and single-use systems for biopharmaceuticals must be managed in terms of drug safety and quality. However, the analysis and evaluation of extractables/leachables from plastic products supplied by suppliers often lack clarity regarding the components, presenting numerous challenges. The wide range of technologies offered by Waters can accurately and cost-effectively identify extractables and leachables in a short period.

To better understand cellular functions and physiology, and to monitor the distribution of drug compounds in tissues or the entire organism, full-spectrum molecular imaging has refined and combined the advantages of several analytical techniques into a single device platform. By integrating MALDI, DESI, ion mobility mass spectrometry, and informatics workflows into a single system, Waters' full-spectrum molecular imaging provides detail and molecular information that surpasses any individual imaging technique.

Can we always reach the correct answer in one go with only high-resolution and high-precision mass data? When faced with complex samples containing multiple components, high resolution and precise mass alone may be insufficient to obtain all the information required for comprehensive analysis. The Vion IMS QTof, which opens the door to a new dimension called collision cross-section (CCS), is an innovative mass spectrometer that has never been seen before. There may be important components that have not been discovered yet, buried somewhere.

The "Xevo TQ-S micro" is a tandem quadrupole mass spectrometer that achieves excellent performance and flexible analysis in a compact design. It can reproduce high-quality analytical performance even with very complex sample matrices. With reliable operation of the device, it achieves outstanding sensitivity while being compact, maximizing the efficiency of the lab. 【Features】 ■ Detects low-concentration compounds even in complex matrices ■ Achieves excellent efficiency with high precision, accuracy, and robustness at lower injection volumes ■ Flexibility is further enhanced with a wide range of ion source and inlet options *For more details, please refer to the PDF document or feel free to contact us.

Rapid Evaporative Ionization Mass Spectrometry (REIMS) is a novel sampling method that allows for the direct acquisition of molecular profiles from the surface of samples. Researchers involved in cutting-edge studies in areas such as food, microbiology, and histology can quickly and easily discern differences between samples and reliably identify the components responsible for those differences through deep insights into chemical or biological systems.

The Xevo TQ-GC is designed with the aim of ensuring reliable results in the measurement of real samples. This system undergoes rigorous testing to reduce the time spent on regular maintenance, maximize uptime with a maintenance schedule tailored to the lab's workload, and minimize downtime.

By extending the range of analysis with extremely high sensitivity, we achieve a high level of reliability, reproducibility, and performance. Through the optimization of each technology, it is designed with a focus on standardization, allowing more users to apply class-leading sensitivity to a greater number of compounds.

By extending the scope of analysis with extremely high sensitivity, we achieve an unprecedented level of reliability, reproducibility, and performance. Through the optimization of each technology, it has been designed with a focus on standardization, allowing a greater number of users to apply top-class sensitivity to a wider range of compounds.

By extending the range of analysis with extremely high sensitivity, we achieve an unprecedented level of reliability, reproducibility, and performance. Through the optimization of each technology, it has been designed with a focus on standardization, allowing more users to apply class-leading sensitivity to a greater number of compounds.

By extending the range of analysis with extremely high sensitivity, we have achieved an unprecedented level of reliability, reproducibility, and performance. Through the optimization of each technology, it has been designed with a focus on standardization, allowing more users to apply class-leading sensitivity to a greater number of compounds.

From standard samples and reagents to separation columns, vials, LC, MS, and software for data analysis, Waters provides comprehensive support for our customers' inquiries. Waters' latest innovations in LC and LC/MS, particularly focused on biopharmaceuticals, are designed to address needs related to applications, the challenges posed by a large number of compounds, and regulatory compliance requirements that trouble development labs. Waters' solutions are adopted by leading companies worldwide, helping to obtain faster and more accurate answers regarding the characteristics and quality of biopharmaceuticals.

The "SYNAPT XS" is a drift time ion mobility mass spectrometer that offers excellent flexibility and provides great freedom in the choice of analytical methods to support scientific creativity and technical success across various applications. Our commitment to generating better science through better data is realized through the reproducibility and continuity of this product both daily and across different instruments. By providing the validity of reliable analysis, we facilitate the discovery process and enable confident progress towards innovation. 【Features】 ■ Provides multi-layered, information-rich data ■ Automation of higher-order structure determination is possible ■ Expands the possibilities of MS/MS ■ Supports various applications *For more details, please refer to the PDF materials or feel free to contact us.

The "Xevo TQ-S cronos" is a tandem quadrupole mass spectrometer developed to meet budgetary requirements while combining reliability and performance, making it suitable for your quantitative workflows. By achieving performance tailored to your objectives, it offers advantages such as targeting more compounds with a single injection and accommodating a wider concentration range. 【Features】 ■ Easily obtain and verify quantitative data to meet analytical and regulatory needs ■ Target more compounds with a single injection and accommodate a wider concentration range ■ Simplify the setup of robust analytical methods and measurement systems *For more details, please refer to the PDF document or feel free to contact us.

Smartly perform routine analysis from exploration, development, process, to quality control! Features of the biopharmaceutical LC/MS system solution equipped with the concept of "SmartMS" ■ A compact and robust benchtop system utilizing SmartMS technology maximizes usability and accessibility ■ Optimized for routine biopharmaceutical analysis of proteins, peptides, and free glycans ■ Workflow-driven to expedite automatic data acquisition, analysis, and report generation ■ Compliance-ready, ensuring regulatory requirements are met *If you would like detailed materials or analysis examples, please feel free to contact us.

Companies dealing with cosmetics and personal care products must continuously launch innovative products in a very short period to achieve growth and profitability goals in a fiercely competitive market. At the same time, they are required to address many challenges, such as responding to increasing demands from regulatory authorities, analyzing complex samples, ensuring product safety and efficacy, and countering the threat of counterfeit goods.

The self-inspection regarding the contamination of nitrosamines in pharmaceuticals, notified by the Ministry of Health, Labour and Welfare in October 2021, has a deadline of August 1, 2025. By the deadline, it is necessary to measure the amount of nitrosamines contained in items at risk of contamination, and if the levels exceed the limit, risk reduction measures such as setting standard values must be taken. When setting standard values for nitrosamines, it is essential to use systems and analytical conditions that enable high-sensitivity analysis, and we also want the systems to have the robustness to withstand daily analysis. Waters supports high-sensitivity and robust analysis of nitrosamines with total solutions including high-sensitivity and robust mass spectrometers, LC systems and columns that achieve high separation, and informatics, as a specialized manufacturer of LC and mass spectrometry. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

In recent years, "functional ingredients" that add value to food have gained attention, and various foods containing these functional ingredients are being developed, manufactured, and sold as Foods for Specified Health Uses (Tokuho) and Foods with Functional Claims. However, in the analysis of functional ingredients contained in food, achieving excellent separation and high sensitivity detection using liquid chromatography (LC) often poses challenges, making it difficult to objectively evaluate flavor components that affect taste. Waters, as a specialized manufacturer of LC and mass spectrometers, supports reliable analysis of functional claim foods with high-sensitivity mass spectrometers, as well as total solutions including LC systems, columns, and informatics that achieve high separation. ★ Application notes and on-demand webinars are now available We are currently offering application notes and various materials related to reliable routine analysis of functional ingredients and flavor components. Please check them out under "Download."

RADIAN ASAP is a new dedicated direct analysis system that enables rapid, easy, and low-cost analysis of liquid/solid samples. Developed by combining proven single quadrupole mass spectrometry technology with an atmospheric pressure solid sample analysis probe (ASAP), RADIAN ASAP is compact yet designed for high quality and ease of use. No special training or expertise, complex sample pretreatment, or separation is required! High-quality mass spectral data can be obtained, eliminating the need to wait for analysis results from other departments. The multivariate analysis software "LiveID" allows for real-time classification of samples analyzed using RADIAN ASAP. Information is immediately provided to the user during analysis, enabling informed real-time decision-making without doubts regarding sample identification. [Examples of applications in various fields] ■Pharmaceuticals: Reaction monitoring in exploratory research ■Chemical industry: Quality control of raw materials ■Food/Environment: Authenticity assessment of food ■Forensics: Rapid triage of seized drugs ■Academia: Education/analytical method development

The introduction of LC/MS in bioprocessing is progressing overseas. You might be thinking, "I use LC, but MS is difficult..." BioAccord is here to solve that concern. With its simple operability and high reproducibility, it is a recommended system for bioprocess engineers. Do you have any such impressions or questions? ■ Is evaluating aggregates sufficient with just LC? With LC/MS, you can also confirm the intact mass. ■ Is it enough to just confirm major post-translational modifications? With LC/MS, you can perform peptide mapping and post-translational modifications in a single analysis. ■ Is it sufficient to monitor only amino acids? With LC/MS, you can comprehensively detect components* in the culture medium, and integration with JMP is also possible. *Dependent on component concentration. ■ How do you preprocess samples taken from a bioreactor? It's easier than you think. After filtering out particulates, you can simply dilute with water or buffer to measure the intact mass of components and antibodies in the medium. Waters has a walk-up solution to automate this process. *For details, please download the catalog.