日本ウォーターズ（米国本社 Waters Corporation）　 Product Lineup

The DAWN series measures the molecular weight and size of macromolecules such as proteins with high precision, using multi-angle light scattering (MALS) without the need for calibration curves created from standard substances. It can be connected to HPLC and UPLC, enabling a wide range of applications. 【Features】 - DAWN (18-angle detector) offers high sensitivity and wide-range measurement. - A diverse lineup including DAWN8 (8-angle detector), miniDAWN (3-angle detector), microDAWN (UPLC-compatible model), and UltraDAWN (process-compatible model). - Automated cell cleaning with built-in ultrasonic cleaner COMET. - Equipped with a dynamic light scattering (DLS) module, allowing measurements from a radius of 0.5 nm (optional). - Real-time display of system status, with troubleshooting guidance functionality. By clicking [Send], you agree that the information provided on this site will be used and processed by Waters in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

In the development of antibody drugs and antibody-drug conjugates (ADCs, etc.), it is essential to maximize the efficiency of the development process while ensuring the quality and safety of the products. By using light scattering detectors to evaluate size variants, aggregates, stability, and other factors from the early stages of development, it is possible to identify the characteristics of potential candidate antibodies early on and avoid risks and dropouts in the later stages of development. Combining this with LC-MS allows for even more comprehensive characterization. By clicking "Submit," you are deemed to have agreed to Waters' use and processing of the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

mRNA has been gaining attention as a modality in recent years, but evaluation methods have not yet been established, posing challenges in product development. SEC-MALS (Size Exclusion Chromatography with Multi-Angle Light Scattering detection) serves as a powerful tool for evaluating important biophysical characteristics. By utilizing SEC-MALS, it is possible to measure molecular weight, size, and three-dimensional structure with high precision, obtaining essential information for the development and optimization of mRNA therapeutics. Furthermore, when combined with LC-MS, it enables more comprehensive characterization and biophysical property analysis. The use of LC-MS for the separation and analysis of synthetic nucleic acids is effective, allowing for the simultaneous acquisition of a wide range of information, including purity, impurity content, and sequence confirmation. With the enhancement of dedicated analysis software, anyone can easily perform data analysis, regardless of their experience with LC-MS. By clicking [Submit], you are deemed to have consented to Waters' use and processing of the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

To quickly deliver safe and highly effective vaccines to the market, thorough characterization analysis is necessary. By using light scattering detectors, a wealth of information can be obtained regarding the vaccine's size, aggregation, stability, interactions, composition, and conformation. By combining MALS (Multi-Angle Light Scattering) and DLS (Dynamic Light Scattering), information about the conformation (shape and structure) of molecules can be derived from the ratio of Rh (hydrodynamic radius) to Rg (radius of gyration). Furthermore, by combining separation techniques such as SEC (Size Exclusion Chromatography) and FFF (Field Flow Fractionation), high-resolution size and molecular weight distribution measurements can be achieved. In LC-MS, peptide mapping allows for the confirmation of primary sequences and monitoring of post-translational modifications. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

To ensure safe and effective treatment, monitoring of the potency and titer of adeno-associated virus (AAV) vectors, encapsulation, aggregation, genome integrity, and other factors is necessary. By combining SEC (size exclusion chromatography), IEX (ion exchange chromatography), and MALS (multi-angle static light scattering), it is possible to accurately and efficiently evaluate critical quality attributes (CQA) such as the Full/Empty ratio, aggregation, and particle concentration of AAV. RT-MALS allows for real-time measurement of these parameters, which is useful for streamlining the manufacturing process. By combining size separation and light scattering analysis, exosomes can be isolated from other biological components, enabling the detection of new subtypes based on size, composition, charge, and even functional differences, allowing for comprehensive characterization. LC-MS enables the identification and quantification of gene sequences and proteins contained in AAV vectors. By clicking [Submit], you are deemed to have agreed that Waters may use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

SEC-MALS, which combines size exclusion chromatography and multi-angle static light scattering, is commonly used for the analysis of polymers but is also suitable for molecular weight analysis of low molecular weight (LMW) peptides. Multi-angle light scattering (MALS) detectors such as DAWN and miniDAWN are very useful for online measurement of the molecular weight of peptides under 1,000 daltons. LC-MS allows for detailed characterization analysis, including amino acid sequences and post-translational modifications. By combining LC-MS with SEC-MALS, comprehensive data can be obtained, ranging from detailed analysis to the overall molecular weight and aggregates of peptides. By clicking "Submit," you agree that Waters may use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy