日本ウォーターズ（米国本社 Waters Corporation）　 List of Products and Services

The DynaPro Plate Reader 3 is a commercially available microplate that is a light scattering measurement device capable of measuring the size, molecular weight, concentration, and interactions of proteins, nanoparticles, and other polymers. This plate-based device allows for very high-throughput measurements compared to traditional cuvette-based light scattering devices. Additionally, after dispensing into the plate, there is no need to touch the liquid, minimizing sample carryover. 【Features】 - Compatible with commercially available microplates - Supports high-throughput measurement of multiple samples and automation - Simultaneous measurement of dynamic light scattering (DLS) and static light scattering (SLS) - Saves time and running costs - Non-destructive measurement allows the measured plates to be repurposed for other analytical devices

The DynaPro NanoStar 2 supports both dynamic light scattering (DLS) and static light scattering (SLS) measurements, allowing for the measurement of particle size distribution, particle concentration, interactions (kD, A2), and weight average molecular weight (Mw) of nanoparticles and proteins. It can be used for the analysis of proteins, gene therapy vectors, viruses and virus-like particles, indiscriminate inhibitors, micelles, liposomes, LNPs (lipid nanoparticles), and metal nanoparticles. To accommodate rare and precious samples, the specially designed quartz cuvette provides robust and accurate measurements with just 2 µL of solution. 【Features】 - Supports both dynamic light scattering (DLS) and static light scattering (SLS) measurements - Easy operation with an intuitive touchscreen - Achieves a wide range of temperature settings (-10 to 120°C) and fast temperature gradient settings - Connects with the multi-angle light scattering detector DAWN to support flow DLS measurements - Abundant cell options (2μL capacity quartz cell, 4μL capacity disposable cell, commercially available 4mL quartz cell, disposable cell (using adapter))

The DynaPro ZetaStar can measure dynamic light scattering, static light scattering, and electrophoretic light scattering (DLS/SLS/ELS) all in one device, allowing for the acquisition of information on a wide range of molecular sizes, polydispersity, zeta potential, particle concentration, molecular weight, and turbidity/milky degree in up to 1/10 the time compared to conventional methods. It can be used for the analysis and quantification of virus vectors, vesicles, LNPs (lipid nanoparticles), inorganic nanoparticles, nanoemulsions, polymers, peptides, proteins, nucleic acids, and more. With high sensitivity even with very small sample amounts, it is suitable for rare and precious samples. 【Features】 - Supports both manual and automatic measurements - Measurement is completed with just a few clicks, making it easy to operate and reassuring for inexperienced users - Wide temperature setting range (-10 to 120°C) allows for evaluation of thermal degradation and behavior under various storage conditions - High salt concentration compatibility enables reliable measurements under physiological conditions and in formulation buffers - A variety of cell options and disposable cell compatibility eliminate the need for cuvette cleaning and sample carryover

In the development of antibody drugs and antibody-drug conjugates (ADCs, etc.), it is essential to maximize the efficiency of the development process while ensuring the quality and safety of the products. By using light scattering detectors to evaluate size variants, aggregates, stability, and other factors from the early stages of development, it is possible to identify the characteristics of potential candidate antibodies early on and avoid risks and dropouts in the later stages of development. Combining this with LC-MS allows for even more comprehensive characterization. By clicking "Submit," you are deemed to have agreed to Waters' use and processing of the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

To quickly deliver safe and highly effective vaccines to the market, thorough characterization analysis is necessary. By using light scattering detectors, a wealth of information can be obtained regarding the vaccine's size, aggregation, stability, interactions, composition, and conformation. By combining MALS (Multi-Angle Light Scattering) and DLS (Dynamic Light Scattering), information about the conformation (shape and structure) of molecules can be derived from the ratio of Rh (hydrodynamic radius) to Rg (radius of gyration). Furthermore, by combining separation techniques such as SEC (Size Exclusion Chromatography) and FFF (Field Flow Fractionation), high-resolution size and molecular weight distribution measurements can be achieved. In LC-MS, peptide mapping allows for the confirmation of primary sequences and monitoring of post-translational modifications. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

To ensure safe and effective treatment, monitoring of the potency and titer of adeno-associated virus (AAV) vectors, encapsulation, aggregation, genome integrity, and other factors is necessary. By combining SEC (size exclusion chromatography), IEX (ion exchange chromatography), and MALS (multi-angle static light scattering), it is possible to accurately and efficiently evaluate critical quality attributes (CQA) such as the Full/Empty ratio, aggregation, and particle concentration of AAV. RT-MALS allows for real-time measurement of these parameters, which is useful for streamlining the manufacturing process. By combining size separation and light scattering analysis, exosomes can be isolated from other biological components, enabling the detection of new subtypes based on size, composition, charge, and even functional differences, allowing for comprehensive characterization. LC-MS enables the identification and quantification of gene sequences and proteins contained in AAV vectors. By clicking [Submit], you are deemed to have agreed that Waters may use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy