TECHNICAL INFOMATION INSTITUTE CO.,LTD List of Products and Services

Book Title: Analysis Techniques for Disease-Causing Genes and Proteins and Their Application in Drug Discovery/Diagnostic Technologies --- ◎ What are the latest disease mechanisms and drug discovery targets revealed by the latest omics research? ◎ Learn tips for utilizing open databases, methods for integrative use of several databases, and important considerations! --- ■ Key Points of This Book 1. Identification of mutated genes through genome and epigenome analysis 2. Elucidation of disease causes through proteomics analysis 3. Elucidation of disease causes through transcriptomics 4. Understanding disease causes through multi-omics and trans-omics analysis 5. Drug discovery applications of genome and omics-related databases 6. Case studies of mutated genes and proteins in specific diseases

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Book Title: How to Promote a New "Work Style Reform" in the Research and Development Department ☆Introducing telework and remote work, utilizing DX (automated experimental devices and digital technology) ⇒ Create an environment and culture that fosters innovation, free from conventional notions of time and place!! ■ Key Points of This Book ◎ Work styles are moving to the next step!! 　　　　　　　The true "work style" reform is set in motion by the pandemic!! ★ Answers to these concerns!! 　1. Are my subordinates making progress while working from home? 　2. How can we advance talent development through remote work? 　3. How can we conduct remote work without lowering researchers' motivation? 　4. What is the evaluation method for researchers working from home? 　5. What is an effective response if an infection occurs in the workplace? 　6. How should we incorporate DX, such as automated experiments? 　7. How to build a team during telework?

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Book Title: Required Properties and Development, Performance Evaluation of Polymer Materials for Architecture and Housing ★ Energy saving through high thermal insulation and high heat shielding! Control of living noise and echo noise, which are issues in high airtight houses! ■ Key Points of This Book ● Improvement of Comfort in Living Spaces - Antibacterial and antiviral properties - Deodorization and odor removal technologies, VOC reduction - Stain and odor prevention technologies - Control of floor impact noise and drainage noise from upper floors, and voices from neighboring rooms - Materials, designs, and decorative methods appealing to sight and touch ● Development of New Materials for Enhanced Thermal Comfort - Balancing insulation and heat shielding with daylighting in openings - Balancing transparency, infrared reflection performance, and radio wave permeability - Condensation suppression and energy-saving effects with resin windows - Development of vacuum insulation materials and smart windows - Temperature rise suppression effects of heat-shielding paints ● Improvement and Evaluation of Safety and Durability - Flame retardant standards for building materials and required flame retardant performance - Enhanced flame resistance and heat resistance of insulation foam - Seismic reinforcement technology using fiber composite materials - Estimation testing methods for the service life of construction adhesives - Improvement of durability of applied waterproof materials and prevention of cracking in floor materials - Performance and testing method regulations for structural materials and adhesives

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◆Fundamentals and Latest Technological Trends in iPS Cells◆ 　　・What are the efficient culture methods for iPS cells? 　　・Key points for differentiation induction of iPS cells using vector technology 　　・Key points in the development of automated culture systems for iPS cells 　　・How to derive bio big data from machine learning and iPS cell research? ◆Research and Commercialization of Materials Expected for Regenerative Medicine Scaffolds◆ 　　・What materials are available and what are the patent trends? 　　・How is biocompatibility evaluated? 　　・Development of scaffold materials for regenerative medicine using bio-nanofibers, collagen, elastin, and polymers ◆Freezing Preservation Techniques for Three-Dimensional Cell Culture and Contamination Prevention◆ 　　・Establishing freezing preservation techniques for cells 　　・Contamination prevention measures in cell culture settings 　　・Development and usage of automated screening systems 　　・How to stabilize the culture process using image analysis technology ◆Management and Educational Guidance for Cell Processing Facilities in Accordance with GCTP Regulations◆ 　　・Management of cell processing facilities with a view to the next ten years 　　・How should standard operating procedures be created? 　　・Key points in the design and maintenance of cell processing facilities 　　・Required computer system validation

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★ How to accurately and efficiently calculate CO2 emissions from raw materials, intermediate products, processing, logistics, use, and disposal! ★ Initiatives for carbon neutrality involving the supply chain revealed by leading companies! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book 1 How to Advance LCA Evaluation - Overview and calculation methods of Scoops 1, 2, and 3 - Calculation of CO2 emissions in the global supply chain - Prediction of GHG emissions using AI - Calculation of CO2 emission reductions Specific Examples of CO2 Emission and Reduction Contribution Calculations - Polymers and composite materials, container packaging - Use of waste plastics and automotive recycling parts - Steel products, cement, concrete - Introduction of IT technologies and digital solutions Overview and Utilization of Carbon Pricing - Creation and trading of J-Credits and bilateral credits - Pricing for internal carbon pricing - Scenario analysis and transition planning related to climate change - Types of international initiatives, characteristics, and participation points

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Book Title: The Latest Technologies in Genome Editing and Their Applications in Pharmaceuticals, Gene Therapy, Agriculture, Aquaculture, and the Production of Useful Substances －－－－－－－－－－－－－－－－－－－－－ ★ How will we overcome the challenges in future genome editing? Unraveling through the latest technologies and abundant case studies! (Safety, Efficacy, DNA Repair, Clinical Trials, Regulations, and Patents) ★ "Latest Technological Trends in CRISPR-Cas" • "What is Non-Cutting Genome Editing?!" • "Clarifying the Causes of Disease Mechanisms" • "Hot Topics such as High-Sugar Tomatoes and Aquaculture" －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ★ The latest technological trends and case studies of the CRISPR-Cas system ★ What is non-cutting genome editing?! Its technological trends ★ Clarification of disease mechanisms and numerous application examples in the pharmaceutical field ★ Theories and technologies related to hot application topics such as high-sugar tomatoes and aquaculture

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★ Surface treatment required for 5G/6G materials! Improved adhesion of low dielectric resin/copper! ★ Mechanisms of dissimilar material bonding in automotive multi-materials, factors causing strength reduction, and countermeasures! －－－－－－－－－－－－－－－－－－－－－ ■ Key points of this book ● How to choose and use silane coupling agents ● How do pre-treatment and modification conditions affect aging changes? ● Surface treatment for poorly adhesive fluorine and polypropylene ● Towards surface treatment for complex shapes ● Evaluation of long-term stability and sustainability after surface treatment ● Measurement of "dynamic wettability" and its precautions ● Surface treatment technology for advanced mobility such as flying cars and drones ● Energy-saving processes and reduction of CO2 emissions

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◎A comprehensive explanation of the current state of carbon recycling technology from various aspects such as environmental impact, thermodynamics, and cost! ◎How can we achieve energy efficiency and low costs in utilization processes? Detailed case studies towards realization! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ◆ CO2 conversion processes for the production of useful chemicals - Design methods for reaction fields to control and enhance the selectivity of CO2 reduction reactions - Approaches to electrode durability in electrochemical processes - Measures against catalyst degradation in high-temperature reaction processes and cooling down the processes - Key points to improve conversion efficiency in bioprocesses! ◆ Production of useful chemicals and fuels using CO2 - Urea compounds, carbonates, polyurethanes, ethylene, carboxylic acids, formic acid, carbon monoxide, polyesters, formaldehyde, calcium carbonate, etc. - Synthetic fuels, methane, methanol, hydrocarbons, dimethyl ether, biofuels, ethanol, etc. Numerous case studies on the production of useful chemicals and fuels! ◆ Direct utilization technologies for CO2 and fixation technologies - Adhesive technologies - Coating technologies - Cleaning technologies - Refrigeration systems - Fixation technologies - Fixation technologies in the ocean?

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Book Title: Methods for Analyzing Protein Structures and Applications in In Silico Screening －－－－－－－－－－－－－－－－－－－－－ ◎ Examples of structural analysis approaches and cases from both wet and dry fields are included!! ◎ Packed with examples of "interaction analysis," which is crucial for drug discovery research, and "how to use various databases"!! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ≪1≫ Tips and examples for protein structure analysis ≪2≫ How to obtain high-quality protein crystals ≪3≫ Introduction of numerous MD simulation examples ≪4≫ Potential of drug discovery using AlphaFold ≪5≫ Diverse hints for successful In Silico drug discovery ≪6≫ Explanation of various databases

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Book Title: Implementation of Accelerated Testing and Product Lifetime Prediction Using Models ---------------------------- ■ Table of Contents Chapter 1: Planning Accelerated Testing, Conditions, and Utilization of Acceleration Models Chapter 2: Weibull Analysis in Lifetime Testing for Beginners Chapter 3: Calculation Methods for Coefficients Used in Lifetime Prediction Models Chapter 4: How to Present and Interpret Plots of Lifetime Prediction Models Chapter 5: Types of Accelerated Testing Equipment, Selection, and Usage Chapter 6: Accelerated Testing of Electronic Components and Batteries and Lifetime Prediction Using Models Chapter 7: Accelerated Testing of Resins, Rubbers, and Various Materials and Lifetime Prediction Using Models Chapter 8: Accelerated Testing of Pharmaceuticals, Cosmetics, and Foods and Lifetime Prediction Using Models Chapter 9: Development of New Accelerated Testing, Accuracy Improvement, and Lifetime Estimation Methods Chapter 10: Data Collection for Lifetime Estimation and Degradation Analysis

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Book Title: Utilization of IoT and Local 5G in the Production Process ☆ The key to further improving labor productivity lies in the use of sensor data! ☆ Examples of data acquisition, collection, and utilization for smart plants and smart factories ■ This book includes the following information: - Latest trends in local 5G and the transition to smart factories - Factor analysis, loss analysis, and monitoring aimed at improving yield and operational efficiency - Data processing required for machine learning and deep learning - Utilization of manufacturing big data and approaches to data science - Improvement activities focused on data utilization, implementation, and systematization - Realization of "connecting" and "visualization" of on-site equipment - Anomaly prediction diagnosis using time-series sensor data - Concepts and approaches for equipment maintenance processes aimed at preventive maintenance - Challenges and solutions for IoT implementation in manufacturing sites - Initiatives related to manufacturing DX and GX, etc.

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Book Title: How to Create Research and Development Themes Based on "Future Forecasting" --- Read the future from a unique perspective and discover the next hit! Delve into the insights and thinking techniques behind it!! ■ Key Points of This Book ◎ AI, quantum computers, 6G, CASE/MaaS, SDGs, etc. The "treasure trove" lies here! How to search for untapped veins!! ◎ Big data, marketing, patent information, scenario planning, etc. How to read the unreadable future! Choosing and using future forecasting methods!! 1. Information gathering and perspective setting for future forecasting! 2. How to create growth scenarios by analyzing the present and future! 3. How to derive future strategies and develop them into a roadmap! 4. Points for assessing the feasibility of themes for a 10-year plan! 5. Progress management and course correction methods for promising future themes! 6. How to allocate personnel to advance research and development based on future forecasting! 7. How to clearly convey the vision of future society to management! 8. The role of leaders in supporting developers who challenge future creation!

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Book Title: Low-Temperature and Low-Pressure Synthesis of Ammonia and New Utilization Technologies －－－－－－－－－－－－－－－－－－－－－ ★ A synthesis method under mild conditions (room temperature and atmospheric pressure) as an alternative to the Haber-Bosch process!! ★ Co-firing and dedicated combustion technology for ammonia fuel! Combustion methods that suppress nitrogen oxide (NOx) emissions!! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ★ Ammonia synthesis and production technology ★ Fuel ammonia (combustion and co-firing) ★ Hydrogen carrier ★ Supply chain development

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★ Formation of Coffee Stains in Thin Film Drying and Countermeasures ★ Transparency of Coatings! Towards Particle Control and Defect Countermeasures! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book <Formula Design> ● Countermeasures for Poor Dispersion Focused on Foam ● Balancing Dripping and Leveling ● Compatibility of Main Agent and Hardener, Ease of Dispersion in Water <Coating and Application> ● Identifying the Cause of Troubles! Is it the Equipment or the Coating Liquid? ● Coating and Application Techniques for Complex Areas! ● Defect Inspection Using Deep Learning <Drying> ● Suppression of Coffee Stains Due to Marangoni Effect ● Control of Evaporation Rate and Measures Against Thickness Variations ● Formation and Progression of Cracks and Their Countermeasures

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Book Title: Latest Trends in Next-Generation Semiconductor Packaging and the Development of Its Materials and Processes ★ As the miniaturization of integrated circuits approaches its limits and the differentiation of advanced semiconductors becomes crucial, packaging technology holds the key! This book covers the transformation of packaging technology associated with chiplets and 3D integration, along with new materials and process technologies. ■ Key Points of This Book - Development status of next-generation packaging technologies such as FOWLP, 2.XD, silicon bridge, and 3D... - Hybrid bonding technology and new bonding materials that are key to 3D stacking. - Required characteristics of encapsulants for new applications and measures to suppress cracks and delamination. - Build-up processes that achieve fine wiring and high density in package substrates. - Package structures that demonstrate the performance of next-generation WBG semiconductors, along with high-temperature resistant encapsulants and bonding materials. - Causes and countermeasures for defects such as cracks, voids, and whiskers in solder mounting. - Compatibility of low dielectric properties and other characteristics (heat resistance, low CTE, etc.) in films for multilayer substrates for high-speed communication. - Techniques for the densest packing of fillers for high thermal conductivity, and the design of heat dissipation materials that are both highly thermally conductive and low dielectric.

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Book Title: Optimization and Analysis Methods for Data Collection in Chemoinformatics ◎ How can we predict unknown areas of chemical substances from "limited data" and "uneven data"? ◎ What kind of data is needed? What are the application examples of analysis methods? What will the prediction accuracy be? ■ Key Points of This Book ≪1≫ Representation and Quantification of Chemical Structures and Descriptor Design Methods ≪2≫ Considerations in Data Collection and Database Construction ≪3≫ Creation of Datasets and Examples of Various Analysis Methods ≪4≫ Specific Applications of Machine Learning and Their Examples ≪5≫ Synthesis Pathway Exploration and Optimization of Reaction Conditions ≪6≫ Applications in Chemical Substance and Material Design and Pharmaceutical Development

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Book Title: Visualization and Countermeasures for Disasters, Accidents, and Various Risks in Factories and Research Institutes －－－－－－－－－－－－－－－－－－－－－－－－－－ ★ Automation of manufacturing lines, mismatches in the transmission of experience from veterans, next-generation worker training using artificial intelligence and virtual reality ★ Maintenance of container piping and chemical storage, measures against the novel coronavirus and various epidemics, safety management in overseas factories, and activity maintenance systems after accidents occur －－－－－－－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ★ Response to earthquakes, wind and flood disasters, and fires ★ Understanding the causes of accidents and countermeasures ★ Utilization of AI and IoT for worker safety ★ Latest technologies for inspection and predictive activities

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★ Achieving both 'heat resistance', 'strength', 'durability', and 'processability' that rival petroleum-derived resins! ★ Allocation of biomass ratio through mass balance method and third-party certification! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of this Document - Policy trends and implementation status of biomass plastics in various countries - Curing characteristics of biomass acrylates and their application in UV-curable resins and coatings - Mechanical properties of biomass epoxy resins, improvement of processability, and enhancement of flexibility - Balancing (marine) biodegradability and durability, improving processability through enhanced fluidity - Component separation of wood biomass, modification and compounding of lignin and cellulose nanofibers - Plastic synthesis from microalgae and large-scale cultivation techniques for algae for this purpose

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Book Title: How to Quantitatively Evaluate "Usability" and Incorporate It into Product Design ---------------------------- ★ Food, Cosmetics, Automobiles, Medical Care ⇒ Full of Case Studies! ★ A Grand Reveal of Practical Ways to Integrate Human-Centered Design! ---------------------------- ■ Key Points of This Book 1. What does it mean to be user-friendly? What is the difference between usability and UX? 2. When and how should usability tests be conducted? 3. Are there differences due to cultural variations between Japanese and foreign users? 4. What are the key points for conducting remote usability tests? 5. How to derive human data for usability design? 6. ECG, EMG, heart rate/breathing, brain waves, facial pulse waves ⇒ Considerations and tips for biometric data measurement, and how to interpret the data? 7. What is the effective use of big data and AI? 8. How to respond to the diversity of color vision! 9. Evaluation of audibility and design of pleasant sounds! 10. What are readable fonts, visibility, and typography? 11. Important points for usability testing with the elderly! 12. How to measure the feelings of newborns who cannot express themselves and bedridden elderly individuals!

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Book Title: Collection of Material Development and Utilization through Materials Informatics ---------------------------- - Database construction, descriptor design methods, model creation - ★ No reliance on researchers' experiences, inspirations, or coincidences! Numerous successful examples of useful and efficient material development are introduced! ---------------------------- ■ Key Points of This Book ● What is Materials Informatics? What can it do? - Current efforts in Japan and around the world - List of MI utilization examples from various companies - Securing and training data scientists ● Collection and organization of material databases - Introduction of efficient and user-friendly databases - Bayesian estimation and inverse problems - How to choose and set descriptors - How to handle small and sparse data - Considerations for good/bad quality data - High-speed and high-precision screening ● Utilization examples in various fields - Challenges in realizing polymer MI - Catalyst informatics - Measurement informatics - Additive exploration and composition optimization - Exploration of unknown materials using metals and inorganic materials - Applications in batteries and thermoelectric materials

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Book Title: Market and Sales Forecasting and Strategy Formulation in Pharmaceutical Marketing ◎ Contains successful experiences and failure cases from experienced authors, along with a wealth of know-how gained from them. ■ Key Points of This Book Point 1: Includes the basic processes of marketing and their practical applications! 　◎ Tips for market and sales forecasting, and how to grasp uncertain elements and variables such as "number of patients" and "drug prices" 　◎ Correct methods and considerations for segmentation and targeting 　◎ Strategic thinking for positioning and successful strategies Point 2: How will the pharmaceutical market change in the future? How should it be approached? 　◎ What can be learned from real-world data? How can it be utilized in market research and marketing? 　◎ Correct approaches to doctors under strict promotion codes, and how to select and support KOLs? 　◎ Pharmaceutical promotion in the multi-channel era: How to effectively utilize digital channels? 　◎ What is the reality of the new drug pricing system that significantly impacts LCM? What are the key points for strengthening market access?

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Book Title: Management Techniques for Long-Term Stable Use of Lithium-Ion Batteries ★ How to estimate degradation, performance decline, remaining capacity, and lifespan? A thorough explanation of estimation model construction techniques! ■ Key Points of This Book ◆ Design for Improving the Safety of Lithium-Ion Batteries ◆ ◆ Degradation and Lifespan Estimation Techniques for Lithium-Ion Batteries ◆ ◆ Design Methods for State Estimation Models and Systems for Lithium-Ion Battery Management ◆

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Book Title: Elucidation of mRNA Control Mechanisms and Their Application in Therapeutics and Vaccines －－－－－－－－－－－－－－－－－－－－－ ☆Improving the permeability of lipid nanoparticles, enhancing translation efficiency, effective utilization of sequences, and elucidating gene expression mechanisms －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book 1. Use analysis programs to analyze three-dimensional structures! 2. Even from non-coding areas, templates for proteins can be found! 3. Identify the factors that promote transcription initiation, elongation, and termination! 4. What does proper mRNA maturation look like from the perspective of the transcription process? 5. How to choose effective and efficient columns for HPLC purification! 6. What are the excessive immune responses observed by practicing physicians after vaccination? 8. Learn about the mRNA synthesis mechanisms established by pharmaceutical companies! 9. The latest trends in nuclear export processes in humans 10. Study global patent trends, research practices, and examination tendencies! 11. Analysis of "novelty," "inventive step," and "description requirements" by a former patent examiner 12. Understand mRNA drug discovery technologies and challenge the mechanisms of virus proliferation and expression.

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Book Title: Adhesion and Joining Technologies of Dissimilar Materials and Application Examples －－－－－－－－－－－－－－－－－－－－－－－－－－ ★ A comprehensive collection of interface design, evaluation methods, and actual examples of multi-material applications! －－－－－－－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book Mechanisms of Adhesion and Joining and Stress Countermeasures - Issues and improvement measures due to residual stress (internal stress) - Adhesive strength and failure conditions of composite materials Design of Adhesion and Joining Interfaces - Design and selection techniques for functional adhesives - Interface modification through plasma, UV irradiation, and coating - Sulfur bonding technology for rubber and metal Joining Technologies Using Laser, Ultrasound, and Friction - Groove processing and anchor structure fabrication using lasers - Examples of ultrasonic joining of dissimilar metals Component Applications and Development Examples of Dissimilar Material Adhesion and Joining - Trends in automotive multi-material applications and required technologies - Plastic flow bonding technology for aluminum die-cast products - Curing of adhesives through localized laser heating Strength and Reliability Evaluation of Adhesion and Joining Interfaces - Impact of galvanic battery corrosion on tensile strength - Analysis of unique stress fields in joined components and strength evaluation methods - CAE technology targeting adhesive joints in vehicle structural components

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Book Title: New DDS Technologies and Formulation for Novel Modality Pharmaceuticals ---------------------------- ■ Table of Contents Chapter 1: DDS Technology Using Polymer Nanoparticles and Particle Creation and Control Chapter 2: Design of Polymer Micelle-Type Drug Carriers Chapter 3: Design and Modification Techniques of Lipid Nanoparticles and Liposome Formulations Chapter 4: Utilization and Design of Exosome DDS Carriers Chapter 5: Development of DDS Technology Using Conjugates Chapter 6: Notable DDS Technologies and Carrier Design Chapter 7: DDS Technology for Peptide Pharmaceuticals and Design of DDS Utilizing Cell Membrane Permeable Peptides Chapter 8: Utilization and Design of Viruses as DDS Chapter 9: Evaluation of Pharmacokinetics of Novel Modality Pharmaceuticals Chapter 10: Functional, Physical, and Chemical Evaluation of DDS Formulations Chapter 11: Utilization of Additives Used in Nanoparticle DDS Formulations Chapter 12: Manufacturing of Lipid Nanoparticles and Plant Design for Modality Pharmaceuticals

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Book Title: How to Introduce Quantum Technology into Practical Applications and Research and Development Operations -------------------------------------------------- Quantum Computing / Quantum Annealing / Quantum Sensing / Quantum Simulation / Quantum Cryptography ☆ Where in your company will you introduce and utilize quantum technology—materials development, drug discovery, logistics, finance...!! ☆ What are the error correction and error mitigation technologies that hold the key to practical application! -------------------------------------------------- ■ Author Comments ★ This book, covering everything from fundamental understanding to social implementation, is a reliable compass for the adventure of commercializing quantum technology. Toru Ueda, Sumitomo Corporation ★ A snapshot of current quantum computing research in Japan, summarizing the progress and achievements of many research and development sites that cannot be understood through academic conferences and research meetings alone. Masafumi Kadowaki, Denso Corporation ★ It is impossible for all business people to grasp the future without understanding the evolution that emerges from this! Hideo Saikou, President and CEO, Groove Notes Inc.

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★ Development of Marine Biodegradable Plastics! Achieving both 'Properties During Use' and 'Biodegradation After Use'! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Document ◆ Organization of Various Regulations, Standards, and Certifications ◆ - Understanding the Plastic Resource Circulation Strategy - Mechanisms and Challenges of Mass Balance and Segregation - Evaluation of Environmentally Friendly Materials from the Perspective of LCA ◆ Establishment of Various Recycling Technologies ◆ - Chemical recycling conducted under mild conditions - Development of decomposition catalysts aimed at polyolefins - Improvement of physically degraded recycled plastics - Prevention of contamination and yellowing - Balancing material properties and recyclability ◆ Case Studies of Environmentally Friendly Material Development ◆ - Realization of mono-materialization → Improvement of barrier properties and optimization of material properties - Development of biodegradable/marine biodegradable plastics → Decomposition control through switch functions and decomposition accelerators - Adoption of biomass plastics → Measures for heat resistance, water resistance, moldability, odor, etc. - Expectations for paper-based materials → Manifestation of functions such as barrier properties and heat sealability

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Book Title: A Collection of Techniques and Use Cases for "Anomaly Detection" Using Machine Learning and Deep Learning －－－－－－－－－－－－－－－－－－－－－ ★ Detailed explanation of the characteristics, advantages, disadvantages, and appropriate selection and usage of machine learning and anomaly detection methods! ★ How to address issues such as "explanation of judgment basis," "collection of abnormal data," "misjudgment," and "reliability of training data"! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book 1. How to reduce the burden of data collection and dataset creation! 2. How to collect and process data for feature extraction! 3. The black box problem of AI! 4. How to consider quality assurance for AI! 5. Building condition monitoring and maintenance in factories and plants! 6. Diagnostic and control methods for machines using physical models and digital twins! 7. Early detection of defects and remaining life estimation methods for rotating machinery! 8. Specific examples of anomaly detection and life prediction in extrusion machines! 9. Evaluation of deterioration and anomalies in social infrastructure! 10. Key points for digitizing and automating visual inspections! 11. Anomaly detection in the medical field and its applications! 12. Anomaly detection in automobiles and intrusion detection in in-vehicle networks!

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Book Title: Mechanisms of Insulation Breakdown and Deterioration in Polymer Materials and Their Countermeasures ★ What are the key points in material design to enhance insulation performance, such as resistance to tracking, arcing, and treeing? ■ Key Points of This Book Mechanisms of Insulation Breakdown in Polymer Materials - Insulation deterioration due to wind, rain, sunlight, high temperatures, and high humidity - Addressing complex tree shapes influenced by material properties and environmental conditions - Factors in electrical treeing mechanisms such as void discharge, ion impact, and dielectric heating - Suppression of electrical treeing through the addition of voltage stabilizers, UV absorbers, and antioxidants - Factors in water treeing mechanisms such as pressure from evaporation/condensation and molecular chain breakage Design and Development of Materials for Enhanced Insulation Performance - Optimal selection of curing agents considering cost, curing properties, heat resistance, and reliability - Material design that balances insulation and heat dissipation - Control of particle orientation in insulating sheets - What electrical properties are required for 5G, autonomous driving, and electric vehicles? Providing High Insulation Properties to Various Devices and Equipment - Development of solder resist with printing stability and high reliability - Enhancing ion migration resistance of FPCs using adhesive sheets - How to achieve thinner and more compact insulating layers?

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Book Title: Flow Synthesis, Process Design for Continuous Production, Condition Setting, and Application Examples －－－－－－－－－－－－－－－－－－－－－－－－－－ ★ To solve the risk of quality variation in continuous production! 'Process Control' 'Real-Time Monitoring Technology'! ■ Key Points of This Book ● Design, selection, and reaction condition setting of flow synthesis equipment and peripheral devices - Types of piping parts and selection methods for liquid delivery devices - Points for monitoring flow rates and switching flow paths - Formation of slug flow and its control methods - Flow and mixing mechanisms in curved pipes - Handling of slurries and measures against flow path blockage - Types of materials for microfluidic devices and their characteristics ● Transitioning from batch production to continuous production - Points for suppressing by-products and improving yields - Design of flow reaction equipment for production scale - Prediction of chemical reactions and condition optimization using machine learning - Real-time monitoring of flow rates, pressure, and temperature, and quality control through the introduction of PAT - Compliance with regulations for safe flow synthesis - GMP compliance for flow synthesis and continuous production processes - Equipment design, troubleshooting measures, and modularization in the continuous operation of unit processes - Continuous production of active pharmaceutical ingredients

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Book Title: Production Technology of Useful Substances Using Bioprocesses －－－－－－－－－－－－－－－－－－－－－ ~ Cultivation, Separation, and Purification Techniques for Animal and Plant Cells and Microorganisms ~ ◎ How to select the appropriate species for the target substance? What are the key points for designing a high-yield process and operating conditions? ◎ Clearly identify the advantages and disadvantages of each method regarding development time, production speed, and cost, and utilize them for problem-solving! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ≪1≫ Design of high-yield bioreactors and optimization of their operating conditions ≪2≫ Selection of cultivation methods and key points for optimal cultivation operations (animal cells / plant cells / microorganisms) ≪3≫ Production technology of useful substances using microorganisms ≪4≫ Separation and purification techniques in bioproduction and key points for their application

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• Technical and Reference Books

Book Title: Development of Optical Circuit Implementation and Devices for Next-Generation High-Speed Communication －－－－－－－－－－－－－－－－－－－－－ ★ Prospects for Silicon Photonics and Optoelectronic Co-Packaging Technologies Towards Beyond 5G and 6G! ■ Key Points of This Book ◆ Silicon Photonics, Integrated Devices ◆ Design and Applications of Photonic Polymers ◆ Optical Connections, Optoelectronic Conversion Devices ◆ Development of Devices Supporting Optical Communication

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Book Title: Development of Ceramics for Electronics, Evaluation Methods, and Applications ---------------------------- ★ Detailed explanation of various control methods for dielectric, piezoelectric, insulating, and heat-resistant properties! ★ A comprehensive overview of the latest manufacturing and development techniques! ■ Key Points of This Book ◆ Development and application examples of ceramics for electronic device materials ◆ Processing and coating technologies for ceramics ◆ Energy-saving techniques for the development and production of new ceramics, crystal orientation technology ◆ Property evaluation and condition observation methods for ceramics

• Technical and Reference Books

Book Title: Factors Leading to Human Errors and Measures for Reduction and Prevention of Recurrence －－－－－－－－－－－－－－－－－－－－－－－－－－ ★ Easier said than done! How to continue and deploy company-wide the basics of error prevention, which are the thorough implementation of '5S', adherence to 'standard operating procedures', and reporting and utilizing 'near misses'? ★ 'New error prevention and training methods' using IoT, artificial intelligence, and VR! ■ Key Points of This Book 〇 Cultivating workers who do not repeat mistakes and can recognize dangers - What are the appropriate training methods for leaders, new and young employees, and part-time or contract workers? - How to instill safety awareness in workers who have no experience with accidents or troubles? - Inheriting the tacit knowledge of skilled technicians using VR! 〇 There are hints in the education and measures conducted in different industries - Preventive measures implemented in the aviation field where mistakes are absolutely not tolerated! - Training and education in chemical plants facing a mass retirement of skilled workers! - Utilizing near misses in pharmacies where highly individualized tasks are required! 〇 Creating an organization and culture that prevents errors in advance - How to instill '5S' activities? - Preventing inappropriate authority gradients and communication failures - Learning from the Toyota method to adhere to standard operations

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Book Title: Development and Process Design of CO2 Separation, Recovery, and Storage Technologies -------------------------------------------------- ★ How to design a low-energy, low-cost recovery process? Detailed explanations of process and cost evaluation cases! ■ Key Points of This Book ◆ CO2 Separation and Recovery Technologies and Material Development - How to design a relatively low-temperature recovery process? Detailed explanations of methods for utilizing unused heat! - Comprehensive guidelines and evaluation methods for designing absorbents with excellent absorption characteristics! - What about recovery processes using amine-based materials? How to reduce thermal energy? - Accelerating CO2 adsorption rates and improving efficiency through selective capture and recovery. ◆ CO2 Absorption and Fixation Technologies and Trends - Mineral fixation, environmentally friendly CO2 absorption materials, utilization of microorganisms and microalgae, chemical fixation through CO2 reduction... - What is the reduction effect of each absorption and fixation technology on atmospheric CO2? Thorough explanations of approaches to enhance reduction effects! ◆ CO2 Storage Technologies and Trends - What are the trends in CCS technology and domestic and international policy? What are the current challenges regarding technology, costs, etc.? - What are the prospects for storage technologies utilizing underground, marine areas, and biomass energy?

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Book Title: New Preparation Techniques and Evaluation for the Stabilization of Emulsions To enhance product value through "Dispersion," "Solubility," "Viscoelasticity," "Affinity," "Transmission," and "Safety"!! ■ Key Points of This Book - Latest trends in adjustment techniques and material creation! - For the design of surfactants and emulsifiers! - How to choose and use stirring machines to ensure successful product manufacturing! - Reflecting groundbreaking evaluation methods in practice! - Effectively utilizing zeta potential for both "dilute" and "concentrated" systems! - Improving the creation and manipulation of phase diagrams to exhibit strong solubilization ability! - Adjustment processes that lead to optimal emulsification methods! - Specific techniques to elucidate changes in user experience due to phase transitions! - Techniques for multifaceted verification of numerical data from abundant experimental results! - Mixing and emulsification techniques to add new functionalities! - "Short time" and "environmentally friendly" adjustment techniques! - Know-how to prevent emulsion breakdown!

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Book Title: Prospects for the Adoption of Cutting-Edge Medical Devices in Hospitals and Future Product Development －－－－－－－－－－－－－－－－－－－－－－－－－－ ◎ How are these devices actually being used in hospitals? What improvements do users feel are necessary? ◎ Examples of unmet needs that should be known in product development, including robotics, IoT, AI, VR/AR, and image processing technologies. －－－－－－－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book 1. Imaging Diagnosis and Radiation Therapy Technologies 2. 3D Printing Related Technologies 3. Surgical Navigation and Simulation Technologies 4. Surgical Assistance Robots 5. Smart Operating Rooms and Hybrid Operating Rooms 6. Aging Market and Home Healthcare Market

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Book Title: "Open Innovation Initiatives in the Development of Pharmaceuticals, Medical Devices, and Regenerative Medicine" Case Studies －－－－－－－－－－－－－－－－－－－－－－－－－－ ◎Aim to achieve innovation in a short period and pursue further profits －－－－－－－－－－－－－－－－－－－－－－－－－－ ■ Key Points of this Book ◆ Points for Building an Open Organizational Structure ◆ ◆ Smooth Licensing Agreements and Patent Strategies ◆ ◆ Initiating Innovation with Venture Companies ◆ ◆ Promoting Early Development through Industry-Academia Collaboration and Project Management ◆

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★ Business opportunities arising from the construction of large-scale supply chains and the utilization of hydrogen! －－－－－－－－－－－－－－－－－－－－－ ■ Key points of this book - Policies of various countries and trends in corporate research and development aimed at realizing a hydrogen society - High efficiency and large-scale equipment for alkaline, PEM, and solid oxide water electrolysis - High efficiency in hydrogen production through artificial photosynthesis and the development of catalysts that operate under room temperature and atmospheric conditions - Types and characteristics of hydrogen carriers and storage materials, along with recent development trends - Construction of international hydrogen supply chains and transportation systems to cities and residential areas - Enhancement of strength in hydrogen storage tanks, piping, and sealing materials, improvement of resistance to hydrogen embrittlement, and evaluation methods - Selective detection technology for trace hydrogen leakage and examples of hydrogen detectors for vehicles - Hydrogen purification and supply technologies for fuel cell vehicles and monitoring of impurities - Market for Power to Gas and technological development towards realization and cost reduction - Synthesis of methane, methanol, and lower olefins using CO2 and hydrogen as raw materials - Procurement, transportation, and storage costs of hydrogen and ammonia fuels, along with challenges for implementation - Reduction of CO2 emissions from office buildings using hydrogen energy utilization systems

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• Technical and Reference Books
• Technical and Reference Books

★ Development points for medical device programs involving "behavioral change"! Technology development and utilization methods aimed at "quantifying symptoms"! ■ Key points of this book ● Development process and considerations for medical apps and medical device programs - General healthcare app development process - Planning, design, development, and operation of behavioral change apps ● Success factors for digital health businesses and directions for business expansion - Concept and success factors of SaMD business - New digital health business as a measure against pre-disease - Key points of intellectual property and patent strategies in digital health ● Regulations and guidelines related to digital health - Digital health regulations and product examples in Japan, the U.S., and Europe - Personal information protection and cybersecurity - Current status of online medical consultations and online medication guidance ● Market trends for digital therapeutics (DTx) and trends in drug regulation and review! - Overseas market trends for DTx and points for commercialization - Development process and considerations for DTx - Current status of insurance reimbursement and medical economic evaluation for DTx

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Book Title: Treatment Methods and Drug Development for Side Effects and Complications Arising from Cancer Treatment In an era where not only life prognosis but also quality of life (QOL) is emphasized, what are the correct coping methods and drug usage in clinical settings, and what kind of drugs will be required in the future? ■ Key Points of This Book 1. What are the side effects and complications that occur with chemotherapy/radiation therapy, and how can they be managed? 2. What is the mechanism of cancer pain and how is it addressed in actual clinical practice? 3. How are ambiguously defined and specific symptoms like cancer cachexia perceived and managed in clinical settings? 4. What impact do side effects and complications have on the continuation or cessation of cancer treatment? 5. What is the research and development of formulations aimed at the treatment and alleviation of side effects? 6. What nutritional supplements are sought by cancer patients?

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Book Title: Development Trends of High-Frequency Compatible Materials and Their Applications in 5G and Millimeter-Wave Radar －－－－－－－－－－－－－－－－－－－－－－－－－－ ★Latest Development Trends of Millimeter-Wave and High-Frequency Compatible Materials for the Upcoming Era of "Autonomous Driving" and "5G" ★From low dielectric constant resins, adhesive technologies for smooth copper/resin, to radar absorbing sheets for the 79GHz band －－－－－－－－－－－－－－－－－－－－－－－－－－ ■Key Points of This Book ●Development Trends and Material Technologies for High-Frequency Compatible Substrates ・Resin materials required for high-speed, high-frequency FPC and reduction of transmission loss ・Development of high-frequency printed wiring boards using low dielectric loss materials ●Miniaturization and High Gain of Antennas for Millimeter-Wave Band ・Antenna design technologies for long-distance and high-resolution applications ・Design and development case of millimeter-wave combline antennas using liquid crystal polymers ●Development of Electromagnetic Wave Absorbing and Transmitting Materials for Millimeter-Wave Radar ・Design methods and performance evaluation of radar absorbers for millimeter-wave radar ・Development of sheet-type radar absorbers for millimeter-waves to prevent malfunctions in autonomous driving ●Design of Millimeter-Wave Circuits and Development of Component Parts ・Low-loss, compact, low-cost narrowband millimeter-wave bandpass filters ・Improved usability (lighter, flexible) of millimeter-wave flexible waveguides

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Book Title: Development and Application Cases of Sensor Fusion Technology ★ A comprehensive explanation of specific strategies for "sensing and image processing resilient to image degradation and environmental changes" and "object and pedestrian recognition using deep learning" by a wealth of authors! ■ Table of Contents Chapter 1: Development of Camera and Image Processing Technologies Leading to Improved Visibility and Detection Accuracy Chapter 2: Sensing Technologies Using Cameras Chapter 3: Sensing Technologies Using Radar Chapter 4: Development and Application of Inertial Sensors Chapter 5: Development and Application Cases of Tactile Sensors for Realizing Collaborative Robots Chapter 6: Development and Application of Semiconductor Devices Supporting Sensing and Machine Learning Chapter 7: Development of Sensor Fusion Technology Chapter 8: AI and Deep Learning Technologies for Autonomous Driving, External Sensing, and Control Chapter 9: Application Cases of Sensor Fusion in Automobiles Chapter 10: Application Cases of Sensor Fusion in Robots

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Book Title: Early Diagnosis Techniques and Progression Suppression/Development of Preventive Drugs and Functional Foods for Dementia －－－－－－－－－－－－－－－－－－－－－－－－－－ ◎ What is the approach to conducting clinical trials that ensures success in linking developed active ingredients to products? ◎ Requirements demanded by the functional labeling system for development and tips for maximizing its use! －－－－－－－－－－－－－－－－－－－－－－－－－－ ■ Table of Contents Chapter 1: Diagnostic Technologies for Early Detection of Dementia and Their Precision Enhancement Chapter 2: Latest Research Trends in Biomarkers for Dementia Chapter 3: Practical Approaches to Preventing Clinical Trial Cancellations and Evaluating Efficacy Chapter 4: Non-Clinical Trials and Model Animal Creation for Dementia to Avoid Failures in Human Clinical Trials Chapter 5: Domestic and International Market Trends and Measures Surrounding the Dementia Issue in 2025 Chapter 6: Research on Targets Expected to Suppress Progression and Prevent Dementia and Their Onset Mechanisms Chapter 7: Current Status of Diagnosis and Treatment in Clinical Settings and Clinical Needs Chapter 8: DDS Technology Enabling Blood-Brain Barrier Passage and Its Evaluation Chapter 9: Development of Functional Foods and Health Foods (Supplements) Expected to Suppress Progression and Prevent Dementia

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Book Title: How to Break Down the Walls Between the Research and Development Department and Other Departments, and Build a Cooperative System －－－－－－－－－－－－－－－－－－－－－ ★ Here is the prescription for vertical organizations and bureaucratic structures! How did we bridge the "too great a distance" between the research and development department and other departments to achieve rapid commercialization! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book 1. How to resolve territorial consciousness and power struggles! Creating systems for mutual exchange and understanding! 2. "It's not my responsibility" and "I'm not at fault" Blaming others will not fill the gaps between departments! How we bridged the gaps with other departments and built cooperative relationships! 3. The inward-looking orientation and self-preservation prevalent in organizations create conflicts between departments! How we reformed a "heavy," "slow," and "rigid" organization! 4. Methods for resolving inter-departmental friction! What are the communication techniques that prevent breakdowns even when opinions clash! 5. What are the strategies for bridging the gaps between departments that simply cannot understand each other! 6. 7. 8. 9. 10.

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• Technical and Reference Books
• Technical and Reference Books