Technical Information Magazine 202303-01 Comprehensive Analysis of Biomolecular Interactions
This paper presents a comprehensive analysis of interactions using multiple methods, including surface plasmon resonance and isothermal titration calorimetry.
The technical information magazine The TRC News provides the latest information on analytical techniques that are useful for research and development, solving production troubles, and quality control. [Abstract] Molecular interaction analysis is an indispensable method in the study of life phenomena and the development of therapeutic drugs. The information on interactions obtained by different methods varies; for instance, surface plasmon resonance provides kinetic parameters of interactions, while isothermal titration calorimetry can acquire thermodynamic parameters of interactions. This paper introduces comprehensive analysis cases of interactions using multiple methods through multifaceted analysis. [Table of Contents] 1. Introduction 2. Surface Plasmon Resonance / Isothermal Titration Calorimetry 3. Analysis of the Interaction between STING and cGAMP 4. Conclusion
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Technical Information Magazine The TRC News "Comprehensive Analysis of Biomolecular Interactions" 【Abstract】 Molecular interaction analysis is one of the indispensable methods in the study of life phenomena and the development of therapeutic drugs. The information obtained from interactions varies depending on the method used; for example, surface plasmon resonance provides kinetic parameters of interactions, while isothermal titration calorimetry can acquire thermodynamic parameters. This paper introduces case studies of comprehensive analysis of interactions using multiple methods for multifaceted analysis. 【Table of Contents】 1. Introduction 2. Surface Plasmon Resonance / Isothermal Titration Calorimetry 3. Analysis of the Interaction between STING and cGAMP 4. Conclusion 【Figures and Tables】 Figures 1 to 9, Table 1 Kinetics analysis results of STING and cGAMP by SRP Thermodynamic analysis results of STING (WT) and cGAMP by SPR Thermodynamic analysis results of STING (R232H) and cGAMP by ITC Comparison of thermodynamic parameters Changes in binding free energy for each STING and cGAMP interaction (differences by amino acid residue) X-ray crystal structures of each STING and cGAMP complex
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