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  6. TOC Standard Solution EP System Compatibility Test Standard Solution Set

TOC Standard Solution EP System Compatibility Test Standard Solution Set

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Sievers

last updated:Oct 09, 2026

セントラル科学
セントラル科学
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Would you like to improve your daily work efficiency with prepared standard solutions?

This is a set of standard solutions compliant with EP 2.2.44. TOTAL ORGANIC CARBON IN WATER FOR PHARMACEUTICAL, accompanied by a NIST certificate. *On July 1, 2026, the European Pharmacopoeia (EP 12.3) was revised, and the standard solutions for sucrose and benzoquinone were changed to Chemical Reference Substances (CRS). ★EP standard material supplier: EDQM (European Directorate for the Quality of Medicines) The Sievers brand TOC analyzer can be used, as well as TOC analyzers from other manufacturers. Since it is pre-prepared, it can be used immediately.

    Water quality testingPharmaceutical water production equipment and facilities
SST.jpg

TOC Standard Solution EP System Compatibility Test Standard Solution Set

SST.jpg
SST.jpg
  • Related Link - https://aqua-ckc.jp/topic/epstandard
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basic information

【Composition】 Blank water: 1 bottle 500μg C / L sucrose standard solution: 1 bottle 500μg C / L 1,4-benzoquinone standard solution: 1 bottle 【Volume】 40 mL This product requires refrigeration.

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P2

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Applications/Examples of results

EP system conformity testing for TOC measurement. There are numerous achievements in pharmaceutical companies.

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SSTD31035-01 TOC Standard Solution EP System Compatibility Test Standard Solution Set

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Sievers standard solution contamination management strategy

Sievers standard solution contamination management strategy

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Traceability of Sievers standard solution and vials

Traceability of Sievers standard solution and vials

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Standard solution for TOC measurement

Standard solution for TOC measurement

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Requirements of the Japanese Pharmacopoeia for TOC standard solutions.

Requirements of the Japanese Pharmacopoeia for TOC standard solutions.

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Understanding the uncertainty of certified reference materials.

Understanding the uncertainty of certified reference materials.

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Suitability of Sievers TOC meter and SDBS standard solution for the Japanese Pharmacopoeia

Suitability of Sievers TOC meter and SDBS standard solution for the Japanese Pharmacopoeia

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Sievers Products Standard Solutions & Consumables Catalog

Sievers Products Standard Solutions & Consumables Catalog

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Revision of EP regulations: New standards for TOC testing and new standard values by container capacity.

Revision of EP regulations: New standards for TOC testing and new standard values by container capacity.

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Are you ready for the system suitability testing of the TOC analyzer compliant with the European Pharmacopoeia (EP 12.3) revision?

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The revision of the EP that came into effect on July 1, 2026, has significantly changed the requirements for the system suitability test (SST) of TOC analyzers. After the implementation of EP 12.3, in order to clarify standardization and traceability within the EP, the standard solutions for the system suitability test of TOC analyzers must use sucrose and 1,4-benzoquinone, which are certified as EP reference substances (Chemical Reference Substances: CRS). With the EP standard solution becoming the new standard, if USP standard solutions are to be continued, it is necessary to explain the validity of adopting USP reference substances. We have published a page on our website that explains the key points of the revision, necessary responses, considerations for continuing to use USP standard solutions, and ways to utilize EP standard solutions to reduce operational burdens. If you are considering how to respond to the EP revision, please take a look at the related links. Additionally, in the related materials, we provide detailed information on the requirements for standard solutions, reference values by container type, and comparative evaluation results using Sievers TOC analyzers, highlighting key points for quality control and regulatory compliance of pharmaceutical water.

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セントラル科学

セントラル科学

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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.

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