テカンジャパン List of Products and Services

Researchers at Tokyo University of Technology's Faculty of Applied Biological Sciences are focusing on the anti-aging functions of food and studying the effects of various food components on mitochondria. Using the "Spark 10M Multi-Detection Mode Microplate Reader," they are screening compounds that promote mitochondrial activity through microplate-based cell assays. By culturing adherent cells in microplates and staining them with fluorescent dyes, changes in mitochondrial membrane potential caused by test compounds can be visualized, and changes in intracellular ROS concentration can also be measured. Additionally, multiple experiments can now typically be run at once using a 24-well microplate. [Case Study] - Installation Site: Tokyo University of Technology, Faculty of Applied Biological Sciences - Installed Product: "Spark 10M Reader" *For more details, please refer to the PDF document or feel free to contact us.

The International Ocean Discovery Program (IODP) is a project that operates scientific drilling vessels to investigate and study seafloor sediments, rocks, and the seafloor environment. Researchers from around the world collect samples suitable for their respective research purposes, conduct some initial analyses on board the vessel, and then return to land for detailed analysis. The focus of the research is the analysis of microbial enzyme hydrolysis. For this purpose, fluorescence measurements are conducted using the "Spark 10M Multi-Detection Mode Plate Reader." [Case Study] ■ Implementation Site: International Ocean Discovery Program (IODP) ■ Implemented Product: "Spark 10M Multi-Detection Mode Plate Reader" *For more details, please refer to the PDF document or feel free to contact us.

At the University of Salzburg's Photodynamic Inactivation Research Laboratory, we are researching technologies that utilize photosensitive substances for human health. Reactive oxygen species (ROS) have the ability to eliminate major pathogens and cancer cells, so we aim to generate ROS using various photoactive compounds and apply this in a wide range of fields from food contamination removal to medical applications. In our laboratory, we use the 'Spark 10M Reader' to evaluate the amount of photosensitive substances taken up by cells. All photosensitive molecules can be tracked over time through fluorescence measurements of their intracellular concentrations. It is very convenient as we can incubate culture plates in the measurement chamber while managing the environment. Additionally, by using the new "Te-Cool Cooling Module," we have made some preliminary experiments possible. We can now study methods to utilize PDI for the removal of surface contamination by mimicking the conditions when microorganisms are placed outside the human body. [Case Study] ■ Installation Site: University of Salzburg, Photodynamic Inactivation Research ■ Installed Product: "Spark 10M Plate Reader" *For more details, please refer to the PDF document or feel free to contact us.

The Department of Medical Bioengineering at Eindhoven University of Technology has achieved a high level of diversification due to the integration of three existing research groups. We present a case study of the "Spark," which features the ability to switch between filter measurements and monochromator measurements, making it ideal for research groups across various fields. 【Overview】 ■ Implementing Company - Eindhoven University of Technology (TU), Department of Medical Bioengineering ■ Implemented Product - Spark Multi-Mode Reader *For more details, please refer to the PDF document or feel free to contact us.

The MATF, a central research facility at Monash University, provides high-quality and high-affinity monoclonal antibodies for biomedical research projects worldwide and has received high acclaim. The facility has taken a new step by incorporating functional screening of antibodies using 'Fluent' into its unique high-throughput service. The process of functional screening, which is essential for many projects, was traditionally carried out by customers at their own facilities and was labor-intensive. However, it will now be possible to outsource this to MATF. MATF utilizes a comprehensive and flexible automation system to complete tests in a short amount of time. [Case Study] ■ Implementation Site: Central Research Facility at Monash University - MATF ■ Implemented Product: "Fluent Laboratory Automation Solution" *For more details, please refer to the PDF document or feel free to contact us.

Dart NeuroScience, Inc. (USA) is a company focused on developing new treatments for neurological disorders, particularly those affecting cognitive functions such as memory. The company synthesizes over 1,000 new compounds each week and sends them to its drug discovery pipeline, making compound management a significant challenge. To ensure processing capacity that can accommodate various drug discovery programs while accurately filling hundreds of assay plates each day, a dispensing system became essential. After seeking a new platform to enhance assay plate production capabilities and considering various solution providers, the decision was made to implement our "Fluent Platform" due to its high capacity on the work table and fast dispensing speed. [Case Study] ■ Client: Dart NeuroScience, Inc. ■ Challenge: Management of over 1,000 new compounds each week Use of specialized 1536-well microplates ■ Product Implemented: "Fluent Platform" *For more details, please download the PDF or contact us.

MorphoSys, a company based in Germany specializing in the research and development of antibodies, has extensive experience in designing novel assays aimed at screening and characterizing therapeutic antibodies. The company's technology development department has secured the processing capacity necessary for the development of its products by utilizing various automation solutions. However, the dilution of antibodies for screening has always been done manually, creating a bottleneck in the workflow. Therefore, we proposed the 'D300e Digital Dispenser,' which can use aqueous solutions. The ability to reduce costs associated with pre-dilution and eliminate waste was the deciding factor for the introduction of this product. [Case Study] - Client: MorphoSys - Challenge: Automated production of dilution antibodies for screening - Product Introduced: "D300e Digital Dispenser" *For more details, please refer to the PDF document or feel free to contact us.*

The Australian Centre for Eye Research (CERA), established in 1996, is an institution that combines public health and clinical epidemiology with cutting-edge research to elucidate the causes of eye diseases and develop new treatments. The Neuroregeneration Research Unit and the Clinical Genetics Unit are creating cell models of diseases that can lead to blindness, such as glaucoma, age-related macular degeneration (AMD), and hereditary retinal dystrophies, using induced pluripotent stem cells (iPS cells) to explore potential therapies. After establishing stem cell lines, the challenge was to develop a reliable protocol for maintaining this cell culture, but the manual process was cumbersome and time-consuming. To address this, a custom-made sterile work 'Freedom EVO System' equipped with an 84-plate LiCONiC incubator was introduced. [Case Study] - Installation Site: Australian Centre for Eye Research (CERA) - Purpose of Installation: To free staff from simple tasks and minimize variability in cultured cells - Product Installed: 'Freedom EVO System' *For more details, please refer to the PDF document or feel free to contact us.

We will introduce case studies of the Tecan Freedom EVO® liquid handling workstation. The International Drug Discovery Incubation Group at Osaka University has opened its doors to drug discovery researchers in the Kansai region, establishing a shared facility where high-throughput technologies, including the Tecan Freedom EVO workstation and the Infinite M1000 microplate reader, are available. [Contents] - The International Drug Discovery Incubation Group at Osaka University has established a shared facility with funding support from JST to assist drug discovery research at universities and companies, promoting collaborative research between academia and industry. - Equipped with the latest high-throughput devices comparable to those used in pharmaceutical companies. - Supports early-stage drug discovery research and the exploration of new target proteins, facilitating the discovery of new drug candidates. For more details, please contact us or download the catalog.

We will introduce a case study of the Tecan Freedom EVO® workstation. At the Department of Bacteriology, Tokyo Medical University, the Freedom EVO workstation equipped with the HydroSpeed Plate Washer and the Infinite F200 PRO Multi-Detection Mode Reader is used for high-throughput screening of compounds in research on refractory bacterial infections. [Contents] - It is expected that understanding the molecular mechanisms of biofilm formation will lead to the development of effective prevention and treatment methods for biofilm infections. - The Freedom EVO is used to screen compounds that inhibit bacterial biofilm formation. - By automating processes such as dispensing compounds and culture media, plate washing, and absorbance measurement, time can be used more effectively. For more details, please contact us or download the catalog.

We will introduce case studies of Tecan's microplate readers. Researchers at Kyoto Institute of Technology are utilizing Tecan's microplate readers and microarray devices in the development of a highly sensitive immunodiagnostic technology using immobilized single-chain antibodies (scFv). [Contents] - Leading research on a new immunodiagnostic technology that immobilizes single-chain antibodies on plastic materials - Can be produced at less than 10% of the cost compared to conventional whole antibodies (mAb), with detection sensitivity improved by 10 to 100 times - Exhibits excellent resolution even with low signal intensity - Offers high convenience for continuous measurements - Creates new scripts to enable the use of multi-well plates in different formats with just a phone call For more details, please contact us or download the catalog.

We introduce a case study on the implementation of the Tecan Freedom EVO 200 workstation. The Life Sciences Research Laboratory at Ishihara Sangyo Co., Ltd. successfully automated efficient siRNA transfection using the Tecan Freedom EVO(R) 200 workstation through collaborative research with Osaka University’s Industry-Academia Collaboration Headquarters, paving the way for high-efficiency high-throughput screening of small RNA libraries. [Contents] - Optimization of the siRNA transfection system using HVJ envelope. - Automation eliminates variations and human errors arising from differences in experimenter skills. - Automation significantly expands the range of applications, and we are considering its use on a larger scale in the future. For more details, please contact us or download the catalog.

We introduce a case study on the implementation of Tecan's Infinite 200 series plate reader. A research group at Nagasaki University has established a highly sensitive diagnostic method for detecting prions in cerebrospinal fluid samples from patients suspected of having Creutzfeldt-Jakob disease (CJD) using Tecan's Infinite 200 series plate reader. This raises expectations for reliable ante-mortem diagnosis. [Contents] - Researching the mechanisms of prions and their properties as infectious agents of transmissible spongiform encephalopathies (TSE) - Utilizing both monochromator-based and filter-based models of the Infinite - Recently introduced a fourth unit - Strongly wishing to use the plate reader for other research as well For more details, please contact us or download the catalog.

Picarro, Inc. uses the Cavro(R) CentrisPump as a component of its atmospheric water vapor isotope analyzer. The company's high-sensitivity devices are designed to operate fully automatically in remote locations, providing environmental scientists with data that helps understand the Earth's climate. For more information, please contact us or download the catalog.

SensiQ Technologies is a company that develops SPR devices for the life sciences field. When designing a new system, there is the option to either develop everything in-house or utilize OEM solutions. We present a case where, after considering various products, we decided to implement the "Cavro Series," which excels in both accuracy and resolution. [Overview] ■ Implementing Company - SensiQ Technologies ■ Implemented Products - Cavro Robotic Sample Processor (RSP) - Cavro Centris Pump *For more details, please refer to the PDF document or feel free to contact us.

We would like to introduce a case study on the implementation of the Tecan Freedom EVO200 workstation. The Japan Livestock Improvement Association has established a database for DNA typing related to parentage determination for pedigree registration, as well as individual identification of all cattle in Japan over the past 10 years. The association is automating DNA extraction using the Tecan Freedom EVO200 workstation equipped with a sample identification module using barcodes. [Contents] - Automation of the DNA extraction process saves manual labor and time. - Managing everything with barcodes is very convenient and eliminates human errors. - Identification using PosID barcodes is particularly important. - It also helps researchers automate tasks in other laboratories. For more details, please contact us or download the catalog.

We will introduce a case study of the Tecan FreedomEVO 75. Toa Eiyo Co., Ltd. is a pharmaceutical company engaged in the research and development of distinctive pharmaceuticals in the field of cardiovascular diseases such as angina and heart attacks. At the Fukushima Research Institute, which is responsible for the company's pharmacokinetic testing, the FreedomEVO 75 equipped with the 8 Plus 1 AccessTM dispensing arm was introduced to automate the sample pretreatment process and significantly improve work efficiency. [Contents] - They wanted to automate the sample pretreatment process to enhance work efficiency. - After processing, samples can be easily transferred to LC/MS/MS for measurement. - Even without specialized knowledge, scripts can be easily created. - By making slight modifications to existing programs, it can be applied to other operations. For more details, please contact us or download the catalog.

The Japan Agency for Marine-Earth Science and Technology (JAMSTEC) conducts extensive foundational research and development related to the ocean, including observations and predictions of the Earth's environment, studies of Earth's internal dynamics, and research on organisms in extreme environments. To support research on Earth's environmental observations, we have developed a compact observation device for measuring carbon dioxide in seawater using the Cavro® XCalibur (Excalibur) Pump from Tecan, which enables precise automatic pipetting. For more details, please contact us or download the catalog.

Surveillant Inc. (USA) supports the monitoring of products and raw materials for food and beverage manufacturers with a reliable high-speed screening method. The company has developed a simple and low-cost fingerprinting method based on the self-fluorescence of food using the "Infinite M1000 PRO." This method is utilized as a high-speed screening technology to detect food fraud. By using this technology in the first stage of inspection, only samples with unclear suspicious data are sent for advanced analysis such as gas chromatography-mass spectrometry, thereby reducing overall costs. 【Case Study】 ■ Client: Surveillant Inc. (USA) ■ Product Implemented: Infinite M1000 PRO *For more details, please refer to the PDF document or feel free to contact us.

The small biotech company WatchFrog, based in Paris, is a spin-off from the Comparative Physiology Laboratory of the French National Museum of Natural History. They develop and manufacture tests capable of detecting various candidate pollutants, including pesticides, plastics, cosmetics, food additives, and pharmaceutical residues. Monitoring the impact of environmental pollution on living organisms has become significantly faster due to the technology developed by the company, which uses the "Infinite F200 PRO Microplate Reader" for screening model aquatic organisms. This technology is one of the validation conditions for tests set by the Organisation for Economic Co-operation and Development (OECD) and plays a significant role in monitoring the aforementioned pollutants. [Case Study] ■ Client: WatchFrog (France) ■ Product Implemented: Infinite F200 PRO Microplate Reader *For more details, please download the PDF or contact us.

Researchers at Giessen University (Germany) have developed a microplate-based assay to test the effects of metal nanoparticles such as silver, iron, and palladium online. To study the potential of artificial metal nanoparticles in water treatment for suppressing bacterial growth during drinking water use and removing drugs and other trace contaminants from wastewater, they introduced the "Infinite M200 Microplate Reader." The system is very user-friendly, significantly reducing the time spent on repetitive tedious tasks. If needed, it can be combined with fluorescence technology to evaluate cell viability in real-time or an injector module can be added for reagent dispensing. [Case Study] ■ Installation Site: Giessen University (Germany) ■ Installed Product: Infinite M200 Microplate Reader *For more details, please download the PDF or contact us.

Researchers at Universitat Autònoma de Barcelona (Spain) have developed an innovative magneto-ELISA for gliadin based on optical detection using the "Sunrise" absorbance reader. Magnetic immunoassays can be performed in various formats for different applications, including the evaluation of protein conjugation to magnetic beads and nanoparticles, as well as the assessment of transducer materials for biosensing. It is also easy to optimize the parameters of solutions and assays, making it ideal for research purposes. [Case Study] - Institution: Universitat Autònoma de Barcelona (Spain) - Product Used: Sunrise Absorbance Reader, Magellan V4.0 Software *For more details, please download the PDF or contact us.*

Our company has partnered with HLFS Ursprung and the beer manufacturer Stiegl to optimize the HybriScan D Beer method for managing the quality of microorganisms that affect beer flavor on the "Infinite M200 PRO" multimode reader. HLFS Ursprung is a boarding school that provides secondary education in the natural sciences, focusing on agriculture and environmental engineering. Tecan has collaborated with this school and the beer manufacturer Stiegl to optimize assays for managing the quality of microorganisms that influence beer flavor using the Infinite M200 PRO plate reader. [Case Study] - Partnership with HLFS Ursprung and the beer manufacturer Stiegl - Introduced product: Infinite M200 PRO reader *For more details, please refer to the PDF document or feel free to contact us.

CIRAD (France) is a public organization specializing in industrial and commercial fields, advancing scientific research in many developing countries and supporting agricultural development on an international scale. After trying multiple options, they introduced the "Infinite M1000 PRO," which features flexibility in format and excellent temperature control capabilities, equipped with a monochromator-based optical system. This system allows for free selection of wavelengths and can be widely used for other research, making it suitable for assay development. Additionally, the ability to expand the device by adding functions such as fluorescence measurement, luminescence measurement, and fluorescence polarization measurement in response to changing needs is a significant advantage. [Case Study] - Installation Site: French Agricultural Research Centre for International Development (CIRAD) - Installed Product: Infinite M1000 PRO *For more details, please download the PDF or contact us.*

●Infinite 200 PRO Multi-Mode Reader As cited in 1,800 papers worldwide, it has a proven track record in research settings. ●Spark Multi-Mode Reader Various modules can be freely combined to create system configurations and upgrades that meet assay needs, such as cell-based assays. It is being utilized in various research settings around the world, starting from Japan.

●MS Sample Preparation Automation System Resolvex Series Concentration and purification of target compounds are performed under pressure. Solid-phase extraction (SPE) using pressurized gas provides maximum reproducibility and uniformity in columns and well plates. ●Multi-Mode Plate Reader Infinite 200PRO As cited in 1,800 papers worldwide, Tecan's plate readers have a proven track record in research settings. They can be used for methods such as ORAC for measuring antioxidant capacity in food and ELISA. ●Colony Picking System Freedom EVO The Freedom EVO automated pipetting system, with over 5,000 units installed worldwide, enables cost-effective automation. Equipped with a colony picker, it allows for reliable picking of various microorganisms. Automation saves valuable time and ensures reproducible results.

zPREDICTA, based in San Jose, USA, has developed new 3D technology that enables a reconstituted organ (r-Organ) platform, which mimics the original structure of human tissues in an organ-specific and disease-specific manner, taking into account human physiology and organ-specific microenvironments. *For more details, please refer to the PDF document or feel free to contact us.*

A dispensing device and analysis device can be easily constructed in a short time! This dispensing system is supplied in a nearly complete state so that it can be directly integrated into your devices or systems. Other devices can be installed here, and all that remains is to adapt the software for end users and apply your company logo. It meets the requirements of ISO 13485, 9001, FDA 21 CFR Part 820, is UL certified, and complies with regulations such as RoHS and REACH for in vitro diagnostic analysis devices and preprocessing devices.

*Please download the practical examples from the images of the cases listed in the "catalog" below.* ＝＝＝＝＝ About the XCalibur Pump ＝＝＝＝＝ The Techan Cavro XCalibur is a compact, lightweight OEM syringe pump with high dispensing accuracy. In recent years, the Excalibur has been applied to analytical devices and clinical diagnostic equipment worldwide due to its performance and robustness, and it is actively incorporated into our automatic dispensing devices. It is suitable for product development that requires space-saving and high dispensing accuracy. It is fully RoHS compliant. The valve supports various liquid path switching. The photo shows a model equipped with a specially customized valve. (*Demonstration and rental available) *For detailed specifications, please click "Download Catalog" below.*

Please click on the "catalog" example collection below to download the examples. Centris Pump The Centris Pump is a compact syringe pump module for device integration that offers high accuracy, reliability, and reproducibility, with extremely low pulsation. The new Centris Pump requires almost no maintenance due to its simple and robust mechanical design. It has the smallest footprint among OEM syringe pumps and is fully RoHS compliant. ★ Please download the catalog to view the technical specifications of the Centris Pump ★ ＝＝＝＝＝　Features　＝＝＝＝＝ - Long-life ceramic valves can also be equipped Capable of handling high liquid temperatures - High reproducibility: less than 0.05% CV/FS - High resolution: 181,490 steps (liquid delivery volume and flow rate can be adjusted in 0.3 nl increments) - Programmable flow rate: 5 nl/s to 5 ml/s (up to one stroke in 50 hours) - Compact size (installation space: 69×45 mm) * For more details, please download the PDF or contact us.

Please click on the images of the case studies displayed in the "catalog" below to download the case studies. Features of the ADP Pipetting Module: A hit product from Tecan (Demo and rental available.) ◎ Independent control with built-in firmware ◎ Double liquid level detection: Liquid levels can be detected through changes in pressure and capacitance within the pipette. ◎ Traceability: Monitoring of dispensing errors such as suction of solids, suction of bubbles, and air suction can be performed using analytical instruments and in vitro diagnostic devices. ◎ Manufacturing management: Monitoring of liquid dispensing operations during the manufacturing process ◎ Detection of non-conductive solutions (such as organic solvents) is also possible ◎ High precision and reproducibility (5-digit step/increment control) ◎ Freely control pipetting speed to accommodate the properties of liquids ◎ No chip eject tool required (the module automatically ejects the pipette tip, minimizing liquid splash contamination during ejection) ◎ Compact We are currently offering this dispensing know-how (speed control and multi-pipetting expertise). If you are interested, please contact Tecan Japan Co., Ltd. http://www.tecan.co.jp/about/profile.html

You can experience the design of a dispensing robot arm with your desired specifications using the design link below! https://apps.kaonadn.net/5463001/robot/index.html#;5 You can design configurations tailored to your needs, such as selecting nozzles and disposable tips, moving tubes and multi-well plates, and automatically loading them into analytical devices. It is possible to have a frame that allows the device to stand alone or a specification without a frame that bridges between devices. This system features liquid handling arms (XYZ) and optional accessories (probes, grippers, etc.) supplied by Tecan, which is involved in the design and contract manufacturing of numerous high-throughput automatic dispensing devices, automatic purification pre-treatment devices, and automatic measurement devices for in vitro diagnostics worldwide. Options for with or without chassis are available. It enables the best arrangement according to your purpose and application using exactly the same components as our proven devices. Robustness with a 2-year warranty. *Click "Download Catalog" for specifications.*