サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K. List of Products and Services

We will introduce analytical instruments that play an important role in quality checks and food analysis in general, including food ingredients, containers and packaging, functional components, flavors, and tastes. ◆ Example Applications ◆ 01 Carbohydrates 02 Bitter components 03 Lipids 04 Polyphenols 05 Antioxidant capacity measurement (ORAC method) 06 Organic acids 07 Amino acids 08 Foreign substances 09 Food contact materials 10 Identification of origin and raw materials 11 Odor analysis 12 Natural toxins 13 Allergens 14 Trace element analysis

High-resolution ICP-MS is an ICP-MS that uses magnetic and electric field convergence in the mass separation section. Unlike quadrupole ICP-MS, it can separate spectral interferences without collision or reaction gases, demonstrating superior performance in terms of analytical reliability, sensitivity, and efficiency. ■ Pursuit of Analytical Reliability - High mass resolution capable of separating most interferences - Visual confirmation of the presence or absence of interferences on the spectrum ■ Pursuit of Detection Sensitivity - Significantly better ion transmission compared to quadrupole ICP-MS - No loss of sensitivity due to scattering of measurement ions in the collision/reaction cell - Jet interface option allows for even higher sensitivity - Wide dynamic range: extendable up to 12 digits with the use of Faraday detectors (ELEMENT XR ICP-MS only) ■ Pursuit of Analytical Efficiency - Multi-element analysis and isotope ratio analysis with excellent scan speed - No need to select plasma conditions, gas types, or measurement modes as in quadrupole ICP-MS, reducing method development time - No need to replace gases for each measured element, shortening measurement time - Elimination of flammable and toxic gases reduces management costs and environmental impact

The "Workflow for the Identification and Quantification of Unknown Impurities in Food Contact Materials, Pharmaceutical Materials, Packaging Materials, and Contact/Sealed Materials" is a catalog published by Thermo Fisher Scientific, which mainly engages in the export and import sales of analytical instruments and maintenance services. The analysis of impurities in packaging materials involves a wide variety of chemicals, ranging from volatile substances to high molecular weight non-volatile molecules, and even metals. The inspection requires absolute reliability in the identification and quantification of unknown substances. This document provides an explanation of food contact materials and pharmaceutical contact/sealed materials, along with products that are useful for inspections, such as the "TriPlus 300 Headspace Autosampler." [Contents] ■ Overview (Food Contact Materials / Pharmaceutical Contact and Sealed Materials) ■ Volatile Substances ■ Semi-volatile Substances ■ Non-volatile Substances ■ Elemental Impurities *For more details, please refer to the PDF document or feel free to contact us.

The laser ablation (LA) system equipped with a high repetition frequency laser and a galvanometric optical system, connected to a robust Thermo Scientific iCAP MX series ICP-MS, enables the acceleration, high precision, and expansion of elemental analysis capabilities. ■ Simplification and acceleration of elemental analysis - Solid sample surfaces are sampled by laser irradiation and analyzed directly with ICP-MS. - Complicated operations such as cleaning of instruments for traditional solution pre-treatment, and management of reagents and waste are no longer necessary, reducing costs, workload, and environmental impact. ■ Achieving sensitivity and precision equal to or greater than solution ICP-MS - Elimination of weighing errors and contamination during traditional pre-treatment, as well as interferences from acids or solvents during measurement, enhances precision. - High sensitivity is achieved through rapid ablation. - Flexible and precise quantitative methods can be applied, allowing for quantitative analysis even without standard samples of the same material as the sample. ■ Expansion of ICP-MS analytical capabilities - Analysis of a wide range of samples, including difficult-to-dissolve samples, powdered samples, and non-conductive samples, is possible. - Wide-area 2D/3D elemental imaging is achievable, covering areas of several square centimeters and depths of several hundred micrometers. - Accurate analysis is possible through imaging based on quantitative concentrations.

We have compiled a comprehensive guide on the analytical methods for chemical compounds found in food contact materials and food packaging. We introduce various analytical methods tailored to the measurement targets. You can directly access more detailed technical information through the links in the eBook. ■ FCM and food packaging material solutions ■ Fast solvent extraction ■ GC and GC-MS ■ GC-HRAM ■ HPLC and UHPLC ■ LC-MS ■ LC-HRAM ■ Elemental analysis ■ Peer-reviewed academic

◆Analysis Applications for Food Contact Materials and Food Packaging◆ Food contact materials include plastics, paper, wood, composites, glass, and metals, and there is a risk of substances such as chemicals and metals migrating from these materials into food. Regulations regarding these materials are complex, so it is necessary to efficiently monitor and control them using appropriate analytical methods. The eBook introduces various analyses of food contact materials, and you can access detailed information through the links in the document. ◆Workflow for Identification and Quantification of Unknown Impurities in Medical Devices, Pharmaceutical Packaging, and Food Contact Materials◆ Components that can cause harm by contaminating products, not only in food contact materials but also in pharmaceutical packaging materials, need to be highly controlled. In addition to explanations of a wide variety of contaminants, from volatile substances to high molecular weight non-volatile molecules and even metals, we also introduce the products necessary for analysis. *Please download from the catalog at the bottom of the page.*

The Thermo Scientific Chromeleon Chromatography Data System (CDS) simplifies the workflows of customers engaged in analytical operations, helps deepen the understanding of data, and achieves ease of use, comprehensive instrument control, automated data analysis, and flexible reporting. In preparation for next-generation lab environments, it also supports the management of complex mass spectrometry data and regulatory compliance. It is compatible with third-party LC and GC systems, allowing for centralized management of the entire chromatography environment in multi-vendor labs. By centralizing the management of tasks related to analysis, from execution to analysis, report output, and data management, it strongly supports compliance with regulations such as 21 CFR Part 11 and GxP.

The Thermo Scientific iCAP PRO Series ICP-OES offers high performance for rapid multi-element and multi-sample analysis, along with a simple design that allows for intuitive and easy operation, making daily trace element analysis comfortable. 【Rapid Multi-Element and Multi-Sample Analysis】 - The high-performance two-dimensional detector detects a very wide wavelength range with high sensitivity, enabling the acquisition of rapid and highly accurate data in multi-element and multi-sample analysis. 【Contributing to Lab Efficiency and Cost Reduction】 - Measurement time and equipment startup time have been significantly reduced, and the required sample volume and purge gas consumption have been minimized. - High matrix samples such as acids, alkalis, and organic solvents can be analyzed with high resistance, providing long-term data stability. 【User-Friendly Design】 - The simple design of the high-performance equipment and software allows for intuitive operation from sample introduction to measurement and data processing, making daily maintenance easy. *For more details, please refer to the PDF document or feel free to contact us.

Protecting food from harmful substances is one of the important concerns of society. Harmful substances can pose health risks to humans through various pathways in the food chain, such as rain caused by industrial and environmental pollution, which increases the need for analysis. Therefore, it is important to use accurate and high-precision analytical methods as the analysis of micronutrients increases. The development of Codex standards, which are global regulations concerning food and consumers, is overseen by the Codex Committee, an intergovernmental body established by the Food and Agriculture Organization of the United Nations and the World Health Organization.

Platinum group elements are a group of metals located around the center of the periodic table and are referred to as PGE. In electronic materials, PGE alloys with diverse compositions are used as substrates for low voltage and low power, thermocouples, furnace construction materials, and electrodes. Additionally, in the chemical and petrochemical industries, the excellent catalytic properties of PGE are utilized in the manufacturing processes of various organic synthesis chemicals. In the automotive industry, PGE is used as a redox agent in catalytic converters to reduce harmful substances emitted from engines, and it is added to ceramic substrates along with metals that control side reactions. The iCAP PRO XP ICP-OES can measure trace amounts of PGE in base metal matrices.

We will introduce the results obtained from the direct analysis of organic solvent samples (xylene and ethanol) using the Thermo Scientific iCAP PRO XP Duo ICP-OES, along with the performance of this device. The Thermo Scientific iCAP PRO XP/XPS ICP-OES, equipped with an excellent RF generator, generates a robust plasma and enables the direct introduction of a wide range of organic solvents by selecting the appropriate introduction system. It has also been demonstrated that the detection performance yields data comparable to that of general aqueous systems. For more details, please refer to the PDF or feel free to contact us.

Using the Thermo Scientific iCAP PRO XP Duo ICP-OES, we directly analyzed certified reference materials for representative river water and tap water in the environmental field, and we will introduce the results obtained and the performance of this device. In the measurement of certified reference materials for river water and tap water, we demonstrated excellent detection limits and quantitative accuracy through direct introduction. The device's introduction system utilized a general aqueous solution introduction system, and the plasma conditions were measured using Thermo Scientific Qtegra ISDS software. The absolute calibration method was adopted, and the validity of the analytical method was proven through the results of spiking recovery tests. Additionally, the eUV mode, specialized for the ultraviolet region, enables highly sensitive measurements of elements such as As, Cd, Pb, Sb, and Se. Furthermore, by measuring the high-concentration elements, which are the main components, using lateral photometry, we were able to measure over a wide dynamic range without dilution while avoiding ionization interference. For more details, please refer to the PDF or feel free to contact us.

This application note introduces the analytical devices necessary to comply with the elemental impurity guidelines for pharmaceuticals issued by the Ministry of Health, Labour and Welfare on September 30, 2015. The Q3D metal elemental impurities are stated to apply to new pharmaceuticals for which approval applications are submitted on or after April 1, 2017, according to this guideline. ICH Q3D establishes a risk-based assessment method to identify and evaluate elemental impurities in formulations and to set management methods. This assessment is required not only for potential elemental impurities in the formulation itself but also for potential elemental impurities that may be introduced from each component of the formulation (active pharmaceutical ingredients, excipients, container closure systems).

This article provides a detailed explanation of ICH Q3D and the 18th edition of the Japanese Pharmacopoeia (JP18), as well as an introduction to appropriate analytical methods and analytical instruments. This is a must-read article for those who fall into the following categories: - Those involved in quality control of pharmaceuticals in the pharmaceutical industry - Those looking for workflows for quality assurance - Those who want to gain a deeper understanding of the Elemental Impurities Guidelines (ICH Q3D) - Those who want to know what the 18th edition of the Japanese Pharmacopoeia (JP18) is.

The Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) ensures data quality and manages all analytical processes, from instrument control to raw data storage and processing, to the creation of final results. Today, data security, data integrity, and compliance are becoming increasingly important. Therefore, comprehensive controls regarding preventive and detection technologies are extremely important. This enables compliance with the latest regulatory requirements and ensures the highest level of data quality. Various tasks arise, such as the preparation of samples before measurement and the creation of reports in HPLC analysis. Chromeleon's e-workflow automates pre- and post-analysis work time, leading to cost reductions. *The percentage of labor reduction is based on workflow analysis results conducted within our company.

The networked or enterprise Thermo Scientific Chromeleon Chromatography Data System (CDS) is essential for compliance, efficiency, and reliable operation in modern chromatography laboratories. It manages all analytical processes, from instrument control to raw data storage and analysis, to the generation of final results. Data integrity, data security, and compliance are always prioritized, and using Chromeleon CDS facilitates audits by providing all necessary traceability. With a user management system and centralized resources, data access and backup are easily managed, ensuring data integrity.

This is a stable isotope ratio mass spectrometer (IRMS) primarily designed for light elements such as carbon, nitrogen, sulfur, oxygen, and hydrogen. It is the latest model in the DELTA series, which has over 30 years of proven performance as a standard in stable isotope ratio analysis. ■ Compatible with various pretreatment devices to support a wide range of isotope ratio analysis applications <Representative pretreatment devices> - Bulk analysis of solid powder samples: EA IsoLink elemental analyzer pretreatment device - Analysis of components separated by GC: GC IsoLink II gas chromatograph pretreatment device - Analysis of oxygen and hydrogen in water, carbon and oxygen in carbonates, etc.: GasBench Plus general-purpose pretreatment device - Analysis of aqueous solutions or components separated by LC: LC IsoLink II liquid chromatograph pretreatment device <Application examples> - Determining the origin of food, additives, and authenticity - Criminal investigations, anti-doping analysis - Environmental dynamics analysis, biogeochemical research, etc. ■ Enables stable analysis and operation of the device - Inherits the high robustness and stability of conventional models ■ Allows for high-sensitivity analysis more easily than conventional models - Equipped with the Qtegra ISDS software, which is even more user-friendly and visually appealing than the traditional ISODAT software - Improved manufacturer-guaranteed sensitivity

The Thermo Scientific AccelerOme automated sample preparation platform uses factory-manufactured reagents and kits, providing on-screen step-by-step instructions for both label-free quantification and tandem mass tag (TMT) multiplexing, allowing complex tasks to be completed in a short time. It executes the steps of a validated sample preparation workflow and simplifies method setup using a software wizard. Additionally, the reagents are pre-prepared and packaged according to purpose, making it ready for use regardless of the user's skill level. 【Features】 - Easy operation - Flexibility to meet demands - Assurance of high-quality samples - Maximization of productivity *For more details, please refer to the PDF materials or feel free to contact us.

Consistent data acquisition across various matrices, from industrial materials to environmental samples, eliminates analytical errors and improves throughput. We offer a lineup that includes a single quadrupole model and a triple quadrupole model with enhanced interference removal capabilities. ■ New technology achieving reliability independent of matrix - Improved chamber and gas dilution system - Voltage-variable skimmer cone: no need for differentiation, one unit accommodates diverse analyses - New feature Intelligent Matrix Handling: optimizes sample intake volume for each step of suction, analysis, and rinsing ■ Versatile accessories to expand analytical capabilities - Automatic dilution and high-speed analysis valve system - Laser ablation system: direct qualitative, quantitative, and imaging analysis of solid samples - Chromatographs: analysis by chemical form, etc. ■ User-friendly operation requiring no advanced skills - Vacuum components that require no user maintenance and a simple introduction system that can be replaced in minutes - Unique function that automatically removes low-mass ions that cause interference - Complex method creation, data monitoring, and equipment operation for the triple quadrupole are handled by software.

Glow Discharge Mass Spectrometry (GD-MS) is a system that samples and analyzes elements on the surface of solid samples using argon plasma. The ELEMENT GD Plus GD-MS employs a high-pressure glow discharge ion source that allows for switching between continuous and pulsed discharge, achieving both speed and flexibility in analysis. ■ Rapid analysis of elemental composition in solid materials - Simultaneous analysis of over 70 elements - A 12-digit dynamic range covering from sub-ppb levels, which are difficult to detect with XRF or OES, to major components - Semi-quantitative analysis without the need for standard samples. Precise quantification is also possible with the use of standard samples - High throughput: Rapid sampling and vacuum evacuation of high-pressure glow discharge allow for analysis in about 10 minutes per sample, including sample exchange ■ Compatibility with a wide range of materials and elements - Rapid analysis of metals and semiconductor materials. Non-conductive ceramics can also be analyzed using pulsed discharge and secondary electrodes - High-sensitivity analysis of C, N, and O with a newly developed ion source option - High-sensitivity analysis of low melting point elements Ga, In, and Te using pulsed discharge and cooling mechanisms ■ Multi-element simultaneous analysis with a wide dynamic range for depth profiling Supports rapid analysis from nm-order thin films using pulsed discharge to depth profiling up to 100 µm, which would take a long time with SIMS.

The laser ablation (LA) system equipped with a high repetition frequency laser and a galvanometric optical system, connected to the robust Thermo Scientific iCAP PRO series ICP-OES, enables the acceleration, high precision, and expansion of elemental analysis capabilities. ■ Simplification and acceleration of elemental analysis - Sampling of solid sample surfaces through laser irradiation, followed by direct analysis with ICP-OES. - Elimination of cumbersome operations such as cleaning of equipment for traditional solution pre-treatment, and management of reagents and waste, thereby reducing costs, workload, and environmental impact. ■ Achieving sensitivity and precision equal to or greater than solution ICP-OES - Elimination of weighing errors and contamination during traditional pre-treatment, as well as interferences caused by acids or solvents during measurement, leading to higher precision. - Increased sensitivity through high-speed ablation. - Application of flexible and high-precision quantification methods, allowing for quantitative analysis even without standard samples of the same material as the sample. ■ Expansion of ICP-OES analytical capabilities - Ability to analyze a wide range of samples, including difficult-to-dissolve samples, powdered samples, and non-conductive samples. - Implementation of analysis tailored to the purpose, from localized to wide-area sampling of the sample.