サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K. List of Products and Services

The Dionex Integrion HPIC system is an ion chromatograph that combines ease of use with various features such as HPIC, consumable tracking, and troubleshooting, built on 40 years of accumulated know-how in addition to the basic performance of traditional ion chromatographs. It has a compact, integrated design that allows for nearly complete access to all consumables from the front by fully opening the door, resulting in a user-friendly design that considers the customer's perspective. Additionally, by using an innovative tablet PC as the analytical device, remote operation becomes possible, allowing control of the system even from outside the lab, enhancing convenience and expanding the ways to use the ion chromatograph. **Features** - Simple plumbing - Integrated structure - Removable tablet - Eluent generator *For more details, please refer to the PDF document or feel free to contact us.*

The Dionex ICS-6000 HPIC system is a high-performance modular ion chromatography system with high reliability. Its robust system design allows for operation at up to 5,000 psi, providing consistently reliable results. As a high-end model of ion chromatography systems, it is designed for users looking to expand the possibilities of ion analysis. 【Features】 ■ High-speed, high-resolution, high-sensitivity analysis ■ Modular design compatible with all applications ■ Capillary IC compatible ■ Can be combined with eluent generators ■ Settable for 2 channels ■ Remote operation via tablet *For more details, please refer to the PDF materials or feel free to contact us.

The "ISQ EC" is a single quadrupole mass spectrometer designed with ease of use in mind. When incorporating mass spectrometry (MS), it provides many advantages while resolving the complexities that arise. It can be seamlessly connected to your IC or LC systems, allowing for easy and quick system usage. By combining IC or LC with MS, it achieves high sensitivity and accurate quantification through improved selectivity, as well as reducing false negatives and false positives by confirming the spectra of chromatographic peaks. 【Features】 ■ High sensitivity and more accurate quantification ■ Confirmation of mass peaks in chromatography, eliminating false negatives and false positives ■ Improved specificity ■ Enhanced resolution for analytes in complex matrices ■ Familiar software interface *For more details, please refer to the PDF materials or feel free to contact us.

◆Measurement of Zinc Oxide in Sunscreen Using Ion Chromatography with Visible Absorbance Detection◆ Sunscreens are classified as over-the-counter (OTC) drugs in the United States, and zinc oxide is one of the active ingredients that has received approval from the U.S. Food and Drug Administration (FDA) for use in sunscreens (with a maximum concentration of 25%). Zinc oxide is a powdered mineral that adheres to the outermost layer of the skin, acting as a broad-spectrum blocking agent that scatters, reflects, and absorbs ultraviolet radiation, providing protection from both UVA and UVB radiation, making it unique among sunscreen ingredients. The United States Pharmacopeia (USP) has developed monographs for FDA-approved drugs, including OTC medications, and is working to obtain the necessary information to maintain high-quality pharmaceuticals. It has also initiated a global effort to update many existing monographs across all official methods. As part of this USP initiative, the addition of an ion chromatography (IC) method for zinc measurement in General Chapter <591> is proposed. This method will serve as an alternative to the existing titration-based analytical methods in the monographs for zinc-containing pharmaceuticals. *Please download from the catalog at the bottom of the page.*

We will introduce analytical instruments that play an important role in quality checks and food analysis in general, including food ingredients, containers and packaging, functional components, flavors, and tastes. ◆ Example Applications ◆ 01 Carbohydrates 02 Bitter components 03 Lipids 04 Polyphenols 05 Antioxidant capacity measurement (ORAC method) 06 Organic acids 07 Amino acids 08 Foreign substances 09 Food contact materials 10 Identification of origin and raw materials 11 Odor analysis 12 Natural toxins 13 Allergens 14 Trace element analysis

◆Analysis Applications for Food Contact Materials and Food Packaging◆ Food contact materials include plastics, paper, wood, composites, glass, and metals, and there is a risk of substances such as chemicals and metals migrating from these materials into food. Regulations regarding these materials are complex, so it is necessary to efficiently monitor and control them using appropriate analytical methods. The eBook introduces various analyses of food contact materials, and you can access detailed information through the links in the document. ◆Workflow for Identification and Quantification of Unknown Impurities in Medical Devices, Pharmaceutical Packaging, and Food Contact Materials◆ Components that can cause harm by contaminating products, not only in food contact materials but also in pharmaceutical packaging materials, need to be highly controlled. In addition to explanations of a wide variety of contaminants, from volatile substances to high molecular weight non-volatile molecules and even metals, we also introduce the products necessary for analysis. *Please download from the catalog at the bottom of the page.*

The "Workflow for the Identification and Quantification of Unknown Impurities in Food Contact Materials, Pharmaceutical Materials, Packaging Materials, and Contact/Sealed Materials" is a catalog published by Thermo Fisher Scientific, which mainly engages in the export and import sales of analytical instruments and maintenance services. The analysis of impurities in packaging materials involves a wide variety of chemicals, ranging from volatile substances to high molecular weight non-volatile molecules, and even metals. The inspection requires absolute reliability in the identification and quantification of unknown substances. This document provides an explanation of food contact materials and pharmaceutical contact/sealed materials, along with products that are useful for inspections, such as the "TriPlus 300 Headspace Autosampler." [Contents] ■ Overview (Food Contact Materials / Pharmaceutical Contact and Sealed Materials) ■ Volatile Substances ■ Semi-volatile Substances ■ Non-volatile Substances ■ Elemental Impurities *For more details, please refer to the PDF document or feel free to contact us.

We have compiled a comprehensive guide on the analytical methods for chemical compounds found in food contact materials and food packaging. We introduce various analytical methods tailored to the measurement targets. You can directly access more detailed technical information through the links in the eBook. ■ FCM and food packaging material solutions ■ Fast solvent extraction ■ GC and GC-MS ■ GC-HRAM ■ HPLC and UHPLC ■ LC-MS ■ LC-HRAM ■ Elemental analysis ■ Peer-reviewed academic

We are pleased to announce the release of the slide materials from the seminar program "Basics of Ion Chromatography," which was popular at the Dionex IC Technology Seminar 2019 - Basic Course on Chromatography! This seminar focuses on understanding and acquiring essential foundational knowledge related to analysis, such as the principles and theories of ion exchange separation and the basic components of the equipment, making it suitable for beginners in ion chromatography.

■Sales Performance Boasting Top Market Share■ Since starting sales of ion chromatography in Japan in 1975, we have pursued ease of use and have delivered over 4,000 units nationwide. We boast a market share of over 65%. *Source: R&D Corporation, Scientific Instruments Yearbook ■High-Level Customer Support System■ To ensure that our equipment can be used stably and for a long time, we collaborate with sales agents nationwide and have over 90 certified service engineers. Additionally, technical support is available from resident engineers, allowing you to use our products with peace of mind. ■Reliable Technical Expertise Supporting Analysts and Labs■ Advanced technologies such as a mobile phase generator capable of automatic generation of elution solutions and suppressors contribute to the efficiency of lab operations. We offer over 90 types of columns for ion chromatography.

The Reagent-Free IC (RFIC) eluent generator system is a groundbreaking system that allows for the inline preparation of eluent at the required concentration simply by sending ultra-pure water from a pump. It not only eliminates the hassle of eluent preparation but also enables the supply of accurate and high-purity eluent. Additionally, gradient analysis can be easily performed with just the concentration settings from the workstation.

The Thermo Scientific Chromeleon Chromatography Data System (CDS) simplifies the workflows of customers engaged in analytical operations, helps deepen the understanding of data, and achieves ease of use, comprehensive instrument control, automated data analysis, and flexible reporting. In preparation for next-generation lab environments, it also supports the management of complex mass spectrometry data and regulatory compliance. It is compatible with third-party LC and GC systems, allowing for centralized management of the entire chromatography environment in multi-vendor labs. By centralizing the management of tasks related to analysis, from execution to analysis, report output, and data management, it strongly supports compliance with regulations such as 21 CFR Part 11 and GxP.

Optimizing separation requires effort and time. Therefore, we introduce the Thermo Scientific Virtual Column Separation Simulator, which can simulate the optimization of separation on a computer.

If optimization of separation cannot be achieved by adjusting the elution solution or temperature, it is recommended to change the type of column. Using columns with different performance can significantly alter the separation depending on the ionic components. We will explain our anion columns.

If optimization of separation cannot be achieved by adjusting the elution liquid or temperature, it is recommended to change the type of column. Using columns with different performance can significantly alter the separation depending on the ionic components. We will explain our cation columns.

Ion exchange separation occurs due to the competition between the measurement ions and the eluent ions on the ion exchange sites. One of the factors that affects this ion exchange separation is the change in the flow rate of the eluent. I will explain the differences in the chromatograms obtained by varying the flow rate of the eluent and the points to be cautious about.

Ion exchange separation occurs due to the competition between the measured ions and the eluent ions on the ion exchange sites. One factor that affects this ion exchange separation is hydrophobic interaction. I will explain this factor of hydrophobicity.

Ion exchange separation occurs due to the competition between the measurement ions and the eluent ions on the ion exchange sites. One of the factors that affects this ion exchange separation is the change in column temperature. When the column temperature is altered, the retention time of the measurement ions changes due to variations in separation equilibrium, diffusion rates, degree of dissociation, and the viscosity of the eluent. The impact of temperature varies depending on the type of measurement ions and also changes with different columns and eluents. This factor of temperature will be explained.

Ion exchange separation occurs due to the competition between the measurement ions and the eluent ions on the ion exchange sites. This explains the concentration and types of eluent that affect this ion exchange separation.

Ion exchange separation is the fundamental mechanism of separation in ion chromatography, where ionic components repeatedly adsorb and desorb between the ion exchange sites and the electrolyte solution. This principle and its characteristics will be explained.

As a separation method in ion chromatography, ion exchange is mainly used. Understanding the principle of ion exchange will help in adjusting the separation to meet measurement objectives and in selecting the appropriate column. This introduces the ion exchangers packed in columns for ion chromatography.

Organic acids have been analyzed using GC, LC, and IC; however, some organic acids lack functional groups that have UV absorption and their response is insufficient, leading to a problem where adequate sensitivity for detection cannot be achieved when analyzed by LC. Additionally, GC requires the derivatization of samples for the analysis of organic acids, which demands more effort and skill. One technique for the separation and detection of various organic acids is ion chromatography with suppressor-type conductivity detection, but some organic acids cannot be separated using common elution solutions. In such cases, connecting a mass spectrometer behind the conductivity detector facilitates the identification and quantification of co-eluting organic acids. The Thermo Scientific ISQ EC single quadrupole mass spectrometer enhances the reliability of analysis by improving sensitivity, precision, and quantitativeness. This application note presents an example of the quantitative analysis of organic acids by combining IC with mass spectrometric detection, where organic acids separated using AS11-HC-4 μm were accurately quantified by mass spectrometric detection.

"Are you spending too much time preparing elution solutions?" "Wouldn't you like to aim for the accurate generation of elution solutions?" "Are you having trouble with condition considerations?" The Thermo Scientific Dionex Integrion RFIC Ion Chromatography System, known for its ease of use and proven delivery numbers, will solve these concerns. 【This is the optimal solution for customers with the following challenges】 - Want to shorten the time for elution solution preparation - Want to eliminate peak overlaps in carbonate anion analysis and gain confidence in component identification - Want to analyze anions and organic acids in a single analysis - Want to conduct analysis of amines - Want to reduce analysis time Currently, users of the Dionex Integrion with carbonate systems can upgrade.

Hydrogen peroxide is used in a wide range of industrial and medical fields as a disinfectant, bleaching agent, atmospheric absorbent, and semiconductor cleaning solution. Depending on the application, trace impurities in hydrogen peroxide can cause problems, so high-purity hydrogen peroxide is required. This paper details the results of anion analysis in hydrogen peroxide using an ion chromatography-mass spectrometry (IC-MS) system, with two measurement methods: direct injection and matrix removal. *For more details, please refer to the PDF document or feel free to contact us.*

Generally, isocratic conditions are used for elution in ion chromatography; however, when analyzing diverse ionic species, separation can be difficult and may not be achievable under isocratic elution conditions. In such cases, using hydroxide ions and performing gradient analysis with a concentration gradient can improve separation. Gradient analysis is a method that enhances separation by increasing the concentration of the eluent from low to high during the analysis, allowing components that are retained more easily to elute faster. We will introduce examples of the separation of inorganic anions and organic acids regarding the separation of ionic species due to changes in eluent concentration and the setting of gradient conditions. By using an eluent generator system, it is possible to supply accurate and high-purity eluent simply by sending ultrapure water. Additionally, gradient analysis can be easily performed with just the concentration settings from the workstation. Furthermore, the Thermo Scientific Virtual Column Separation Simulator can generate virtual chromatograms under gradient conditions online. Please utilize it for examining analytical conditions.

Leave the ion chromatography to Thermo Fisher Scientific! ■ Proud of our top market share sales record ■ Since we began selling ion chromatography in Japan in 1975, we have pursued ease of use and have delivered over 4,000 units nationwide. We boast over 65% market share. *Source: R&D Corporation, Scientific Instruments Yearbook 2019 ■ High-level customer support system ■ To ensure that you can use our equipment for a long time and reliably, we collaborate with sales agents nationwide and have over 90 certified service engineers. Additionally, you can receive technical support from resident engineers, allowing you to use our products with peace of mind. ■ Reliable technical capabilities supporting analysts and labs ■ Advanced technologies such as automatic eluent generators and suppressors contribute to the efficiency of lab operations. We offer over 90 types of columns for ion chromatography. Furthermore, we provide a wide range of application notes tailored to various analytical fields. We also offer on-demand e-learning that can be accessed easily anytime and anywhere.

To accommodate a variety of eluents in a wide range of ion chromatography applications, we offer six types of suppressors for continuous removal and regeneration. The selection of suppressors depends on the type of eluent used, the presence or absence of organic solvents, the concentration of the matrix, the total ion concentration in the sample, and the type of chromatography being performed.

In ion chromatography, depending on the component to be measured, it is possible to combine various detectors such as conductivity detectors, electrochemical detectors, and spectrophotometric detectors. By using a mass spectrometer as a detector, it is possible to obtain mass information of the target ion species in addition to retention time. Furthermore, IC and MS can complement each other for comprehensive analysis, resulting in higher qualitative accuracy. Additionally, there are many advantages, such as the ability to directly apply IC methods to IC-MS. We will also introduce the powerful features of the Thermo Scientific ISQ EC, a single quadrupole mass spectrometer designed for ion chromatography. *This document is based on the presentation titled "!!IC-MS!! Introduction of Convenient Functions for Ion Analysis Using Thermo Scientific IC-ISQ EC," which was presented at the JASIS 2019 New Technology Seminar.

Among the various ion chromatography (IC) devices available in the world, what reasons do analysts have for choosing Thermo Fisher Scientific? We asked our customers who currently use our ion chromatography devices about their reasons for choosing us and the current trends in their analytical work. This information is published on our blog site "Learning at the Bench." https://www.thermofisher.com/blog/learning-at-the-bench/icms_voc_cmd_mkt_1/ You can also download a PDF summarizing the interview, which may help you in selecting an ion chromatography device.

Ion chromatography (IC) is a widely accepted method for monitoring inorganic anions present in water, such as surface water, groundwater, drinking water, and wastewater. We present the measurement results of inorganic anions in drinking water using the Thermo Scientific Dionex IonPac AS22 column with the Thermo Scientific Dionex Easion ion chromatography system in the chemical regeneration suppression (DCR) mode.

Ion chromatography (IC) is a widely accepted method for monitoring inorganic anions present in surface water, groundwater, drinking water, and wastewater. In the United States, common alkali metal, alkaline earth metal cations, and ammonium are not considered major contaminants in drinking water, whereas in Europe and Japan, they are routinely monitored, reported, and regulated. We present the measurement results of cations and ammonium in environmental water using the Thermo Scientific Dionex IonPac CS16 column with the Thermo Scientific Dionex Easion ion chromatography system in the chemical regeneration suppression (DCR) mode.

The Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) ensures data quality and manages all analytical processes, from instrument control to raw data storage and processing, to the creation of final results. Today, data security, data integrity, and compliance are becoming increasingly important. Therefore, comprehensive controls regarding preventive and detection technologies are extremely important. This enables compliance with the latest regulatory requirements and ensures the highest level of data quality. Various tasks arise, such as the preparation of samples before measurement and the creation of reports in HPLC analysis. Chromeleon's e-workflow automates pre- and post-analysis work time, leading to cost reductions. *The percentage of labor reduction is based on workflow analysis results conducted within our company.

The networked or enterprise Thermo Scientific Chromeleon Chromatography Data System (CDS) is essential for compliance, efficiency, and reliable operation in modern chromatography laboratories. It manages all analytical processes, from instrument control to raw data storage and analysis, to the generation of final results. Data integrity, data security, and compliance are always prioritized, and using Chromeleon CDS facilitates audits by providing all necessary traceability. With a user management system and centralized resources, data access and backup are easily managed, ensuring data integrity.

PFAS compounds include perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), and due to the increasing number of organic fluorine compounds that impact the environment and precursors that cannot yet be analyzed, there is a demand for the development of suitable analytical methods. As a result, there is a growing need for a single analytical workflow that can directly quantify as many PFAS as possible. Traditional ion chromatography (IC) cannot directly analyze non-ionic perfluoroalkyl substances (PFAS). However, using continuous ion chromatography (CIC), it is possible to measure organic halogen contaminants such as AOX. Unlike the conventional titration AOX method, which only measures the total organic halogens, CIC provides additional information on adsorptive organic fluorine compounds and allows for the speciation of halogens. *Please note that the ion chromatograph introduced in this application note has been discontinued. The successor model is the Thermo Scientific Dionex Inuvion IC system.*

The industries where the use of ion chromatography is recommended are diverse, as follows. Our ion chromatograph features high speed and high separation, making it suitable for trace analysis of ionic compounds, impurities, and contaminants required in these fields, and it can be utilized in research and development as well as quality control. We have a wealth of measurement examples as listed below, so please make use of them to solve your current challenges and improve the efficiency of your analytical operations. - Semiconductors - Batteries - Electronic devices - Chemical products - Materials - Oil and gas - Biofuels - Power

N-nitrosodimethylamine (NDMA) is an organic compound represented by the chemical formula (CH3)2NNO. NDMA is a known carcinogen found in some fermented foods. The measurement of nitrite ions can be performed using wet chemical analysis, but a representative method in instrumental analysis is ion chromatography (IC). In IC, separation is achieved using an ion exchange column, and detection is carried out using conductivity detection, electrochemical detection, UV detection, or mass spectrometry. Methods using IC typically require little to no sample pretreatment for many pharmaceutical samples, and derivatization of the target components is also unnecessary.

The analytical methods for high-concentration sodium hydroxide (NaOH) are specified in JIS K1200 Industrial Sodium Hydroxide Parts 1 to 10. Among these, the methods for measuring chlorides include the mercuric thiocyanate spectrophotometric method, the modified Holthart method, and the ion chromatography analysis method. The mercuric thiocyanate spectrophotometric method is often avoided due to the strict handling and management of mercury compounds. The modified Holthart method quantifies chlorides by adding an excess of silver nitrate solution and performing back titration with ammonium thiocyanate solution, but it is not suitable for quantifying low-concentration chlorides in samples. The ion chromatography analysis method involves complex pretreatment operations and carries the risk of sample contamination; however, this application note introduces a method that automates the pretreatment step using cation exchange resin inline. This automated pretreatment is a technique for inline neutralization using our suppressor technology. It can accommodate not only NaOH but also many high-concentration basic samples, allowing for the analysis of anionic components in the samples.

Features of the Thermo Scientific Dionex Inuvion IC System • Compact and stylish design • Smart design focused on functionality allows for maintenance without special tools • Advanced high-performance pump technology and electronics reduce analysis time and improve result quality • Highly flexible, multipurpose platform allows for system configurations tailored to current needs and budget, with future upgrade options • Device control and analysis through Chromeleon software *For more details, please refer to the PDF document or feel free to contact us.*

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are currently one of the most concerning emerging contaminants. The detection and quantification of known PFAS, as well as the discovery of unknown PFAS substances, are becoming increasingly important. This catalog introduces the following: - PFAS transport pathways - Target analysis and screening of unknown compounds - PFAS sampling - PFAS analytical methods - PFAS analysis in drinking water and wastewater - Target analysis of PFAS by direct injection - AOF using combustion ion chromatography - Extraction and analysis of PFAS in soil

Cindion combustion ion chromatography has become an essential tool for screening solid, liquid, and gas samples containing corrosive and toxic halogens and sulfur components, removing potentially interfering sample components. The C-IC system is designed to simplify combustion IC analysis and offers the flexibility to expand application capabilities as needed. *For more details, please refer to the PDF materials or feel free to contact us.*

This document introduces a new total organic fluorine (TOF) analytical method for efficiently screening for PFAS contained in food contact materials (FCM) such as food packaging and cooking containers. Due to their high persistence and toxicity, several states in the U.S. are strengthening regulations on PFAS in food packaging, creating a demand for rapid and reliable assessment methods. This technology utilizes the Thermo Scientific Cindion combustion IC system to measure total fluorine (TF) and inorganic fluorine (TIF) through combustion-ion chromatography (C-IC), calculating TOF from the difference. The new system incorporates a z-fold combustion tube that enhances combustion efficiency and control through a single software, achieving reduced analysis time and improved operability. It provides reproducible results compared to conventional methods, offering an effective assessment tool for compliance with PFAS regulations. *This is an English document.*

This document provides a detailed explanation of the usefulness of combustion ion chromatography (C-IC), the latest analytical method, for the high-precision monitoring of halogen and sulfur elements, which are becoming increasingly important in the chemical industry. As halogen regulations tighten, the comprehensive management of fluorine, chlorine, bromine, and even PFAS (perpetual chemicals) that pose environmental persistence issues is an unavoidable challenge from the perspectives of product quality, equipment maintenance, and regulatory compliance. For chemical manufacturers dealing with particularly complex solid and liquid matrices, traditional sample preparation and analysis processes have been labor-intensive and have faced challenges in ensuring reproducibility and sensitivity. C-IC achieves automation and high reproducibility in analysis by integrating matrix removal through combustion with IC analysis. This document details the processes of sample introduction, combustion control, absorption, and IC detection, emphasizing the importance of low background and high sensitivity detection enabled by PFAS-free structures. It also introduces the compact design of the Cindion C-IC system, the reduction of PFAS contamination, and stable operability provided by the eluent generator. *The main text is in English.*