サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K. List of Products and Services

The "Vanquish UHPLC System" is a UHPLC device built to enhance operational efficiency while leveraging the excellent performance of the column. It is designed to accommodate all applications, regardless of HPLC or UHPLC, the size of molecules, or the complexity of the matrix. It offers high operability and maintainability, demonstrating consistent separation performance. Additionally, this system can directly plug into chromatography data systems from other manufacturers. 【Features】 ■ Pump that achieves high speed and high separation ■ Autosampler with improved sample capacity, injection accuracy, and durability ■ Reliable reproducibility and control of separation ■ Trace detection through increased sensitivity *For more details, please refer to the PDF materials or feel free to contact us.

The "Vanquish Flex UHPLC System" is a UHPLC device that improves performance and reproducibility without sacrificing quality, robustness, or ease of use. It is suitable for assays that require flexibility in solvent selection and can accommodate a wide range of applications. It provides excellent performance from method development to routine analysis. Additionally, the 2-component and 4-component mixing pump options deliver outstanding performance in LC and LC-MS workflows. 【Features】 ■ Choose the pump type suitable for your application ■ Obtain reliable results with precise handling ■ Optimize chromatography with temperature control ■ Gain an overall view using multiple detection options ■ Achieve excellent LC-MS performance using dedicated solutions *For more details, please refer to the PDF document or feel free to contact us.

The Vanquish Duo HPLC system achieves increased productivity and uptime without compromising the high performance, robustness, and ease of use that the Vanquish platform offers. Furthermore, it enables a deeper understanding of samples and allows for a quicker return on investment. 【Features】 ■ Three configurations possible by combining the Vanquish platform: ・Tandem LC: A system for effective utilization of detectors ・Dual LC: Two completely independent LCs realized in a single device ・Reverse gradient system: A system for quantitative analysis using charged particle detectors ■ The dual autosampler's injection unit is completely independent to avoid cross-contamination ■ Regulatory-compliant operating environment with Chromeleon *For more details, please refer to the PDF document or feel free to contact us.

The "Vanquish CAD・Corona Veo Technical Guide" is a catalog published by Thermo Fisher Scientific, which mainly engages in the export and import sales of analytical instruments and maintenance services. The Charged Aerosol Detector (CAD) achieves high sensitivity detection with consistent responsiveness regardless of the chemical structure of the analyte, and a wide dynamic range. This catalog includes the principles of the Charged Aerosol Detector, as well as applications such as glycan and adjuvant. [Contents] ■ Charged Aerosol Detector (CAD) ■ Principles of the Charged Aerosol Detector ■ Applications ■ Glycan (non-derivatization method) ■ Adjuvant *For more details, please refer to the PDF document or feel free to contact us.

The "ISQ EC" is a single quadrupole mass spectrometer designed with ease of use in mind. When incorporating mass spectrometry (MS), it provides many advantages while resolving the complexities that arise. It can be seamlessly connected to your IC or LC systems, allowing for easy and quick system usage. By combining IC or LC with MS, it achieves high sensitivity and accurate quantification through improved selectivity, as well as reducing false negatives and false positives by confirming the spectra of chromatographic peaks. 【Features】 ■ High sensitivity and more accurate quantification ■ Confirmation of mass peaks in chromatography, eliminating false negatives and false positives ■ Improved specificity ■ Enhanced resolution for analytes in complex matrices ■ Familiar software interface *For more details, please refer to the PDF materials or feel free to contact us.

【Triple Quadrupole Mass Spectrometer Lineup】 ■Thermo Scientific TSQ Altis Plus LC-MS/MS for high-sensitivity pharmacokinetics testing and biopharmaceutical analysis ■Thermo Scientific TSQ Quantis Plus LC-MS/MS for pharmacokinetics testing and analysis of pesticides and toxic substances requiring high sensitivity ■Thermo Scientific TSQ Fortis Plus LC-MS/MS for analysis related to environmental and food safety, as well as toxic substance analysis *The liquid chromatographs that can be connected range from general-purpose UHPLC to nano-flow LC for high-sensitivity analysis, two-dimensional LC for automated sample preparation, multi-channel LC for throughput improvement, and ion chromatography suitable for the separation of ionic compounds, allowing you to choose according to your analytical needs. Of course, these systems can be operated seamlessly with a single software.

We will introduce analytical instruments that play an important role in quality checks and food analysis in general, including food ingredients, containers and packaging, functional components, flavors, and tastes. ◆ Example Applications ◆ 01 Carbohydrates 02 Bitter components 03 Lipids 04 Polyphenols 05 Antioxidant capacity measurement (ORAC method) 06 Organic acids 07 Amino acids 08 Foreign substances 09 Food contact materials 10 Identification of origin and raw materials 11 Odor analysis 12 Natural toxins 13 Allergens 14 Trace element analysis

A universal charged aerosol detector (CAD) that measures various analytical target substances with consistent responsiveness can provide consistent area response on chromatograms regardless of the chemical structure of non-volatile analytes, ranging from ions to proteins. Additionally, its wide dynamic range allows for high-sensitivity detection. HPLC-CAD is utilized for the detection and quantification of compounds that are difficult to measure with UV detectors in various fields such as food, pharmaceuticals, and materials science. Please refer to the PDF for practical examples.

The "Workflow for the Identification and Quantification of Unknown Impurities in Food Contact Materials, Pharmaceutical Materials, Packaging Materials, and Contact/Sealed Materials" is a catalog published by Thermo Fisher Scientific, which mainly engages in the export and import sales of analytical instruments and maintenance services. The analysis of impurities in packaging materials involves a wide variety of chemicals, ranging from volatile substances to high molecular weight non-volatile molecules, and even metals. The inspection requires absolute reliability in the identification and quantification of unknown substances. This document provides an explanation of food contact materials and pharmaceutical contact/sealed materials, along with products that are useful for inspections, such as the "TriPlus 300 Headspace Autosampler." [Contents] ■ Overview (Food Contact Materials / Pharmaceutical Contact and Sealed Materials) ■ Volatile Substances ■ Semi-volatile Substances ■ Non-volatile Substances ■ Elemental Impurities *For more details, please refer to the PDF document or feel free to contact us.

We have compiled a comprehensive guide on the analytical methods for chemical compounds found in food contact materials and food packaging. We introduce various analytical methods tailored to the measurement targets. You can directly access more detailed technical information through the links in the eBook. ■ FCM and food packaging material solutions ■ Fast solvent extraction ■ GC and GC-MS ■ GC-HRAM ■ HPLC and UHPLC ■ LC-MS ■ LC-HRAM ■ Elemental analysis ■ Peer-reviewed academic

The "TSQ Altis" is a triple quadrupole mass spectrometer designed to achieve highly reliable results. Built on advanced hardware and software components, it offers unparalleled flexibility and robustness for extremely demanding applications, delivering excellent performance. With sensitivity at the attogram level, it maximizes the utilization of samples. It can reliably quantify low-concentration compounds even in very challenging matrices. 【Features】 ■ Achieves uncompromising top-level quantification performance ■ High sensitivity, high selectivity, speed ■ Robustness, reliability, reproducibility ■ Increases productivity ■ An ideal tool for developing target quantification assays *For more details, please refer to the PDF document or feel free to contact us.

The "TSQ Quantis" is a triple quadrupole mass spectrometer designed with usability in mind, allowing all users in every lab to access high-quality data. It maintains the sensitivity necessary to meet your workflow needs, enabling robust and highly reliable quantification. It can be combined with various high-performance Thermo Scientific inlet systems, such as the "Vanquish UHPLC System" and the "Vanquish Flex Binary & Quaternary UHPLC Systems." 【Features】 ■ Reliable quantification throughput ■ High sensitivity, high selectivity, speed ■ Robustness, reliability, reproducibility ■ Easy maintenance *For more details, please refer to the PDF document or feel free to contact us.

This is a triple quadrupole mass spectrometer designed for high robustness, operability, and accurate quantitative analysis of complex matrix components found in samples such as food. 【Features】 ■ Maintenance-friendly OptaMax NG ion source ■ Sweep cone that reduces contamination in the ion source ■ Matrix separator ion guide introduction system ■ Neutral blocker that enhances robustness ■ Active collision cell that avoids crosstalk effects in multi-component analysis and improves sensitivity ■ Segment quadrupole that enhances consistency in ion behavior ■ Compatible with a method library for 440 pesticide components *For more details, please refer to the PDF document or feel free to contact us.

The tribrid structure optimizes data accuracy and high qualitative capabilities, including various MSn analyses, for low molecular identification and structural analysis. The newly implemented data acquisition algorithm, AcquireX, selectively and automatically acquires comprehensive and high-quality mass spectra for a wide range of low molecules. 【Features】 ■ Equipped with quadrupole, Orbitrap, and ion trap ■ Resolution of 500,000 (FWHM @ m/z 200) ■ Two dissociation methods: CID and HCD ■ High-speed switching measurement for positive and negative ions ■ Dynamic scan management function ■ Built-in internal standard substance introduction system (optional) ■ Calibration and analysis parameters optimized for low molecular analysis ■ Automated efficiency of MSn spectrum acquisition by AcquireX ■ Assisted CE for real-time optimization of collision energy during analysis *For more details, please refer to the PDF document or feel free to contact us.

The Q Exactive UHMR quadrupole mass spectrometer boasts significantly improved sensitivity and high m/z mass resolution, providing a unique high-performance analytical solution suitable for studying the structure and heterogeneity of protein complexes. The Q Exactive UHMR mass spectrometer can perform native intact mass analysis and top-down analysis, offering structural details that cannot be elucidated by other methods. This enables a deeper understanding of protein functions, disease mechanisms, potential therapeutic targets, and biotherapeutic compounds.

The "LTQ XL" is an ion trap mass spectrometer equipped with CID and PQD dissociation methods, and it can also be optionally equipped with ETD, making it suitable for routine structural elucidation. PQD is a patented technology that eliminates concerns about low mass cut-off in MS/MS. This allows for detailed structural information to be obtained not only for expected metabolites but also for unexpected metabolites, and it can accommodate peptide quantification using isobaric labeling. More structural information can be obtained for applications in proteomics and metabolite analysis. 【Features】 ■ PQD with no low mass cut-off ■ High-resolution isolation ■ Fast positive-negative switching ■ ETD upgradeable (optional) *For more details, please refer to the PDF document or feel free to contact us.

"TraceFinder" is software that can simplify and accelerate the complex steps of target and non-target analysis, making them more productive. It can be used in combination with our range of quantitative mass spectrometers (MS) for method development, data acquisition and processing, and report generation. Additionally, it comes equipped with all the necessary features tailored to the analytical needs of laboratories, integrating all front-end chromatography systems. [Features] ■ Achieves unprecedented simplicity and speed ■ Enhances laboratory productivity ■ Customizable report creation templates ■ Efficient method development regardless of expertise *For more details, please refer to the PDF materials or feel free to contact us.

The "Q Exactive Focus" is a hybrid mass spectrometer (MS) designed with an emphasis on operability and maintainability, combining a quadrupole and an Orbitrap (a type of Fourier transform mass spectrometer). With high resolution and mass accuracy, it enables precise qualitative analysis and also allows for quantitative analysis. Based on the proven technology of the Q Exactive, it offers excellent analytical performance and stability, making routine analysis possible across a wide range of applications. Additionally, it allows for both target screening and non-target screening in a single analysis, providing the ease of use, robustness, and functionality necessary for routine analysis. 【Features】 ■ Accurate identification with high-resolution Orbitrap ■ Covers a wide concentration range ■ Highly reliable analytical data ■ Robustness suitable for routine analysis *For more details, please refer to the PDF document or feel free to contact us. *The "Q Exactive series has been discontinued, and we now offer the more compact and robust Orbitrap Exploris series as its successor."

The Thermo Scientific Chromeleon Chromatography Data System (CDS) simplifies the workflows of customers engaged in analytical operations, helps deepen the understanding of data, and achieves ease of use, comprehensive instrument control, automated data analysis, and flexible reporting. In preparation for next-generation lab environments, it also supports the management of complex mass spectrometry data and regulatory compliance. It is compatible with third-party LC and GC systems, allowing for centralized management of the entire chromatography environment in multi-vendor labs. By centralizing the management of tasks related to analysis, from execution to analysis, report output, and data management, it strongly supports compliance with regulations such as 21 CFR Part 11 and GxP.

Robust system performance built on the fundamental principles of ease of use and high reliability of hardware improves sample throughput. Achieving selectivity with high-resolution accurate mass (HRAM), high-speed scan rates, and class-leading mass spectrum quality in a compact footprint that saves bench space ensures data integrity. Equipped with smart scheduling features, it provides rich and reliable analytical results for a wide range of applications, from small molecules to peptides and intact proteins, for users of all skill levels by executing the scan types selected by the user with simple operations.

Hydrogen peroxide is used in a wide range of industrial and medical fields as a disinfectant, bleaching agent, atmospheric absorbent, and semiconductor cleaning solution. Depending on the application, trace impurities in hydrogen peroxide can cause problems, so high-purity hydrogen peroxide is required. This paper details the results of anion analysis in hydrogen peroxide using an ion chromatography-mass spectrometry (IC-MS) system, with two measurement methods: direct injection and matrix removal. *For more details, please refer to the PDF document or feel free to contact us.*

The Thermo Scientific Vanquish Core HPLC system is based on the innovative Vanquish platform, achieving reliable performance and durability through excellent analytical precision, detector sensitivity, and operability. Designed for routine analysis laboratories, it features: - Regular automatic system health checks and improved robustness to provide reliable data throughout uptime. - Simple operability through the Thermo Scientific Chromeleon Chromatography Data System (CDS), maximizing performance while ensuring data integrity and preventing data tampering and falsification. - System diagnostics that can identify equipment issues and a solvent monitoring system that measures mobile phase consumption and waste volume in real-time, minimizing unexpected or non-compliant results. - Intuitive operability and simplified maintenance supported by videos, enhancing productivity regardless of the operator's skill level. - Easy method transfer from various HPLC systems without hardware configuration changes, making it suitable as a backup system.

- I want to measure various chemical structures at once. - I don't have a standard sample, but I want to know the content. - It is difficult to detect with only a UV detector. In response to such requests, the Charged Aerosol Detector (CAD) is an HPLC detector that can be widely used for analysis. Keywords: quality control, product profiling, surfactants, additives, adjuvants, etc. The Charged Aerosol Detector (CAD) is the solution. The Charged Aerosol Detector (CAD) is a universal detector that provides consistent responsiveness regardless of the chemical structure of the analyte and achieves high-sensitivity detection with a wide dynamic range. *For more details, please refer to the PDF document or feel free to contact us.

Excipients are substances added for the purpose of shaping, bulking, and diluting solid formulations, and they consist of a mixture of compounds with various chemical properties. Both excipients and active ingredients need to be managed appropriately, and profiling their impurities is also important. What analytical methods are suitable for the detection and quantification of a wide range of excipients? Check out our ebook that covers analytical examples solved by Charged Aerosol Detectors (CAD). You are sure to find the excipient analysis you are looking for. This ebook (in English) includes the following information: • Excipients applicable to pharmaceutical manufacturing and their uses • What columns are effective for excipient analysis? Selection considering sample amount and hydrophobicity • How to detect excipients using Charged Aerosol Detectors (CAD) • Examples of excipient analysis in formulations using CAD and information from scientific papers

Surfactants and emulsifiers are common compounds found in a wide range of everyday products, including chemicals, industrial products, food, and pharmaceuticals. Analyzing these components is crucial for understanding and managing product quality. Generally, these compounds are in liquid samples and possess various chemical properties, making analytical columns and detectors key points for their analysis. Please take a look at our collection of case studies that cover surfactant analysis, which is addressed by the combination of our columns and Charged Aerosol Detector (CAD), one solution for improving analytical efficiency. This case study collection (in English) includes the following information: • Classification of surfactants and emulsifiers, as well as the applicable industrial fields and their uses • Methods for detecting surfactants and emulsifiers using the Charged Aerosol Detector (CAD) • Limitations of analyses using UV detectors and mass spectrometers that CAD overcomes • Examples of surfactant analysis from a wide range of samples and information from scientific papers using CAD

Transferring methods from old HPLC equipment to new devices or between devices from different manufacturers is a challenging task for many HPLC users. Differences in hardware design, such as the temperature control mode of the column oven, pre-column heater, and specifications of the pump—critical for gradient methods—as well as the design of the auto-sampler and the system volume determined by the plumbing, can affect the results of chromatography. This technical note introduces the gradient delay volume, which is extremely important in method transfer.

Transferring liquid chromatography (LC) methods between instruments is a challenging task that many analytical laboratories frequently face. The success of this method transfer depends on many factors, making it important to reduce the differences between the systems being transferred and the robustness of the method being transferred. This application note presents a smooth transfer from the Thermo Scientific UltiMate 3000 HPLC system to the Thermo Scientific Vanquish Core HPLC system using an HPLC method from the European Pharmacopoeia.

■Versatility to Support a Wide Range of Applications It provides excellent data quality regardless of analytical applications or sample complexity, from reliable identification and quantification of low molecules, broad proteome analysis, to characterization of biopharmaceuticals and detailed sample profiling. ■Outstanding Mass Accuracy and Intelligence-Based Data Acquisition With easy and rapid mass calibration and the Easy-IC ion source for internal calibration, sub-ppm mass accuracy is maintained over long periods. Additionally, intelligent data acquisition features tailored to specific purposes maximize the potential of high-resolution Thermo Scientific Orbitrap technology, allowing for quick retrieval of necessary information. ■Combination of Simple Usability and Robustness By simply selecting one of three different analytical modes (low molecules, peptides, intact proteins), the instrument settings are optimized for each mode, enabling rapid measurement initiation using a wealth of method templates for each analysis. Furthermore, the compact Orbitrap mass spectrometer features a maintenance structure design and software automation that minimizes maintenance, allowing for confident long-term research.

■Reliable and Accurate Detection and Quantification With Orbitrap technology, which provides high-resolution precise mass measurements, it is possible to distinguish between interfering ions and target ions with a mass resolution of up to 120,000 at m/z 200, even for slight mass differences. Utilizing excellent precision mass and MS/MS for superior quantification with a linear dynamic range exceeding four digits, it can be used for both method development and routine analysis. ■Minimize Downtime and Operate the Laboratory Smoothly By simplifying tasks necessary for maintaining equipment performance, downtime is minimized. The entire mass range of bipolar m/z 40–3000 can be calibrated at once, and with the built-in internal calibration ion source, sub-ppm mass accuracy can be maintained for over 15 days without maintenance. Additionally, the compact footprint allows easy access to internal components, enabling a quick return to measurements with minimal downtime. ■Rapid Method Setup to Focus on Result Processing Equipped with a variety of ready-to-use method templates tailored for diverse analytical applications, it allows for quick analysis of samples, enabling more time to be dedicated to interpreting the results obtained.

To ensure sufficient performance of the chromatographic system, the system suitability test (SST) requires the injection of standard samples and evaluation according to the procedure manual. The European Pharmacopoeia (EP) general chapter (Chromatographic Separation Techniques 2.2.46) defines the acceptable deviations for EP methods. Particularly, since only slight changes are permitted under gradient conditions, it is crucial to ensure that sufficient results are obtained with the original method. In high-performance liquid chromatography (HPLC), minimizing the system's dead volume can lead to a mismatch between the sample solvent and the initial gradient composition, resulting in inadequate mixing and the appearance of front peaks or split peaks. Therefore, a custom injection program can be used to reduce the impact of the injection solvent without changing the injection volume or the solvent used to dissolve the sample. This document demonstrates the usefulness of the custom injection program for meeting system suitability criteria such as symmetry, resolution, and efficiency, without altering the EP method for mebendazole.

Thermo Scientific WebSeal well plates and mats suitable for chromatography requirements can be easily selected using our selection tools and resources. Our well plates are designed for chromatography analysts using autosamplers compatible with well plates. We not only promise reliable results but also have built a wealth of experience and a proven track record as a leading company in the development of sample containers for chromatography, offering various benefits through the handling of samples using our plates.

The Thermo Scientific Vanquish HPLC system offers the highest level of flexibility, efficiency, and productivity for single and dual-channel applications, addressing the challenges faced by routine analysis laboratories. This system is built on the Vanquish platform, which incorporates many innovative features that are further enhanced to achieve system intelligence, excellent usability, and smart diagnostics. From the perspective of reducing running costs, we will quantify and present the direct benefits these features bring to the laboratory.

Before starting the analysis, it is extremely important to verify the suitability of the HPLC equipment to be used. Therefore, a system suitability test (SST) is conducted before analyzing the samples. If the integrity of the HPLC equipment is evaluated solely based on the implementation of the SST, the results of any nonconformities may lead to troubleshooting for potential issues that are time-consuming and costly. By adding a system health check to the SST, a sense of assurance regarding the system is obtained. These are diagnostic tests that are automatically performed when the HPLC system is not in use.

The transfer of liquid chromatography (LC) methods between devices is a challenging task that many analytical labs frequently face. The success of this method transfer depends on many factors, making it important to reduce the differences between the systems being transferred and the robustness of the method being transferred. We present a smooth analytical method transfer from the Agilent 1260 Infinity LC system to the Thermo Scientific Vanquish Core HPLC system.

Transferring liquid chromatography (LC) methods between instruments is a challenging task that many analytical laboratories frequently face. The success of this method transfer depends on many factors, making it important to reduce the variability between the systems involved and the robustness of the method being transferred. This presentation introduces a smooth transfer of an analytical method from the Waters Alliance HPLC system to the Thermo Scientific Vanquish Core HPLC system using the HPLC method from the European Pharmacopoeia.

Polyamines are a general term for linear alkyl amines that contain two or more amino groups in their molecules. They are present in the cells of almost all living organisms and are essential substances for cell proliferation and differentiation. They are also found in food, making their measurement indispensable. On the other hand, because polyamines do not absorb UV light, they are components for which establishing analytical methods is challenging. This application note introduces an analytical method in which a total of 26 components, including amino acids and polyamines, are eluted in 15 minutes using a pre-column derivatization method.

Arsenic exists in various forms in nature, including in water and food. It can be detected using Inductively Coupled Plasma Mass Spectrometry (ICP-MS), but the amount detected represents the total arsenic content, and it does not indicate the specific forms present. Arsenic compounds include inorganic arsenic and organic arsenic, making speciation analysis very important. In the case of arsenic analysis, connecting HPLC before ICP-MS allows for the separation of different forms using HPLC, enabling speciation analysis through detection by ICP-MS. The "Testing Methods for Pet Feed" established by the Food and Agricultural Materials Inspection Center (FAMIC) included a testing method using Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry for arsenic testing in 2018. This document presents examples of measuring inorganic arsenic in its trivalent and pentavalent forms as part of this testing method.

The robustness of HPLC equipment and trouble-free continuous operation are essential for obtaining high productivity and reliable results in analytical facilities. Analytical facilities face the challenge of handling samples with minimal human intervention. This requires robust equipment and remote monitoring technologies, such as continuous solvent monitoring. When used together, the Thermo Scientific Vanquish solvent monitor (patented technology) and Thermo Scientific Vanquish HPLC and UHPLC systems can help avoid unexpected solvent shortages and enable continuous analysis. In regulated environments, the Vanquish solvent monitor can save costs associated with creating additional regulatory documentation due to sequence interruptions, unexpected equipment shutdowns, loss of valuable samples, and depletion of mobile phases.

Resins used in various products in daily life contain a variety of additives to enhance their durability and functionality. Even in small amounts, these additives can compromise the performance of the final product if they remain in it, or lead to the byproducts of undesirable components during the manufacturing process. Additionally, the impact of the leaching of additives on human health is receiving significant attention. Against this backdrop, the importance of identifying and quantifying the additives contained in resins is increasing. In this application note, we conducted an analysis of resin additives using the Thermo Scientific ISQ EC single quadrupole mass spectrometer. Simultaneously, we assumed qualitative and quantitative analysis of byproducts and performed measurements using three detectors, including a diode array detector (DAD) and a charged aerosol detector (CAD). Furthermore, using a dual pump with a reverse gradient method and CAD, we enabled semi-quantification of unknown peaks. For HPLC, we used the Thermo Scientific Vanquish Core HPLC system, which is specialized for routine analysis. This time, we conducted measurements utilizing the capabilities of this device and confirmed its usefulness.

Quality control of oligonucleotides requires confirmation of mass, determination of sample purity, and yield. Oligonucleotides show strong absorption at 260 nm, making quantification easily achievable through UV detection. However, mass confirmation of the analyte requires mass spectrometry. Additionally, quality control necessitates fast and robust methods to ensure high throughput. These can be achieved by combining instruments such as the Thermo Scientific ISQ EM single quadrupole mass spectrometer and the Thermo Scientific Vanquish Flex binary UHPLC system. This paper introduces two workflows for data analysis. Both use peak areas from UV and MS detection to determine the relative abundance of analytes within the sample. However, the first workflow identifies analytes based on the ion species with the highest signal intensity at m/z. The second workflow employs deconvolution of mass spectra for mass determination and analyte identification.

To achieve work style reform and remote work, there is a demand for liquid chromatography that can shorten working hours in the lab. We have compiled a case study of the Vanquish Core HPLC system, which is equipped with smart features that automate manual tasks related to conventional measurements, promoting the modernization of labs and facilitating method transfer from various HPLCs, thereby contributing to a reduction in downtime due to troubles. By pressing "Download PDF," you can download the technical documents listed below in bulk. Please feel free to contact us for more details.

The Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) ensures data quality and manages all analytical processes, from instrument control to raw data storage and processing, to the creation of final results. Today, data security, data integrity, and compliance are becoming increasingly important. Therefore, comprehensive controls regarding preventive and detection technologies are extremely important. This enables compliance with the latest regulatory requirements and ensures the highest level of data quality. Various tasks arise, such as the preparation of samples before measurement and the creation of reports in HPLC analysis. Chromeleon's e-workflow automates pre- and post-analysis work time, leading to cost reductions. *The percentage of labor reduction is based on workflow analysis results conducted within our company.

The networked or enterprise Thermo Scientific Chromeleon Chromatography Data System (CDS) is essential for compliance, efficiency, and reliable operation in modern chromatography laboratories. It manages all analytical processes, from instrument control to raw data storage and analysis, to the generation of final results. Data integrity, data security, and compliance are always prioritized, and using Chromeleon CDS facilitates audits by providing all necessary traceability. With a user management system and centralized resources, data access and backup are easily managed, ensuring data integrity.

This product is a universal charged particle detector that measures various analytes with consistent responsiveness. Its wide dynamic range allows for high-sensitivity detection. It is utilized for the detection and quantification of compounds that are difficult to measure with UV detectors in various fields such as food, pharmaceuticals, and materials science. 【Features】 - Simple and intuitive operability - Compatible with UHPLC/HPLC - Easy switching function for parallel detection (such as MS) - Allows changing the mobile phase from volatile to non-volatile without removing the detector from the system - Wide flow range (0.01 to 2.0 ml/min) *For more details, please refer to the PDF document or feel free to contact us.

The "Vanquish Neo UHPLC System" is an all-in-one low-flow UHPLC system that delivers excellent performance at nano, capillary, and microflow rates without any hardware modifications. With a high-pressure design of 1,500 bar and an ultra-low gradient delay volume (GDV), it establishes a new standard for low-flow LC, maximizing the number of identifications in proteomics and enabling high-throughput, high-sensitivity analysis. Through an intuitively operable user interface, remote control, system status monitoring, self-checks, and guided maintenance tutorials, high-quality results can be obtained even by those who are not experts in analysis. 【Features】 ■ Supports flow rates from nano to 100 μL/min without hardware modifications ■ Vial bottom detection function allows for injection of small sample volumes ■ Improved quantitation performance due to excellent injection volume linearity and precision ■ High sample throughput achieved with high-pressure design and ultra-low GDV ■ Enhanced usability with a visually operable user interface *For more details, please refer to the PDF materials or feel free to contact us.