サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K. List of Products and Services

We have compiled a comprehensive guide on the analytical methods for chemical compounds found in food contact materials and food packaging. We introduce various analytical methods tailored to the measurement targets. You can directly access more detailed technical information through the links in the eBook. ■ FCM and food packaging material solutions ■ Fast solvent extraction ■ GC and GC-MS ■ GC-HRAM ■ HPLC and UHPLC ■ LC-MS ■ LC-HRAM ■ Elemental analysis ■ Peer-reviewed academic

◆Analysis Applications for Food Contact Materials and Food Packaging◆ Food contact materials include plastics, paper, wood, composites, glass, and metals, and there is a risk of substances such as chemicals and metals migrating from these materials into food. Regulations regarding these materials are complex, so it is necessary to efficiently monitor and control them using appropriate analytical methods. The eBook introduces various analyses of food contact materials, and you can access detailed information through the links in the document. ◆Workflow for Identification and Quantification of Unknown Impurities in Medical Devices, Pharmaceutical Packaging, and Food Contact Materials◆ Components that can cause harm by contaminating products, not only in food contact materials but also in pharmaceutical packaging materials, need to be highly controlled. In addition to explanations of a wide variety of contaminants, from volatile substances to high molecular weight non-volatile molecules and even metals, we also introduce the products necessary for analysis. *Please download from the catalog at the bottom of the page.*

We will introduce analytical instruments that play an important role in quality checks and food analysis in general, including food ingredients, containers and packaging, functional components, flavors, and tastes. ◆ Example Applications ◆ 01 Carbohydrates 02 Bitter components 03 Lipids 04 Polyphenols 05 Antioxidant capacity measurement (ORAC method) 06 Organic acids 07 Amino acids 08 Foreign substances 09 Food contact materials 10 Identification of origin and raw materials 11 Odor analysis 12 Natural toxins 13 Allergens 14 Trace element analysis

The "Orbitrap GC-MS HRAM Metabolomics Library" is a high-resolution accurate mass (HRAM) metabolomics library for electron ionization (EI) GC-MS. The library contains over 900 unique entries with retention indices derived from more than 800 metabolites, covering a wide range of primary and secondary metabolites (including volatile compounds) from plants, animals, and microorganisms. When used in conjunction with powerful Orbitrap GC-MS technology and proprietary software data processing tools, the identification of challenging metabolites in non-targeted experiments becomes easier than ever. 【Features】 ■ High-resolution and high mass accuracy spectra acquired at 60,000 RP (m/z 200) ■ Curated spectra refined with the elemental composition of each verified EI fragment ■ Kovats retention index entries ■ PubChem IDs for specific metabolites ■ Compatible with existing integer mass libraries *For more details, please refer to the PDF document or feel free to contact us.

The "Workflow for the Identification and Quantification of Unknown Impurities in Food Contact Materials, Pharmaceutical Materials, Packaging Materials, and Contact/Sealed Materials" is a catalog published by Thermo Fisher Scientific, which mainly engages in the export and import sales of analytical instruments and maintenance services. The analysis of impurities in packaging materials involves a wide variety of chemicals, ranging from volatile substances to high molecular weight non-volatile molecules, and even metals. The inspection requires absolute reliability in the identification and quantification of unknown substances. This document provides an explanation of food contact materials and pharmaceutical contact/sealed materials, along with products that are useful for inspections, such as the "TriPlus 300 Headspace Autosampler." [Contents] ■ Overview (Food Contact Materials / Pharmaceutical Contact and Sealed Materials) ■ Volatile Substances ■ Semi-volatile Substances ■ Non-volatile Substances ■ Elemental Impurities *For more details, please refer to the PDF document or feel free to contact us.

The Thermo Scientific Chromeleon Chromatography Data System (CDS) simplifies the workflows of customers engaged in analytical operations, helps deepen the understanding of data, and achieves ease of use, comprehensive instrument control, automated data analysis, and flexible reporting. In preparation for next-generation lab environments, it also supports the management of complex mass spectrometry data and regulatory compliance. It is compatible with third-party LC and GC systems, allowing for centralized management of the entire chromatography environment in multi-vendor labs. By centralizing the management of tasks related to analysis, from execution to analysis, report output, and data management, it strongly supports compliance with regulations such as 21 CFR Part 11 and GxP.

Strengths • By innovatively and accurately controlling the pressure of both the vial and sampling loop before transferring to the GC column, highly reliable results are achieved, ensuring excellent injection reproducibility. • Efficient heating of the entire sample path significantly reduces the risk of contamination from high-boiling solvents, enhancing system robustness. This increases productivity with year-round operation and reduces downtime. • Effective purging with more than five flow rates and a short sample path eliminates the hassle of removing residual signals from larger molecular weight polar compounds, minimizing or even eliminating carryover.

The RoHS Directive is a European law concerning the regulation of chemical substances in electrical and electronic equipment. It defines a wide range of substances, from inorganic to organic materials, as regulated items and establishes specific threshold values for each. When domestic companies export products related to electrical and electronic equipment to Europe and other regions, they must demonstrate that the concentration of all these items is below the specified threshold values. This e-learning will provide an overview of GC/MS analysis related to phthalate esters in accordance with the RoHS Directive, as well as solutions for improving operational efficiency using the Thermo Scientific Chromeleon 7 Chromatography Data System. Additionally, the latest information on effective confirmation methods for the additive TOTM, which affects the false positive results of DEHP, will also be presented. https://www.thermofisher.com/jp/ja/home/technical-resources/e-learnings/gc-ms.html

Helium gas is facing issues of rising costs and unstable supply due to the increasing demand year by year while the means of production are limited. The Helium Saver Module is designed to reduce helium gas consumption by adjusting the flow rate of the split line when measurements are not being taken or during the measurement process. By installing our GC-specific Helium Saver Module, helium gas is directly supplied to the carrier gas entering the analytical column, while nitrogen gas is used for the split flow. This significantly reduces the consumption of helium gas that was previously used for the split flow, which accounted for the majority of carrier gas consumption. Furthermore, since there is no need to change the carrier gas, the hassle of re-evaluating analytical conditions is eliminated.

In recent years, the demand for non-target analysis has been increasing in many fields, such as odor analysis and impurity analysis, using GC-MS. This involves conducting comprehensive measurements without specifying the measurement targets through full scan MS and extracting valuable information from the vast spectral data obtained. Since the full scan MS data obtained from GC-MS can contain information on hundreds to thousands of compounds, efficiently identifying valuable information from this data is a very important challenge. Additionally, it is crucial to select the optimal pretreatment device considering high extraction capability, broad coverage, and the form and properties of the sample, in order to comprehensively extract samples without loss and introduce them into GC-MS. This application note presents a case study of non-target analysis that combines a system connecting a pretreatment device to a Thermo Scientific GC-MS instrument with AnalyzerPro, a deconvolution software from SpectralWorks.

This is a technical document regarding the development of analytical methods for volatile E&L compounds by SGS in the United States. A rubber plunger stopper was used as a sample, and headspace was employed for sample extraction. This sampling technique allows for easy method setup and optimization, making it highly suitable for testing volatile leachables from polymer materials. Furthermore, by combining it with a high-resolution GC-MS system, it confidently and rapidly identifies volatile impurities in polymer materials with excellent sensitivity and mass resolution.

The detection and quantification of pesticides, contaminants, and other chemical residues is particularly important when the food is intended for infants. Many pesticide products have a maximum residue limit (MRL) typically set at 10 μg/kg, but the European Union (EU) has established MRLs for certain pesticides banned for use in baby food at 3 to 8 μg/kg. In the worst-case scenario, such pesticides and their metabolites can exceed the acceptable daily intake (ADI) for infants. The high sensitivity and selectivity of GC-MS/MS allow for the detection and quantification of regulated residues even in baby food containing multiple ingredients. This application note presents a case study of the analysis of pesticide residues in baby food using a high-sensitivity Advanced EI ion source. The increased sensitivity allows for the dilution of sample extracts, reduces system contamination, and is expected to enhance laboratory productivity.

Odor analysis is an important analytical theme that is widely conducted not only in food but also in exhaust from equipment, the atmosphere, and the construction field. Among these unpleasant-smelling compounds that humans find distasteful, many have low olfactory thresholds. Technological advancements related to measurement, such as methods for collecting odor compounds, separation in gas chromatography, and the development of detectors, have been rapidly progressing to improve performance. In this context, improvements to ion sources in gas chromatography-mass spectrometry (GC-MS) have also been made as part of efforts to enhance sensitivity, with reports indicating sensitivity improvements of more than ten times compared to conventional types in recent years. This application note presents the results of an investigation into how the Advanced EI (AEI) ion source, which has improved sensitivity compared to the standard ion source (Thermo Scientific ExtractaBrite ion source), can provide advantages in qualitative analysis, using geosmin, one of the compounds responsible for unpleasant odors, as an example.

Organic solvents are often used in the manufacturing and purification of active pharmaceutical ingredients, but due to their potential toxicity, it is necessary to verify whether they are present in pharmaceuticals to ensure patient safety. The United States Pharmacopeia (USP) method <467> provides detailed procedures for the screening, confirmation, and quantification of residual solvents, including sample preparation and analytical conditions. Gas chromatography (GC) combined with headspace (HS) sampling technology and a hydrogen flame ionization detector (FID) is an analytical method specified in USP <467>, where most target compounds are organic solvents with relatively low boiling points and good thermal stability. This technical note presents a rapid and cost-effective analysis of residual solvents using nitrogen as the carrier gas.

The detection and identification of illegal substances or suspicious materials of unknown origin is difficult, often involving complex analytical processes, which can take time to yield final results. Furthermore, high reliability, confirmed by many points, is essential for final identification. Generally, all suspicious substances seized by law enforcement agencies must be sent to scientific investigation agencies for testing. Drug testing kits can be used for the identification of certain classes of drugs, but identifying the exact active substances in unknown powders or liquids, especially new substances in drugs like "legal highs," is often challenging. When using mass spectrometry, high mass accuracy data is essential to gain the necessary selectivity in complex matrices and enhance the reliability of compound identification. By measuring the molecular weight of chemical substances with sufficient accuracy, analysts can determine the elemental composition and identify the chemical structure of substances using isotope ratios and fragmentation patterns. This application note describes a method for reliably identifying unknown substances almost instantaneously. This method connects a direct insertion probe (DIP) to the mass spectrometer and rapidly identifies compounds using both electron ionization (EI) and chemical ionization (CI).

Packaging materials are essential for maintaining the integrity of food and for safe handling, transportation, and storage. Common food packaging materials include polymer-based films and paper-based coatings, which are often layered and printed on the outside with inks, dyes, or coatings for consumer appeal and convenience. The chemical components of such food packaging (particularly those derived from polymers, dyes, and inks) can migrate into food, altering its sensory properties and composition, and potentially posing health risks to consumers. Therefore, regulatory measures are implemented to prevent the migration of food contact material components that could affect human health, alter composition, or change the sensory properties of the product. This application note reports quantitative results of residual solvent analysis in food packaging materials.

Information has become increasingly diverse in recent years, and there is a growing demand for tools that can handle vast amounts of data accurately and conveniently. For example, analytical researchers may find it sufficient to obtain calibration curves and quantitative data from chromatograms and spectral information as chromatography data. However, it may be necessary to ensure that these data were obtained under conditions where the equipment operated correctly. Computerized systems used in the development and manufacturing of pharmaceuticals and medical devices must be properly developed, implemented, and operated, leaving evidence that proves there are no issues with the quality of the pharmaceuticals or medical devices, as well as their quality assurance. Computerized System Validation (CSV) is mandated by pharmaceutical regulations. Achieving Data Integrity (DI) requires essential support from software. This technical note outlines the overview of DI and the software functions required for DI, and introduces examples of residual solvent testing as specified in USP<467> using a headspace-specific autosampler and gas chromatograph that comply with DI.

Surgical masks are worn by healthcare professionals during tasks such as surgeries, and like other medical devices, they need to be sterilized to eliminate bacteria and viruses. In some countries, sterilization using ethylene oxide is performed. On the other hand, the Centers for Disease Control and Prevention (CDC) has stated that "ethylene oxide may have harmful effects on the wearer, and therefore is not recommended for the sterilization of masks that are worn on the face," and the Occupational Safety and Health Administration (OSHA) does not approve the use of ethylene oxide as a sterilant. Therefore, it is necessary to test that ethylene oxide and 2-chloroethanol, which is generated during its sterilization process, are sufficiently removed from the final product. This technical document introduces a high-sensitivity and cost-effective analysis method for ethylene oxide and 2-chloroethanol in medical masks using capillary column GC-FID analysis.

The Thermo Scientific Orbitrap Exploris GC mass spectrometer enables reliable detection and high-precision quantification even in complex matrices, maximizing productivity with minimal method development. It combines excellent mass resolution, sensitivity, speed, and linear dynamic range, delivering accurate results even for samples that are particularly challenging to detect. ■ Increased Productivity By utilizing versatile high-resolution precise mass full scan data for screening and quantification, you can streamline your analytical workflow. ■ Assurance of Analytical Results High-resolution full scan data allows for multifaceted compound identification considering spectral matching, isotope patterns, and elemental composition, reducing the time to obtain results. ■ Maximized Uptime You can produce results on time and easily. Intuitive instrument control and method templates allow all members of the analytical team to easily access the system.

Using the Thermo Scientific Orbitrap Exploris GC 240 mass spectrometer elevates research capabilities to an unprecedented level of performance, accelerating scientific discoveries. Its unique features provide high-quality, information-rich data, simplifying the challenges of the most complex analyses. ■ Exceptional performance and accuracy Delivers groundbreaking 240,000 mass resolution, MS/MS capabilities, and excellent sensitivity across a wide range of applications. ■ Generating discoveries with minimal effort An integrated informatics solution for quantitation and compound exploration facilitates detailed characterization of the most challenging samples, deriving scientific understanding from the data. ■ Versatility to address diverse analytical challenges The Thermo Scientific ExtractaBrite electron ionization/chemical ionization (EI/CI) ion source, direct injection probe, MS/MS capabilities, and GC modules expand the possibilities of analysis.

The Thermo Scientific Chromeleon 7.3 Chromatography Data System (CDS) ensures data quality and manages all analytical processes, from instrument control to raw data storage and processing, to the creation of final results. Today, data security, data integrity, and compliance are becoming increasingly important. Therefore, comprehensive controls regarding preventive and detection technologies are extremely important. This enables compliance with the latest regulatory requirements and ensures the highest level of data quality. Various tasks arise, such as the preparation of samples before measurement and the creation of reports in HPLC analysis. Chromeleon's e-workflow automates pre- and post-analysis work time, leading to cost reductions. *The percentage of labor reduction is based on workflow analysis results conducted within our company.

The networked or enterprise Thermo Scientific Chromeleon Chromatography Data System (CDS) is essential for compliance, efficiency, and reliable operation in modern chromatography laboratories. It manages all analytical processes, from instrument control to raw data storage and analysis, to the generation of final results. Data integrity, data security, and compliance are always prioritized, and using Chromeleon CDS facilitates audits by providing all necessary traceability. With a user management system and centralized resources, data access and backup are easily managed, ensuring data integrity.

Routine labs involved in food, environmental, and forensic/toxicological analysis are facing a changing environment characterized by regulatory requirement changes, lower detection levels, an increase in compounds, reduced turnaround times, decreased profits, and intensified competition. In such circumstances, your GC-MS/MS system must deliver high performance and consistently reliable quantitative results. The Thermo Scientific TSQ 9610 Triple Quadrupole GC-MS/MS system features a vacuum-free ion source and column exchange with NeverVent technology, a long-life detector, and intelligent software, which reduce unnecessary downtime, improve sample throughput, and provide a high return on investment (ROI). Additionally, the optional He-Saver H2-Safer module addresses helium shortages by significantly reducing consumption when using helium or hydrogen gas, ensuring safety. *For more details, please refer to the PDF document or feel free to contact us.*

In analytical testing labs, it is desirable to obtain reliable results easily and consistently at any time. The ISQ 7610 GC-MS is a system that provides consistent results across all lab systems due to its simplified operation, automated workflow, and wide dynamic range. With NeverVent technology, long-life detectors, and intelligent software, unnecessary downtime is reduced, and sample throughput is improved. This system can be upgraded from a basic configuration to an advanced configuration to address various analytical challenges. It offers high cost-effectiveness for regulatory-compliant GC-MS analysis. *For more details, please refer to the PDF materials or feel free to contact us.*

If your customer's GC is only operating intermittently, they are losing the profits that could have been generated by continuous operation. The Thermo Scientific TRACE 1600 series gas chromatograph (GC) was developed with time and space efficiency in mind. Our patented modular design features plug-and-play injectors and detectors, enabling offline maintenance and allowing for easy changes to different configurations with a single GC, thereby enhancing productivity. When combined with the Thermo Scientific AI/AS 1610 liquid autosampler, this system enables simple and reliable automatic sample injection, meeting a wide range of sample throughput demands. Additionally, the optional He-Saver H2-Safer module addresses helium shortages, significantly reducing helium consumption. *For more details, please refer to the PDF document or feel free to contact us.*

The processed foods we consume develop unique flavors and aromas due to various differences in the quantities and origins of the ingredients used, as well as cooking times, even if they share the same name. Understanding these differences at the component level is crucial in food research, and the use of GC/MS methods is expected to shed light on volatile components, which are believed to be factors influencing aroma. Non-target analysis that encompasses all contained components has been considered challenging due to the vast amount of information and the complexity of analytical operations. To obtain reliable results, efficient sampling methods, chromatographic separation, advanced mass separation, and software for smooth statistical analysis of the data are required. In this technical document, we present a workflow using high-resolution GC-MS (Orbitrap GC-MS) and Compound Discoverer software for low molecular analysis, as a solution to smoothly and accurately address this complex food comparison, exemplified by the inter-sample comparison of commercially available meat sauces from three food manufacturers.

Polycyclic aromatic hydrocarbons (PAHs) are components generated from the heating of organic materials, and due to concerns about their carcinogenicity and other health effects, PAHs present in food are regulated in some countries and regions. In particular, edible oils may undergo heating as a pretreatment during extraction from raw materials, which raises the possibility that PAHs could be generated during the thermal processing, even if the raw materials themselves do not contain PAHs. Since various countries have established standard values for PAHs, safety inspections may be required when exporting food abroad. These standard values are becoming stricter year by year, and high-sensitivity detection measurement devices are needed to accurately quantify these standard values. This application note presents a case of highly sensitive quantification of PAHs without interference from matrix components, achieved using the high mass resolution and mass accuracy of the Orbitrap GC-M system, a high-resolution GCMS. Data acquisition is performed through full scan measurements, making method development easier and enabling retrospective analysis (such as checking whether newly regulated components were present in previously measured samples).

In the quantitative analysis of pesticide residues in food, triple quadrupole mass spectrometers such as GC-MS/MS and LC-MS/MS are commonly used. This is because they can separate trace amounts of pesticides from the food matrix and detect peaks with high sensitivity. On the other hand, our Orbitrap mass spectrometer allows for advanced mass separation, enabling the detection of pesticide peaks without interference from the food-derived matrix. This application note introduces a simultaneous analysis of 325 pesticide components using a GC-Orbitrap mass spectrometer. The Orbitrap mass spectrometer facilitates method development for data acquisition in Full MS measurements, and its high mass accuracy allows for the precise estimation of molecular formulas for each fragment ion, providing reliable quantitative information.

Organic solvents are widely used in the synthesis of pharmaceuticals, but they cannot always be completely removed during the manufacturing process. To ensure safety, the final product is tested to evaluate whether the solvents used have been efficiently removed and, if any remain, whether their concentrations are within acceptable limits. The United States Pharmacopeia (USP) method <467> provides detailed procedures for screening, confirming, and quantifying residual solvents, including sample preparation and analytical conditions. The new TriPlus 500 HS autosampler adopts an innovative design with a flow path that directly connects the heated valve to the GC column. This means high-precision sample introduction and excellent reproducibility of peak areas. Furthermore, by continuously purging the sample path, the robustness and reliability of the system are ensured, reducing the risk of contamination and carryover (which is important when analyzing high-boiling residual solvents). This technical document reports the results of residual solvent analysis conducted in accordance with USP <467>, using the TriPlus 500 HS autosampler and FID as the optimal detector.

The chemical components of food packaging (especially those derived from polymers, dyes, and inks) can pose health risks to consumers by migrating into food. In the United States, the migration limit applicable to residual solvents and non-volatile food additives is 50 ppm. Additionally, the accurate quantification of residual solvents in flexible packaging is regulated by established methods such as EN 13628-1:2002. When analyzing volatile impurities in solid polymers using liquid injection, a cumbersome process of dissolving the sample in an appropriate solvent is required. Furthermore, high-viscosity solutions containing non-volatile long-chain polymers can contaminate the GC injector port, leading to increased analysis costs due to frequent maintenance. On the other hand, using headspace sampling allows for the rapid and easy extraction of volatile components from food packaging samples, eliminating the need for time-consuming sample preparation. This technical document presents the quantitative results of residual solvent analysis in food packaging materials conducted using the TriPlus 500 headspace (HS) autosampler. The dual detector configuration of FID/MS enabled the detection, identification (using hydrogen flame ionization detection), and confirmation (using mass spectrometry detection) of unknown impurities.

The detection and identification of compounds of unknown origin is challenging, often involving complex volcanic processes, and it takes time to obtain results. Additionally, high reliability is required for final identification, which necessitates the confirmation of multifaceted information. By measuring the molecular weight of chemical substances with sufficient accuracy, it is possible to determine the elemental composition and identify the chemical structure of the substance using isotope ratios and fragmentation patterns. Using high-resolution GCMS allows for the reliable detection of target components from complex matrices due to its high mass resolution and mass accuracy. This technical document introduces a method for reliably identifying unknown substances almost instantaneously. It connects a direct injection probe to our high-resolution GCMS (Orbitrap GC-MS system) and rapidly identifies compounds using both electron ionization and chemical ionization.

This is a dual convergence high-resolution gas chromatography mass spectrometer (GC-HRMS) for ultra-trace quantitative analysis of dioxins and persistent organic pollutants (POPs). It complies with all official methods and regulations for dioxin analysis and is used worldwide due to its excellent performance. ■ Flexible Equipment Configuration - Unique Dual GC configuration (2 GCs for 1 MS, up to 4 columns) allows for expanded flexibility (optional) - Sophisticated space-saving design - Environmentally friendly low power consumption design ■ Excellent Sensitivity and Reliability of Dual Convergence HRMS - Reliable analysis of trace samples: Guaranteed specification value of S/N ≧ 200 for 20 fg TCDD - High ion transmission rate and reproducibility achieved through optical system design - Cleaning and replacement of filaments and ionization chambers do not require vacuum release ■ GC that Enhances Productivity - Modular inlet to maximize uptime - Helium saver module: Reduces helium consumption while maintaining analysis conditions (estimated example: approximately 84% reduction) - Multifunctional auto-sampler For more details, please download the PDF or feel free to contact us.

TD-GC-MS/MS is a system suitable for the analysis of volatile PFAS in the air. TD concentrates the target substances from hundreds of liters of air and connects to a high-sensitivity triple quadrupole GC-MS/MS to detect concentrations in pg/m3. Since PFAS exist in low concentrations in the air, the system requires a low detection limit. Additionally, because PFAS are widely used in various products, it is crucial to ensure there is no contamination from the system or components. Evaluating background levels is essential for obtaining reliable analytical results. The technical documentation for PFAS analysis in indoor air presents examples of screening analysis using full scan and high-sensitivity analysis using target SRM for 19 PFAS components emitted from indoor air and everyday products. It evaluates the emissions from indoor air in diverse workplace spaces and everyday items. Methods for measuring PFAS released from solid samples, such as everyday products, without pre-treatment are also introduced. The technical documentation for PFAS analysis in the atmosphere introduces high-throughput analysis of neutral and ionic PFAS. It also shares know-how for improving analytical accuracy using samples collected from three locations in an industrial park.

The Purge and Trap GC-MS system is specialized for trace analysis of volatile organic compounds (VOCs) contained in water samples. After collecting VOCs on an adsorption trap, they are rapidly desorbed and injected into the GC-MS system. By automatically pre-treating large volumes of water samples, it achieves detection limits at the ppt level, meeting domestic regulatory requirements for drinking water testing. It is compatible with the Thermo Scientific HeSaver-H2Safer option, which reduces the consumption of helium carrier gas, thus effectively lowering the running costs of analysis. The Thermo Scientific Chromeleon Chromatography Data System (CDS) allows for a series of operations from control to analysis, simplifying daily tasks. System Configuration: • Teledyne LABS Lumin Purge & Trap CONCENTRATOR and AQUATek LVA liquid autosampler • Thermo Scientific ISQ 7610 single quadrupole GC-MS system

This technical document introduces a highly sensitive quantitative analysis method for volatile perfluoroalkyl substances (PFAS) in environmental samples. By combining the Thermo Scientific Orbitrap Exploris GC high-resolution accurate mass spectrometer with Thermo Scientific SPME Arrow fibers, PFAS in complex environmental samples can be efficiently analyzed. This method allows for the detection of low concentrations of PFAS compounds with high sensitivity while minimizing sample pretreatment. Furthermore, by utilizing HRAM full scan data, both targeted compound quantification and non-target analysis can be achieved, rapidly expanding the analytical scope. In actual sample applications, PFAS compounds were detected in all samples, with particularly high concentrations confirmed in untreated wastewater and landfill leachate. 【Features】 ■ High sensitivity and high selectivity analysis through high-resolution accurate mass spectrometry ■ Efficient sample pretreatment using SPME Arrow ■ Flexible data processing with full scan data ■ Low LOD (0.1–1.4 ng/L) meets stringent reporting limits ■ Detection of a wide range of PFAS compounds in complex environmental samples

This technical document introduces a workflow for metabolomics analysis using the Orbitrap GC-MS system and Compound Discoverer software. Data acquisition through EI full scan with a mass resolution of 60,000 and data extraction and deconvolution analysis with Compound Discoverer accurately extracts peaks characteristic of the sample. It also includes statistical analysis functions to identify differences between sample groups, designed to allow visual confirmation of results. Furthermore, the workflow for identifying unknown compounds using precise mass information from EI, PCI, and MS/MS quickly lists candidate compounds by comparing mass accuracy within a few ppm, PCI's adduct ion information, and in silico MS/MS fragment information. Features: - The Orbitrap GC-MS HRAM metabolomics library includes information on over 800 metabolites and Kovats retention time information. - Compatible with commercially available integer mass libraries. - Reliable compound identification using precise mass information from EI, PCI, and MS/MS. - Detection of component differences through multivariate statistical analysis and pathway analysis.

The Thermo Scientific Orbitrap Exploris GC mass spectrometer demonstrates excellent performance in pesticide analysis in baby food. This system provides high selectivity and sensitivity with mass resolutions set at 30,000 and 60,000, accurately detecting low concentrations of pesticides from complex sample matrices. The QuEChERS method using citrate buffer was employed for sample preparation. This technical document presents the performance evaluation results of linearity, sensitivity, mass accuracy, and ion ratios for 18 types of pesticides in baby food extracts. All pesticides were detected and identified at the lowest standard concentration of 0.005 mg/kg, with mass accuracy showing high reliability within 1.5 ppm across all concentration levels. 【Features】 ■ Accurate mass measurement at high resolution ■ High selectivity and sensitivity even in complex sample matrices ■ Easy data acquisition and analysis using Thermo Scientific Chromeleon chromatography data system (CDS) software ■ Good linearity with a coefficient of determination of over 0.99 ■ Mass accuracy within 1.5 ppm across all concentration levels

This application note introduces a workflow for the differential analysis of whiskey using the Thermo Scientific Orbitrap Exploris GC 240 mass spectrometer. By combining HS-SPME Arrow with high-resolution full scan measurements, we efficiently profile different origins, aging periods, and types through mass spectrum deconvolution and statistical analysis. The high mass resolution and precise full scan analysis enhance the reliability of counterfeit prevention and quality control. 【Features】 ■ High-precision analysis excellent for detecting counterfeits and adulteration ■ Profiling of whiskeys from different origins, aging periods, and types ■ Efficient identification of chemical differences through a non-targeted statistical workflow ■ Efficient sample extraction and analysis using SPME Arrow ■ Accurate identification through high mass resolution full scan measurements and mass spectrum deconvolution