HIGUCHI INC. List of Products and Services

The "resin additives" handled by our company from SI Group have been expanded to a wide range of additives that are effective for various resins and elastomers due to the integration with Addivant. We offer a wide selection of antioxidants, including phenolic, phosphite, amine, thioester types, as well as packaged products, ranging from typical ones to high-performance options with excellent extraction resistance, tailored to various applications. Additionally, we also provide light stabilizers, UV absorbers, and polymer modifiers. 【Features】 ■ A wide range of additives effective for various resins and elastomers has been expanded due to the integration with Addivant. ■ A broad selection of antioxidants is available, including phenolic, phosphite, amine, thioester types, and packaged products, from typical ones to high-performance options with excellent extraction resistance, tailored to various applications. ■ Light stabilizers, UV absorbers, and polymer modifiers are also available. * You can download the English catalog. * For more details, please refer to the PDF materials or feel free to contact us.

Evaluation of Drug Permeability from Cell Membranes Using Artificial Membranes In the development of new drugs, the examination of the pharmacological properties and toxicity of compounds, along with the study of absorption characteristics from intestinal membranes, is considered one of the important factors. The evaluation of absorption characteristics is generally conducted using Caco-2 cell tests. To perform Caco-2 tests, cell culture on the membrane of test well plates is required, but this cultivation demands significant time and effort. Issues may arise with the reproducibility of permeability tests due to the heterogeneity of the culture. The Permeapad Plate, which laminates phospholipids with a special film, serves as an alternative method for compounds where membrane permeability is rate-limiting in Caco-2 tests. Since the phospholipids are laminated with a film, they can be stored at room temperature and used immediately. The homogeneous film allows for high measurement reproducibility.

SBECD dramatically improves the solubility in water and the stability of drugs by encapsulating compounds, making formulation easier. It enables the application of poorly water-soluble drugs to injectable preparations such as intravenous injections. Additionally, it can also be used for oral preparations and eye drops. This product is adopted in multiple formulations and is manufactured and supplied stably. For purchases, there is usually stock available from the manufacturer, so please consult us regarding delivery times. Samples for consideration are also available.