HIGUCHI INC. List of Products and Services

The dissolution tester 708-DS features one-touch centering with the TruAlign vessel, and its design minimizes the risk of misalignment after installation, reducing the risk of failure during mechanical calibration. It supports Japanese language, has a two-piece paddle, and significantly improves basic operability with an expanded space between the drive unit and the vessel plate. It accommodates a wide range of dosage forms for dissolution testing, including tablets, capsules, rotating cylinders, and the paddle-over-disk method.

BIO-DIS is a dissolution tester for conducting release rate tests, compliant with USP Apparatus 3 and EP Reciprocating Cylinder tests. It is an ideal dissolution tester for formulations that require sustained release formulations and dissolution profiles at multiple pH levels.

The Cary 60 spectrophotometer, when combined with a pump in an online UV system, along with the sampling station 850-DS, allows for filter filtration and simultaneous sampling into test tubes or HPLC vials after filtration. **Evaluation Method for Drugs in Dissolution Testing Using Fiber Optics** Using fiber optics enables direct quantification of drugs within the vessel without the need for sampling. For example, when using fiber optics in dissolution testing for the evaluation of crystallization suppression of solid dispersions aimed at improving solubility, detailed dissolution profiles can be obtained through measurements at short intervals, as no sampling is required.

The 400-DS, which enabled dissolution testing for stent formulations, contact lenses, and microneedles that previously had no testing methods, allows for tests that require extremely small volumes and long durations.

The taste recognition device TS-6000A has the same mechanism as the human tongue and can quantify the "taste" of various foods, pharmaceuticals, and more. Additionally, it is possible to easily obtain analysis results through a comprehensive analysis application. As a support tool for sensory testing, it demonstrates its power in any situation where objective evaluation of "taste" is needed, such as product development, marketing, and sales.

SCAT SAFETY CAPS and SAFETY WASTE CAPS from SCAT are designed to prevent indoor diffusion and exposure of organic solvents used in HPLC experiments. The common method of sealing mobile phases/waste liquids with aluminum foil at the neck of sample vials cannot be considered a complete containment, leading to changes in the composition and volatility of the mobile phase/waste over time. By using SCAT SAFETY CAPS, evaporation of the mobile phase is minimized, ensuring reliable test data and a clean laboratory. In recent years, ISO 14001 and corporate CSR (Corporate Social Responsibility) have gained importance. SCAT SAFETY CAPS can improve operator health and working conditions.

OD-mate was developed for the automatic measurement of disintegration time of orally disintegrating tablets. The testing device is a compact and cost-effective solution. The development of this product was made possible with the cooperation of Kyoto Pharmaceutical Industry Co., Ltd. Additionally, using the small taste recognition device SA501C from Intelligent Sensor Technology Co., Ltd., it is possible to measure the bitterness intensity of solutions measured for disintegration time with OD-mate.

The "Paddle Over Disk Method" and "Cylinder Method" are testing methods already included in the USP, and Agilent Technologies has a wealth of delivery experience with them. Additionally, we offer accessories such as the "Enhancer Cell" for ointments and creams. Even when using these accessories, Agilent's dissolution testers allow for easy height adjustment (25mm). *Refer to the Japanese Pharmacopoeia and USP 1724.

The Nano Dis system is a new option that uses conventional dissolution testing equipment. Currently, many new drug candidates are poorly soluble compounds, and improving the solubility of these compounds is important. One attractive solution for improving solubility is nanoparticle formulation. To facilitate the selection of compounds in nanoparticle development, an efficient dissolution testing method is necessary. In the current dissolution testing systems, insufficient filtration of nanoparticles from the test solution leads to variability in test results, resulting in unreliable outcomes. The Agilent NanoDis system addresses these issues and provides researchers with accurate dissolution profiles of active pharmaceutical ingredients through an automated system. This functionality allows researchers to optimize nanoparticle formulations more quickly and bring them to market faster. The automated process yields consistent and reliable dissolution test results for nanoparticle formulations.

Evaluation of Drug Permeability from Cell Membranes Using Artificial Membranes In the development of new drugs, the examination of the pharmacological properties and toxicity of compounds, along with the study of absorption characteristics from intestinal membranes, is considered one of the important factors. The evaluation of absorption characteristics is generally conducted using Caco-2 cell tests. To perform Caco-2 tests, cell culture on the membrane of test well plates is required, but this cultivation demands significant time and effort. Issues may arise with the reproducibility of permeability tests due to the heterogeneity of the culture. The Permeapad Plate, which laminates phospholipids with a special film, serves as an alternative method for compounds where membrane permeability is rate-limiting in Caco-2 tests. Since the phospholipids are laminated with a film, they can be stored at room temperature and used immediately. The homogeneous film allows for high measurement reproducibility.

- Circadian Rhythm Circadian rhythm is a physiological phenomenon that regulates certain processes in the body on an approximately 25-hour cycle. Most processes in the body, including wakefulness rhythm, autonomic nervous system, endocrine hormone system, immune system, and metabolic system, are regulated by circadian rhythms. Disruptions in these rhythms are correlated with numerous diseases (obesity, cancer, new vascular diseases, diabetes, sleep disorders, etc.) and skin conditions (dark circles, wrinkles, fatigue, etc.). - Circadian Rhythm Monitor Cells This product is a monitor cell developed to find components that regulate circadian rhythms. It is a mouse embryonic fibroblast that can measure the expression rhythm of the bmal1 gene, one of the clock genes that form the body clock. It is derived from a transgenic mouse (Bmal1-ELuc mouse) created using a construct that links the luminescent protein Eluc downstream of the bmal1 gene promoter, prepared from mouse embryos. - Details Cell Name: Circadian Rhythm Evaluation Cells (Bmal1-Eluc MEF) Origin: Mouse Cell Count: 5.0×10^5 cells/vial Storage Method: Liquid nitrogen tank Ultra-low temperature freezer (-140°C) Deep freezer (-80°C)