DKSHマーケットエクスパンションサービスジャパン List of Products and Services

heliX/heliX+ is a high-sensitivity device for analyzing molecular interactions and protein properties that adopts a new principle called "SwitchSENSE," which uses DNA nanolevers as a immobilization tool. It has approximately 100 times the sensitivity of existing biosensors and possesses a wide range of applications and analytical capabilities, including the analysis of high-affinity interactions that are difficult to measure with conventional devices, dual specificity interaction analysis, and enzyme kinetics analysis of nucleic acid-related enzymes. Additionally, the chip can be reused multiple times. Since DNA is used for immobilization, it allows for a high degree of freedom in presenting molecules on the chip, such as immobilizing two types of molecules. There are also no effects from the immobilization matrix. Furthermore, being a sensor that uses nucleic acids allows for easy implementation of enzyme kinetics analysis for nucleic acid-related enzymes such as polymerases and endonucleases, and it demonstrates significant power in evaluating inhibitors of viral proliferation. The modular design of the device also enables easy high-throughput capabilities. It can be utilized in a wide range of research, from drug discovery to biophysical fundamental research on biomolecules.

heliXcyto, which employs the Single Cell Interaction Cytometry (scIC) method that combines the biophysical measurement principles of biosensors with cytometry, enables the automatic analysis of binding constants (affinity, avidity) while maintaining the complexity of biological systems by directly measuring the kinetics of molecular binding and dissociation on the cell surface.

The ZetaView x30 series nanoparticle tracking analysis (NTA) device can analyze the size and concentration of individual particles, such as exosomes and liposomes, by capturing video of Brownian motion. It can be equipped with up to four wavelengths of lasers. The high-speed laser/filter switching suppresses fluorescence fading and accurately determines the particle size distribution of fluorescently labeled particles. Additionally, a new feature called Colocalization option allows for the determination of the ratio of double-stained particles. 【Features】 ■ Scanning measurement at up to 11 locations ■ Auto-alignment and auto-focus functions ■ Equipped with up to 4 lasers, allowing for particle size distribution measurement using various fluorescent labels ■ Capable of measuring zeta potential

Features - Measurement possible with a small sample volume (100 μL and above) - Measurable particle size: 0.3 μm to 600 μm - High-resolution image analysis through threshold optimization - Equipped with autofocus function - Capable of saving raw image (video) files - No sheath fluid required - Easy replacement of flow cell and simple cleaning - Lens interchangeable (2X, 4X, 10X, 20X) - Compatible with dedicated auto-sampler - Compliant with 21 CFR Part 11

The Oryx series is a micro-dispensing system for protein crystallization manufactured by Douglas Instruments, capable of setting diverse crystallization conditions. Through Microseed Matrix Screening (MMS), it allows for the acquisition of crystal hits under a wide range of conditions and enables the rapid attainment of higher resolution crystals. Additionally, by taking each additive from a 96-well plate pre-filled with various additives and mixing it with the protein and reservoir solution to create each drop, it is easy to create crystallization plates for screening the effects of various additives on crystallization.

We would like to introduce the "ultra-micro sample viscometer" manufactured by Leosense, handled by DKSH Japan Co., Ltd. Our lineup includes the portable "micro VISC," which completes measurements in 1 to 2 minutes, the easy and fast-operating "m-VROC," and the fully automatic "VROC initium," which supports temperature and shear rate scanning. 【Features】 ■ High precision and high reproducibility ■ Application of Microfluidics and MEMS technology ■ Measurement of pressure using multiple sensors arranged in the flow path ■ Viscosity calculated from the slope of the graph *For more details, please refer to the PDF document or feel free to contact us.

A new ultra-micro viscometer utilizing microfluidic control and microelectromechanical systems technology. The VROC Initium is a fully automated model that handles everything from sample introduction to channel cleaning, solving the issues of traditional viscosity measurement that required cumbersome procedures and large sample volumes. It contributes to research and development and quality control across a wide range of fields, including biopharmaceuticals, biological samples, inkjet inks, various petrochemical products, and battery materials. [Features] - Fully automated system compatible with 96 wells - High precision and high reproducibility - Supports temperature and shear rate scanning - Small sample volume (10 μL and up) - Wide measurement range (0.2 to 100,000 cp) - High shear rate capability (up to 1.6 million /sec) - Accurate temperature control (4 to 70 °C) - Closed system measurement - Compatible with non-Newtonian fluids

The Hielscher UIP400MTP is a dedicated ultrasonic processing device for 96-well plates. The purpose of cell and bacterial disruption is generally to extract specific components within the cells or bacteria (such as proteins and nucleic acids). Ultrasonic cell disruption has been a reliable method with established reproducibility over many years, but it has traditionally been difficult to uniformly process multiple sample specimens simultaneously. The UIP400MTP ultrasonic device can uniformly process 96 samples across various shapes of 96-well plates, achieving excellent cell disruption and extraction yields. Thanks to the custom-made sonotrode for wide areas, which is unique to Hielscher, uniform cavitation allows for uniform processing of 80-90% of the tubes in a 96-tube setup. Recovery rate = 80-90%.

Heelscher Company primarily designs and manufactures large and powerful ultrasonic equipment, providing laboratory equipment, prototype benchtops, and production-level devices. Effective and energy-efficient technology is necessary to harness ultrasonic capabilities. Furthermore, even with the same ultrasound, the results are completely different from immersion-type ultrasonic cleaners. It is the high amplitude and high surface strength of Heelscher's powerful ultrasound that enables this technology. Until now, Heelscher ultrasonic equipment has achieved high output (50,000W) and guarantees 24-hour continuous operation, which was impossible with ultrasonic devices. Its dispersion method differs from shear mixers, ultra-high-pressure homogenizers, and stirring bead mills that use shear force, achieving what was unattainable with shear force through 100% cavitation erosion dispersion using ultrasound. The ancillary equipment and control for the system are manufactured in Japan, allowing us to provide exactly what the user requests, ensuring safe operation. <Applications> Nanodispersion of aggregates, reduction of particle size, extraction, emulsification, dissolution, Chemical reactions (sonochemistry) <Fields> Nanomaterials, paints, inks, pigments, fuels, chemicals, cosmetics, biology, Food & beverages,

We are pleased to announce that SOTAX, in close collaboration with the National University of Singapore, has developed a new BioJECT cell (patent pending) compatible with the CE7smart (SOTAX JP3 (USP4) flow-through cell dissolution testing device) as a new solution for in vitro testing of subcutaneous injection drugs such as insulin. This cell features a small container called a biomatrix for filling samples, allowing for testing that simulates subcutaneous tissue. By combining the BioJECT cell with the CE7smart, we support the development of effective testing methods for various subcutaneous injection drugs, including in-situ implants, peptides, and low molecular weight compounds. ■ Exhibition Name: 7th Pharma Lab EXPO Tokyo ■ Dates: July 9 (Wed) - 11 (Fri), 2025 ■ Time: 10:00 AM - 5:00 PM ■ Venue: Tokyo Big Sight ■ Booth Number: E6-26

The Sotax dissolution testing device AT XtendTM is capable of conducting dissolution tests for various dosage forms such as tablets and ointments. Additionally, it complies with JP1,2 (USP1,2,5,6), and through automation of the device and unified data management, it enables the production of more efficient and highly accurate products.

You will be able to reuse lab staff for mission-critical tasks such as data analysis, report creation, and notebook documentation. Additionally, automated procedures will reduce solvent usage and the generation of hazardous waste, while minimizing analysts' exposure to dangerous reagents and samples, thereby improving their safety.

We propose the ideal equipment for customers who want to examine the conditions and parameters of a filter press but find it too large and cumbersome. The LAB60 laboratory device from Strassburger Filter in Germany allows for testing that simulates a filter press by simply installing a single Φ60mm filter in a clamped chamber. It is perfect for preliminary studies before pilot or mass production, addressing requests such as: - Reducing material loss - Testing various small quantities and types - Minimizing cleaning efforts Additionally, by using a dedicated cake chamber, filtration aids for pre-coating or body feed can also be utilized, allowing for verification of the amount of filtration aids used. It can also be used for cake recovery purposes. Filters can be selected from 13 types of depth filters manufactured by Strassburger, so even those with no prior filtration experience will have no issues. Sterilization-specific sheets are also available.

The German company Strassburger is located near the Rhine River in the Rheinhessen region, 90 km south of Frankfurt, and has been developing filter systems for wine clarification in collaboration with local wineries for many years. Even today, due to its high quality, it continues to provide a wide range of filter press equipment to many wineries. Currently, its products are used not only for alcohol but also for juices and food, and they meet the high cleanliness and stringent design standards required for pharmaceutical manufacturing, with a customer network that spans the globe. What we are introducing this time is the SF series of plate and frame filter press equipment, which is optimal for wine and continues to meet Germany's high standards for beer, a tradition that has been upheld since the company's founding. Additionally, by combining it with Strassburger's depth sheets, even higher levels of clarification filtration can be achieved.

The KFP chamber filter press is specifically designed for the filtration of beverages, particularly wine, and features a highly hygienic structure (it is also compatible with CIP). The filter media is made of specially designed polypropylene, allowing for repeated use, making it very economical. By adopting a chamber type for the cake retention section, it is possible to incorporate the media into the chamber, enabling a large capacity for cake retention relative to the size of the device, which supports long operating times. Additionally, it is designed to facilitate easy cake release and cleaning. A membrane type can also be selected for the chamber section, allowing for stronger compression of the cake, thus improving filtration efficiency while simultaneously performing cake dewatering. Filtration aids such as diatomaceous earth or perlite can, of course, be used to enhance filtration efficiency. Furthermore, there is no worry about leaks due to the sealed sealing. It is also compatible with sterilization, allowing for use in various applications. Of course, it can be used for purposes other than wine!

We would like to introduce the newly developed small "hermetic" filter press from Strassburger Filter, a long-established manufacturer of filter presses based near the Rhine River in Germany, which has been in operation for over 100 years. The HERMETIX Lab220 is a new filter press developed for laboratory use or small-scale pilot processing, incorporating the leak-free technology that prevents liquid leakage, which is featured in the conventional HERMETIX series. Its filtration performance is comparable to that of standard filter presses, capable of accommodating 1 to 4 filters, and is designed to allow for CIP/SIP processes. It is designed in accordance with GMP standards to meet the requirements of pharmaceutical development. This design is ideal for customers who find conventional small filter presses too large, while traditional laboratory equipment is either too small or lacks GMP design, and who require CIP/SIP even in laboratory machines.

The German company Strasbourg Filter (SBF) is a filter equipment manufacturer with a history of 100 years. It has long been engaged in the design of systems for wine clarification filtration, and its equipment is used in countries around the world. The hollow fiber module specially designed by SBF has proven to be optimal for the filtration of wine, fruit juices, vinegar, and more, based on its delivery record worldwide. One reason for this is the adoption of an asymmetric membrane structure to enhance filtration performance. The pores are larger on the outside, while the inside has a completely smooth surface, resulting in a high flux rate and preventing the adsorption of colorants and fragrances. Backwashing and cleaning can restore the original output level.

The microVISC PRO is a micro-sample viscometer capable of measuring viscosity with temperature control for a minimum of 100 µL. It features a built-in touch screen and temperature control function (15-60°C), allowing for smart measurements to be completed in under one minute. It uses disposable syringes. It is suitable for viscosity measurement of a wide range of samples, including pharmaceuticals, chemicals, and food. Compliant with 21 CFR Part 11.

In recent years, protein-nucleic acid conjugates have been utilized in many applications, such as proximity ligation assays, immuno-PCR, DNA PAINT, CITE-Seq, and SwitchSENSE biosensors. There are commercially available kits for conjugating oligonucleotides and proteins, but many of them are costly or do not yield sufficiently pure conjugates. ProFIRE is a conjugate purification system optimized for the preparation, purification, and analysis of such protein-nucleic acid conjugates. High-quality conjugate purification can be achieved with simple operations. A dedicated conjugation creation kit is also provided.

NanoLab 3D is a high-precision DLS device for measuring particle size distribution. Its patented groundbreaking modulated 3D cross-correlation technology allows for the measurement of high-concentration samples without dilution. - Measurement of particle size in turbid samples without dilution - Equipped with a high-output laser, capable of measuring highly diluted or highly absorbent samples - Minimum sample volume of 4 µL - Viscosity determination in zero shear viscosity measurement mode

Nanoparticle tracking analysis device equipped with the new technology "Concentration Scanning Technology" - Analyze particle size distribution, particle concentration, and zeta potential with one click - Supports both scattered light and fluorescence measurements, capable of using up to 4 lasers - Scans the entire sample regardless of measurement settings, providing reliable concentration determination - No calibration needed between scattered light and fluorescence, compatible with unknown samples - Market-leading high-sensitivity NTA device - New software "ZetaSphere"

Pipe Tight is an innovative piping cover made of silicone rubber, unlike anything seen before. Compared to traditional caulking methods, it offers: - No worries about cracking - A visually appealing and clean space - Airtight seals that prevent the intrusion of water, insects, dirt, mold, and dust - Reduced risk of piping damage from earthquakes and machine vibrations - Easier installation and shorter time required (for ceiling applications, drying time, etc.) - Mitigation of adverse effects on piping penetrations caused by water hammer during CIP cleaning - Reduced condensation For more details, please download the catalog.

The "Countstar Mira HT" is a cell counter that can be integrated with automation systems and robotic arms, similar to the "FL Plus." The product dimensions are 308×335×354mm, and it weighs 8.6kg. Additionally, it has a storage capacity of 1TB and a screen size of 8 inches. It complies with GMP and FDA 21 CFR part 11. 【Features】 ■ Same performance as Mira FL Plus ■ Up to 24 samples per run (can dispense with 8/12 channel pipettes) ■ Complies with GMP and FDA 21 CFR part 11 *For more details, please refer to the related links or feel free to contact us.

The "Countstar Mira FL Pro" is the top model cell counter in the series. The measurable consumable is the Countstar Slide-M, with a throughput of 5 per run, and a cell size range of 1-10um. It is capable of cell counting for samples such as yeast, platelets, and E. coli, as well as measuring smaller particle samples with AOPI staining. 【Features】 ■ Bright field and fluorescence two-channel model ■ Fixed focus and AI-based accurate image analysis algorithm ■ Measures 5 samples per run with dedicated slides ■ 10x optical magnification with a high-resolution 8.3MP CMOS camera (target sample size: 1-10um) ■ Compliant with FDA 21 CFR part 11 *For more details, please refer to the related links or feel free to contact us.

The "Countstar Mira BF/FL Plus" is a cell counter that serves as an upgraded model for both BF and FL. The cell size ranges from 2-180um, and it has a storage capacity of 128G. This series is a smart and flexible cell analysis device equipped with AI intelligent algorithms. 【Features】 ■ Resolution: 5M → 8.3M pixels ■ Fluorescence sensitivity: 580 → 5970 mv/lx/s ■ Imaging area: 1 → 2.8mm² ■ Software: Compliant with FDA 21 CFR part 11 *For more details, please refer to the related links or feel free to contact us.

The "Countstar Mira BF/FL" is a compact and smart cell counter. Application examples include Trypan Blue cell counting, AOPI staining, blood cell counting, confluent evaluation (BF only), GFP/RFP transfection (FL only), and organoid counting. Please feel free to contact us when you need assistance. 【Features】 ■ BF bright field, FL bright field, and fluorescence two-channel models ■ Can be used with various consumables using a dedicated adapter (BF only) ■ Fixed focus and AI-based accurate image analysis algorithm ■ Measures 5 samples per run with dedicated slides ■ Three magnifications (5.0, 6.6, 8.0x) *For more details, please refer to the related links or feel free to contact us.

- It can process 5-channel or 8-channel independent control multi-dispensing in parallel. - High precision and reliability enable miniaturization of assays in HTS due to high reproducibility. - In a flexible and user-friendly software assay development environment, complex logs can be created intuitively and easily. - When using low dead-volume expensive or rare reagents, it is possible to directly mount a syringe (1ml or more) to the reagent dispensing valve instead of using a reagent bottle. - Independently variable valve control pressure (0 to 1 bar) allows optimal dispensing of viscous liquids and cells. - High-speed dispensing to 96 to 3456 well plates; common plate formats are stored in the software as a library, and new formats can be easily edited and saved. - Compatible with lab automation (HTS), compliant with SiLA industrial standards, and supports easy integration. Its compact size allows for space-saving installation.

Modular Micro Reaction System MMRS Achieves Optimization of Reaction Conditions in the Shortest Time! This microreactor can handle everything from laboratory synthesis to production of chemicals and pharmaceuticals. It contributes to the high efficiency of medicinal chemistry and pharmaceutical and chemical processes. Ehrfeld Mikrotechnik BTS, based in Germany, is a member of the Bayer Group, a comprehensive chemical manufacturer. We offer a wide range of micro reaction devices and process measurement and control products that can accommodate both lab-scale and production-scale needs, providing high-quality solutions through continuous technological innovation.

In food factories, foreign matter contamination during the manufacturing process is a serious issue that not only compromises product quality but also undermines corporate trust. In particular, pipe wall penetrations are prone to becoming entry points for foreign substances from the outside, necessitating thorough countermeasures. "Pipe Tight" is a silicone sealing cover developed to reduce the risk of foreign matter contamination in food factories. It can be easily installed without the need for caulking, and its high sealing performance effectively prevents the intrusion of water, dust, insects, mold, and other foreign substances. 【Usage Scenarios】 - Food manufacturing lines - Clean rooms - Pharmaceutical factories 【Benefits of Implementation】 - Reduction of foreign matter contamination risk - Improvement in product quality - Enhancement of corporate reliability - Improved cleanliness

In the pharmaceutical industry's clean rooms, contamination during the manufacturing process is a serious issue that not only compromises product quality but can also lead to regulatory violations. In particular, wall penetrations are prone to becoming entry points for foreign substances from the outside, necessitating thorough countermeasures. "PipeTite" is a silicone sealing cover that strongly supports hygiene management in clean rooms. 【Usage Scenarios】 - Pipe penetrations within clean rooms - Piping for pharmaceutical manufacturing equipment - Cable penetrations within clean rooms 【Benefits of Implementation】 - Reduced risk of contamination - Improved cleanability - Long-term cost savings

In data centers, air conditioning efficiency significantly impacts operational costs. Gaps in pipe penetrations reduce heating and cooling efficiency and increase energy costs. Traditional caulking has faced challenges with gaps caused by aging and the maintenance effort required. PipeTite addresses these issues and contributes to improving air conditioning efficiency. 【Usage Scenarios】 - Pipe penetrations in data centers - Around air conditioning equipment piping - Cable penetrations 【Benefits of Implementation】 - Improved air conditioning efficiency - Reduced energy costs - Decreased maintenance frequency

In hospitals, thorough hygiene management is required to prevent hospital-acquired infections. In particular, pipe penetrations are prone to dust and bacteria entering through gaps, which can increase the risk of infection. "Pipe Tight" is a silicone sealing cover that completely seals the gaps in pipe penetrations to maintain a clean environment. 【Usage Scenarios】 - Operating rooms - Clean rooms - Patient rooms - Examination rooms 【Benefits of Implementation】 - Reduced risk of infection - Improved cleanliness - Long-term cost savings - Ensuring safety for patients and healthcare workers

In research facilities, it is essential to thoroughly prevent the intrusion of foreign substances from the outside to ensure the accuracy and safety of experiments. In particular, pipe wall penetrations are prone to becoming pathways for contaminants to enter, which can compromise the reliability of experimental results. Traditional caulking often requires rework due to cracking and deterioration, which always carries risks. PipeTite was developed to reduce the risk of foreign substance intrusion in research environments and enhance the safety of experiments. 【Usage Scenarios】 - Clean rooms - Biotechnology research facilities - Chemical laboratories - Pharmaceutical research facilities 【Benefits of Implementation】 - Improved reliability of experimental data - Reduced contamination risks - Maintenance of hygienic environments in facilities - Ensured safety for researchers

In care facilities, odor and hygiene management are crucial, and odors or foreign substances entering through piping penetrations can pose significant problems. Particularly, resolving these issues is essential to protect the health and comfortable living environment of residents. Traditional caulking may allow odors to leak due to cracks or peeling caused by aging. "Pipe Tight" is a silicone sealing plate developed to address these issues. 【Usage Scenarios】 - Areas around piping that can be sources of odors or unpleasant smells - Water-related areas or places with high humidity - Surroundings of kitchens or garbage disposal areas 【Benefits of Implementation】 - Prevents odor leakage and improves the air quality within the facility - Reduces the risk of infections caused by foreign substances - Alleviates the burden of cleaning and maintenance

In restaurants, hygiene management is extremely important, and the intrusion of pests is a significant issue. In particular, gaps in plumbing can easily become entry points for pests, increasing the risk of foreign substances contaminating food and food poisoning. Traditional caulking tends to develop gaps due to cracking and deterioration, requiring regular maintenance. Pipe Tight addresses these issues and effectively prevents pest intrusion. 【Usage Scenarios】 - Kitchen - Dining area - Food storage room - Areas with exposed plumbing 【Benefits of Implementation】 - Prevents pest intrusion and maintains a hygienic environment - Reduces the risk of foreign substances contaminating food - Enhances reliability from customers - Reduces costs for regular maintenance

In the hotel industry, it is crucial to thoroughly prevent the intrusion of pests in order to maintain the comfort of guest rooms. In particular, plumbing penetrations are prone to being entry points for pests, and inadequate measures can not only compromise the sanitary environment of the guest rooms but also lead to a decrease in customer satisfaction. Traditional caulking has allowed insects to enter through cracks caused by aging. "Pipe Tight" completely seals the gaps in plumbing penetrations, effectively preventing pest intrusion. 【Usage Scenarios】 - Plumbing penetrations in guest rooms - Plumbing penetrations in kitchens - Plumbing penetrations in air conditioning systems 【Benefits of Implementation】 - Prevents pest intrusion and improves the sanitary environment of guest rooms - Reduces complaints from customers and enhances customer satisfaction - Lowers cleaning and maintenance costs