Advantages of 4'-thioribonucleoside phosphoramidites!
"Three Innovations Brought by 4'-Thio Modification" 1. Excellent Nuclease Resistance (Approximately 600 Times Higher than Natural) 4'-thioRNA has a structure in which the oxygen at the 4' position of the ribose ring is replaced by sulfur. This slight change creates stability. 2. Strong and Accurate Hybridization Ability In addition to stability, the binding strength to the target (Tm) is also enhanced, which is a strength of 4'-thio. - Increase in Tm: An increase of approximately 1°C in Tm is expected per modification, providing a stabilization effect comparable to that of 2'-O-methyl modifications. - Maintenance of A-type Structure: By inducing the sugar moiety into an RNA-like "C3'-endo conformation," it improves thermal stability while maintaining a structure close to natural RNA. 3. Compatible with Existing Platforms Despite being a new technology, its low introduction cost is a significant advantage. - Standard Synthesis Method: Supplied in DMTr-protected and phosphoramidite form, it can be used directly with your existing automated synthesizers. - Smooth Transition: Base protection uses standard methods (such as Bz, iBu), allowing the deprotection and purification processes to be optimized based on existing protocols.
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In the research and development of nucleic acid medicines, the "instability" of RNA has always been a significant barrier. Please utilize "4'-thio modified nucleic acids" as a hint to solve this issue. We also offer custom synthesis services for sequence design based on 4'-thio introduction and for examining conditions for scale-up.
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Ayurveda is well-known, but historically, India has been significantly involved with "medicine." Sapala Organics was established in 2005 in Hyderabad, located in the central part of the Deccan Plateau. The state government is actively investing to make this area a "Pharma City" (a treasure trove of medicine). Sapala has gained recognition from major pharmaceutical companies in the United States and Europe, steadily achieving results. To further provide the technological capabilities developed globally to Japan, Sapala Corporation was established in February 2018 as a local subsidiary in Japan. Recently, the Japanese government has also been focusing on projects that promote advanced pharmaceutical development and drug discovery, including nucleic acid-related drugs. We encourage you to consider the technological expertise of "Sapala," which excels in these fields.
