Advantages of C5'-extended 2'-substituted phosphoramidites!
In the development of oligonucleotide drugs, precise structural control of the backbone will be the key to the next generation. Sapala Organics proposes the "C5'-extended 2'-substituted phosphoramidite" to overcome this challenge. Features of C5'-extended 2'-substituted phosphoramidite: The most significant feature of this product is that it physically extends the "distance" between nucleotides by elongating the C5' position. This allows for the resolution of steric hindrance that was difficult to avoid with conventional nucleic acid structures and enables optimal orientation control towards target molecules. Furthermore, a diverse range of modifications such as H, OMe, MOE, and F are available at the 2' position, supporting the advanced coexistence of nuclease resistance and binding affinity.
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Applications/Examples of results
Main Utilization Methods and Targets 1. Suppression of siRNA Off-Target Effects By introducing modifications at specific positions in the guide strand or passenger strand of siRNA, it can be utilized for structural design to adjust the loading onto the RISC (RNA-Induced Silencing Complex) and avoid unintended gene suppression. 2. Improvement of Aptamer Dynamics By introducing modifications into critical structural elements (bulges or internal loops) that are important for binding to the target protein, it can induce stronger or more specific binding while ensuring stability in the bloodstream. 3. DNA/RNA Origami and Structural Biology It functions as a "spacer unit" to fine-tune angles and distances in the construction of nanostructures. It is optimal as a precise tool for accurate distance measurements and for positioning specific functional groups in designated spaces. Supply System of Sapala Organics Our company (Sapala Organics) has over 10 years of leadership and manufacturing experience in nucleic acid chemistry. • Diverse Base Lineup: We can provide C5' extended and 2' substituted versions for all major bases: A(Bz), G(iBu), U, C(Bz).
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Company information
Ayurveda is well-known, but historically, India has been significantly involved with "medicine." Sapala Organics was established in 2005 in Hyderabad, located in the central part of the Deccan Plateau. The state government is actively investing to make this area a "Pharma City" (a treasure trove of medicine). Sapala has gained recognition from major pharmaceutical companies in the United States and Europe, steadily achieving results. To further provide the technological capabilities developed globally to Japan, Sapala Corporation was established in February 2018 as a local subsidiary in Japan. Recently, the Japanese government has also been focusing on projects that promote advanced pharmaceutical development and drug discovery, including nucleic acid-related drugs. We encourage you to consider the technological expertise of "Sapala," which excels in these fields.
