Tohoku Techno Arch Co., Ltd. Product Lineup

　In recent years, bioreactors that utilize living microorganisms as catalysts to decompose harmful substances and synthesize valuable products have gained significant attention. To enhance reaction efficiency and operational convenience in such systems, it is essential to immobilize targeted microorganisms at high density onto a carrier. Calcium phosphate, a material known for its low toxicity to living organisms, environmental compatibility, and excellent adsorption properties, is expected to be used as the carrier. 　However, achieving a microbial carrier that ensures a predetermined amount of microorganisms within the carrier while maintaining their biological activity has been a challenge. 　The present invention relates to a method for obtaining a microbial carrier in which a predetermined amount of living microorganisms exist in a uniform density in calcium phosphate cement (CPC). * As the patent has not been disclosed, please contact the following our company counter for the carrier manufacturing method.

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　Currently, most perovskite solar cells use lead (Pb)-based materials, but tin (Sn)-based alternatives are gaining attention for their environmental benefits and potential performance improvements. Sn offers higher light absorption efficiency without Pb, but challenges such as easy oxidation and the need for environmentally harmful organic solvents remain. 　To solve these issues, the inventor utilized ascorbic acid (AA) and found that adding it to a Sn aqueous solution greatly improves water solubility and prevents Sn oxidation. The precursor solution prepared using this method was mixed with MAI (methyl ammonium iodide) and coated onto a substrate, resulting in a highly oriented perovskite layer. 　This innovation paves the way for eco-friendly solar cells that use green processes, representing a major step toward sustainable energy solutions.

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Topology optimization is a machine-aided design technique that optimizes material structure and enhances performance. Applying this technique to the design of an optical antenna provides an optical antenna with a nanogap structure with the following features: Circular Polarization Identification Responses to left and right circular polarized light can be significantly enhanced for incident circular polarized light. For example, the chiral identification of trace chiral molecules can be achieved using this invention. Circular polarization generation and control Circular polarization can be radiated by placing a light source in a gap structure, and the polarization state can be controlled according to the direction of the light source. A polarization-generating device is anticipated.

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　In civil engineering works, the need for unmanned construction of construction machinery is increasing, and it is required to ensure safety and improve work efficiency not only during disaster recovery but also in normal times. However, the current unmanned construction is only monitored by cameras, and the work efficiency is worse than manned construction. The shortage of ground information is a problem as a factor of this efficiency lowering. 　Generally, the cone index, an indicator to assess the running ability of construction equipment, is measured using a cone penetration tester, but the number of measurement points increases in a wide area of land due to ground variations from place to place. In addition, the measurement needs to be carried out independently from excavation and other earthworks, which is time-consuming. 　This invention is based on the relationship between the fracture morphology of soil excavated by hydraulic excavators widely used in the field and the cone index. It is possible to automatically estimate the strength of the ground from visual information by photographing the fracture morphology of the soil being excavated and extracting the features of the fracture morphology. In addition, the visual information can be combined with the force sense information acting on buckets. Since the invention can estimate in real time while excavating, it is expected to greatly improve the work efficiency in unmanned construction.

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　In protein production using Aspergillus oryzae, the introduction of multi-copy genes encoding target proteins can be used as a means of improving productivity. However, if the DNA fragment to be introduced is tandemly inserted at one chromosomal locus and the repair through homologous recombination is repeated, the sequence may be excised, and the production cannot be increased as a result. 　Dr. Zhang and colleagues at the Graduate School of Agriculture, Tohoku University have developed a method to introduce DNA fragments into multiple loci of the chromosome of A. oryzae in a single transformation, and succeeded in obtaining a new A. oryzae in a short period of time. The A. oryzae of the present invention has been confirmed to have improved material productivity. Furthermore, by using a highly dispersible strain of mycelium as a host, it is expected to be low in viscosity when cultured in a fermenter, enabling continuous culture.

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　Nitrogen-vacancy center (NV center) in diamond satisfies the characteristics required for qubits, and expected to be applied to quantum computers and quantum sensors. Other candidate materials are divacancy centers (VV centers) in SiC and Ce-implanted Yttrium Aluminum Garnet (YAG). However, the problem with all of these materials is the high cost of raw materials, and it is expected to be difficult to scale up. 　The present invention demonstrates that light emitting centers (Ce3+) can be formed in Ce implanted SiO2 or MgAl2O4 substrates. Optically Detected Magnetic Resonance (ODMR) measurements demonstrate the feasibility of write operations in quantum dots. It is possible to realize a quantum bit / quantum sensor at low cost.

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Oxidative stress is a phenomenon in which excessive reactive oxygen species are produced, increasing biological oxidative damage such as DNA and RNA mutations and protein denaturation, and is said to lead to various diseases and accelerated aging. More than 90% of reactive oxygen species in living organisms are generated in mitochondria, where oxygen respiration occurs, and mitochondria are known to be susceptible to oxidative damage. However, there is no mitochondria-specific oxidative stress marker until now. 　The present invention finds ms2A as an oxidative stress marker for mitochondrial tRNA for the first time, and provides a method for evaluating mitochondria-specific oxidative stress levels.

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To diagnose circadian rhythm sleep-wake disorders, sleep diaries and actigraphy are used, but the need to keep records for a long period of time and the cost are a burden on users. In addition, due to low awareness of the disease, few people visit a medical institution to take proper treatments of their symptoms. 　According to the present invention, symptoms that may be circadian rhythm sleep-wake disorders can be identified based on the daily operation history of home appliances and smartphone applications, creating an opportunity for an early visit to a medical institution to get an early treatment.

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Carboxylic acid compounds containing aromatic rings are important molecular structures as bioactive compounds and their precursors. For example, aromatic carboxylic acids such as aspirin and telmisartan and aromatic ring-containing carboxylic acids such as atorvastatin are known as important drugs. Therefore, it is desired to develop carboxylation reactions of organic molecules that can efficiently synthesize aromatic carboxylic acid compounds. On the other hand, introduction of the 12C isotope 13C into organic molecules is important for elucidating the mechanism of chemical reactions or monitoring in vivo. For the conventional method, 13CO2 gas is reacted as the 13C source, but special equipment and technology are required, and thus it is difficult to accurately control the amount of the gas. This invention provides to a novel 13C immobilizer in a liquid form that is easy to handle.

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　Angiogenesis is known to be involved in the development and progression of cancer, diabetic nephropathy, heart failure, arteriosclerosis, and nervous system diseases. The inventors have discovered Vasohibin1 (VASH1), an angiogenesis inhibitor produced by vascular endothelial cells, Vasohibin2 (VASH2), a homolog of Vasohibin1, and Small Vasohibin Binding Protein (SVBP), which enhances their stability, and have developed new therapies based on enhancing the effects of VASH1 or inhibiting VASH2 (see "Related Inventions"). 　The present invention was screened from a small molecule compound library, and obtained five small molecule inhibitors that do not inhibit the binding of VASH1 and SVBP, but selectively inhibits the binding of VASH2 and SVBP. Since the patent application has not been published, the structural of the five screened compounds have not been disclosed. Please feel free to contact us as we can disclose the information after signing a non-disclosure agreement.

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　In a conventional X-ray monochromator, the spectroscopic crystal is elastically bent slightly, then polished to obtain a uniform diffraction. However, this method where the crystal is deformed within the elastic limit, cannot be applied for a large curvature bending, so it can only be used for a big X-ray device. Moreover, there is also an issue on the deformation stability and aging due to keeping the crystal deformed.　 　This invention is able to realize a distributed curvature crystal lens with a wide incident angle and high light focusing accuracy. This distributed curvature crystal lens is made by plastic deformation of Ge or Si (110) single crystal plate pressed by a mold at high temperature. The X-ray reflectance measurement system of this invention is equipped with above lens which enables to focus a wide angle and significantly increase X-ray intensity.

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Intermittent computing enables continuous processing under unstable energy supply. In edge device implementation, a nonvolatile logic circuit using nonvolatile registers is promising as it retains internal state with only local data transfers.　 Conventional nonvolatile registers, composed of multiple 1-bit memory circuits (NV-FFs), require two MTJ devices per bit, leading to high area and energy overhead. The reference-load sharing scheme (RLSS) was proposed to solve this issue, however, a new issue arose as the required operation time increased in proportion to the number of register bits. This invention introduces a differential information storage scheme (DISS), which stores 1-bit data via resistance differences between adjacent MTJ devices. This allows two-cycle backup and restore, reducing energy and area while maintaining conventional operation speed, as confirmed by simulations.

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Intermittent computing executes tasks as energy accumulates, enabling continuous edge computing under unstable, low-power energy harvesting conditions. Ensuring processing continuity before and after frequent power interruptions is essential. A nonvolatile logic circuit using nonvolatile registers allows internal state retention with only local data transfers, making it a promising option. Conventional nonvolatile registers connect 1-bit memory circuits (nonvolatile flip-flops, NV-FFs) per bit, requiring two MTJ devices per bit, leading to significant area and energy overhead. This invention proposes the Reference-Load Sharing Scheme (RLSS), where 1-bit information is retained between an MTJ device and a reference MTJ device using a sequential backup-restore process. This reduces MTJ device count, shares circuit functions, and achieves 49% lower energy consumption and 34% area reduction, as confirmed by simulations.

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2D codes are used in various situations such as information transmission, tickets such as airline tickets, product management in stores, and robot control. However, only one information is usually obtained from 2D codes. Therefore, composite markers are developed by superimposing multiple markers. 　In the conventional hue specific superimposed marker “HueCode ” devised by the inventors, different markers are superimposed on the area of one marker, and two pieces of information can be acquired simultaneously. However, HueCode can only read markers with a reader that implements a special algorithm. In order to read markers under various lighting conditions, prior learning is required, and HueCode may not be recognized in unknown environments. 　The present invention is a “Universal HueCode” that solves the above problem by superimposing two or more markers and adopting a color scheme that appears to be the first marker when converted to greyscale, even though the distance between the colors of each marker = RGB u-grid distance is maximally separated. By replacing commonly used QR codes and AR markers with Universal HueCode, it is possible to embed additional information into the marker while continuing to use it for its current purpose. Furthermore, by improving the recognition algorithm, recognition under various lighting conditions is possible without prior learning.

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　Although invasive methods involving blood sampling are the mainstream methods for blood glucose measurement in diabetic patients, it is desirable to develop non-invasive methods that do not cause physical pain or risk of infection from the puncture site. As one of the non-invasive measurement methods, a method using a microphone to detect acoustic waves generated when a measurement object is irradiated with light has been proposed. However, the above method has a problem that it is easily affected by environmental sounds and water vapor generated from living organisms.　 　This invention is a method for measuring blood glucose levels by a transducer method using a piezoelectric element to detect ultrasonic waves generated when a measurement object is irradiated with mid-infrared light. The advantage of the transducer method is that it is not easily affected by environmental sounds and water vapor, which are problems in the microphone method. Furthermore, the photoacoustic cell used in the microphone method is not required, allowing for a simpler system configuration. It is expected that this invention makes it possible to measure blood glucose levels simply and non-invasively.

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Filamentous fungi represented by Aspergillus oryzae have high production capacity of proteins and low molecular weight compounds and are utilized for industrial production by fermentation. However, in liquid culture, hyphae are entangled and clump together, and there is a limit to maximizing the space of the culture tank and increasing the production of substances. Highly dispersible filamentous fungi (AGΔ-GAGΔ, see Related Inventions and Documents), in which the viscosity of the culture solution and the formation of clumps are drastically reduced compared to the wild-type strain, is a technology to solve this problem.　 　On the other hand, AGΔ-GAGΔ has excellent culture properties as a filamentous fungus, but the viscosity of the culture solution is still higher than that of yeast and bacteria. Therefore, it is required to develop a low viscosity strain that enables high gas dispersion and product yield under lower agitation power (energy). 　The present invention relates to the next generation highly dispersible filamentous fungus AGΔ-GAGΔ-ΔX, in which a deletion of the novel property modifying factor X gene is additionally introduced into AGΔ-GAGΔ strain. In this new strain, a significant drop in culture viscosity improved agitation efficiency and led to enhanced productivity compared to AGΔ-GAGΔ. Furthermore, the addition of a deletion of the rolA gene encoding surface-active protein RolA enhances the efficiency.

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Filamentous fungi represented by Aspergillus oryzae have higher production capacity of proteins and complex low-molecular compounds than bacteria and yeast, and are utilized for industrial production of a wide variety of useful substances by fermentation. However, in liquid culture, hyphae entangle and clump together, and there is a limit to high-density culture and increased production of useful substances by maximizing the space of the culture tank. Highly dispersible filamentous fungi (AGΔ-GAGΔ, see Related Inventions and Documents), which drastically reduce the viscosity of the culture solution and the formation of clumps, is a technology to solve these problems. On the other hand, even in the case of AGΔ-GAGΔ, the adhesion of the fungus to the inner structure of the culture tank, such as the inner wall of the culture tank and the agitation blade/shaft, is observed as in the case of the wild strain, and it remains to be solved in order to achieve further improvement of the productivity. The present invention relates to a new highly dispersible filamentous fungus AGΔ-GAGΔ-ΔrolA strain, in which a deletion mutation of the rolA gene encoding the surface-active protein is additionally introduced into AGΔ-GAGΔ strain. Compared with the AGΔ-GAGΔ strain, the adhesion to the inner structure of the culture tank is suppressed, and the productivity is also improved. In addition, the reduction of the agitation power and the cultivation time are also obtained by the reduction of the viscosity of the culture solution in a large-scale real machine (tank).

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In the treatment of bipolar disorder, which is characterized by recurrent manic and depressive episodes, it is essential for the affected person to be aware of the ups and downs of their mood and to maintain their regular lifestyle. Monitoring mood states by patients and clinicians is essential for preventing and timely intervention of relapses. However, differentiating mild hypomanic episodes from normal mood variations remains challenging for both patients and clinicians. Especially recognition of hypomanic status is difficult for patients. In addition, clinicians see outpatients once a couple of weeks or months in regular clinical settings and, therefore, may potentially look over patients’ mood swings during the intervals. This invention is a program consisting of machine learning algorithms integrated into a smartphone application for evaluating the affected person's current mood and mood within a few weeks based on objective information, such as body motion, heart rate variability, and voice collected through a wearable device and the application. The present invention enables accurate evaluation and prediction of the mood while reducing the burden on the affected person. It enables the maintenance of appropriate treatment of bipolar disorder and the prevention of relapses. Since this patent has not been disclosed, disclosure of the specification will be possible after the conclusion of the intellectual property agreement.

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・ Electronic holography for displaying three-dimensional (3D) information is required for entertainment, industrial design, measurement, and head-up display for automobiles. ・3D information is displayed by reconstructing an image through a spatial light modulator(SLM). SLM cannot narrow the pixel pitchbecause the electric field leaks out to adjacent pixels, resulting in a narrow viewing-zone angles. ・Therefore, the invention introduces a liquid crystal driving system in a lateral electric field by a continuous potential difference and fine ground electrodes into the SLM. ・As a result, the electric field leakage is reduced, the pixel pitch of less than 1 μm is achieved for the first time. ・Using the pixel pitch of 1μm, it is possible to achieve practical viewing-zone angels of 30°. invention is expected to enlarge electronic holography application field.

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Introduction to Tohoku University Technologies (T21-112_T21-284_T20-030) ■Spherical gear mechanism with high stiffness and 3 degrees of freedom of rotation A spherical gear mechanism realizes 3 degrees of freedom of rotation while reducing high rigidity and number of parts. (IP No. ：JP2021-145050,Admin No. ：T21-112) ■Self-healing robot Self-healing robot technology considering readiness. (IP No. ：JP2020-090978,Admin No. ： T20-030) ■Sprocket adjusts slack in caterpillars etc. A sprocket for adjusting and solving sagging of a caterpillar or the like. (IP No. ：JP2022-031799,Admin No. ：T21-284)

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・ At millimeter wave communication, there is a concern about increasing coverage hole which is area where the communication becomes impossible.　 ・ Therefore, installing the reflect array for all over city that can control the direction of electromagnetic wave is proposed. ・ A conventional reflect array composed of liquid crystal (LC) has problem of slow response. ・ In the invention, reduction of response time is achieved by forming a stripe electrode on　substrate which can be applied vertical and horizonal electric field. ・ The invention is not only expected to apply for reflect arrays, but also phase modulators and phased array antennas.

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Conventionally, a hard disk drive using a magnetic recording medium is widely used as an information recording and reproducing device capable of random access with high density and large capacity. To further increase the capacity of a hard disk drive, it is required to improve the recording density, but there is a problem that the recording information is disturbed by thermal disturbance of the magnetic medium. Therefore, a dielectric recording and reproducing device using a dielectric material has been proposed as one which can be expected to increase the density than magnetic recording. However, there is a problem that the reproduction speed of recorded data is in the order of Mbps, and it is necessary to improve the reproduction speed for practical application. The present invention has made it possible to provide a dielectric reproducing device and a dielectric recording and reproducing device capable of improving the reproduction speed. The present invention is characterized in that, when detecting the polarization state of each bit formed in a data recording layer composed of a dielectric material, the temperature of the bit detected by a heating means can be increased. As a result, since the nonlinear dielectric constant of each bit increases, it is possible to detect a reproduced signal having a large S/N ratio between the reproduced signal and the noise, thereby improving the reproduction speed of the data.

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Garden asparagus is a dioecious species, with male [XY] and female [XX] individuals. Since male individuals are preferred over females for agricultural production, all-male cultivars have agronomic advantages over mixed-sex cultivars. 　To produce an all-male cultivar, it is important to obtain a supermale [YY]. Given their morphological similarities, males and supermales are usually distinguished by genetic analysis. Although two sex-linked codominant markers (Asp2-SP6 and RM17) have been reported previously, their ability to distinguish the sex in A. officinalis and other dioecious Asparagus species was limited. 　We developed a new CAPS marker (SSM01). SSM01 is applicable for discrimination between X- and Y-specific sequences in various A. officinalis and purple asparagus cultivars, also in three dioecious Asparagus species.

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In recent years, deformable image registration (DIR) has been used to create radiotherapy treatment plans in medical practice. The accuracy of DIR is evaluated by the small difference between the image after deformation by DIR and the image obtained by imaging. To evaluate this, the common point (landmark point) between two images is found and compared. However, since the deformation by DIR is a non-rigid deformation, the relative positional relationship of each position such as the distance between the vertices of the image to be mapped to the image and the angle of the vertices is not necessarily preserved. Therefore, it is necessary for the coordinator to make a judgment based on his/her experience, and there is a problem that the burden on the coordinator is large.　 　To solve this problem, the inventors developed a phantom in which a rod simulating a tumor and an organ can be inserted, and an algorithm for verifying the accuracy of DIR using this phantom, and completed the present invention. 　In addition to being able to reproduce various shape changes easily by replacing the rod, the phantom of the present invention can automatically set thousands of landmark points by applying position information at the time of medical image acquisition, and can automate all DIR accuracy evaluations.

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　In recent years, the development of irradiation equipment capable of pinpoint irradiation by accurately grasping the position of the cancer affected area has advanced, making it possible to perform highly accurate treatment. Deformable image registration (DIR), which is the alignment using images obtained by 4D-CT, etc. is often used to prepare the treatment plan. Although the use of DIR is expected to expand in the future, the accuracy of images obtained as a result of DIR and the accuracy of the calculated combined dose remain controversial.　 　To solve the above problem, the inventors devised a Dynamic deformable phantom that can perform complex movements as if it were a patient's organ, and can insert acrylic markers and dosimeters. 　The present invention makes it possible to evaluate the combined dose distribution using image deformation techniques. It is possible to accurately evaluate the dose distribution in cases where a treatment plan is to be reformulated or where some irradiation fields overlap between past and present treatments. These effects are expected to improve treatment outcomes and reduce side effects.

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　Robots that explore extreme environments such as planets, caves, and volcanoes are being developed. In such environments, it is difficult to survey topography in advance, so robots that can move on unknown surfaces are required. In addition, due to the recent labor shortage, there is a great demand for mechanizing operations in factories and warehouses. In order to mechanize operations performed by human hands, robot hands capable of grasping various objects by one mechanism are required. As described above, if a gripper capable of grasping unknown shapes can be realized, there will be a great demand. 　The present invention relates to a gripper that can grasp unknown shapes by fitting and deforming with the shape of the object. The ordinary grippers usually cannot grasp the concave shapes, but the present mechanism can grasp by fitting them. In addition, it is advantageous that both convex and concave shapes can be grasped by the same operation using only one actuator. 　In the Related Works No.2, it is possible to view a video (Japanese).

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Robots that search for planets and collect damage information on disaster-stricken areas need to be able to cope with both rough terrain, such as steep slopes and uneven surfaces, and flat terrain. However, it is difficult to improve the mobility efficiency of both rough and flat terrain. For example, a robot that can climb by grasping steep slopes has poor mobility efficiency on flat terrain, and a robot that can move by wheels on flat terrain is not suitable for moving steep slopes and uneven surfaces. 　The present invention relates to an end effector that acts as a gripper when traveling on rough terrain and a wheel when traveling on flat terrain. By applying the end effector to a robot, a robot with high moving efficiency can be realized on both rough and flat terrain.

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- Transporting device capable of moving even object difficult to grasp　 　To provide a mechanism capable of moving even an object having a shape difficult to be gripped, and capable of moving the object without applying force to the object during movement. (IP No. ：JP2021-201325, Admin No. ：T21-217) - Highly rigid hand while remaining thin　 Hand and grip mechanism utilizing deformation mechanism which can enhance rigidity while remaining thin. (IP No. ：JP2021-082469、 Admin No. ： T20-3132)

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- Composite type wheel having high running performance in step and groove　 Composite type wheel with high running performance in steps and grooves and capable of moving in multiple directions.　 (IP No. ：JP2022-085688、 Admin No. ：T22-014) - Small, high stiffness, low backlash wheels A 2-way drive wheel that achieves small size, high rigidity, and low backlash. (IP No. ：JP2021-144398、 Admin No. ：T21-111) - High maintenance, moving mechanism capable of moving in multiple directions High maintainability, moving mechanism capable of moving in multiple directions. (IP No. ：JP2022-085565、 Admin No. ：T22-013)

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　The limited number of drugs available for the treatment of inflammatory bowel disease(IBD) and their severe side effects, including immunosuppression, have led to calls for research into drugs without side effects.　 　The inventors focused on the role of xCT, a cystine/glutamate antiporter, in IBD. Their research suggests that xCT inhibitors or glutamine synthetase inhibitors may be therapeutic/preventive agents for inflammatory diseases. [RESULTS] ・Mice with intestinal epithelium-specific xCT deficiency showed anti-inflammatory effects on dextran sulfate sodium(DSS) colitis(Fig.1). ・Glutamine synthetase inhibitor (MSO：Methionine sulfoximine) showed anti-inflammatory effects on DSS colitis(Fig.2).

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The measurement of pH is critical in environmental analysis. This invention introduces an advanced pH sensor with an outer diameter of just 1 mm, designed for precise measurements in confined spaces. The core of this invention is a pH sensor probe, integrating a 1-mm square semiconductor chip, known as a Light-addressable Potentiometric Sensor (LAPS). This LAPS is attached to the tip of a uniquely structured fiber with an optical fiber, a conductor, and a hollow flow path. A unique feature of LAPS is its light addressability. Upon exposure to alternating light via the optical fiber, LAPS generates a photocurrent. The amplitude of this photocurrent is directly influenced by localized surface potentials, thereby indicating the localized pH levels. This enables it to perform real-time pH distribution imaging via illumination with multiple lights, each modulated at distinct frequencies. Furthermore, this sensor is not limited to liquid environments. It is equally adept at measuring the pH on dry surfaces, such as metal and concrete. This capability is facilitated by the introduction of an electrolytic solution through the sensor's hollow channel. The lower right panel of the application illustrates the sensor’s performance in measuring the pH within a rat's deep brain with a high spatial resolution of 250 µm and a rapid frame rate of 33ms.

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Vasohibin-2 (referred to as VASH2) knockdown significantly reduced metastasis of pancreatic cancer cells (Fig. 1) and prolonged survival period after orthotopic transplantation (Fig.2). The mechanisms of action are;　 (1)VASH2 knockdown reduces cancer cell invasion through suppressing of tubulin carboxypeptidase activity within the cell. (2) VASH2 secreted by cancer cells stimulates tumor angiogenesis, so when VASH2 was knocked down, tumor angiogenesis was prevented. (3) VASH2 regulates the production of inflammatory chemokines and cytokines in cancer cells, which in turn, accelerates the recruitment of MDSC and TAM and prevents the infiltration of cytotoxic T lymphocytes. The inhibition of VASH2 eliminates immune suppression in pancreatic cancer.

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While NK cells have been expected to be used in the treatment of cancer and infectious diseases, their limitations in medical applications have been pointed out because they can not recognize cancer cells or infected cells having MHC class I molecules expressed therein. The present invention is about the use of chimeric proteins comprising a variable region of a T-cell receptor and an Fc region of an immunoglobulin, which can make NK cells easily recognize target cells. 　It was found that by using the chimeric proteins of the present invention, in addition to the previously reported T-cell receptor chimeric protein-dependent cellular cytotoxicity (TDCC) activity, down-modulation of MHC complexes on the target cells: the expression of MHC class I molecules can be reduced and converted into the target of NK cells' intrinsic cytotoxic activity (see the right figure). 　The combination of T-cell receptor repertoire analysis (see WO 2016/136716) enables rapid chimeric protein development and the design of NK cell-based therapies tailored to individual cancers, viral infections, autoimmune diseases, allergies and other clinical manifestations.

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Anti-EGFR treatment for colorectal cancer is effective for patients without RAS mutation. However, response rate of the treatment is no more than 30%. This inventor analyzed the DNA methylation status of tissue samples from patients treated by anti-EGFR antibody. The result showed that highly methylated colorectal cancer (HMCC) has higher drug resistance than low methylated colorectal cancer (LMCC).

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In conventional systems, processing must be performed on the user's computer in order to understand the user's viewing status, resulting in the fatal problem of being interrupted by a malicious user. In this system, it is possible to understand the viewing status on the network under the control of the distribution side, and since the contents of the communication data are not directly referenced, it is a safe method for the user.　 　Specifically, it is a method to determine the degree of similarity by the correlation coefficient between a specific video or audio pattern and a previously recorded pattern based on the change in the output pattern of traffic data provided as standard equipment in the router.

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Recent large-scale genomic and postmortem brain analyses have indicated that synaptic dysgenesis may be involved in the pathogenesis of schizophrenia, but the detailed mechanisms remain unclear. Drugs mainly blocking dopamine D2 receptors have been used for the treatment of schizophrenia, but they are mainly used for symptomatic treatment and have insufficient effects on negative symptoms and cognitive dysfunction. Therefore, it is desirable to develop new drugs based on new molecular mechanisms.　 　The inventors have discovered that the decreased function of the PPARA gene, which encodes the nuclear receptor PPARα, is involved in the pathogenesis of schizophrenia [1]. Since PPARα is a transcription factor that can be activated by its ligand, they considered the possibility that activation of PPARA might lead to the improvement of schizophrenia, and found that fenofibrate, a PPARa agonist, is actually effective in improving synaptic function [2]. In this study, they found that pemafibrate, a PPARa agonist, helps to improve cognitive function at the same time as restoring spine density in mice. The invention could lead to the discovery of novel mechanisms for schizophrenia. Furthermore, since decreased spine density and cognitive decline are similar symptoms in other psychiatric disorders such as Alzheimer's, it could also be a therapeutic agent for these disorders.

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The inventors found that Liphagal and its analog Siphonodictyal B inhibited multiple kinase activities in addition to PI3K.　　 　The inhibitors can be used as inhibitors of CDK7, CDK4, CDK6, PIM2, TSSK3, MST4, NEK6, MAP3K, MST3, DDR1, SPHK1, CaMK1, AurA, BRK, CaMK4 and PIM1 kinases. 　Studies using human colorectal cancer cells revealed that Siphonodictyal B induces expression of pro-apoptotic proteins by activation of the P38 MAPK pathway following an increase in intracellular reactive oxygen species, leading to apoptosis. 　In addition, Siphonodictyal B showed anti-tumor effects in a human colorectal cancer cell line tumor-transplanted mouse model.

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In a 3D concrete printer (3DCP), discontinuous layers are formed between layers of laminated mortar, so it is weak to shear force in the layer direction. Therefore, a measure to increase the strength and toughness has been taken by vertically inserting metal reinforcing materials so as to penetrate the layers. However, the conventional reinforcing method is a method of directly inserting reinforcing materials, and if the cementitious material starts to harden over time, it becomes difficult to insert reinforcing materials as desired. In addition, since conventional reinforcement is carried out only in a specific direction, it is not possible to freely reinforce molding without anisotropy. 　The present invention enables reinforcement of molding without anisotropy by a mechanism capable of automatically inserting screws from multiple directions. The screw can be inserted at a desired angle while suppressing displacement by releasing the holding when the screw is driven to a predetermined depth in the object to be driven while maintaining the attitude of the screw. Moreover, the screw can be efficiently driven by providing a cartridge capable of loading the screw.

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There are known compounds that exhibit phase separation when solutes dissolved in solvents exceed a certain temperature (LCST). Poly (N-isopropylacrylamide) (PNIPAm) has been studied as a representative of these compounds, and applications to temperature-responsive smart windows have been reported. However, since the LCST of PNIPAm is constant at 31°C, a compound that can flexibly respond to the LCST depending on ambient temperature has been desired in industry. 　The inventors succeeded in synthesizing a new compound. This compound is characterized by the ability to control the LCST within the range of about 25~55°C by modifying a part of its structure. When applying to smart windows, most of them require a power supply because they switch between transmission and non-transmission by turning the voltage on and off. On the other hand, smart windows using this compound can be used in places without a power supply because they switch between transmission and non-transmission spontaneously according to changes in the outside temperature. Furthermore, by controlling the heat according to the degree of light transmission, it is expected to be effective against heat.

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　Solid wastes, including industrial wastes, rocks, and polluted soils, contain various elements such as hazardous heavy metals and rare earth metals. Conventionally, strong acids have been used as extractants to enhance the leaching of these metal ions, which are subsequently recovered using electrochemical methods. However, these methods have environmental and economic problems because they consume a large amount of chemicals and electricity. The inventors have successfully developed a process that uses a recyclable solution containing an environmentally friendly chelating agent as the extractant for metal ions and anions extraction from solid wastes, which are efficiently recovered from the extractant, enabling the regeneration and reuse of the extraction solution. 　The present invention is expected to be applied to the removal of toxic ions from polluted soil. It is also expected to be used for the collection of resources such as rare earths from minerals. Furthermore, it can be combined with CO2 mineralization technology using solid wastes. (E.G., Patent No. 7345791)

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　Helium is difficult to obtain and expensive, so cooling systems that use helium are expected to be difficult to continue using. 　 The invention enables rapid cooling without helium by continuously spraying a two-phase flow of cryogenic gaseous N2 and solid N2 (SN2 ). Specifically, it is characterized by continuously generating slush N2 by spraying at transonic speed using a Laval nozzle. 　In an example of cell freezing, a 23% improvement in cell survival rate during thawing was achieved compared to liquid nitrogen immersion. This invention has the potential for application in various cooling systems beyond this specific example. Additionally, its application for resist removal in semiconductor cleaning without harmful chemicals is also under consideration.

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Aluminum borate whiskers have excellent mechanical strength and heat resistance, and are mainly used as reinforcing materials for metal materials. For example, a flux method using a melting agent is used as a manufacturing method. However, at the end of the manufacturing process, it is necessary to separate the melting agent from the whisker, which requires time and effort.　 The present invention solves the problems of the conventional method by constructing a reaction process using a liquid solvent, and demonstrates the simple and large-scale production of aluminum borate whiskers. More specifically, the process involves dissolving metallic aluminum in alcohol by adding halide ions and adjusting the pH, mixing the boron compound with water, and calcining the precipitated precipitate by adjusting the pH. The aluminum borate whiskers produced in this way have a high affinity for light metals such as aluminum and magnesium, and are expected to be used in automobile engine parts and semiconductor manufacturing.

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　In recent years, there has been a demand for mass culture of cells in fields such as pharmaceutical manufacturing. Ammonia accumulating in the culture medium must be removed in order for cells to grow stably during culture. Ammonia is known as a typical waste product that adversely affects cells. Until now, waste products were removed from the culture using the principle of dialysis. However, in order to remove waste products sufficiently, the volume of the component preparation liquid tank was set to be more than 10 times the volume of the cell culture tank, so there was a problem that the required volume of liquid was enormous and costly.　 　The present invention made it possible to provide a new ammonia removal technology. Embodiments of the present invention are an ammonia adsorbent and an ammonia removal method. The ammonia adsorbent of the present invention comprises at least one substance among L-type zeolite, ferrierite, ZSM-5 type zeolite, a strong acid cation exchange resin and a Prussian blue type complex. Thus, cells can be cultured more efficiently.

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Some semiconducting ferroelectric ceramics exhibit positive temperature coefficient (PTC) thermistor behavior, in which their electrical resistivity increases drastically above the Curie temperature. Materials based on perovskite-type barium titanate (BaTiO₃) are widely used as circuit protection devices under conditions of high temperature or large current surges.　 　Conventional methods to change originally insulating BaTiO₃ powders to semiconductor require highly reducing atmospheres and high sintering temperatures near 1400 ℃. 　This invention proposes a low-temperature and cost-effective fabrication method for BaTiO₃-based semiconducting ceramics using sodium (Na) vapor. Grain size control in ceramic products is also possible upon sintering using the present technique.

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Radiomics, a technique for calculating quantitative features, is used to diagnose tumors in medical images. However, this technique requires preparation of a mask image from which the outline of the affected area is extracted, which places a heavy burden on physicians. In addition, since the target of the calculation is limited to the area surrounded by the mask image, the relationship between the tumor and the surrounding tissue cannot be evaluated. 　This technology relates to a tumor image diagnosis method and program that calculates the image frequency included in the transition of the correlation coefficient by enclosing the area including the tissue surrounding the tumor in a square and performing Fourier analysis on the correlation coefficient of the area. Features： 1. No mask image required, just specify the user interested area by drawing a square 2. The relationship between tumor and surrounding tissue can be analyzed 3. Fast calculation (a few seconds per case)

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