メトロームジャパン List of Products and Services

**Features** ● Outstanding stability with a 5-ring electrical conductivity measurement cell ● Wide measurement range of 5 to 20,000 μS/cm (ideal) ● Compliant with FDA 21 CFR Part 11 and GLP ● Capable of measuring pH and conductivity simultaneously ● Supports measurements combined with automatic titration devices ● Allows for continuous measurement of multiple samples when combined with an auto-sampler All Metrohm devices come with a **3-year warranty** Accessories are guaranteed to be supplied for **10 years** after production ends, ensuring peace of mind in use.

• Water quality testing
• Environmental Test Equipment
• Conductivity Meter

Measurement of alendronate using anion exchange chromatography.

• Ion Chromatography
• Pharmaceutical Intermediates
• Pharmaceutical materials and carriers

Duloxetine hydrochloride is an active pharmaceutical ingredient (API) for the treatment of depression and other neurological disorders. This technical document presents the analysis of nitrite in duloxetine hydrochloride using ion chromatography (IC) with a Metrosep A Supp 10 column equipped with direct UV/VIS detection at 215 nm.

• Ion Chromatography
• Pharmaceutical Intermediates
• Pharmaceutical materials and carriers

The presence of carcinogenic nitrosamines in pharmaceuticals poses a threat to patient safety. By controlling the concentration of nitrites in drugs and processes, the formation of nitrosamines can be prevented, making it essential to have a highly sensitive method for analyzing nitrites in pharmaceuticals and their raw materials. In many cases, dimethylamine is used in the synthesis of various drugs. Under acidic conditions, it reacts with nitrites to form nitrosamines. This also applies to the production of hydroxypropyl methylcellulose (HPMC), a common excipient. This technical document introduces the quantification of nitrites in hydroxypropyl methylcellulose using ion chromatography (IC) with direct UV/VIS detection.

• Ion Chromatography
• Pharmaceutical Intermediates
• Pharmaceutical materials and carriers

A list of comprehensive measurement examples using process analyzers.

• Wafer
• Semiconductor inspection/test equipment
• Semiconductors and ICs

Boric acid is used in many primary circuits of nuclear power plants, nickel plating baths, and the production of optical glass. Furthermore, boron compounds are also included in detergents and fertilizers. This report will explain the quantitative methods for boric acid using the potentiometric method and the temperature method. Additionally, it will describe the quantitative methods for other boron compounds using acidic decomposition methods.

• Analytical Equipment and Devices
• Plating Equipment
• Glass

At the refinery, high-octane products are required for the production of premium gasoline. This introduces a method for monitoring the octane rating in fuel with high precision in "real-time" using near-infrared spectroscopy (NIRS) technology.

• Analytical Equipment and Devices
• Spectroscopic Analysis Equipment
• Weighing Control

2060 MARGA is a fully autonomous sampling and measurement system that can continuously measure water-soluble gases and aerosol components that directly affect air quality. The measurement results can be used in research to identify the structure of aerosols and to investigate how their concentration and composition change with diurnal and seasonal cycles.

• Environmental Test Equipment
• Water quality testing
• Ion Chromatography

Introduction of hydrogen permeation technology using a single apparatus in accordance with ASTM G148.

• Other electric meters
• Steel
• Corrosion evaluation test

The US EPA Method 300.1 (Parts A and B), ISO 10304-1, and ISO 10304-4 are conducted to ensure compliance when monitoring water quality contaminants that affect human health. In particular, disinfection by-products (DBPs) are associated with carcinogenicity and reproductive effects. EPA Method 300.1 Part A and ISO 10304-1 specify the requirements for quantitative analysis of major inorganic anions by ion chromatography.

• Ion Chromatography
• Water quality testing
• Water treatment equipment and technology

We conducted the analysis by connecting the Metrohm ion chromatography (IC) to an Agilent triple quadrupole mass spectrometer (MS). This high-sensitivity method does not require sample extraction and can eliminate interferences from the eluent due to the Metrohm suppressor module. The matrix spike recovery rate for all target analytes at 1 μg/L was between 65% and 115%, and good results were obtained even with highly contaminated water samples.

• Ion Chromatography
• Food/beverage component analyzer
• Water quality testing

Free download available

• Moisture Measuring Device
• Analytical Equipment and Devices

Battery research and development includes a wide variety of development processes, from theoretical validation and proof of concept for new materials to the characterization and quality control of battery materials and finished products. In the pursuit of high energy density, power density, and efficient energy storage, advanced analytical equipment is essential for evaluating the properties of materials and battery cells. Metrohm supports your research and development with the highest quality analytical instruments, expertise, and top-level on-site service.

• Analytical Equipment and Devices
• Lithium-ion battery
• Secondary Cells/Batteries

Near Infrared Analyzer Technical Data 31 Petroleum Related This technical document measures important quality parameters of diesel oil, including cetane index (ASTM D613), flash point (ASTM D56), CFPP: cold filter plug point (ASTM D6371), D95 (ISO 3405), and viscosity at 40 °C (ISO 3104).

• Spectroscopic Analysis Equipment
• Fuel system parts
• Near-infrared spectrophotometer

Research institutions need to expand their ability to routinely analyze candidate microplastics from environmental samples. Spectroscopic techniques are suitable for identifying polymers, as they assist in origin identification and help predict biological impacts. Laboratory Raman spectroscopy is a method that enables rapid identification of polymer materials, serving as an alternative to confocal Raman microscopy and Fourier-transform infrared (FTIR) microscopy. However, very small samples are not suitable for conventional Raman analysis. This application note discusses the use of Raman microscopy for the identification of very small microplastic particles.

• Raman Spectrophotometer
• Spectroscopic Analysis Equipment
• Environmental Test Equipment

The Handheld Raman Spectrometer TacticID can identify unknown substances on-site during tactical activities such as those conducted by emergency responders, security personnel, HazMat teams, and military advance teams. TacticID is rugged and suitable for field use, helping to mitigate risks and manage uncertainty and response times without compromising sample integrity or the chain of evidence.

• Raman Spectrophotometer
• Defect Inspection Equipment
• Material Evaluation Test

The OMNIS NIR Analyzer is a Swiss-made near-infrared analyzer that performs quality control of liquid, viscous, and solid samples in just a few seconds.

• Spectroscopic Analysis Equipment
• Near-infrared spectrophotometer
• Food Testing/Analysis/Measuring Equipment

Most organic fluorine compounds are assumed to be the total of all adsorbable organic fluorine (AOF) compounds in water. The measurement of AOF is simpler and faster than target analytical methods, and it is more sensitive than total fluorine (TF) measurements (which include all organic and inorganic F). Measuring AOF in water samples as an initial screening process allows for the screening of the actual amounts of organic fluorine compounds present. Following this, if indicated by high AOF concentrations, it can serve as a criterion for conducting target analysis of individual PFAS.

• Ion Chromatography
• Environmental Test Equipment
• Water quality testing

During the charging and discharging of lithium-ion batteries (Li-ion batteries), lithium ions are transported from one electrode through the electrolyte to the other electrode. Knowing the chemical diffusion coefficient of the electrode materials is very important. The potentiostat intermittent titration technique (PITT) is one of the most commonly used methods to gain insights into the diffusion coefficients of electrode active materials.

• Other electric meters
• Secondary Cells/Batteries
• Lithium-ion battery

Lithium-ion (Li-ion) batteries are one of the most researched energy storage devices due to their relatively high energy levels and excellent power performance. During charging, lithium ions are moved from the positive electrode to the negative electrode through the electrolyte. During discharging, lithium ions move in the opposite direction, from the negative electrode to the positive electrode. At the electrode surface, the diffusion of Li-ions into the bulk occurs. Here, the performance of Li-ion batteries largely depends on the diffusion coefficient of the active materials present in the electrodes. Therefore, knowing the chemical diffusion coefficient of the electrode materials is very important. Additionally, understanding the thermodynamic properties of the electrode materials provides a more detailed insight into their electrochemical behavior.

• Other electric meters
• Secondary Cells/Batteries
• Lithium-ion battery

Cell culture plays a crucial role in monitoring the health of cells in the biopharmaceutical industry. To overcome undesirable side reactions and yield reductions, it is necessary to strictly control this process. This technical document introduces a method for accurately monitoring cell proliferation inside a bioreactor in "real-time." In cell culture, inline process analyzers are a preferred solution to ensure high quality and avoid contamination during measurements. Online analyzers, process analyzers, inline analyzers, Raman spectroscopy.

• Analytical Equipment
• Culture tank
• Raman Spectrophotometer

Corrosion applications using potentiostat/galvanostat

• Analytical Equipment and Devices
• Etching Equipment
• Wafer

Free download available

• Moisture Measuring Device
• Analytical Equipment and Devices
• Food Testing/Analysis/Measuring Equipment

The use of zero-calorie sweeteners as sugar substitutes in food products has dramatically increased over the past decade in soft drinks and snacks. Two examples of this are stevia, derived from the leaves of the Stevia rebaudiana plant, and sucralose, a chlorinated sucrose derivative. Both are much sweeter than sugar and are used at much lower concentrations in food. On the other hand, regulations regarding zero-calorie (non-nutritive) sweeteners have become stricter to ensure food safety. In response to these regulations, various sweeteners can be measured using high-performance liquid chromatography (HPLC), ion chromatography, and thin-layer chromatography; however, these measurement methods are time-consuming and have high running costs. By using near-infrared spectroscopy (NIRS), it is possible to simultaneously quantify several types of sweeteners in under one minute without the use of chemicals and without the need for sample pretreatment.

• Food Testing/Analysis/Measuring Equipment
• Near-infrared spectrophotometer
• Food/beverage component analyzer

The Metronome Process Analytics 2060 XRF Process Analyzer is a suitable device among online energy-dispersive X-ray fluorescence (EDXRF) spectrometers. Its design philosophy focuses on quality and process management, taking into account multiple sample points and user-friendly operability. It enables online XRF analysis with up to 10 channels.

• Analytical Equipment and Devices
• X-ray fluorescence analyzer

Electrochemical Raman (EC-Raman) spectroscopy is a powerful analytical tool that enhances the understanding of the functioning of energy storage devices by monitoring physicochemical changes. This application note describes insights gained from EC-Raman during simulation experiments of charging and discharging nickel-hydrogen batteries.

• Raman Spectrophotometer
• Spectroscopic Analysis Equipment
• Secondary Cells/Batteries

The OMNIS NIR Analyzer is a Swiss-made near-infrared spectrometer that performs quality control of liquid, viscous, and solid samples in just a few seconds.

• Analytical Equipment and Devices
• Spectroscopic Analysis Equipment
• Food Testing/Analysis/Measuring Equipment

By using the 2060 Raman analyzer for continuous inline process monitoring, we can deepen our understanding of the process. This ensures consistent product quality by collecting information on every aspect of the manufacturing line without the need to transport samples to the laboratory.

• Analytical Equipment and Devices
• Raman Spectrophotometer
• Food Testing/Analysis/Measuring Equipment

【Near Infrared Analyzer Technical Data 29 Pharmaceuticals】 Cannabis has a long medical history as a recreational drug and as an analgesic and antispasmodic. The discovery of the major cannabinoids tetrahydrocannabinol, cannabidiol, and cannabigerol (THC, CBD, and CBG) has increased interest in its medical effects. THC is psychoactive and classified as an illegal drug in most countries, while CBD is legally accepted for medical purposes in many regions around the world. CBD is believed to alleviate anxiety and stress and promote better sleep. Due to the various effects and potential legal implications, determining the cannabinoid profile in cannabis has garnered significant interest. Generally, efficacy testing of cannabis is conducted using HPLC analysis. HPLC can detect low concentrations of cannabinoids but requires chemical reagents and is quite time-consuming. This technical document explains why near-infrared spectroscopy (NIR) is an excellent method for quantifying THC, CBD, and CBG in dried cannabis, as it provides results in less than one minute and does not require chemical reagents.

• Near-infrared spectrophotometer
• Other physical property measurements and component analysis
• Pharmaceutical materials and carriers

Near Infrared Analyzer Technical Data 28 Pharmaceuticals Cosmetics Cannabidiol (C-B-D) is a popular natural remedy used in many pharmaceuticals, foods, and cosmetics. CBD is just one of over 100 chemical compounds found in the cannabis plant. Unlike tetrahydrocannabinol (THC), CBD is non-psychoactive. This characteristic makes CBD an attractive option for those seeking relief from pain and other symptoms without the psychoactive effects associated with marijuana or resin concentrates. CBD oil is produced by extracting the compound from the plant and then diluting it with a carrier oil (such as coconut oil or hemp seed oil). The standard HPLC method takes a skilled analyst 45 minutes to perform the measurement. In contrast, the near-infrared analyzer (NIR) is a cost-effective and rapid analytical method for measuring cannabinoid content in oils.

• Spectroscopic Analysis Equipment
• Analytical Equipment
• Near-infrared spectrophotometer

【Near Infrared Analyzer Technical Data 27 Food and Confectionery】 The production of food requires strict quality control to ensure its quality and protect consumers. Confectionery products, such as chocolate, are required to manage the final product to meet regulations and ensure consistent quality, which is especially important for luxury items. Near-infrared spectroscopy is a fast analytical method that requires no sample preparation and does not use chemicals, allowing for the determination of many important quality control parameters of chocolate bars. Near-infrared analyzers are easy to use and can be utilized in quality control laboratories as well as in environments close to the production site.

• Near-infrared spectrophotometer
• Food Testing/Analysis/Measuring Equipment
• Food/beverage component analyzer

Near Infrared Analyzer Technical Data 26 Agriculture Moisture in fertilizers is one of the most commonly measured parameters. Globally, regulations regarding different fertilizers vary, but local legal restrictions must not exceed the maximum moisture content. Various analytical techniques can be used for this moisture measurement. Following the gravimetric method, the Karl Fischer moisture meter is commonly used for accurate moisture measurement. Compared to these methods, near-infrared spectroscopy has unique advantages. It does not use chemical reagents and provides reliable results in just a few seconds. This application note introduces the analysis of moisture content in various fertilizer products using a near-infrared analyzer that allows for rapid and reagent-free analysis.

• Near-infrared spectrophotometer
• Biofertilizer for Agriculture
• Moisture Measuring Device

Portable Series of Electrochemical Analysis Devices from Metronome ● μSTAT-i400: Voltammetry, amperometry, and potentiometric measurements. Can connect 1 or 2 channel electrodes. Battery operated. ● STAT8000P: Voltammetry and amperometric measurements. In multi-channel mode, can connect up to 8 working electrodes and reference electrodes. Battery operated. ● 910PSTAT mini: Ultra-compact potentiostat/galvanostat the size of a smartphone.

• Other electric meters
• Analytical Equipment and Devices
• Secondary Cells/Batteries

Autolab's potentiostat/galvanostat, compact series ● PGSTAT101: Compact electrochemical measurement device ● PGSTAT204: Space-saving modular electrochemical measurement device Autolab is a manufacturer of electrochemical measurement devices under the Metrom group. In Japan, Metrom Japan Co., Ltd. serves as the exclusive distributor.

• Other electric meters
• Analytical Equipment and Devices

The 202X Process Analyzer is a compact and easy-to-use online wet chemical analysis process analysis device that enables reliable process monitoring and control around the clock, contributing to time and cost savings. The 202X series includes the following three types: - 2026 Titrator: Ion measurement using titration or ion-selective electrodes (up to 2 lines) - 2026 pH Analyzer: pH measurement with automatic cleaning and automatic calibration functions - 2029 Process Photometer: Absorbance measurement (up to 2 lines)

• Analytical Equipment and Devices
• Spectroscopic Analysis Equipment
• pH meter

The method for refining alumina from bauxite is called the "Bayer process." Since it is more cost-effective and energy-efficient to refine aluminum directly from alumina, this method involves dissolving crushed bauxite in high-temperature calcium oxide (hereafter referred to as CaO) and sodium hydroxide (hereafter referred to as NaOH) to create an "aluminate solution." Additionally, CaO is causticized and removed by the carbonate generated from the decomposition of organic matter in the alkaline solution and the absorption of CO2 from the atmosphere. Impurities are removed at various stages of the process. The aluminate solution is filtered, and the alumina crystals that remain as solids are returned to the dissolution process for reuse. Before utilizing the filtered aluminate solution, it is necessary to measure the concentrations of hydroxides (caustic), carbonates, and alumina. This technical document focuses on online monitoring of the concentrations of hydroxides, carbonates, and alumina in the aluminate solution using the temperature titration method of the Metrohm Process Analytics 2060TI Process Analyzer or 2035 Process Analyzer. Online analyzers, process analyzers, inline analyzers.

• Analytical Equipment and Devices
• aluminum
• Non-ferrous metals

Lithium-ion batteries (LIBs) are currently the most common rechargeable option available. The manufacturing of LIBs must adhere to strict quality standards. Moisture content, residual alkali levels, or ionic impurities can adversely affect the safety and capacity performance of LIBs. On the other hand, the composition of cathode materials or battery electrolytes can influence the manufacturing cost and performance quality of the product. This white paper provides a detailed explanation of how to monitor various battery quality parameters using titration and ion chromatography.

• Secondary Cells/Batteries
• Lithium-ion battery
• Analytical Equipment and Devices

Even in customized online industrial processes with multiple parameters and streams, monitoring using ion chromatography becomes possible. The 2060 IC Process Analyzer, based on the 2060 online analysis platform, is a highly flexible and perfect system suitable for online monitoring of ionic compounds in aqueous media at concentrations ranging from ng/L to the % order.

• Analytical Equipment and Devices
• Ion Chromatography
• Water quality testing

[Near Infrared Analyzer Technical Data 25 Food and Beverages] Near Infrared Spectroscopy (NIRS) is an analytical method suitable for analyzing the density, water activity, and moisture content of green coffee beans. It does not require any chemicals or sample pretreatment, and NIRS can be easily used anywhere, whether near warehouses, roasters, or in analysis rooms.

• Near-infrared spectrophotometer
• Food/beverage component analyzer
• Moisture Measuring Device

Generally, the measurement of hardness, which is the total amount of magnesium and calcium contained in water, is performed through visual manual titration (such as ASTM D1126, ASTM D511, EPA 130.2, EPA 215.5, APHA 130.2, APHA 2000, etc.), a method prone to human error and lacking reproducibility and reliability in the measurement results. The new standard (ASTM D8192) allows for the objective measurement of water hardness using an automatic titration device, eliminating the need for visual endpoint determination.

• Analytical Equipment and Devices
• Water quality testing
• Other water quality analysis

【List of Products】 ■ Potentiometric Automatic Titration Device ■ Sample Processor ■ Electric Burette ■ Temperature Titration Device ■ pH and Ion Meter ■ Ion Chromatograph ■ Potentiostat/Galvanostat ■ Electrochemical Analysis Device VA/CVS ■ Oxidation Stability Testing Device ■ Karl Fischer Moisture Measurement Device ■ Vaporization Device for Moisture Measurement ■ Process Analytical Instrument * We offer a variety of analytical instruments. For more details, please contact us or download the catalog.

• Analytical Equipment and Devices
• Food Testing/Analysis/Measuring Equipment
• Spectroscopic Analysis Equipment

Adsorptive Organic Fluorine (AOF) is the sum value that covers a wide spectrum of organic fluorine. AOF analysis is an appropriate screening analytical method for PFAS in water. DIN 38409-59 conducts AOF analysis using combustion ion chromatography (CIC), which combines a pyrolysis device and an ion chromatograph – AOF analysis can be performed using Metrohm's combustion ion chromatography system.

• Analytical Equipment and Devices
• Ion Chromatography
• Water quality testing

【Near Infrared Analyzer Technical Data 24 Food and Beverages】 When considering root juice as a product, the sugar content in the product is a very important parameter because it is a sweet beverage. Among these, the contents of fructose, glucose, and sucrose are considered very important sugars for quality control. Traditionally, to measure these sugars in fruit juice through laboratory analysis, liquid chromatography is used along with refractive index measurement. When there are multiple analytical methods like this, each analysis requires time and expertise, as well as the need for different analytical instruments. Near Infrared Spectroscopy (NIRS) is an analytical technique that can simultaneously measure glucose, fructose, sucrose, and Brix in fruit juice in under one minute. Furthermore, it does not require chemical reagents, and no sample pretreatment is necessary.

• Near-infrared spectrophotometer
• Spectroscopic Analysis Equipment
• Food/beverage component analyzer

Near Infrared Analyzer Technical Data 23 Food and Beverages Sucrose, glucose, and fructose are three common sugars that are absorbed in different ways in the body. These sugars have slightly different effects. A key factor in their impact on our health is whether these sugars are naturally present in food or added during processing. The measurement of individual sugars and Brix (sugar content; °Bx, a scale for dissolved sugar content) is an important quality parameter in the food industry. These measurements can be performed using High-Performance Liquid Chromatography (HPLC), Ion Chromatography (IC), or Thin Layer Chromatography (TLC). However, these methods tend to be time-consuming and have high running costs. On the other hand, Near Infrared Spectroscopy (NIRS) can measure many sugars simultaneously within one minute without the need for chemicals or sample pretreatment.

• Near-infrared spectrophotometer
• Food/beverage component analyzer
• Brix Meter

【Near Infrared Analyzer Technical Data 22 Food and Beverages】 Near Infrared Spectroscopy (NIRS) allows for the rapid analysis of caffeine, water activity, and moisture in roasted coffee beans and ground coffee without the use of any chemicals. Analysis using NIRS requires no sample pretreatment and is easy to operate. The analytical device introduced in this article can be placed near the roaster or in a quality control lab for analysis.

• Near-infrared spectrophotometer
• Food/beverage component analyzer
• Spectroscopic Analysis Equipment