Nippon Cobetter Technology Product Lineup

The Lifemeta Tube Welder is an automatic sterilizing tube welding machine specially designed for welding TPE tubes of single-use products such as liquid storage bags and sampling bags. It is suitable for welding empty tubes to empty tubes, tubes filled with liquid to tubes filled with liquid, and tubes filled with liquid to empty tubes. The welding of tubes and liquid pipes can be achieved. Even in sterile environments, the Lifemeta Tube Welder ensures sterile and reliable welding of TPE pipelines.

• Other physicochemical equipment

The Lifemeta Tube Sealer is a handheld sterilization tube sealer specially designed for cutting TPE tubes of single-use products such as refill bags and sampling bags, capable of sealing both empty tubes and tubes containing liquid. The Lifemeta Tube Sealer enables sterile and reliable cutting of TPE tubes even in non-sterile environments.

• Other physicochemical equipment

Single-use technology is widely applied in the fluid transport of both upstream and downstream processes of biopharmaceuticals. Compared to traditional stainless steel systems, single-use technology can reduce capital investment costs and has advantages such as eliminating the need for cleaning, which can accelerate research and development as well as production speed. Currently, it is widely used in various processes in fields such as vaccines, antibodies, and gene and cell therapies.

• Other physicochemical equipment

Cobetter's Consieve TFF cassette is available in two materials: Polyethersulfone (PES) and regenerated cellulose (RC). The PES membrane features a wide range of chemical compatibility, high throughput, low protein adsorption, and high recovery rates. The RC membrane has excellent hydrophilicity, resistance to organic solvents, minimal protein adsorption, and high product yield. The RC membrane excels in anti-fouling properties and is suitable for the concentration of high-concentration formulations. The Consieve TFF cassette is available in two types: lab type and flow type, facilitating process scale-up and meeting the needs of ultrafiltration from lab to process production scale. The Consieve MET precision filtration TFF cassette is commonly used in the clarification process of supernatant after centrifugation of fermentation broths and dissolution liquids. It features high processing capacity, high load capacity, good clarification effect, and easy cleaning. The open channel is suitable for filtration liquids with a certain amount of solids and high viscosity.

• Other physicochemical equipment

The Lifecask RW single-use bioreactor bag is specially designed for rocking mode bioreactors. The bag is sterilized through in-house gamma irradiation to ensure good mechanical performance and biocompatibility, and it is packaged in a double Lifecask KAPE bag to avoid cross-contamination. It is manufactured using bioreactor film. The Lifecask RW single-use bioreactor bag can be widely applied in processes that incorporate multiple upstream blends of biopharmaceuticals such as antibodies, vaccines, and CGT. In addition to the basic bag configuration, RW Perfusion is launched, featuring RW PRO with built-in optical sensors for pH and DO to meet multiple culture modes such as seed train deployment, feed batch, and perfusion processes. Furthermore, fabric carriers and microcarriers can be applied to the bag for adherent cell culture.

• Other physicochemical equipment

Cobetter Lifecask RG single-use bioreactor bags are designed to provide reliable upstream process solutions for biopharmaceutical companies. They are available in sizes ranging from 50L to 2000L, covering the requirements from laboratory to manufacturing processes. Our proprietary patented split aeration disk design meets the dissolved oxygen requirements at each scale. The Lifecask RG single-use bioreactor bags eliminate the need for complex and time-consuming SIP and CIP compared to stainless steel, contributing to the simplification and time reduction of upstream processes. The RG bioreactor bags utilize our unique LifemetaTM KA film, which has low extractables and excellent mechanical properties, making them suitable for cell culture. Multiple tubes and ports are designed to accommodate each stage of cell culture.

• Other physicochemical equipment

Our single-use accessories are widely used for connecting single-use bags, tube assemblies, and stainless steel process equipment in biopharmaceutical manufacturing. All of our single-use accessories are manufactured in ISO Class 7 cleanrooms, ensuring consistent quality and compliance with numerous regulations. They can be customized in size according to customer needs, contributing to shorter lead times and cost reduction.

• Other physicochemical equipment

The Cobetter Claricap M02 depth filter capsule is formulated with high-purity cellulose fibers and inorganic filtration aids using a special manufacturing process. Its internally three-dimensionally woven structure exhibits excellent filtration efficiency and high retention capacity as a depth filtration material. The manufacturing of depth filter capsules employs a highly automated production process. All raw materials undergo strict quality control inspections, ensuring consistent product quality and filtration performance.

• Other filtration and separation equipment

Purcise Q Membrane is a new anion exchange medium that modifies specific functional groups in cross-linked polymer coatings to achieve the separation and purification of negatively charged components. The Purcise Q Membrane Adsorber (chromatography) medium features large pore channels, allowing larger biomolecules to pass through, while simultaneously enabling convective mass transfer on the channel surface, which facilitates rapid binding to the ligand sites of target molecules. Compared to conventional column chromatography media, the membrane adsorber medium provides high processing flow rates to reduce processing time and has a high dynamic binding capacity for biomolecules (such as plasmid DNA, enveloped viruses, host cell proteins, etc.), which can help reduce processing costs.

• Other physicochemical equipment

Cobetter Biophsep hollow fibers have good filtration resolution and low fouling properties. They help reduce manufacturing costs to improve the yield and filtration load of biopharmaceutical customers' products.

• Other physicochemical equipment

The Cobetter Lifecube SSB single-use bioprocess bottle is suitable for most bioprocessing scenarios. It meets needs for liquid storage, transfer, sampling, dispensing, freezing, and other requirements. The bottle's neck features a high-strength threaded design to avoid the risk of leaks during transport and storage.

• Other physicochemical equipment

To better support the research and development processes of pharmaceutical companies, we have developed and designed the small TFF (Tangential Flow Filtration) ultrafiltration system, Minilab. We focus on solving many of the issues encountered in research and development testing. The Minilab TFF system features free combinations and flexible matching, allowing it to adapt to various complex usage environments of our customers.

• Other physicochemical equipment

This is a comprehensive catalog of filtration, separation, and purification solutions for biopharmaceuticals.

• Other physicochemical equipment

High reliability and effective new generation virus removal filter! Based on the first generation Viruclear VF, we have optimized the membrane treatment process and launched the optimized composite PES membrane virus removal filter, Viruclear VF Plus. The strength of the optimized membrane structure is more assured, the filtration capacity for proteins has effectively improved, and adaptability to relatively complex products has also been enhanced. Viruclear VF Plus is part of the PES membrane virus removal product line promoted by Covetter, primarily aimed at the purification of biological preparations such as recombinant proteins expressed in animal cells, monoclonal antibodies, ADCs, and high purity/stability bispecific antibodies.

• Other physicochemical equipment

The Cobetter Claricap CSD & Roheap CSD series filters are composed of high-purity lignocellulose and inorganic filter aids through special technology. The internal structure of the filter is three-dimensional, allowing for depth filtration while demonstrating excellent filtration efficiency and high retention of contaminants. The filters are manufactured using a super-matic production line, and all raw materials are inspected through a strict quality control process, ensuring the quality and high performance of the filters for all applications.

• Other physicochemical equipment

Western blotting is a method for analyzing and quantifying proteins. Proteins are separated by gel electrophoresis and transferred to a solid support (PVDF membrane). Antibodies can induce an antigen-antibody immune reaction with the target proteins attached to the PVDF membrane. The Western blotting technique is used to identify specific proteins and analyze them semi-quantitatively.

• Other physicochemical equipment

Microbiological quality control is a routine task in the pharmaceutical, food, and beverage industries. Cobetter provides sterilized MCE grid membrane filters, filtration units, and stainless steel manifolds necessary for microbiological testing.

• Other physicochemical equipment

Cobetter's centrifugal ultrafiltration filters are commonly used for the separation, concentration, and buffer exchange of biological samples such as proteins, nucleic acids, plasmids, and viruses. Concentrating samples with Cobetter's centrifugal ultrafiltration filters yields highly reliable protein recovery.

• Other physicochemical equipment

Various validations (E/L, BCT, physical property analysis, virus spike) can also be performed in-house, achieving short delivery times, stable supply, and high cost performance.

• Other physicochemical equipment