マツボー List of Products and Services

Selected for the SBIR Program Phase I of the U.S. National Science Foundation. Mass production of uniform nanoparticles ranging from 50 to over 500 nm at a continuous rate of over 100 mL/min. Functionality for nanoparticle concentration and organic solvent dilution is provided by a TFF unit. Achieved a filling rate of over 99% through active loading of liposomes. Scale-up from lab-level to mass production, which was impossible with conventional equipment, is now feasible. Additional processing steps such as crystal injection and surface modification can be added to the manufactured liposomes, enabling highly flexible continuous production.

This is a centrifuge manufactured by Heinkel, characterized by a completely sealed mechanism and fully automated processes. By incorporating the PAC pressurized filtration system, it further enhances dewatering capabilities and enables the filtration of difficult-to-filter substances. It also boasts a high centrifugal force of up to 3,000 G. The synergy between high G and the PAC system allows for a reduction in size compared to centrifuges from other manufacturers. It is an ideal device for applications in pharmaceutical active ingredients, intermediates, and high-performance resin electronic components. It enables centrifugal dewatering of hazardous raw materials while contained, and with automatic liquid injection and cake discharge, it allows for safe, secure, and labor-saving operations without the need for operator intervention.

1. A special film with extremely high resistance and stability against a wide variety of solvents is adopted. 2. The film is FDA, USP, and EP approved. It has antistatic properties and does not generate dioxins during incineration. 3. Compared to hard wall isolators, the initial investment is about one-tenth and the delivery time is shorter. Design changes after delivery are also easy. 4. Customizable design allows for adaptation to various concepts and can be flexibly applied to existing equipment. 5. Due to the disposable concept, cleaning validation is unnecessary, and complicated verification processes are not required. 6. A unique dedicated crimping tool allows for easy separation of sleeves and bags without exposing them. 7. Containment level achieves OEL < 1μg/m³. 8. It also supports negative pressure management.

The crushing method involves pressing the raw material in the center as if bridging it to break it apart. The raw material introduced is crushed with cracks as the peaks on the surfaces of two rotating rolls serve as the points of force. The crushed material then moves to the next roll, where it is progressively refined into smaller particles. The target particle size can be freely adjusted based on the width of the roll peaks, the number of roll stages, and the gap between the rolls. Compared to conventional crushing methods, this method offers superior crushing efficiency and reproducibility, significantly reducing running costs.

Milder is an inline emulsifying disperser that can handle both batch processing and continuous processing.

This is a device that automatically inspects defective products, such as foreign matter adhesion, dirt, chips, shape defects, stray hairs, and printing defects, on the entire circumference of tablets at high speed using a high-sensitivity color line sensor camera. It is capable of reading high-quality images and achieves a detection accuracy of 50μm through a combination of a unique optical system and advanced algorithms. With a dual-lane conveyor, it can achieve a maximum processing capacity of 600,000 tablets per hour. Additionally, by adopting high-brightness LED lighting and illuminating the subject with stable and uniform lighting, it ensures a stable lighting environment.

The Kalix tube filling machine from France is equipped with hot air sealing technology that allows for various designs of the sealing section. It can process tubes into various shapes, including simple shapes, radii, euro slots, round corners, and original designs. Additionally, it features a simple structure that makes switching between product types easy, making it ideal for small-batch, diverse production. It boasts a track record of 5,000 units delivered worldwide, including to top manufacturers in the cosmetics industry. 【Features】 ■ High-performance hot air method recognized worldwide, with easy nozzle replacement ■ Simple design for easy and very user-friendly operation ■ Product type switching takes about 10 minutes, ideal for small-batch, diverse production ■ A proven track record of 5,000 units delivered worldwide, including to top manufacturers in the cosmetics industry *For more details, please download the catalog or contact us.

We conduct high-precision foreign matter contamination inspections on various powders and granules, such as raw materials like crystallized lactose and different types of powders, granules, and fine particles, and automatically expel detected foreign matter through suction. By reliably detecting foreign matter mixed in various powdered substances, we strongly support the improvement of product quality and safety management.

The industry's lowest-priced X-ray foreign object inspection machine. It uses X-ray image analysis to detect and remove foreign objects mixed into packaged food products. The operation is simple with a touch panel interface. Power consumption has been significantly reduced for energy efficiency. The smallest model, SX2040D/W, is the most compact in the industry. The design is innovative and won the grand prize at the Niigata Design Competition.

The forced collision scattering method (patent registered) allows for continuous degassing and defoaming treatment of various gases from low viscosity to high viscosity. It is also compatible with laboratory equipment for research institutions.

Both routine and emergency decontamination can be automated using Bioquell ProteQ as part of contamination management, allowing for the decontamination of rooms and areas. The latest 35% hydrogen peroxide vapor decontamination system can decontaminate everything from small laboratories to large bioprocessing areas. Powerful dispersion reduces cycle times, and new wireless features enable networking of multiple units, making it ideal for areas of any size. For GMP and non-GMP applications, you can choose from pre-registered time cycle or parametric cycle control. Bioquell ProteQ has a built-in aeration function, but you can further optimize the cycle with an optional wireless aeration unit that can be stored directly in the main unit. Validated high-level decontamination allows for easy coverage of all exposed surfaces with vapor in a single cycle.

The L-4 can be used for the multipurpose elimination of biological contamination in machines or small enclosure systems, open spaces, and rooms. It allows for quick connections and easy room setups, achieving validated 6-Log kill decontamination. Bioquell's hydrogen peroxide vapor technology effectively decontaminates contaminants such as isolators, BSCs, freeze dryers, pass-throughs, and rack washers connected to the Bioquell L-4. The room decontamination option further enhances the system's versatility. The Bioquell L-4 can be used by installing an indoor distribution head or by connecting from outside the zone to meet specific needs. When using Bioquell products, there is no need to wait for limited temperature or humidity ranges. From the start, the dual-loop technology of the Bioquell L-4 releases steam first and then rapidly converts hydrogen peroxide vapor into water vapor and oxygen, demonstrating its effectiveness. Details of all cycles are printed, and real-time cycle data can be recorded via Ethernet for LIMS, BMS, SCADA, or other data collection systems.

The Sepha Multi-Q is a multifunctional leak tester that can perform multiple types of leak tests with a single device. By changing attachments, it can accommodate leak testing for all types of packaging, including vials, syringes, ampoules, pillow packs, pouches, four-way/three-way seal packages, and MAP (modified atmosphere packaging). It complies with data integrity standards, 21 CFR Part 11, and CCIT. It can detect pinholes as small as 1µm, and testing methods include vacuum differential pressure (ASTM F2338-09(2013)), pressurized differential pressure, and pressure decay methods.

High-Speed Inline Total Leak Testing Device for Vials, Syringes, BFS, and IV Bags This device is designed to enable non-invasive, non-destructive testing of various types of pharmaceutical containers and their contents at high production speeds in a 100% inline state. The tests are fast, highly reliable, reproducible, and provide consistent results, allowing for complete batch control without compromising the functionality of the containers or contents. The empty leak or pressure leak methods fully comply with current GMP international regulations. The container integrity test (CCIT) is based on ASTM F2338-09 (Standard Test Method for Non-Destructive Leak Detection of Packages) using vacuum and pressure decay methods. High-class machine design and automation solutions facilitate operations and support the reduction of downtime. The device is equipped with electronic batch record management or manufacturing execution systems and can be integrated into an Industry 4.0 environment.

By supplying pre-degassed raw materials horizontally within a vertically configured upper and lower roll, compared to a horizontally arranged roll type, there is less powder drop, and stable flakes can be obtained with high yield. 1. High bulk density products can be continuously and stably obtained, and low bulk density raw materials can also be compacted due to continuous pre-treatment with the hopper, horizontal screw, and degassing device. 2. High product yield is achieved through the selection of pre-degassing and breakers, resulting in high flake yield with minimal generation of fine powder. 3. The installation area and height per processing capacity are small, making it easy to scale up to larger machines. 4. As it is a dry process, intermediate processes such as wetting, mixing, and drying are unnecessary, allowing for reductions in both initial and running costs, easy condition changes with small sample sizes, and no need for binders. 5. The compression rolls are designed to accommodate a range from low to high loads, suitable for soft to hard flakes, and there are also cantilever roll types like the FR type that enhance disassembly and cleaning, offering a wide lineup. 6. Maintenance-free Our machines are highly durable, requiring only routine inspections even after continuous operation for 24 hours a day for one year, with no special maintenance needed (excluding consumables).

The FAMAT sampling valve is used by major pharmaceutical companies, biotechnology companies, and chemical companies around the world (Roche, Novartis, Merck, Johnson Matthey, Pfizer, Basf, GSK, Bayer, Lonza) and has received high acclaim. Designed for powder sampling, it eliminates dead space, improves cleanliness, and is designed to prevent cross-contamination. The globally patented Expanding Piston Technology (EPT) is uniquely designed to allow for the most typical sampling, where the piston expands directly against the inner wall of the valve body to seal, eliminating the need for O-rings or seats, thus reducing the risk of sample contamination. Flexible materials utilize the dedicated ILC Dover's AmorFlex anti-static, chemical-resistant reinforced film (https://www.ilcdover.com/products/armorflex-films/), ensuring clean and safe containment while providing the convenience and productivity of single-use.

- High-speed vibration of the container along a programmed trajectory, mixing solely by the inertial force of the raw materials - Usable for any combination of powder-powder, powder-liquid, and liquid-liquid - Processing in an overwhelmingly short time - Contamination-free - Simple structure for easy cleaning - No wear parts - Minimal heat generation - Scalable from small quantities to mass production - Energy-saving and reduces environmental impact with less waste liquid