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Selected for the SBIR Program Phase I of the U.S. National Science Foundation. Mass production of uniform nanoparticles ranging from 50 to over 500 nm at a continuous rate of over 100 mL/min. Functionality for nanoparticle concentration and organic solvent dilution is provided by a TFF unit. Achieved a filling rate of over 99% through active loading of liposomes. Scale-up from lab-level to mass production, which was impossible with conventional equipment, is now feasible. Additional processing steps such as crystal injection and surface modification can be added to the manufactured liposomes, enabling highly flexible continuous production.

This device has made continuous measurement of nanoparticles possible for the first time in the world, and if used for evaluating and managing processes from research to production, it can significantly improve quality control and production efficiency.