Interfex Week Tokyo Exhibition & Seminar!

Seamlessly transition from formulation condition screening to scale-up and GMP manufacturing. Accelerate LNP product development.

The development of lipid nanoparticles (LNPs) faces many challenges. The formulation, optimization, and scale-up for clinical trials are complex, costly, and a race against time. Our LNP solutions are designed to accelerate all steps of LNP synthesis and characterization. Sunscreen accelerates LNP formulation screening by reducing costs and time, generating up to 96 unique LNP formulations within 6 hours. Next, using Sunshine, you can develop, optimize, and scale up protocols with the appropriate formulations obtained from Sunscreen. When it comes to the clinical trial phase, Sunbather can accommodate LNP production in a GMP environment using the same processes and microfluidic chips (Sunny) utilized by Sunscreen and Sunshine. In this way, the Sun series allows for a seamless transition from screening formulation conditions to scale-up and GMP manufacturing, as they all use the same pumps and microchannel chips. *For product details, please download various materials.

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

• Other Physics and Chemistry Equipment

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

Simultaneous measurement of 12 applications such as thermal stability, sizing, and viscosity from trace samples.

"Uncle" is a product that allows for the acquisition of more data with a small amount of protein. The required sample volume is only 9μL. By combining three different measurement modes—fluorescence, SLS, and DLS—it is easy to evaluate the optimal formulation and the stability of proteins or viral vectors. 【Features】 ■ Measure up to 48 samples in as little as about 2 hours with just 9μL. 【Applications】 ■ Tm & Tagg ■ Tm via SYPRO DSF ■ Isothermal stability ■ Sizing and polydispersity ■ Sizing via thermal gradient ■ Refolding measurements ■ Viscosity ■ kD ■ B22 ■ G22 ■ ΔG ■ Stability of viral capsids *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

[Video Available] Are you spending a lot of time and effort on buffer exchange and concentration work? You can streamline the sample preprocessing steps with this device.

Buffer exchange and concentration must be performed as a pre-treatment of the sample, which is a time-consuming task. This process takes a long time, and you have to be present the entire time. "UNAGI" is a fully hands-free benchtop buffer exchange solution designed to perform this tedious task for you. You can be anywhere during the process, eliminating the need to stay in the laboratory the whole time. 【Features】 ■ Simultaneous processing of up to 8 samples ■ Efficient solvent removal to prevent sample adsorption, achieving over 96% recovery rate ■ Built-in recipes for UF/DF buffer exchange ■ User-friendly software ■ Concentration of up to 8 diluted samples from 48mL to 8mL in one go *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research Software
• Other filtration and separation equipment

No complicated workflows needed! Only 2μL of sample volume required. Measure up to 96 samples in just 5 minutes.

"Lunatic" is a product that allows for easy simultaneous quantification of proteins, DNA, and RNA. The required sample volume is only 2μL, and up to 96 samples can be measured in 5 minutes. High-concentration samples can also be measured directly without dilution. 【Features】 ■ Measure 2μL, up to 96 samples in 5 minutes ■ Dynamic range coverage from 0.02 to 200 mg/mL* *for mAb ■ Outstanding accuracy and precision ■ Automation is also possible *For more details, please refer to the PDF document or feel free to contact us.

• Analytical Equipment
• Other protein analysis
• Other measurement and measuring equipment

Up to 8 samples can be processed simultaneously! Automatic and hassle-free buffer exchange and concentration that used to be complicated!

Buffer exchange and concentration must be performed as a sample preprocessing step. This is a labor-intensive task that takes a long time, requiring your presence throughout the process. "UNAGI" is a fully hands-free benchtop buffer exchange solution designed to take over this tedious task. It can process up to 8 samples simultaneously. The software is very easy to operate, allowing you to be anywhere during the work, eliminating the need to stay in the laboratory the entire time. 【Features】 ■ Simultaneous processing of up to 8 samples ■ Efficient solvent removal prevents sample adsorption, achieving over 96% recovery rate ■ Built-in recipes for UF/DF buffer exchange ■ User-friendly software ■ Concentrates up to 8 diluted samples from 48mL to 8mL in one go *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research Software
• DNA analysis

It enables the monitoring of potency and purity throughout the entire workflow of lentivirus research and development, accelerating gene therapy development.

"Leprechaun" is a system that analyzes whether lentivirus particles are of the correct size and structure, and can measure viral titer. It allows for the determination of the titer of lentivirus present in a sample without being misled by confusing noise (such as incomplete viruses or contamination). Not only can it measure information that was previously only obtainable separately through conventional methods like ELISA, qPCR, and transduction assays, but it also enables structural analysis that those methods could not provide, all on a single platform. Capabilities: ■ Lentivirus titer ■ Lentivirus structure ■ Exosome concentration ■ Analysis of contamination (impurities such as extracellular vesicles) Features: ■ No sample purification required ■ Physical structural analysis possible ■ Distinction between virus integrity and impurities ■ Up to 16 samples can be measured at once *For more details, please refer to the PDF document or feel free to contact us.

• Other measurement and measuring equipment

Automating powder weighing with high precision. The number of samples that were difficult to handle manually can now be processed in a single day.

"JUNIOR" is a product that enables high-precision weighing and dispensing of various powders and solids. With its built-in tapping function, it allows for high-precision weighing of smaller amounts without particle size bias. Additionally, it uses adaptive learning algorithms to accurately distribute and measure various samples. 【Features】 ■ Compatible with various vial sizes, plates, capping, and complex sample transport ■ LEA software: Intuitive operation from the front end, automatically integrates analysis data ■ Supports complex sample transport ■ Compatible with vials and plates ■ Manages the condition of samples with images *For more details, please refer to the PDF document or feel free to contact us.

• Other balances and scales

High-throughput screening for new material development. The number of samples that were difficult to handle manually can now be conducted in one day.

"BIG KAHUNA" is a product capable of organic synthesis screening, catalyst screening, and the development of metal catalysts. The high-pressure reactor for reaction screening is suitable for high-throughput catalyst screening. You can use 48 or 96 vials. It can be utilized for reactions under moderate high-pressure conditions or under high-pressure and high-temperature conditions. 【Features】 - High-precision weighing and dispensing of various powders and solids - Accurate distribution and weighing of various samples using adaptive learning algorithms - A dedicated hopper with an integrated stirring wire enables suitable powder dispensing without particle size bias - The built-in tapping function allows for smaller, high-precision powder weighing without particle size bias *For more details, please refer to the PDF document or feel free to contact us.

• Other counters and measuring instruments

[Lecturer] NTT Corporation, Network Service Systems Research Institute Network Infrastructure Technology Project, Project Manager Fujihiko Tamura [Key Lecture Content] The All-Photonics Network (APN), which is a core component of the IOWN concept proposed by NTT in 2019, is a high-capacity, low-latency, and low-power optical infrastructure that began commercial service as APN IOWN 1.0 in 2023. Currently, it is offered as a bandwidth-guaranteed communication service between user sites at speeds of up to 800 Gbps, and APN is steadily evolving. In the future, to respond to the rapid development of AI and data centers, as well as the diversifying user needs, we are advancing research and development for APN Step 3, which aims to provide on-demand, end-to-end optical connections on a broad scale. In this lecture, I will explain the world that APN Step 3 aims for, the technologies that support its realization, and our efforts in standardization activities and demonstration experiments at IGF (IOWN Global Forum) and ITU-T.

[Speaker] Hajime Hiraki, CEO of Chemistry Cube, Innovation Consultant [Key Lecture Content] Inventorying technology is not merely about listing and categorizing technologies or creating a technology inventory; in other words, it is not just about managing technology stock. It is a process that visualizes technology as a "structure" and reconstructs the researcher’s own thinking, fundamentally enhancing the strategic planning and theme creation capabilities in R&D settings. In this lecture, we will explain how technology generates value and how it can be utilized across organizations using the technology structuring method iMapR practiced by Chemistry Cube. We will also discuss how the speed and quality of inventorying can be improved through collaboration between generative AI and engineers/researchers. This is essential content for executives and technology leaders who want to accelerate transformation in R&D. [Lecture Items] 1. Introduction 2. What is technology inventorying? 3. How technology inventorying changes R&D settings 4. Practical application of the technology structuring method iMapR 5. Technology inventorying in the era of generative AI 6. Towards deployment in R&D settings 7. Q&A / Business card exchange

Announcement of a workshop hosted by Fukushima Prefecture High-Tech Plaza. Creating the Future of Manufacturing: Problem-Solving Workshop ~ Learn approaches to identify and solve on-site challenges ~ Are you interested in generative AI but haven't taken the plunge yet? Let's take that step together. We will hold an intensive workshop where you can learn the basics of "safely, smartly, and practically" using AI and problem-solving techniques in just 2.5 hours. <Recommended for> - Those who want to eliminate daily "minor inconveniences" and "vague inefficiencies" with AI - Those who want to quickly catch up on the basics of generative AI and safe usage - No restrictions on industry or job type. Those who want to work hands-on in teams and experience concrete outputs <What you will gain> - Experience a problem-solving framework starting from problem discovery → definition → visualization → solution proposals based on on-site challenges - Acquire the basics of generative AI prompts and risk management (copyright, confidentiality, hallucination) from a practical perspective - Take home improvement ideas that can be used starting tomorrow through group work <What to bring/wear> No specific items required. Dress is casual. Please feel free to join us. We sincerely look forward to your participation!

Ladies and gentlemen, do you have any concerns about using Excel for data aggregation and report creation in your daily work? - Spending hours every month matching multiple Excel files through copy-pasting or VLOOKUP - When opening large datasets, your PC freezes, and you have to wait until the processing is complete - The macros you've created are too complex for anyone other than the creator to fix (dependency on individuals) Alteryx is generally recognized as a "self-service data analytics platform" and a "no-code/low-code ETL tool." While the first benefits that come to mind when implementing Alteryx may be efficiency and automation, the advantages of adopting Alteryx go beyond just that. In this seminar, we will introduce how Alteryx can streamline and automate the tasks you struggle with daily in Excel, and how it can help you step up to more advanced analysis, along with specific use cases.

[Speaker] Tadahiro Maruyama, Director of the Business Creation Division, Chubu Electric Power Co., Inc. (Also Deputy COO of Chuden Telemetering LLC) [Key Lecture Content] Chubu Electric Power is expanding telemetering through a smart meter communication network to gas and water services. In the next phase, we aim to integrate these accumulated data into a multi-infrastructure DX business, merging with energy and water services, and striving for a circular and sustainable community across our entire group. This time, I will explain the actual initiatives related to these efforts. [Lecture Items] 1. Automatic Meter Reading by Chubu Electric Power 2. Current Status of Chubu Electric Power's Telemetry Business 3. Business Transformation through Infrastructure DX in the Electric Power Sector 4. Horizontal Expansion of Infrastructure DX to Water Services 5. Smart City Services through Data Utilization 6. Q&A / Business Card Exchange