TECHNICAL INFOMATION INSTITUTE CO.,LTD List of Products and Services

Book Title: Development of High Heat-Resistant and High Heat-Dissipating Materials for Next-Generation Power Devices and Thermal Management －－－－－－－－－－－－－－－－－－－－－ ◎ Thorough explanation of Si, SiC, GaN, gallium oxide, required characteristics in automotive environments, and implementation examples! ◎ Detailed design guidelines for TIMs and heat dissipation sheets that balance "thermal characteristics" and "operational reliability"! －－－－－－－－－－－－－－－－－－－－－ ■ This book includes the following information: - Improvement of resin heat resistance and measures against material expansion - Composite materials of thermally conductive fillers and resins - Development trends of resin substrates, ceramic substrates, and metal substrate materials - Countermeasures for warping, delamination, and breakage caused by inter-material stress due to linear expansion coefficients - Support for high-temperature operation above 300°C and low-temperature operation below freezing - Balancing thermal conductivity, mechanical properties, electrical insulation properties, and strength reliability - Improvement of thermal fatigue characteristics against repeated stress due to heat resistance and differences in linear expansion, and crack prevention - Suppression of electromigration and electrochemical migration - Ensuring moisture resistance, oxidation resistance, heat resistance, and long-term reliability of metal sintered materials

What are the design guidelines for coating films that ensure uniformity, wettability, and adhesion, as well as the challenges associated with coating and drying technologies? ---------------------------- ■ This document contains the following information: - Development of particle dispersion coating films - Development of emulsion-based paints - Preparation of sol-gel coating solutions - Design techniques for pigments and particle dispersion in coating films - Coating and application technologies

★ Development of materials with "hydrophilicity," "antithrombotic properties," "cell affinity," and "antibacterial properties" approached from the latest mechanisms! ★ What are the materials and modification technologies that achieve both "water resistance, solvent resistance, mechanical strength" and "biocompatibility"? －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of this Book Mechanisms of protein adsorption on polymers, inorganic materials, and metal surfaces, as well as cell adhesion Coatings and surface modification technologies that suppress the adsorption of proteins, cells, and bacteria Development of surface treatment technologies and materials that promote the adsorption of proteins and cells Evaluation of protein adsorption amounts Applications to medical containers, antithrombotic, antibacterial, and anti-biofilm materials

Book Title: Practical Compliance with the Latest GMP and Related ICH Guidelines －－－－－－－－－－－－－－－－－－－－－ ★ Thorough and comprehensive explanation of key points of the revised GMP, including data integrity, risk management, PQS, and supply chain management! ★ Requirements and countermeasures for related guidelines such as ICH Q3C, Q3D, M7 (Impurities GL), and Q13 (Continuous Manufacturing GL)! －－－－－－－－－－－－－－－－－－－－－ ■ Breakdown of GMP requirements in response to changing regulations and ongoing transformations in digital technology! 【1】 Requirements for building a Quality System (PQS) and specific countermeasures 【2】 GMP documentation and its creation and management 【3】 Quality assurance and audits in line with PQS 【4】 Response to Data Integrity (DI) 【5】 Prevention of cross-contamination 【6】 Impurity regulations and required management strategies 【7】 Promotion of digital transformation (DX) in pharmaceutical factories and response to GMP and DI 【8】 Management strategies for continuous manufacturing, GMP compliance, and implementation examples

Book Title: How to Advance AI and Machine Learning with Limited Data, and Develop Explainable AI －－－－－－－－－－－－－－－－－－－－－ ☆ Why did AI come to that answer! What are the grounds for judgment and reliability! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of Each Chapter Chapter 1 ★ Analytical methods based on types/models! ★ How to accurately measure model performance! Chapter 2 ★ Identifying truly necessary data and recognizing missing data! ★ The impact of data missingness on decision-making! Chapter 3 ★ How to properly document experimental records! ★ How to appropriately accumulate and manage research data! Chapter 4 ★ Simply repeating learning does not lead to improved prediction accuracy! ★ Data augmentation methods that take advantage of hallucinations in generative AI! Chapter 5 ★ Reducing development costs through shortened learning time, rapid model updates! ★ How to achieve advanced language processing capabilities through performance improvement!! Chapter 6 ★ Ensuring fairness, explainability, and transparency in AI and machine learning! Chapter 7 ★ Considerations when using data for machine learning! ★ To realize trustworthy AI!

★ Towards new material development and database construction through materials informatics! ★ Utilization for intellectual property operations! Research on prior technologies and competitors, analysis of similar patents, interpretation of patents! －－－－－－－－－－－－－－－－－－－－－ ■ Key points of this book How to effectively provide optimal prompts (instructions)? How to improve the language model's understanding performance? Digital transformation of research and development, business processes.

Book Title: Fine Chemicals, Continuous Production Processes for Pharmaceuticals ---------------------------- ★ Case studies of proof-of-concept experiments at lab/pilot scale and implementation in commercial facilities revealed by leading companies! ★ Development of requirements and management strategies for ICH Q13, and how to respond! ---------------------------- ■ Key Points of This Book Continuous Mixing and Reaction Processes - Design of flow microreactors, scale-up, and measures against flow path blockage - Automation of reaction condition exploration using Bayesian optimization - Case studies on catalyst and process development for continuous production - Continuous culture for biopharmaceutical production Continuous Separation Processes - Selection of operating conditions for continuous crystallization, control of particle size/shape, and productivity improvement - Design of continuous distillation columns and automated exploration of efficient operating conditions - Continuous processing of membrane filtration, rotary filtration, and centrifugation, along with case studies - Continuous separation of proteins, chiral compounds, and viruses for pharmaceutical production Continuous Powder Processes - Continuous granulation, configuration of direct compression systems, and setting of operating conditions

Book Title: Discovering New Business and R&D Themes through Technology Marketing －－－－－－－－－－－－－－－－－－－－－ ★ How to capture latent needs that customers are not even aware of and translate them into R&D themes! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ◎ In an era of diversifying customer needs and accelerating technological innovation, how to gather, interpret, and connect market information with technology! ◎ How to create a system that links your company's proprietary technology with customer needs! Delving into the initiatives, operational innovations, and key points of various companies! ◎ How to interpret customer information, make selections, and translate them into R&D themes!

Book Title: Analysis of Organic Materials by NMR and Its Sample Pretreatment, Data Interpretation －－－－－－－－－－－－－－－－－－－－－－－－－－ ★ Key Points for Interpreting the Relationship Between Structure ⇔ Properties ⇔ Spectra! A New Analytical Method Using Machine Learning! －－－－－－－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ● Sample Pretreatment and Measurement Condition Setting - Removal of impurities and insolubles, extraction and concentration of target substances from mixtures, homogenization of sample concentration - Peak position shifts due to derivatization, high-sensitivity analysis of trace components - Adjustment of NMR resolution, optimization of tuning - Adjustment of flip angle, waiting time, decoupling conditions, and CP conditions in solid-state NMR - Improvement of S/N ratio through function processing ● Application Examples - Molecular structure evaluation of polymer materials - Network structure analysis of rubber materials - Structural analysis of polymer alloys - Structural analysis of trace graft monomers - Evaluation of crosslink density in resins and rubber materials - Quantification of degradation in polymer materials - Reaction analysis of fillers/silanes coupling agents - Visualization of fine particle dispersion state in concentrated slurries - Interaction analysis of binders/pigments in paints - Observation of the curing process of adhesives - Analysis of the three-dimensional structure of proteins

Book Title: Development Trends and Characteristic Improvements of Perovskite Solar Cells －－－－－－－－－－－－－－－－－－－－－ ★ Examples of material development aimed at "improving photoelectric conversion characteristics" and "ensuring long-term reliability" ★ Detailed explanation of printing and film formation process technologies for further high quality and large area －－－－－－－－－－－－－－－－－－－－－ ■ This book contains the following information 【Perovskite Materials】 - Stabilization of materials - Improvement of photoelectric conversion characteristics - Lead-free perovskite materials 【Hole and Electron Transport, Transparent Electrode Materials】 - PTAA - Applications of TiO2, SnO2, ZnO, CuSCN - Dopant-free materials - Fullerene derivatives, electron transport layers - Carbon electrodes 【High-Quality Film Formation】 - Orientation control, film formation conditions - Interface passivation - Vacuum deposition method, mist deposition method, mist CVD method - Densification, flattening 【Solar Cell Fabrication Technology】 - Inkjet method - Film formation in atmospheric conditions - Mist method - Roll to Roll mass production 【Modularization, Barrier Sealing Technology】 - Increased efficiency, improved durability - Formation of integrated structures - Glass building material integration - Barrier technology

★5G/6G and the proliferation of generative AI support high-speed, high-capacity communication devices and materials all in one place! ★Requirements for materials used in 2.xD, 3D implementation, chiplets, and next-generation packaging, along with development examples from various companies. －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book 【Low Dielectric Loss Materials】 - Achieving low dielectric constant and adhesion - Design of PPE resin - Solvent-soluble polyimide resin - Fluorine resin with adhesion properties - Film formation of liquid crystal polymers - Olefin-based low dielectric films - Low dielectric halogen-free flame retardants - Development of glass cloth 【Fine Circuit Formation】 - Improving adhesion of difficult-to-bond materials - Copper sulfate plating process - High-adhesion Cu seed layer - Low-resistance, adhesive Cu layer formation technology 【Semiconductor Package Substrate Materials】 - Reducing thermal expansion of organic core materials - Interlayer insulating films - Solder resist - Photosensitive films - For high-end computers - FO-WLP, FO-PLP - For WOW process 【Co-Packaged Optics】 - Co-Packaged Optics - Compact and high-density optical packaging - Silicon photonics - Optical transceivers

◎A comprehensive collection of development and application examples of functional materials in the fields of electronics, semiconductors, sensing, optics, and batteries! －－－－－－－－－－－－－－－－－－－－－ ■ This book contains the following information: - How to synthesize and grow CNTs at low pressure, low temperature, and high speed? - Key points for the growth and synthesis of carbon nanotubes with small diameters and long lengths. - Thorough explanation of methods for grinding surface treatment, surface chemical modification, and introduction of functional groups. - What are the key points for solubilization through physical adsorption and chemical modification? - How to maintain properties and functionality when compounded with other materials? - What is the dispersion mechanism of CNTs? What methods stabilize dispersion without reaggregation? - Applications in thermoelectric conversion, photocatalysis, and as heat storage materials. - Applications as electrode materials, actuators, and memory devices. - Trends in sensor development and sensing technology. - Applications as transparent conductive materials, nanowires, and optical materials. - Applications in lithium-ion batteries, metal-air batteries, and fuel cells. - Research and development of space elevators. - Evaluation of fundamental physical properties, particle size, cutting state, length, and linearity. - Evaluation of dispersion state, aggregation state, and interfacial properties. - Evaluation of strength, mechanical properties, electrical properties, thermal properties, and thermal resistance.

■ Points of this book ● Mechanisms of gelation and evaluation methods for gel properties - Mechanisms of polymer crosslinking and gelation - Measurement and evaluation of dynamic viscoelasticity and swelling properties of gels - Evaluation of network structure and environmental responsiveness - Structural analysis of coexisting gels of polysaccharides and proteins ● How to create gels with strength and stability? - Toughening polymer gels through stretch-induced crystallization - Methods for producing high-strength PVA hydrogels and their applications - High-strength nanochitin composite gels - High-strength biodegradable cellulose nanofiber gels ● Development of gel electrolytes and power-generating gels - Highly stable gel electrolytes using inorganic nanofibers - Prolonging the lifespan of lithium metal anodes - Gel-based electrochemical transistors - Development of power-generating gels ● Development of gels with stimulus responsiveness and new functions - Thermoresponsive, potassium ion, and glucose-responsive gels - Gels for medical adhesives, DDS, and cell culture substrates - Gels as actuators, conductive materials, and sensors - Development of superabsorbent gels and synthesis of spherical absorbent gels - Utilization of gels in protein crystallization

★ Techniques for improving the quality of the crystallization process based on the mechanisms of crystal growth and crystal states! ★ Considerations for operational conditions that affect crystallinity, such as temperature, stirring, and addition rates! ★ Specific points and case studies on particle growth, thermal management, and solvent selection to prevent troubles during scale-up! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book 【1】 Mechanisms of crystallization that enhance crystal quality 【2】 Techniques useful for practical crystal analysis Pre-treatment techniques, spectral analysis, diffraction patterns, and intensity data analysis 【3】 Technologies and strategies for controlling crystal polymorphism and co-crystallization 【5】 Key points of crystallization operations that determine crystal quality 【6】 Approaches for scale-up and troubleshooting in industrial production 【7】 Tips for controlling crystal growth during continuous production and designing a smooth production process

★ A comprehensive showcase of the latest examples in energy-saving chemical reactions and material processing, as well as the development of new processes! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ● Fundamentals of Microwave Processes - Basic characteristics of microwaves such as wavelength, frequency, and distribution of electric and magnetic fields - Principles of microwave generation and heating mechanisms - Current challenges and trends in microwave chemistry abroad ● Considerations for Process Implementation - Design of efficient and safe heating furnaces - Control of heating processes - Evaluation of heating efficiency for target materials ● Diverse Industrial Application Examples - Reduction of polymerization and hydrolysis times in polymer synthesis - Advantages of reactions using transition metal catalysts and highly selective processes - Synthesis of nanoparticles with high crystallinity and uniform particle size - Sintering processes for high-density ceramics at low temperatures and in a short time - Decomposition treatment of exhaust gases and wastewater - High-efficiency and energy-saving hydrogen production from seawater and biomass - Chemical recycling of waste plastics - Reduction of reaction times for pharmaceutical intermediates, achieving high yields and selectivity - Pre-treatment of analytical samples using microwave acid decomposition methods

☆What is the appropriate and specific way to give "instructions" to maximize the capabilities of generative AI! ☆It's not just an efficiency tool! Unlocking the secrets to achieving results through examples from advanced companies!! －－－－－－－－－－－－－－－－－－－－－ ■ Key points of this book ◎ How to evaluate the proposals and answers generated by AI! ◎ Building a collaboration model that maximizes the strengths of both humans and generative AI!! Introduction, promotion, and security measures for generative AI Improving business efficiency and creative utilization through generative AI

★ Explanation of the selection and determination points for multiple material properties related to objective and explanatory variables! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book Exploration of new materials, automation and acceleration of formulation design - Optimization of multiple material composition ratios - Extraction of desired material properties from limited experimental data - Improvement of model accuracy through descriptor selection - Discovery of unknown components through the fusion of domain knowledge Practical informatics for process and equipment development - Quantification of the tacit knowledge of experienced engineers - Setting the exploration space and selecting initial data - Measures against temperature changes, equipment variability, measurement errors, etc. - Detailed explanation of tips for choosing surrogate models Utilization and operational examples - Monomer sequences of biodegradable polymers - Prediction of tensile strength of synthetic rubber - Development of CO₂ resource recycling catalysts - Development of low-temperature manufacturing processes for ceramics - Exploration and selection of pharmaceutical additives formulations

Book Title: Development Trends and Performance Evaluation of Non-Fluorinated Water-Repellent and Oil-Repellent Technologies －－－－－－－－－－－－－－－－－－－－－ ★ With the acceleration of PFAS regulations worldwide, the development of water-repellent and liquid-repellent technologies that do not use organic fluorine compounds is urgently needed! ★ This book explains methods and effects that achieve excellent water-repellent and oil-repellent properties without using fluorine! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book 【Development Cases of Fluorine-Free Water-Repellent and Oil-Repellent Materials and Products】 【Surface Functionality Granting Technology Utilizing Biomimetics】 【Technology for Forming Microstructures and Fabricating Non-Fluorinated Water-Repellent and Oil-Repellent Surfaces】

★What digital tools should you choose? How to switch from the old system! ★A comprehensive guide to improving efficiency in intellectual property operations using AI, generative AI, and RPA, along with practical know-how!! ■ Key Points of This Book 1. Detailed explanation of the steps for implementing DX and promoting it, as well as points for internal dissemination! 2. How to set internal rules to effectively utilize generative AI! 3. Current status of intellectual property research and analysis through DX, and how to choose and use it! 4. What are the possibilities and key points for applying AI to intellectual property operations!

Book Title: Development and Utilization Cases of Materials and Thermal Conversion Technologies for Heat and Heat Recovery －－－－－－－－－－－－－－－－－－－－－ ★ Thorough explanation of the application and research cases of heat utilization technologies aimed at achieving decarbonization －－－－－－－－－－－－－－－－－－－－－ ■ This book includes the following information: 【Thermal Storage Materials】 【Thermoelectric Conversion Materials】 【Heat Pump Technology】 【Utilization Cases】

Book Title: AI, Deterioration and Destruction Evaluation and Lifetime Prediction Using Simulation －－－－－－－－－－－－－－－－－－－－－ ★ An objective lifetime prediction method that replaces the experience of skilled analysts and advanced expertise through machine learning! ★ Rapid strength evaluation combining equipment analysis and computational science, detecting slight deterioration, deformation, and defects! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ● Preparation of data for evaluation and prediction, key points for prediction formulas and model building ● Evaluation and prediction examples using machine learning and simulation

Book Title: Web Handling: Production Techniques and Troubleshooting Using Roll to Roll -------------------------------------------------- ◎ Comprehensive coverage of web friction characteristics, transport, winding, slitting troubleshooting, and quality improvement techniques! -------------------------------------------------- ■ This book includes the following information: - The relationship between friction and tribology - The effects of transitioning from vacuum to atmosphere, air entrapment, and fluid lubrication - Tension control in web handling - Mechanisms for web separation and expansion by rolls - Changes in winding and internal stress in rolls, measures against winding misalignment and wrinkles - Non-destructive, non-contact detection technology utilizing deep learning - Mechanisms of static electricity generation and decharging measures - Foreign matter countermeasures, sterilization treatment, and cleaning - Material design for imparting slip properties - Blocking phenomena and anti-blocking - Types, shapes, materials of blades and their characteristics - Selection criteria for various blades and optimization of dimensions, optimization of slitting conditions - Measures against uneven thickness, edge issues, end face defects, winding misalignment, and blade troubles - Pre-processing steps for slitting, measures to reduce losses during the process

Book Title: Measurement Evaluation and Visualization of Skin, Imaging Technology －－－－－－－－－－－－－－－－－－－－－ ★ A multifaceted evaluation method for skin from the surface to the depths, including the stratum corneum, epidermis, and dermis! －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book ● Analysis, estimation, and prediction technology for skin conditions utilizing AI ● Evaluation and visualization of the internal structure of the skin ● Various evaluation methods essential for assessing cosmetics, beauty devices, topical agents, health foods, etc. ● Safety evaluation using cells, artificial skin, and human skin

Book Title: Data Analysis, Modeling, and Application Development in Process Informatics －－－－－－－－－－－－－－－－－－－－－ Understanding where to apply the latest technologies to change processes through data-driven approaches －－－－－－－－－－－－－－－－－－－－－ ■ Key Points of This Book: A practical guide filled with actionable know-how for practitioners ◆ "From Basics to Applications" of Data Analysis and Modeling ~ Variable selection, model building, sensor design, Bayesian optimization, autonomous experiments ◆ Reasons Why Process Informatics "Fails" and How to Address Them ~ Challenges in the implementation process, data shortages, examples of variable selection failures ◆ How to "Transform Data into Usable Forms?" ~ Data alignment between experiments and manufacturing, equipment integration, real-time analysis ◆ Richly includes case studies of implementation and deployment by process area and stage! ~ Specific examples of "which industries," "what equipment or processes," and "how they were designed" ■ Manufacturing Processes Covered in This Book - Synthesis, drying processes, crystallization, granulation, stirring, cultivation, freezing, coating, film formation, rolling, pressing, fluid dynamics, reactions, gas absorption, fermentation