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山口ティー・エル・オー

addressYamaguchi/Ube-shi/2-16-1 Tokiwadai, within the Yamaguchi University Industry-Academia-Government Collaboration Innovation Promotion Organization
phone0836-22-9768
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last updated:Sep 30, 2021
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山口ティー・エル・オー List of Products and Services

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[We accept inquiries for development] Development of cloud sea forecasting using AI technology.

"Will the sea of clouds be visible tomorrow?" Automatic forecast at least the day before.

The "sea of clouds," which can only be seen when multiple conditions such as weather conditions, humidity in the atmosphere, temperature changes, mainly during early morning hours, and elevation are met, lacks established prediction technology, making it difficult to witness even when one actually goes to the location. Therefore, we have developed a technology that utilizes AI (machine learning), which has rapidly advanced in recent years, to predict sea of clouds at local tourism spots. This technology can predict sea of clouds using only weather data from the Japan Meteorological Agency's AMeDAS, making it applicable anywhere in the country as long as there is an AMeDAS observation point nearby. Please feel free to consult us first. ■ Features - Predicts the probability of sea of clouds occurring over a relatively wide area (region) - Predictions can be made based solely on data publicly available from the Japan Meteorological Agency - A system equipped with weather data acquisition means and sea of clouds prediction means - Utilizes machine learning by computers - The prediction accuracy for model cases has a hit rate of up to 81.8%

  • Prototype Services

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Nutrient medium for culturing Escherichia coli that shows significant proliferation.

Excellent nutrient medium for promoting the growth of E. coli (Samples available before official sales start)

● The OD600 after 24 hours will exceed 20 (in the case of the MG1655 strain). ● Even without adding nutrients during the process, it continues to proliferate and the OD will exceed 35 after 4 days (in the case of the MG1655 strain). ● It can be offered at a low price (planned). [Currently, we are providing small sample quantities. We will begin production of the sale items once we have a forecast for orders.]

  • others

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Materials that change color reversibly with temperature and light.

I have gathered materials that change color with temperature and light, and return to their original color when the temperature and light are restored.

1. Temperature-sensitive liquid material that changes color When mixed with a transparent liquid, it becomes cloudy depending on the temperature, allowing three-dimensional observation of temperature changes. The clouding temperature can be adjusted between approximately 30°C and 100°C. <Application examples> - Science teaching materials for convection observation - Visualization applications for heat transfer https://www.ipros.jp/product/detail/2000711146 2. Temperature-sensitive solid material that changes color The color tone changes reversibly according to the external environmental temperature. The color tone can be adjusted. <Application examples> - High-temperature warning paint for plant piping - Overheat warning for motors, etc. - High-temperature warning for cooking utensils, etc. https://www.ipros.jp/product/detail/2000722254 3. Transparent film that changes to a deep blue under light Once colored, it retains the color for a long time. It can be used for photosensitive materials such as blueprints. The fading time can be adjusted. <Application examples> - Film for smart windows (applied to windows to control indoor brightness) - Rewritable paper (prints and copies with light, returns to transparent after a few hours) https://www.ipros.jp/product/detail/2000710310

  • Chemicals

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Visualization technology for ultraviolet exposure using photochromic film.

A film that combines oxidized tungsten nanoparticles and cellulose derivatives, which strongly colors under ultraviolet irradiation and returns to colorless transparency when darkened.

This is about a new thermosensitive material that changes color according to the external environmental temperature, and it has the following features: (1) It has excellent film-forming properties and transparency in the dark, and demonstrates high light-blocking ability due to strong blue coloration when exposed to light, making it useful as a dimming film. (2) It develops sufficient color when exposed to sunlight, and since the composite film takes time to completely lose its color after developing, it can be used as a photosensitive material for blueprints. The fading time can also be adjusted. (3) Particularly when containing organic acids such as oxalic acid or glycolic acid, the time until the color completely disappears is even longer, making it suitable for use as a recording medium. (4) Since it can be made primarily from environmentally friendly materials, disposal is easy, and it can be used in various applications including energy-saving measures through dimming. <Applications> (1) Film for smart windows (applied to windows to control indoor brightness) (2) Rewritable paper (prints/copies with light, returns to transparency after a few hours) ****Please contact us if you would like a sample****

  • Other metal materials
  • Non-ferrous metals

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Immunoglobulin preparation with 10 times higher anti-inflammatory effect.

We propose an immunoglobulin preparation with significantly higher anti-inflammatory effects compared to conventional immunoglobulin preparations, along with its manufacturing method.

Intravenous immunoglobulin (IVIG) preparations have recently seen an increasing demand as treatments for autoimmune diseases such as Kawasaki disease. However, there are concerns about future supply issues since the raw materials are derived from plasma components obtained from many healthy donors. The new immunoglobulin preparation introduced here exhibits approximately ten times the anti-inflammatory effect compared to conventional products, which could significantly reduce the amount of raw materials used and also considerably lower costs. [Features] - A manufacturing method for galactosyl non-fucosylated (G2) serum IgG has been established. - (G2) IgG is a natural component found in the blood of healthy individuals, and by binding to the FcγIIIa receptor on natural killer (NK) cells, it suppresses immune overreaction and inflammation. - Its efficacy has been confirmed through experiments conducted on mice.

  • Other medical supplies and cosmetic manufacturing materials

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A liquid material that reversibly changes from colorless and transparent to white upon heating.

Adjustable to around 30 to 100℃! You can clearly observe the temperature changes of the liquid due to heating!

We would like to introduce a liquid material that reversibly changes color according to the surrounding temperature. When mixed with a transparent liquid, the temperature changes of the mixed liquid can be observed in three dimensions. For example, it is possible to observe how heat is transmitted and the convection process through heating. The temperature at which it turns white can be adjusted to around 30°C to 100°C. 【Features】 ■ The temperature changes of the mixed liquid can be observed in three dimensions. ■ It is possible to observe how heat is transmitted and the convection process through heating. ■ The temperature at which it turns white can be adjusted to around 30°C to 100°C. *For more details, please feel free to contact us.

  • Other analyses

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Color change of thermosensitive material composed of synthetic saponite and crystal violet.

A material that reversibly changes color according to the surrounding temperature! It exhibits significant color changes around 100°C.

This is about a new thermochromic material that changes color according to the external environmental temperature, featuring various characteristics. We will introduce the color change of the thermochromic material made from synthetic saponite and crystal violet. This material reversibly changes color according to the surrounding temperature, exhibiting significant color changes around 100°C. It can be processed into powder or thin film and can be applied regardless of the surface shape. Please contact us if you would like a sample. 【Features】 ■ The color of this material gradually changes slightly with the increase in temperature from room temperature, but shows significant color change around 100°C. ■ When the temperature is lowered back to room temperature, it returns to the color before the temperature increase. ■ Repeated color changes are observed on both the high-temperature and low-temperature sides of a specific temperature. ■ It can be produced through simple preparation. *For more details, please refer to the PDF document or feel free to contact us.

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Methods for artificially controlling the blood-brain barrier function - Overcoming refractory neurological disorders.

We have discovered functional molecules that artificially and reversibly open and close the blood-brain barrier.

*Looking for partner companies for joint development* The blood-brain barrier (BBB) has an important function in preventing harmful substances from entering the brain and maintaining a healthy environment within it. However, due to the presence of the BBB, water-soluble drugs administered peripherally cannot be delivered to the brain, and conversely, it has not been possible to restore the function of the BBB once it has opened due to pathological conditions such as neurodegenerative diseases. Recently, Yamaguchi University has established a method to artificially and reversibly open and close the BBB. By identifying the key factors involved in the opening and closing of the BBB and utilizing its physiological functions, it is now possible to reversibly open the BBB under conditions with minimal concerns about side effects, paving the way for drug delivery to the brain, which has been challenging. Additionally, restoring the function of the pathologically opened BBB is expected to improve disease conditions. <Target Diseases> - Closing an opened BBB: cerebral infarction, diabetic retinopathy, Alzheimer's disease, Parkinson's disease, etc. - Opening a closed BBB: brain tumors, neurological diseases, etc. <Benefits for Companies> - The development of new, highly safe therapeutic drugs is now possible through a novel mechanism that allows for the artificial and reversible opening and closing of the BBB.

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Paper feeding technology utilizing electrostatic adhesion.

Wear and degradation similar to rubber components are almost nonexistent, allowing for long-term performance maintenance. Voltage control enables adaptation to changes in the material of the paper medium and environmental conditions.

Conventional paper media feeding was done using rubber rollers and pads, which wear out over time, leading to feeding failures. To address this issue, Yamaguchi University of Science and Technology in Sanyo-Onoda City developed a paper media feeding technology that utilizes electrostatic adhesion. Since the wear of the electrostatic pads that generate electrostatic adhesion is extremely low, it is expected to maintain feeding performance even after long-term use. Additionally, by controlling the applied voltage and waveform, it is possible to change the force acting on the paper media, allowing for adaptation to changes in the conditions of the paper media or the usage environment without modifying the mechanism.

  • Other machine elements
  • Other FA equipment
  • Printer

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Speech Privacy Protection Device

A simple structure and cost reduction! Invention of a privacy protection device that does not cause discomfort to third parties.

In response to situations where conversations should not be overheard by third parties, sound masking devices have already been developed, but these require the installation of multiple speakers. Our company has invented a "Speech Privacy Protection Device" consisting of a conversation communication unit, a masking sound generation unit, and a masking sound control unit. The masking sound does not cause discomfort to third parties and can protect speech privacy for multiple sets of conversations within a single room. [Research Overview] - Capable of protecting speech privacy for multiple sets of conversations within a single room - The masking sound does not cause discomfort to third parties - Simple configuration and cost reduction *For more details, please refer to the PDF materials or feel free to contact us.

  • Other security

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Class classification method and device

Applicable to various types of biological image analysis! Introducing an invention that can accurately perform class classification.

Regarding the analysis of intravascular ultrasound catheter images, the majority vote filter is excellent as a method for removing a small number of errors. However, since it executes class classification independently for each pixel, it becomes difficult to obtain valid judgment results when there is significant overlap in the distribution between different class data sets. Our company has invented a "class classification method and device" that can accurately perform class classification even when there is overlap in the distribution of data sets between different classes. This method can be applied to various types of biological image analysis and is not limited to biological images; it can also be applied to other image analyses and data analyses beyond images, such as audio. [Research Overview] - It can accurately perform class classification even when there is overlap in the distribution of data sets between different classes. - It can be applied to various types of biological image analysis and is not limited to biological images; it can also be applied to other image analyses and data analyses beyond images, such as audio. - As a signal for obtaining observation data, it can use not only ultrasound but also sound waves and electromagnetic waves, and it can similarly be applied in cases where the physical characteristics of the transmitted and received signals differ, such as in photoacoustic methods. *For more details, please refer to the PDF document or feel free to contact us.

  • Other information systems
  • Other analyses

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Analog Coding System (2)

Easy to handle with a simple structure! It guarantees high quality and has a high level of confidentiality.

In recent years, we are approaching a ubiquitous network society where information transmission and storage have become easier for analog information such as voice and images. However, there is a growing demand for communication aimed at protecting information from being intercepted by others. This system is an "analog coding system" that implements a partitioned multidimensional orthogonal transformation using multiple partitioned multidimensional orthogonal series. To achieve high speed while maintaining safety as much as possible, multivalued data is partitioned and can be synthesized using other multivalued information as keys. [Research Overview] ■ It has a simple structure that is easy to handle, ensures high quality, and features high confidentiality. ■ To achieve high speed while maintaining safety as much as possible, multivalued data is partitioned and can be synthesized using other multivalued information as keys. *For more details, please refer to the PDF document or feel free to contact us.

  • Other information systems

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Analog Coding System (1)

An easy-to-handle encryption system with a simple structure that is expected to meet a wide range of versatile needs!

The encoding method targeting analog information, with a focus on information protection and reliability improvement, typically involves converting analog information into digital information and combining scrambling and encryption techniques. However, the method of encoding after converting to digital once leads to variations in the amount of information at the most significant bit and the least significant bit, making it difficult to guarantee quality and not efficient as an analog encoding method. This system is expected to meet high versatility needs as an encryption system for constructing highly confidential networks and transmitting voice, images, and information signals. [Research Overview] - By executing multidimensional orthogonal transformations using multidimensional orthogonal series, it can be easily handled with a simple configuration. - It can provide a highly confidential analog encoding system that ensures high quality. - It is expected to meet high versatility needs as an encryption system for constructing highly confidential networks and transmitting voice, images, and information signals. *For more details, please refer to the PDF document or feel free to contact us.

  • Other information systems

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Methods for collecting sludge from lakes and marshes and sludge collection devices.

We have invented a device that can automatically and efficiently collect sludge without human intervention!

The purification methods for rivers, lakes, and ponds require a complex and large-scale purification system consisting of the purification device itself and a post-treatment device, and there has been a significant cost issue associated with the recovery of sludge accumulated in rivers and lakes. In this invention, the wind speed near the surface of the lake is measured, and the pump that takes in water from the lake into the duct is activated only during strong winds that exceed a pre-set value. Therefore, there is no need for a person to constantly monitor the wind speed to determine the timing for operating the pump, allowing for the efficient and automatic recovery of sludge accumulated in the lake without human intervention. [Research Overview] - Can be used for the removal and recovery of sludge accumulated on the bottom of natural or artificial lakes, ponds, and rivers. - Measures the wind speed near the surface of the lake and activates the pump to take in water from the lake into the duct only during strong winds that exceed a pre-set value. - Enables the efficient and automatic recovery of sludge accumulated in the lake without human intervention. *For more details, please refer to the PDF document or feel free to contact us.

  • Other energy equipment

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Structure of the water storage chamber for a movable object type wave energy conversion device.

We would like to introduce an invention that can efficiently harness energy by moving to wave generation areas.

Inside the frame that partitions the water area established around the movable object, that is, in the water chamber, there exists a horizontal motion component in the movement of the water, which poses a problem where the wave energy conversion device utilizing the vertical movement of the movable object cannot operate smoothly. In this invention, multiple small water chambers are arranged in the lower part of the water chamber where the movable object is floated, thereby regulating the horizontal movement of the seawater in the water chamber, allowing the float to remain stable and buoyant in the vertical direction. Additionally, since no horizontal impact forces act on it, the movable object and its supporting parts can float stably without damage, allowing for the stable and reliable extraction of wave energy through the vertical movement of the movable object. [Research Overview] - This can be implemented not only for breakwaters but also for large floating structures (mega floats) equipped with water chambers on their outer periphery. - In the case of large floating structures shaped like barges, they can be towed to evacuate the movable object-type wave energy conversion device during typhoons and other events. - It can move to wave generation areas to efficiently capture energy. *For more details, please refer to the PDF document or feel free to contact us.*

  • Converters and Transducers
  • Other energy equipment

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High-capacity PCR device capable of mass-producing DNA.

DNA production without using E. coli is now possible! This can dramatically reduce the cost and time required for DNA manufacturing.

*Looking for partner companies for practical application* The "large-capacity PCR" developed by Yamaguchi University and a kamaboko manufacturing equipment company in Yamaguchi Prefecture can produce DNA in quantities more than tens of thousands of times that of conventional PCR devices used for testing, in a short time, replacing the current mainstream method of DNA production through E. coli culture. Through PCR synthesis, it is possible to synthesize DNA that does not contain unnecessary replication origins or drug resistance genes for vaccines. Additionally, because PCR-synthesized DNA is produced through enzyme reactions, the purification process can be simplified, and there will be no E. coli components when crushing and extracting E. coli plasmids. [Device Configuration] - Large-capacity dedicated thermal cycler - Large-capacity dedicated reaction liquid bag - Large-capacity dedicated reaction liquid (heat-resistant polymerase, etc.)

  • Other physicochemical equipment

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Gelling agent that gels organic liquids (ionic liquids, liquid crystals, etc.) in trace amounts.

It can gel alcohol, oil, liquid crystals, ionic liquids, fluorinated solvents, etc., at a trace amount (1%), and can change between sol and gel through heating and cooling.

The "gelling agent" developed by Yamaguchi University gels organic liquids in small amounts (1%). The formed organic gel can change between sol and gel through heating and cooling. Examples of organic liquids that can be gelled include alcohols, oils, liquid crystals, ionic liquids, and fluorinated solvents. Additionally, this gelling agent does not contain hydrogen bonds, boasting high chemical stability. The gelling in small amounts allows for immobilization while maintaining the properties of the solvent, such as ionic conductivity, enabling applications in ionic liquid gels, liquid crystal gels, gel electrolytes for fuel cells, and carbon dioxide separation membranes. Structural optimization tailored to needs is also possible. 【Expected Use Cases】 Immobilization of functional organic liquids (liquid crystals, ionic liquids), immobilization of electrolyte solutions for dye-sensitized solar cells, gel electrolytes for fuel cells, immobilization of carbon dioxide separation absorbents, cosmetic materials, oxygen transport materials, ink materials, lubricants, thickening agents. ★Samples of the gelling agent are available! It can be customized according to applications (viscosity, solvents to be gelled, etc.). *For more details, please refer to the PDF document or feel free to contact us.

  • Other polymer materials

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Dust measurement methods and dust measurement devices

For improving the work environment against dust and cement particle dispersion! Easily measure dust concentration in tunnels and similar areas.

Conventional dust measurement involves taking air samples and subjecting them to measurement devices, which is labor-intensive and the measurement equipment is expensive. The present invention aims to enable easy dust measurement using portable imaging devices such as digital cameras, not limited to tunnel construction sites. It allows for easy measurement of dust concentration in places like tunnels using portable imaging devices. The photographer holds the camera at eye level to capture images, making it easy to measure dust concentrations in areas where workers are highly likely to inhale dust. The captured images can be easily analyzed on a computer to calculate the concentration. [Key Points (Excerpt)] - A dust measurement method characterized by counting the number of white spot images. - Estimating the particle size of fine particles by measuring the brightness of white spot images. *For more details, please refer to the PDF document or feel free to contact us.*

  • Other measurement, recording and measuring instruments

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Semiconductor substrate and its manufacturing method, as well as a vapor phase growth apparatus used for it.

Warping caused by differences in physical constants is canceled out between both surfaces! It is possible to manufacture semiconductor substrates with minimal warping!

The issue of warping in GaN substrates leads to high costs due to low yield, as well as low crystal quality and small areas of low quality, which in turn becomes the biggest factor hindering the widespread adoption of GaN substrates. The present invention aims to produce semiconductor substrates with minimal warping using a vapor phase growth method. By alternately growing semiconductor crystals on both sides of the base substrate using the vapor phase growth method, the warping caused by differences in physical constants such as the thermal expansion coefficients of the base substrate and the semiconductor is canceled out between the two sides, making it possible to manufacture semiconductor substrates with minimal warping. 【Key Solutions】 - Manufacturing semiconductor substrates by growing semiconductor crystals on the base substrate using the vapor phase growth method. - A process in which raw gas is brought into contact with one principal surface of the base substrate to grow semiconductor crystals on the base substrate. - Another process in which raw gas is brought into contact with the other principal surface of the base substrate to grow semiconductor crystals on the base substrate. - Alternating between the first process and the other process. *For more details, please refer to the PDF document or feel free to contact us.

  • Other semiconductors

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Method for manufacturing semiconductor substrates

In the technical field of semiconductor substrate manufacturing, it is possible to obtain a high-quality HT-semiconductor layer.

The present invention aims to obtain a semiconductor layer with good crystal quality on a base substrate. A semiconductor is deposited at a relatively low temperature from the surface of the exposed base substrate through numerous openings formed in a thin film that covers the surface of the base substrate, thereby forming an LT-semiconductor layer on the thin film. Subsequently, a semiconductor is crystallized at a relatively high temperature from the LT-semiconductor layer, forming an HT-semiconductor layer on the LT-semiconductor layer, which allows for the acquisition of an HT-semiconductor layer with good crystal quality on the base substrate. [Key Points of Resolution] (1) In the method for manufacturing a semiconductor substrate, the surface of the base substrate 11 is covered with a thin film 12 having numerous openings formed therein. (2) A semiconductor is deposited at a relatively low temperature from the surface of the exposed base substrate 11 through the numerous openings in the thin film 12, forming an LT-semiconductor layer 13 on the thin film. (3) A semiconductor is crystallized at a relatively high temperature from the LT-semiconductor layer 13, forming an HT-semiconductor layer 14 on the LT-semiconductor layer 13. *For more details, please refer to the PDF document or feel free to contact us.

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Electrostatic actuator (2)

Introducing an invention that efficiently converts the electrostatic attraction between electrodes into mechanical work, resulting in a significant generation of force.

Electrostatic attraction has the characteristic of increasing sharply as the distance between electrodes decreases. In conventional electrostatic actuators, the initial driving force is weak, and furthermore, the driving force is consumed in the deformation of the supporting members for the movable components, resulting in a reduced force that can be extracted externally. In this invention, by utilizing nonlinear springs and the like as members for storing mechanical energy, an electrostatic actuator is produced. By using springs, particularly nonlinear expanding and contracting springs, to convert the work done by electrostatic attraction into elastic energy, it is possible to efficiently convert electrostatic attraction into mechanical work, generate large forces and work, and also create a compact design. [Research Overview] ■ Efficiently converts electrostatic attraction between electrodes into mechanical work, resulting in a large generated force. ■ Ultra-compact. ■ Current flows only during the initial charging phase, making it energy-efficient. *For more details, please refer to the PDF document or feel free to contact us.

  • Solenoid Actuators
  • Actuator

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Electrostatic actuator (1)

Efficiently convert electrostatic attraction into mechanical work! Invention of a small electrostatic actuator.

In this invention, the electrostatic actuator utilizes the phenomenon where the gap distance between a pair of opposing electrodes changes due to the electrostatic attraction generated when a voltage is applied to the electrodes. To achieve a sufficient amount of displacement as an actuator, the electrostatic attraction was initially small, making it difficult to obtain a large output, which was a challenge. Therefore, an elastic body, such as a spring, was used not only as a support but also as a component to store mechanical energy. As a result, a compact electrostatic actuator was developed that efficiently converts electrostatic attraction into mechanical work by transforming it into elastic force. [Research Summary] - Capable of performing work after converting electrostatic attraction into elastic force - Efficiently converts electrostatic attraction into mechanical work - Can generate large forces and work while being compact *For more details, please refer to the PDF materials or feel free to contact us.

  • Solenoid Actuators
  • Actuator

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Method for producing a layered cell sheet and layered cell sheet.

Extremely useful in that it does not cause immune rejection! A method for producing a layered cell sheet that induces an increase in the healing rate.

In cell transplantation therapy, cell sheets cultured in a sheet form are used because it is difficult for cells to adhere to tissues. The objective of this invention is to provide a method for producing a laminated cell sheet that is difficult to shrink even when peeled off from the substrate and is easy to manufacture. Cell sheets produced from fibroblasts derived from patients receiving the transplant are extremely useful in that they do not cause immune rejection reactions. It is possible to freeze and preserve the cell sheets in a laminated state. 【Research Summary】 ■ A method for producing laminated cell sheets that significantly increases the production of vascular growth factors and induces an increase in healing rates through transplantation to skin wound sites. ■ It is possible to freeze and preserve the cell sheets in a laminated state. ■ Extremely useful in that it does not cause immune rejection reactions. *For more details, please refer to the PDF document or feel free to contact us.

  • others

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Tau protein aggregation inhibitor

We would like to introduce an invention that can suppress the aggregation of tau proteins.

Various therapeutic agents have been developed for neurodegenerative diseases up to now, but all of those actually used in treatment are symptomatic therapies, and no successful development of curative drugs has been achieved. The purpose of this invention is to provide a agent that suppresses the aggregation of tau protein, which is a cause of Alzheimer's disease and frontotemporal dementia. By suppressing the aggregation of tau protein, it becomes possible to prevent or treat neurodegenerative diseases caused by the aggregation of tau protein. [Research Overview] - Creation of a tau protein aggregation suppressor with phorbol esters as the active ingredient - It is preferable that the phorbol ester is phorbol 12-myristate 13-acetate - Capable of suppressing the aggregation of tau protein - Capable of preventing or treating neurodegenerative diseases *For more details, please refer to the PDF document or feel free to contact us.

  • others

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In vitro model of the blood-brain barrier and its production method.

Barrier function has increased by 25% compared to conventional methods! Successfully built an in vitro BNB model with a two-layer structure.

Many peripheral nerve diseases are associated with the disruption of the blood-nerve barrier (BNB), and it is urgent to clarify the physiological and pathological functions of the BNB. The present invention aims to provide a method for creating in vitro models that reproduce the anatomical structure of the BNB using cell sheet engineering technology with human-derived peripheral nerves. It has become possible to create an in vitro BNB model using all cell lines that make up the BNB (pericytes and endothelial cells), resulting in a 25% increase in barrier function compared to conventional methods. [Research Overview] - Successfully constructed an in vitro BNB model that maintains a two-layer structure, reproducing the original anatomical structure and physiological functions of the BNB. - Enabled the creation of an in vitro BNB model using all cell lines that make up the BNB, resulting in a 25% increase in barrier function compared to conventional methods. *For more details, please refer to the PDF document or feel free to contact us.

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Anti-histidine tag antibody

You can detect histidine-tagged fusion polypeptides with 5 to 20 times greater sensitivity than before!

The present invention aims to provide a highly efficient purification method and purification kit for histidine-tagged fusion polypeptides. It enables the detection of histidine-tagged fusion polypeptides with 5 to 20 times the sensitivity compared to conventional methods. Histidine-tagged fusion polypeptides contained in unpurified or crude extracts, which could not be detected previously, can now be detected without purification. Additionally, it allows for the efficient purification of histidine-tagged fusion polypeptides, excelling in cost-effectiveness and time efficiency. [Research Overview] ■ Enables the detection of histidine-tagged fusion polypeptides with 5 to 20 times the sensitivity compared to conventional methods. ■ Allows for the detection of histidine-tagged fusion polypeptides in unpurified or crude extracts without purification. ■ Capable of efficiently purifying histidine-tagged fusion polypeptides. ■ Superior in terms of cost-effectiveness and time efficiency. *For more details, please refer to the PDF document or feel free to contact us.

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Screening vector

Easily identify the presence or absence of GFP fluorescence! You can reduce the cost of using reagents in agar media.

The present invention aims to provide a vector that allows for the screening of strains containing a vector with inserted DNA by selecting strains that emit fluorescence. Since it does not require any specific reagents other than standard culture media, it can reduce the cost of using reagents in agar media. It can also be effectively used when employing seamless cloning, which is widely used in the current research industry. [Research Summary] ■ Cost reduction for using reagents in agar media ■ Confirmation of successful gene insertion can be achieved through the appearance of GFP fluorescence ■ Can be effectively used when employing seamless cloning *For more details, please refer to the PDF document or feel free to contact us.

  • others

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DNA that encodes a secretory signal peptide

We would like to introduce an invention that enables the efficient production of various proteins without breaking down cells.

The present invention aims to provide DNA that encodes a highly versatile secretion signal peptide capable of high secretion ability and secreting multiple proteins. By using the DNA that encodes the secretion signal peptide of the present invention to produce the target protein through secretion, it is possible to efficiently produce various proteins without breaking the cells. The new DNA that encodes a secretion signal peptide capable of secreting the target protein expressed in yeast cells can be utilized for the high secretion production of useful proteins. [Research Overview] - Efficient production of various proteins without breaking the cells - Usable for high secretion production of useful proteins - Characterized by culturing transformants and recovering the target protein from the culture supernatant *For more details, please refer to the PDF document or feel free to contact us.

  • others

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Forward primer

No need for DNA fragment preparation! It is possible to connect sequences with promoter activity upstream of the target gene using only PCR.

The forward primer of the present invention does not require complicated operations such as restriction enzyme treatment or ligation, nor the preparation of DNA fragments containing promoter sequences. It is possible to link a sequence with promoter activity upstream of the target gene using only PCR. Even if a promoter sequence is already linked upstream of the target gene, if the expression of the target gene is low, the expression of the target gene can be enhanced by linking a sequence with promoter activity upstream of the target gene sequence or the existing promoter sequence. 【Research Overview】 - No need for complicated operations such as restriction enzyme treatment or ligation, nor the preparation of DNA fragments containing promoter sequences. - It is possible to link a sequence with promoter activity upstream of the target gene using only PCR. - Linear double-stranded DNA with a sequence containing promoter activity can be easily produced upstream of the target gene. - By linking sequences, the expression of the target gene can be enhanced. *For more details, please refer to the PDF document or feel free to contact us.

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Gelling agent and gel

Maintains the basic performance of various organic liquids! A gelling agent that keeps a gel state with a small amount and at relatively high temperatures.

Gelling agents are used for purposes such as solidifying and thickening liquid substances. When the upper limit of the gelling temperature is low, a slight increase in temperature can cause the shape to be lost, leading to fluidization and potential leakage. In this invention, we have developed a gelling agent that maintains a gel state with a smaller amount and at relatively high temperatures. With the addition of a small amount of organic gelling agents that do not contain hydrogen bonds, various liquids can be freely gelled. It is possible to create gels using molecular nanofibers with thicknesses ranging from tens to hundreds of nanometers while maintaining the basic properties of various organic liquids such as ionic liquids, liquid crystals, and organic electrolytes. [Creation of Non-Protonic Organic Gelling Agents] - Non-hydrogen bonding: High electrochemical stability - High gelling: Approximately 2 wt%, with electrolyte content over 98 wt% - Wide range of applicability - Applicable not only to alcohols and hydrocarbon solvents but also to various good solvents such as PC, DMF, and ionic liquids. *For more details, please refer to the PDF document or feel free to contact us.

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Organic liquid gelling agent consisting of aromatic compounds with perfluoroalkyl groups.

Gelation is possible with a small amount of additive! High dielectric constant solvents suitable for organic electrolytes can also be gelled.

This invention is a study on the development of an organic low-molecular-weight gelling agent that can gel with a small amount of additive. This gelling agent can gel a wide variety of organic liquids and can gel organic liquids with a small amount of additive. It can also gel high-dielectric solvents suitable for organic electrolytes. Moreover, the gel produced by gelling high-dielectric solvents has a low concentration of gelling agent, which allows for an increased content of organic electrolyte when used as an electrolyte gel. [Research Summary] ■ A wide variety of organic liquids can be gelled ■ Organic liquids can be gelled with a small amount of additive ■ High-dielectric solvents suitable for organic electrolytes can also be gelled ■ It is possible to increase the content of organic electrolytes when used as an electrolyte gel *For more details, please refer to the PDF document or feel free to contact us.

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Gelation agent for ionic liquids

We would like to introduce an invention that makes it possible to create magnetic ionic liquid gels, which was previously not achievable.

The present invention aims to provide a gelling agent that can gel a large number of organic liquids, particularly magnetic ionic liquids, with a small amount of additive. It is possible to gel a large number of organic liquids, especially magnetic ionic liquids, with a small amount of additive, enabling the production of magnetic ionic liquid gels that were previously unattainable. This can be utilized in medical settings, as fine actuators for robotic components, and in the market for magnetic sensors. [Research Overview] - Enables the production of magnetic ionic liquid gels that were previously unattainable. - A physical gel (thermoreversible gel) that transitions between sol and gel upon heating and cooling. - The magnetic susceptibility of commercially available and constructed magnetic ionic liquid gels is almost unchanged. - Gelling of ionic liquids that do not exhibit magnetism is also possible. - Can be utilized in medical settings, as fine actuators for robotic components, and in the market for magnetic sensors. *For more details, please refer to the PDF materials or feel free to contact us.

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Method for producing long metal nanotubes generated by electric field spinning.

Method for producing long metal nanotubes generated by electric field spinning.

This is a technology for producing hollow metal and metal compound fibers ranging from several tens of nanometers to several tens of micrometers. It has been made possible by combining electrospinning and electroless plating methods. 【Features】 ● Diversification of materials is possible ● A wide range of sizes can be produced ◇◆ For more details, please request materials or download the catalog ◆◇

  • Other metal materials

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Two-photon absorption materials usable for optical devices and bioimaging.

Two-photon absorption materials usable for optical devices and bioimaging.

Two-photon absorption (TPA) refers to the ability to spatially select the location where light absorption occurs in three dimensions, and the probability of two-photon absorption is proportional to the square of the intensity of the incident light. For practical applications, materials with high two-photon absorption efficiency are required at necessary wavelengths (short wavelengths for optical recording, long wavelengths for bioapplications) and under specific environments (solid state for optical recording, underwater for bioapplications). ● New molecular design guidelines: Azulenyl compounds - Significant increase in two-photon absorption efficiency - Achieving the levels required for applications ● High-efficiency materials in solid state - Approximately tenfold increase in two-photon absorption efficiency ● Solubilization of high-efficiency materials in water ◇◆ For more details, please request materials or download the catalog ◆◇

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A method for manufacturing patterned media that can uniformly fill materials deep inside the pores.

A method for manufacturing patterned media that can uniformly fill materials deep inside the pores.

This is a technology for manufacturing patterned media and the like by embedding magnetic materials in nanosized fine pores. 【Features】 ● By using a sputtering method combined with ion irradiation, it is possible to efficiently fill magnetic materials into the depths of the pores, forming layers of magnetic materials with extremely few voids and impurities. ● Using a plating method with supercritical or subcritical fluids, it is possible to uniformly fill magnetic materials into the interiors of pores distributed over a large area of the disk, thanks to the properties of low viscosity, high diffusivity, and zero surface tension. ◇◆ For more details, please request materials or download the catalog ◆◇

  • Other metal materials

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