What is the "robust analysis and evaluation" required for gene and cell therapies? [CPHI Japan 2026 (International Pharmaceutical Development Exhibition)] Latest Products and Technologies Seminar

Direct measurement of the mass of giant molecules ranging from megadaltons to gigadaltons with just a few µL of sample.

By clicking [Send], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with the Waters Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy CDMS stands for Charge Detection Mass Spectrometer, which separates individual ions and simultaneously captures both m/z and charge to calculate the true mass of molecules with unparalleled accuracy. It can directly and accurately measure large and heterogeneous molecular species, such as viruses and protein complexes, that traditional techniques cannot handle. 【Features】 - Accurate - Direct measurement of charge and mass for individual ions without the need for deconvolution. - Fast - Results can be obtained in less than 10 minutes, streamlining workflows and accelerating decision-making. - Clear - Reliable identification of empty particles, partial particles, and complete particles of viral vector capsids. - High sensitivity - Detectable with up to 1/100th of the sample amount compared to traditional methods.

• Analytical Equipment and Devices
• Mass Spectrometer

Uncompromising performance and speed - high resolution across a wide m/z range, regardless of scan rate.

By using the state-of-the-art Xevo MRT mass spectrometer, which operates at 100 Hz with a mass resolution of 100K FWHM and mass accuracy within ppm, reliable identification and increased productivity can be achieved in the lab. The Multi-Reflection Time-of-Flight (MRT) technology ensures consistent mass resolution across a wide m/z range, regardless of the scan rate, even at the highest acquisition rates. This system guarantees excellent data quality, enabling scientific analysis, making it ideal for large cohort studies in biopharmaceutical research. 【Features】 - Reliable separation of analytes in complex matrices - Improved reliability of compound identification - Reproducible results due to high stability and robustness

• Analytical Equipment and Devices

Reliable characteristic analysis - A mass spectrometer that maximizes information about the analysis species.

By using the Xevo G3 QTof, you can maximize the information about the analysis species from samples, enhancing the reliability of results from detailed characterization to accurate quantification. It simplifies and expands the characterization and evaluation of properties, from unstable low molecular weight compounds to complex biopharmaceuticals. By updating the design of the ion optical system and incorporating core technologies that achieve comprehensive quantification capabilities, consistent robustness and performance have been achieved. 【Features】 - Improved permeability of unstable low molecular compounds maximizes coverage of analysis species - Enhanced quantitativeness and expanded dynamic range within and between spectra enable optimal comprehensive quantification/qualitative analysis for screening and target applications - Improvements in the ion optical system lead to a more reliable and robust system - Achieves high levels of accuracy and reproducibility

• Analytical Equipment and Devices

High-precision measurement of absolute molecular weight in the range of hundreds to hundreds of millions Da for the characterization of polymers, proteins, and nanoparticles!

The DAWN series measures the molecular weight and size of macromolecules such as proteins with high precision, using multi-angle light scattering (MALS) without the need for calibration curves created from standard substances. It can be connected to HPLC and UPLC, enabling a wide range of applications. 【Features】 - DAWN (18-angle detector) offers high sensitivity and wide-range measurement. - A diverse lineup including DAWN8 (8-angle detector), miniDAWN (3-angle detector), microDAWN (UPLC-compatible model), and UltraDAWN (process-compatible model). - Automated cell cleaning with built-in ultrasonic cleaner COMET. - Equipped with a dynamic light scattering (DLS) module, allowing measurements from a radius of 0.5 nm (optional). - Real-time display of system status, with troubleshooting guidance functionality. By clicking [Send], you agree that the information provided on this site will be used and processed by Waters in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Analytical Equipment and Devices
• High Performance Liquid Chromatograph

Easy-to-use dynamic/static light scattering (DLS/SLS) measuring instrument - Conveniently and quickly measures particle size distribution, particle concentration, stability, and molecular weight.

The DynaPro NanoStar 2 supports both dynamic light scattering (DLS) and static light scattering (SLS) measurements, allowing for the measurement of particle size distribution, particle concentration, interactions (kD, A2), and weight average molecular weight (Mw) of nanoparticles and proteins. It can be used for the analysis of proteins, gene therapy vectors, viruses and virus-like particles, indiscriminate inhibitors, micelles, liposomes, LNPs (lipid nanoparticles), and metal nanoparticles. To accommodate rare and precious samples, the specially designed quartz cuvette provides robust and accurate measurements with just 2 µL of solution. 【Features】 - Supports both dynamic light scattering (DLS) and static light scattering (SLS) measurements - Easy operation with an intuitive touchscreen - Achieves a wide range of temperature settings (-10 to 120°C) and fast temperature gradient settings - Connects with the multi-angle light scattering detector DAWN to support flow DLS measurements - Abundant cell options (2μL capacity quartz cell, 4μL capacity disposable cell, commercially available 4mL quartz cell, disposable cell (using adapter))

• Light Scattering Photometer

This single device supports dynamic, static, and electrophoretic light scattering (DLS/SLS/ELS) measurements - providing reliable measurement results even with a small sample volume.

The DynaPro ZetaStar can measure dynamic light scattering, static light scattering, and electrophoretic light scattering (DLS/SLS/ELS) all in one device, allowing for the acquisition of information on a wide range of molecular sizes, polydispersity, zeta potential, particle concentration, molecular weight, and turbidity/milky degree in up to 1/10 the time compared to conventional methods. It can be used for the analysis and quantification of virus vectors, vesicles, LNPs (lipid nanoparticles), inorganic nanoparticles, nanoemulsions, polymers, peptides, proteins, nucleic acids, and more. With high sensitivity even with very small sample amounts, it is suitable for rare and precious samples. 【Features】 - Supports both manual and automatic measurements - Measurement is completed with just a few clicks, making it easy to operate and reassuring for inexperienced users - Wide temperature setting range (-10 to 120°C) allows for evaluation of thermal degradation and behavior under various storage conditions - High salt concentration compatibility enables reliable measurements under physiological conditions and in formulation buffers - A variety of cell options and disposable cell compatibility eliminate the need for cuvette cleaning and sample carryover

• Light Scattering Photometer

High-throughput dynamic and static light scattering (DLS/SLS) measurements using commercially available microplates - Reducing time and running costs.

The DynaPro Plate Reader 3 is a commercially available microplate that is a light scattering measurement device capable of measuring the size, molecular weight, concentration, and interactions of proteins, nanoparticles, and other polymers. This plate-based device allows for very high-throughput measurements compared to traditional cuvette-based light scattering devices. Additionally, after dispensing into the plate, there is no need to touch the liquid, minimizing sample carryover. 【Features】 - Compatible with commercially available microplates - Supports high-throughput measurement of multiple samples and automation - Simultaneous measurement of dynamic light scattering (DLS) and static light scattering (SLS) - Saves time and running costs - Non-destructive measurement allows the measured plates to be repurposed for other analytical devices

• Light Scattering Photometer

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely invite you to visit us during this busy time. 【 Exhibition Name 】 Automotive Technology Exhibition 2025 YOKOHAMA https://aee.expo-info.jsae.or.jp/ja/yokohama/ (An "online exhibition" will also be held during and around the event period) 【 Dates 】 May 21 (Wednesday) - 23 (Friday), 2024 10:00 AM - 6:00 PM *On the final day, 9:00 AM - 4:00 PM (Online exhibition: May 14 (Wednesday) - June 4 (Wednesday)) 【 Venue 】 Pacifico Yokohama (1-1-1 Minatomirai, Nishi-ku, Yokohama, Kanagawa Prefecture) Our booth number: "Concourse 505"

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to attend this event. 【 Exhibition Name 】 27th INTERPHEX Week Tokyo https://www.interphex.jp/tokyo/ja-jp.html 【 Dates 】 July 9 (Wednesday) - 11 (Friday), 2025 10:00 AM - 5:00 PM 【 Venue 】 Tokyo Big Sight (3-11-1 Ariake, Koto-ku, Tokyo 135-0063)

[Lecturer] Taku Ito, Partner, Mori Hamada & Matsumoto Foreign Law Joint Enterprise Yoshifumi Nagakubo, Senior Associate [Key Lecture Content] As we move towards a carbon-neutral society, the large-scale introduction of renewable energy sources is progressing, making the enhancement of market design that balances stable electricity supply and economic efficiency an urgent issue. In this context, the "simultaneous market," which integrates the trading of electricity (kWh) and adjustment capacity (ΔkW), is being discussed as a core component of future electricity systems, and serious considerations for its implementation are underway. In this lecture, a lawyer who has led discussions at the forefront of national system design will explain in an easy-to-understand manner the background and necessity of the simultaneous market, as well as the overall picture of its complex mechanisms, based on practical experience. Furthermore, the lecture will clearly outline the latest developments in current discussions, realistic challenges for implementation, and prospects for future electricity business in Japan, incorporating perspectives and insights as a system designer and practitioner.

[Instructor] Hirokazu Shibata, President and CEO of ZAZU Design Co., Ltd. [Key Lecture Content] As the importance of heat dissipation design increases in daily operations, it is necessary to study a range of books on thermal engineering to learn the overall picture of heat dissipation design. However, books on thermal engineering typically start with the basics of heat transfer and cover topics such as temperature boundary layers and dimensionless numbers related to heat transfer, making it quite difficult for beginners to grasp the overall picture in a short period. This seminar is aimed at engineers who will begin thermal design in the future, focusing on various heat dissipation devices as specific subjects. The goal is to understand the basics of thermal design while learning about the characteristics and usage of these heat dissipation devices. After attending this seminar, participants are expected to acquire knowledge equivalent to that gained from studying a range of thermal engineering books. [Lecture Topics] 1. Current Status and Challenges of Thermal Design 2. How "Thermal Resistance" Determines Heat Dissipation Pathways 3. Fundamental Laws Governing Heat Transfer 4. Air Cooling through Heat Transfer 5. Heat Diffusion through Thermal Conduction 6. Heat Transfer via Two-Phase Flow of Gas and Liquid 7. Q&A Session

[Lecturers] Accenture Ltd. Business Consulting Division Strategy Group, Technology Strategy Senior Manager Mamoru Yoneshige Accenture Ltd. Technology Consulting Division CDAI Consulting Principal Director Hiromichi Sugiyama [Key Lecture Content] While system development using AI agents is gaining attention, the challenges of AI-driven development in brownfield projects for enterprises with existing assets and technical debt are significantly greater. The introduction of coding support tools alone does not lead to company-wide transformation, and there exists a structural gap between the success of Proof of Concept (PoC) and the success of company-wide deployment. In this lecture, based on practical insights from Accenture's comprehensive support from strategy formulation to implementation, we will systematically explain the essentials for successful company-wide deployment, including the six principles of AI-driven development, categorization of brownfield types and deployment strategies, context engineering, the systematization of methodologies such as harness engineering and specification-driven approaches, promotion systems and in-house production strategies, and KPI design as a management agenda.