関東化学株式会社 List of Products and Services

This is metallic magnesium for Grignard reactions. This product is sealed with argon gas in the container to prevent surface oxidation, and it has a high purity of 99.9%. 【Features】 ■ Low cost ■ High purity (99.9% purity) ■ Sealed with argon gas Prevents surface oxidation (available in 10 g, 100 g, 250 g packaging) ■ Large specific surface area Facilitates the synthesis of Grignard reagents For more details, please download the catalog or feel free to contact us.

Reactions using organometallic complexes as catalysts are widely used in organic synthesis, but there have been cases where separating the target product from the catalyst after the reaction is difficult. Our company offers R-Cat-Sil (a metal scavenger with functional groups attached to silica gel), which allows for easy removal of metals. 【Features】 ■ High metal adsorption capacity due to large surface area ■ Does not swell and can be used with a wide range of solvents ■ Physically and thermally stable For more details, please download the catalog or feel free to contact us.

Adamantane possesses excellent properties such as heat resistance, lipid solubility, sublimation, moisture resistance, high refractive index, and chemical resistance. Additionally, adamantane derivatives are used in the electronics field as photoresists for semiconductor manufacturing and in the pharmaceutical field as raw materials. For more details, please download the catalog or feel free to contact us.

Our company offers a lineup of perfluoroalkyl sulfonic acid derivatives. Perfluoro compounds are used in the semiconductor field as surfactants and antistatic agents, and in the organic synthesis field as reaction catalysts and polymerization catalysts. Perfluoroalkyl sulfonic acid derivatives possess high thermal and chemical stability, super acidity, high ionic conductivity, weak coordination ability, flame retardancy, and have a non-PFOS structure. 【Features】 ■ Super acidity ■ High heat and chemical resistance (salt) ■ High ionic conductivity ■ Weak coordination ability ■ Non-PFOS structure For more details, please download the catalog or feel free to contact us.

At Kanto Chemical, we offer dehydrated solvent products with minimal moisture content. We have prepared the following grades and specifications. 【New Products】-NEW- ◆ Anisole (Dehydrated) -Super- ◆ Mesitylene (Dehydrated) -Super- ◆ Monochlorobenzene (Dehydrated) -Super- ◆ Butyl Acetate (Dehydrated) 【Grades and Specifications】 ■ Low Moisture Guarantee Dehydrated Solvent Series Guarantees moisture content of 20 ppm to 50 ppm or less. ■ Ultra Low Moisture Guarantee Dehydrated Solvent -Super- Series Guarantees moisture content of 10 ppm or less. Additionally, the -Super Plus- Series guarantees moisture content of 10 ppm or less, along with dissolved oxygen levels of 1 ppm or less. These can be used for delicate organic synthesis reactions that are sensitive to moisture. ■ Ultimate Ultra Low Moisture Guarantee Dehydrated Solvent -Super2- Series Guarantees moisture content of 1 ppm or less. Furthermore, the -Super2 Plus- Series guarantees moisture content of 1 ppm or less, along with dissolved oxygen levels of 1 ppm or less. These high-quality dehydrated solvents can be safely used not only as solvents for organic synthesis reactions affected by moisture but also in material research and battery research fields.

Conventional ether-based solvents (such as THF) are still used in many laboratories today, but there is a desire to replace them with safer and more environmentally friendly solvents. At Kanto Chemical, we have developed a lineup of products that function as solvents for many organic synthesis reactions and can be used as alternatives to traditional ether-based solvents and harmful halogenated solvents, making them useful from the perspective of green chemistry. 【Features】 ■ Solubility equivalent to THF Enables a wide range of applications ■ Higher boiling point than THF Expands the range of reaction conditions For more details, please download the catalog or feel free to contact us.

Our company offers half cans of solvent with a capacity of 1/2 of a standard 18-liter can. 【Benefits】 ■ Reduction in storage quantity ■ Reduction in transportation weight ■ Prevention of back pain For more details, please download the catalog or feel free to contact us.

In organic synthesis, effectively utilizing protecting reagents is extremely important. Protecting group compounds require the following characteristics based on the functional groups to be protected and the desired reactions, necessitating the selection of the optimal protecting group compound. ● The ability to selectively react with the functional group to be protected and introduce the protecting group with high yield. ● The ability to obtain derivatives in which the protecting part is inert to the desired reaction. ● The capability of deprotection under specific conditions. For more details, please download the catalog or feel free to contact us.

A new molecule with linking sites such as NHS esters and maleimides has been added as a derivative of the catalyst-free click reaction element (DACN) developed by the research group of Tomooka, Ikawa, and Kawasaki at Kyushu University’s Institute of Advanced Material Chemistry. In these new DACN derivatives, molecular linking at the alkyne site via the Huisgen reaction can be easily performed without interference from another site of molecular linking. They can be utilized in various fields such as peptide engineering, protein and antibody engineering, glycoengineering, nucleic acid engineering, coordination chemistry, and the synthesis of functional molecules. For more details, please download the catalog or feel free to contact us.

Potassium carbonate and sodium carbonate are used in a wide range of fields and play an important role in organic synthesis as bases and additives, among other things. However, they generally have low solubility in organic solvents, and in some reaction systems, efficient dispersion using smaller particle sizes is required. Please consider this product, which excels in handling and dispersibility. 【Features】 ■ Guaranteed particle size ■ Good handling and dispersibility ■ Low cost For more details, please download the catalog or feel free to contact us.

This is a highly active reductive amination catalyst that can synthesize primary, secondary, and tertiary amine compounds from carbonyl compounds in a one-pot reaction under mild conditions. 【Good Reactivity】 ■ High Catalytic Activity Under conditions of S/C=10,000, it is possible to synthesize 1-phenylethylamine from acetophenone. ■ High Functional Group Selectivity It can synthesize primary amines from acetophenone derivatives containing nitro or cyano groups without compromising the functional groups. ■ High Diastereoselectivity It can synthesize primary amines with high diastereoselectivity from substituted aliphatic cyclic ketones. 【Simple Reaction Operation】 ■ No Special Reaction Equipment Required Using ammonium formate or formic acid as the hydrogen source eliminates the need for special equipment such as pressure vessels. ■ Mild Reaction Conditions It can be used under reaction conditions of 60°C to reflux, making it highly practical. ■ Stable in Air This catalyst can be handled stably in air, allowing for weighing with standard laboratory equipment. For more details, please download the catalog or feel free to contact us.

At Kanto Chemical, we have developed and sold practical reductive amination iridium catalysts that can synthesize amines under mild conditions, and we have now developed a new asymmetric reductive amination catalyst. In particular, in the reductive amination reaction combined with amino alcohols as asymmetric auxiliaries, it has become possible to easily synthesize optically active amines, which have been difficult to synthesize asymmetrically until now. We are pleased to announce the addition of the PSA18 series, which has high reactivity with linear ketone substrates, to our product lineup. We encourage you to utilize it in product development and research. 【Features】 ■ High performance High catalytic activity, high stereoselectivity, high functional group selectivity ■ Short reaction process No need for isolation of imines; reactions can be performed in one pot up to deprotection ■ Easy operability No need for hydrogen gas or pressure-resistant containers for both reductive amination and deprotection processes For more details, please download the catalog or feel free to contact us.

We sell an iridium catalyst for amine synthesis developed by Professor Emeritus Ryohei Yamaguchi and Professor Kenichi Fujita of Kyoto University. This catalyst allows for the synthesis of amine compounds using alcohol as an alkylating agent and ammonia or amine compounds as a nitrogen source, even under aqueous or atmospheric conditions. 【Features】 ■ Reactions proceed under aqueous and atmospheric conditions ■ Achieves high atomic efficiency ■ Catalyst can be reused multiple times For more details, please download the catalog or feel free to contact us.

■Asymmetric Hydrogenation Catalyst (IPHAN, DMAPEN Catalyst) In asymmetric hydrogenation catalysts, diamin ligands such as DPEN and DAIPEN are commonly used. At Kanto Chemical, we offer asymmetric hydrogenation catalysts (IPHAN, DMAPEN catalysts) that demonstrate high enantioselectivity in the asymmetric hydrogenation of cyclic ketones and amino ketones by changing the diamin ligands to different structures like IPHAN and DMAPEN. ■Asymmetric Phase Transfer Catalyst (DIOXEAZEPINE) The metal-free DIOXEAZEPINE catalyst is expected to be an effective means for the synthesis of optically active pharmaceuticals, as it avoids contamination of the product with metal derived from the catalyst. This catalyst is useful for the synthesis of optically active α-α-dialkyl amino acids. For more details, please download the catalog or feel free to contact us.

Metal-free asymmetric organic catalysts are environmentally friendly catalysts that can avoid the contamination of waste liquids and products with metals after the reaction. The asymmetric phase-transfer catalyst (simplified Maruoka catalyst) developed by Professor Maruoka and his team at Kyoto University can synthesize important natural and non-natural α-amino acids, which are raw materials for pharmaceutical intermediates, with high efficiency and high selectivity. For more details, please download the catalog or feel free to contact us.

This is a new asymmetric hydrogenation ruthenium catalyst developed in collaboration with Professor Okuma from Hokkaido University, featuring a unique substrate applicability range that has never been seen before. It efficiently converts ketones into optically active alcohols with high efficiency and high enantioselectivity. By selecting the reaction conditions, it is also possible to reduce keto esters to diols. The catalyst is suitable for bulk supply, making it useful for industrial processes. **Features** - Unique substrate applicability range: It hydrogenates bulky multi-substituted ketones, unprotected heteroaromatic ketones, and keto esters with high efficiency and high enantioselectivity, which conventional catalysts could not efficiently react with. - Proven performance at kg scale: There is a track record of asymmetric hydrogenation reactions at tens of kg scale. Reactions are also possible with a substrate/catalyst molar ratio (S/C) of over 10,000. For more details, please download the catalog or feel free to contact us.

Asymmetric ruthenium catalysts using diphosphines and diamines as ligands exhibit extremely high catalytic activity and enantioselectivity in the asymmetric hydrogenation of ketones. At Kanto Chemical, we have examined the structure of diphosphine ligands and are selling a highly selective asymmetric hydrogenation catalyst (XlySKEWPHOS catalyst) that uses XlySKEWPHOS as a ligand, which provides higher enantioselectivity. For more details, please download the catalog or feel free to contact us.

■Improved Asymmetric Reduction Catalyst Asymmetric ruthenium complexes with optically active tosyl diamines as ligands are very useful as asymmetric reduction catalysts for ketones; however, sufficient enantioselectivity may not be achieved for bulky substrates. At Kanto Chemical, we offer an improved asymmetric reduction catalyst with modified sulfonyl groups that exhibits high enantioselectivity for bulky substrates. ■Triflate Catalyst By introducing dissociative anionic ligands into hydrogen transfer-type asymmetric ruthenium catalysts with arene ligands and tosyl diamine ligands, hydrogen is activated, allowing for more efficient asymmetric hydrogenation reactions of ketones compared to hydrogen transfer-type asymmetric reduction catalysts. The triflate catalyst does not contain strong bases, so the reaction proceeds under neutral to weakly acidic conditions. Therefore, it is useful for the asymmetric hydrogenation of unstable cyclic ketones, phenacyl chloride, α-hydroxyacetophenone, and other compounds under basic conditions. For more details, please download the catalog or feel free to contact us.

The importance of technology for the selective and efficient synthesis of optical active substances is increasing year by year. Among these, asymmetric synthesis using transition metal complexes with chiral phosphine ligands is one of the useful methods for synthesizing optical active substances, and it has been widely researched for many years, including asymmetric hydrogenation, asymmetric hydroboration, and asymmetric hydroacylation. At Kanto Chemical, in addition to BINAP ligands, we also handle SKEWPHOS ligands with flexible frameworks. They are expected to demonstrate unique stereoselectivity not seen before, so please make use of them in your research. For more details, please download the catalog or feel free to contact us.

At Kanto Chemical, we are selling a nickel catalyst (Ni-dcype) developed by Professor Kenichiro Itami from Nagoya University’s Institute of Transformative Bio-Molecules (WPI-ITbM) and Professor Junichiro Yamaguchi from Waseda University’s School of Advanced Science and Engineering. By using this catalyst, it is possible to synthesize coupling compounds between hetero compounds and phenolic derivatives, aromatic esters, enol derivatives, or unsaturated esters with high efficiency. 【Features】 ■ Enables coupling reactions with combinations that were previously impossible ■ Minimal environmental impact as it does not use organometallic reagents or organic halides ■ Utilizes ubiquitous nickel instead of the rare metal palladium For more details, please download the catalog or feel free to contact us.

The dcypt ligand developed by Professor Kenichiro Itami from Nagoya University’s Institute of Transformative Molecular Science (WPI-ITbM) and Professor Junichiro Yamaguchi from Waseda University’s School of Advanced Science and Engineering is stable in air, making it easy to handle. It has the property of catalyzing various new reactions when combined with different metal species, so please make use of it in your research. 【Features】 ■ Catalyzes a variety of novel reactions ■ Stable in air and easy to handle ■ Potential to catalyze new reactions For more details, please download the catalog or feel free to contact us.

The cobalt catalyst for carbon-hydrogen bond activation (Cp*Co(CO)I2), identified for its usefulness by Professor Motoharu Kanai of the University of Tokyo, Professor Shigeki Matsunaga of Hokkaido University, and Assistant Professor Tadahiko Yoshino, can be handled stably in the air and allows for the easy generation of cationic catalytic active species by mixing with silver salts in the reaction vessel. Additionally, it exhibits catalytic performance equivalent to that of rare and expensive rhodium, enabling cost reduction in the process. 【Features】 ■ Alternative to Rhodium (Rh) It demonstrates equivalent performance without using expensive and rare rhodium (Rh). ■ Cost Reduction It can be used as a substitute for rhodium (Rh), allowing for cost reduction in the process. ■ Easy Handling It can be handled stably in the air. For more details, please download the catalog or feel free to contact us.

At Kanto Chemical, we sell biaryl monophosphines developed by Buchwald and others at the Massachusetts Institute of Technology (MIT). These phosphines have a rich electronic structure and a bulky configuration, making them highly effective ligands in cross-coupling reactions. 【Features】 - Useful for reactions using aryl chlorides and tosylates as substrates - Effective for reactions involving sterically hindered aryl compounds as substrates - Applicable not only for research purposes but also for industrial applications For more details, please download the catalog or feel free to contact us.

Tert-Butylphosphine (TTBP) has a significant steric hindrance effect and shows high electron-donating ability, making it one of the useful ligands for organometallic catalysts. Kanto Chemical has traditionally handled phosphine ligands and various organometallic catalysts, and we have prepared TTBP in 50g packages, which can be used for Suzuki Coupling, Stille Cross Coupling, Heck reactions, and more. We can also supply it on an industrial scale, so please feel free to consult with us. For more details, please download the catalog or contact us at your convenience.

In the field of organic synthesis, reactions such as Suzuki Coupling, Sonogashira Coupling, Heck Reaction, and Hartwig-Buchwald Coupling, which are very useful methods, are catalyzed by palladium complexes with trialkylphosphines as ligands. However, trialkylphosphines are prone to oxidation in air, making them very difficult to handle. At Kanto Chemical, we offer phosphonium borate derivatives that have similar properties to trialkylphosphines and are very stable in air. For more details, please download our catalog or feel free to contact us.

At Kanto Chemical, we sell iridium catalysts developed by Professor Emeritus Ryohei Yamaguchi and Professor Kenichi Fujita of Kyoto University, which can oxidize primary and secondary alcohols into the corresponding aldehydes, ketones, and carboxylic acid compounds with high efficiency without using oxidants. Please utilize them as one of the synthetic tools in product development. 【Features】 ■ Cp*Ir cat. 1 For ketone synthesis, reacts under neutral conditions, cost-effective ■ Cp*Ir cat. 2 For ketone and aldehyde synthesis, reacts under neutral conditions and in air atmosphere, reusable catalyst ■ Cp*Ir cat. 3 For ketone and aldehyde synthesis, reacts under neutral conditions and in air atmosphere, higher activity compared to Cp*Ir cat. 1 and 2 ■ Cp*Ir cat. 4 For carboxylic acid synthesis, under basic, aqueous conditions For more details, please download the catalog or feel free to contact us.

At Kanto Chemical, we sell anionic iridium complex catalysts (Cp*Ir catalyst) developed by Professor Emeritus Ryohei Yamaguchi and Professor Kenichi Fujita of Kyoto University. This catalyst demonstrates high performance in the dehydrogenation reaction that occurs during the hydrogen generation process, allowing for the efficient production of hydrogen from methanol aqueous solution under milder conditions than conventional methods. 【Features】 ■ Mild reaction conditions (dilute base concentration, no need for excess organic solvent, low reflux temperature) ■ High catalytic activity ■ Stable in aqueous media For more details, please download the catalog or feel free to contact us.

Our company sells the "asymmetric cyanation catalyst" developed by Professor Okuma and others at Hokkaido University. This asymmetric cyanation catalyst is stable in air and easy to handle. This complex does not exhibit catalytic activity on its own, but by adding lithium sources such as lithium chloride, lithium carbonate, or lithium phenoxide to the reaction system, it forms a complex with lithium, demonstrating high catalytic activity and stereoselectivity. This catalyst can react not only with aldehydes and ketones but also with α,β-unsaturated ketones and aldimines, which have not previously been known to react efficiently, allowing for the easy and high-yield production of cyanides with high optical purity. The recovery and reuse of the complex are also possible. For more details, please download the catalog or feel free to contact us.

At Kanto Chemical, the chiral spirodiamine ligands SPYMOX and SQUMOX, developed by Professor Kazutaka Shibatomi and others at Toyohashi University of Technology, efficiently facilitate asymmetric halogenation of various β-keto ester compounds through complex formation with copper. They also demonstrate a broader substrate generality and asymmetric induction capability compared to conventional methods. These ligands can coordinate with various transition metals and can be utilized as optically active diamine ligands in various catalytic reactions. 【Features】 - Achieves broad substrate generality and advanced stereocontrol for activated methine compounds. - Uses ubiquitous copper instead of rare metals. - Enables highly enantioselective asymmetric fluorination and asymmetric chlorination of active methine groups. - Allows for sequential asymmetric chlorination and fluorination in one pot by using different halogenating agents in succession on activated methine groups. For more details, please download the catalog or feel free to contact us.

We offer a variety of deuterated compounds used for nuclear magnetic resonance spectroscopy (NMR). We have products with different deuteration levels available for your specific needs. Additionally, we provide both general packaging options ranging from 10 mL to 500 mL, as well as ampoule packaging for single-use. Our ampoule packaged products come with labels attached, making it easy to verify the contents even without a box. The removed labels can be directly affixed to your lab notebook, facilitating the management of the solvents used. For more details, please download our catalog or feel free to contact us.

Conventional ether-based solvents (such as diethyl ether and THF) are still used in many laboratories today, but there is a desire to replace them with safer and more environmentally friendly solvents. This product functions as a solvent for many organic synthesis reactions and can be used as an alternative to conventional ether-based solvents, making it a useful solvent from the perspective of green chemistry. 【Features】 ◆ Solubility equivalent to THF It has solubility comparable to THF for organic compounds and inorganic salts, allowing for a wide range of applications. ◆ Higher boiling point than THF Expands the range of reaction conditions that can be selected. ◆ Less prone to peroxide formation Favorable for solvent reuse. ◆ High degradability with water Simplifies processes and reduces wastewater load. For more details, please download the catalog or feel free to contact us.