重松貿易 List of Products and Services

The "Spin Coater" achieves easy and efficient high-quality thin film formation through an innovative chuck design that does not require a vacuum pump. It significantly reduces the hassle of equipment maintenance and meets diverse needs in the laboratory. In particular, it demonstrates excellent performance in research and development for solar cells, OLEDs, sensors, and other applications where uniform formation of organic thin films is required. 【Features】 ■ Wide range of applications ■ Exceptional convenience without the need for a vacuum pump ■ High-performance rotation up to 10,000 RPM ■ Flexible preset saving function ■ Compact and space-saving design ■ Choice of durable chuck types *For more details, please download the PDF (English version) or feel free to contact us.

• Cells and batteries

The G2009B1 is a solar simulator suitable for evaluating the characteristics of small-area solar cells. It accurately reproduces the AM1.5G solar spectrum, achieving a precision that is extremely close to natural sunlight. It can be utilized for measuring the efficiency of solar cells and for research on photovoltaic devices. 【Features】 ■ Class AAA spectral performance in a 15mm diameter area, and Class ABA spectral performance in a 25mm diameter area (IEC standard 60904-9:2020) ■ High-output light source with Class A temporal stability ■ Easy setup and operation, allowing for immediate implementation in research and testing ■ Compact design saves laboratory space ■ Low-cost with efficient specifications that meet fixed conditions ■ 2-year quality warranty *For more details, please download the PDF (English version) or feel free to contact us.

• Other measurement and measuring equipment

We would like to introduce the CAR-T cell detection products offered by Cytoart. The generation of CAR-T cells requires the transfection of CAR genes into T cells via viral or non-viral systems. The CAR-positive T cells that express CAR on their membrane have the ability to recognize and damage target cells, making the detection of CAR-positive T cells a crucial step in the quality control of CAR-T cell therapy, as well as an important criterion for managing clinical doses, process monitoring, and diagnostic assistance. Cytoart's antibody development platform focuses on targeting the scFV region on CAR-T cells. Advantages of using scFV for target detection in CAR-T cell therapy: - High specificity: Ensures accurate target binding and reduces off-target complications. - Sensitivity: The detection of targets using scFV allows for real-time monitoring of the activity and distribution of low levels of CAR-T cells in samples. - Versatility: scFV target detection can be applied to various types of research related to CAR-T cells.

• Flow cytometer

Cytoart is a company located in Arizona, USA, that has product technology for the detection of CAR-T cells using flow cytometry. The sensitivity and accuracy of the company's products are exceptional, making them useful for the development, quality control, and clinical monitoring of CAR-T cell therapy. The manufacturer of the products is BioSwan Laboratories, Inc., which is responsible for sales and marketing. 【Products Offered (Partial)】 ■ Rabbit Anti-Mouse FMC63 scFv Monoclonal Antibody (R19M) (100 tests) ■ Rabbit Anti-Mouse FMC63 scFv Monoclonal Antibody (R19M) (1 mg) ■ Rabbit Anti-Mouse FMC63 scFv Monoclonal Antibody (R19M), Alexa Fluor 647 (25 tests) *You can download the English version of the catalog. For more details, please feel free to contact us.

• Flow cytometer

Solvionic is a French company established in May 2003 that develops chemistry utilizing ionic liquids within the framework of "sustainable growth in the chemical industry." The company is actively involved in industrial projects in the fields of manufacturing ionic liquids, developing their applications, energy storage technologies, new materials, and catalysts. Innovation, high-tech control, and high quality have led the company to success, and its products and services are now sold and supported worldwide. 【Products Offered】 ■ High-quality electrolytes and materials ■ Electrolytes ■ Ionic liquids ■ Metal salts ■ Monomers and polymers *For more details, please refer to the PDF document or feel free to contact us.

• Other electrochemical analysis equipment

"Amytracker" is a fluorescent tracer molecule provided by Ebba Biotech that highly visualizes protein aggregates. The company offers fluorescent tracer molecules for visualizing and distinguishing macromolecules such as carbohydrates and protein aggregates. These optotracers are non-toxic and emit fluorescence only when bound to the target, minimizing background fluorescence. Specifically, it enables the visualization of amyloids and bacterial biofilms. Users include not only neuroscientists and microbiologists but also plant physiologists, who utilize the company's products because they require anatomical maps of carbohydrates in their specimens. [Features] ■ Non-toxic molecules ■ Products for x-vivo are useful for the following experiments: - Staining of tissue sections - Live cell imaging - Amyloid fibrillation assays *For more details, please refer to the PDF materials or feel free to contact us.

• Bio-related product films and sheets
• Other protein analysis

"Ebba Biolight" is a fluorescent tracer molecule provided by Ebba Biotech for detecting bacterial biofilms. The company offers fluorescent tracer molecules for visualizing and distinguishing polymers such as carbohydrates and protein aggregates. These opto-tracers are non-toxic and emit fluorescence only when bound to the target, minimizing background fluorescence. Specifically, they enable the visualization of amyloids and bacterial biofilms. Users include not only neuroscientists and microbiologists but also plant physiologists, who utilize the company's products as they require anatomical maps based on carbohydrates in their specimens. [Features] - Stable against light and heat - Real-time tracking and visualization of bacterial growth and biofilm formation - Direct visualization of bacteria and their biofilms - Free from components that inhibit bacterial growth or biofilm formation *For more details, please refer to the PDF materials or feel free to contact us.*

• Bio-related product films and sheets

We would like to introduce our "In Vivo Antibodies." There are two types: "Low Endotoxin" and "Ultra Low Endotoxin." They are suitable for fields such as cancer immunology, neuroscience, immunology, immune checkpoints, and isotype controls. Additionally, they feature low endotoxin levels (≦1.0 EU/mg), a purity of ≧95%, and do not contain preservatives, stabilizers, or carrier proteins. 【Features】 ■ Low endotoxin (≦1.0 EU/mg) ■ Purity ≧95% ■ Free from preservatives, stabilizers, and carrier proteins *For more details, please refer to the PDF document or feel free to contact us.

• Research Antibodies

LGC Biosearch Technologies (hereinafter referred to as LGC Biosearch) supports the development of nucleic acid medicines with a diverse portfolio that includes oligonucleotide modifiers, solid-phase support carriers, and other reagents. LGC Biosearch products are used in the manufacturing and development of over 100 approved or in-development therapeutics, with at least one product being utilized in each. LGC Biosearch simplifies the journey from drug discovery to commercialization through reliable technical support and industry-leading products.

• Fine chemicals (compounds, derivatives, catalysts, etc.)
• Others Synthesis
• Pharmaceutical Intermediates

Genovis provides rapid and user-friendly proprietary enzyme tools primarily for the biopharmaceutical industry. These tools, available worldwide, are called SmartEnzymes and are highly useful for the following applications: ● Analysis and characterization of antibody drugs and antibody-drug conjugates (ADCs) ● Conversion of antibody glycosylation ● Automation of antibody subunit analysis ● Antibody modification (fluorescent labeling, biotinylation, azidation, etc.) ● Research and development of antibody-drug conjugates (ADCs) ● De-fucosylation of glycoproteins ● Removal of glycans from proteins You can check the features and usage examples of various enzymes by downloading the PDF. Please feel free to take a look.

• Other bio-related products
• Other protein analysis
• Other analytical and testing equipment

Lucent360" is a multipurpose photoreactor that accommodates various purposes and conditions. It can handle everything from small-scale screening to scale-up in visible light redox reactions, and it allows for simultaneous examination of light intensity and wavelength with just one device. Additionally, it is designed with a focus on reproducibility, requiring no special skills for experimental setup. 【Features】 ■ Equipped with a light source LED with a total output of approximately 350W (365nm to 525nm) ■ Five light source LEDs, each configurable to different intensities and wavelengths ■ Designed to prevent light leakage, eliminating irradiation loss and contributing to reproducibility ■ Adjustable reaction temperature (0 to 80°C) ■ Capable of simultaneously screening multiple wavelengths and light intensities ■ Reaction capacity: 0.3ml to 20ml, 700ml (batch synthesis), flow synthesis *Demo units are available. Please contact us if you wish to request a demo. *For more details, please refer to the catalog available for "PDF download.

• Other reaction equipment

"GlycOCATCH" is an affinity resin for the purification of mucin-type O-glycosylated proteins and peptides. This affinity resin is based on an inactive OpeRATOR (enzyme) designed to bind with high affinity to O-glycosylated proteins and peptides. Applications include specific enrichment or removal of O-glycosylated proteins and peptides, glycomics, research on complex samples, and characterization of biopharmaceuticals. 【Features】 - Provided in a spin column format for easy concentration of mucin-type O-glycosylated proteins. - Binds with high affinity due to strong interactions with O-glycosylated proteins, allowing elution using 8M urea. - Elution can also be performed by using the included OpeRATOR (enzyme) to cleave the N-terminal of the O-linked glycan sites of the bound O-glycosylated proteins. *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

The enzyme 'GalNAcEXO' is an α-N-acetylgalactosaminidase that efficiently hydrolyzes terminal GalNAc on glycoproteins. GalNAc, which is bound to serine or threonine and referred to as the Tn antigen, is rapidly and efficiently hydrolyzed by GalNAcEXO, and it also shows activity against α1-3 linked GalNAc. This enzyme serves as a valuable tool in the analysis of complex O-glycosylated proteins that have α-linked GalNAc as a core 1 with a sugar chain that has stopped elongating, reducing sample heterogeneity. 【Features】 ■ Hydrolyzes GalNAc on glycoproteins under native conditions ■ Shows activity in the pH range of 6.0 to 7.6 ■ No cofactors or special buffers are required ■ Reactions on glycoproteins are completed in 2 hours (depending on the nature of the substrate) ■ Complex samples may require overnight incubation *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

"GalactEXO" is a mixture of β-galactosidases that hydrolyze terminal galactose linked by β1-3,4 bonds in N- and O-glycosylated proteins. This enzyme is useful for trimming galactose on free glycan structures in exoglycosidase arrays and for producing antibodies with a homogeneous G0/G0F glycan profile. 【Features】 ■ Mixture of β-galactosidases ■ Efficiently promotes the hydrolysis of β1-3,4-linked galactose on glycoproteins ■ Acts on both N- and O-glycosylated structures ■ Completes the hydrolysis of terminal galactose within 2 hours ■ Applicable for glycan sequencing and trimming of glycans in the antibody Fc region *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

The enzyme 'SialEXO' is a sialidase useful for the removal and analysis of sialic acid. This enzyme shows activity on both N- and O-linked glycans present in native glycoproteins and free glycans. It is used for the processing of O-glycosylated proteins before digestion with OpeRATOR or OglyZOR, and other applications include reducing sample complexity, charge variant analysis, and exoglycosidase arrays. 【Features】 ■ Useful for the removal and analysis of sialic acid ■ Shows activity on both N- and O-linked glycans present in native glycoproteins and free glycans ■ Used for the processing of O-glycosylated proteins before digestion with OpeRATOR or OglyZOR ■ Hydrolyzes glycoproteins under native conditions, demonstrating high activity over a wide pH range of 6.5 to 9 *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

"OglyZOR" is an endoglycosidase (O-glycosidase) that specifically hydrolyzes two core 1 O-linked glycans on native glycoproteins. It is used for the removal of O-linked glycans for glycan analysis, confirmation of the presence of O-linked glycans, and reduction of sample heterogeneity. For activity, it is necessary to remove the terminal sialic acid from the O-linked glycans, so SialEXO, a mixture of multiple sialidases, is included, and optimal activity is achieved at pH 6.5 to 7.5 and 37°C. 【Features】 ■ Specifically hydrolyzes two core 1 O-linked glycans on native glycoproteins ■ Used for the removal of O-linked glycans for glycan analysis, confirmation of the presence of O-linked glycans, and reduction of sample heterogeneity ■ Generally does not require denaturation of the substrate ■ Includes SialEXO, a mixture of multiple sialidases ■ Optimal activity is achieved at pH 6.5 to 7.5 and 37°C *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

"OpeRATOR" is a specific protease that cleaves the N-terminal residues of Ser and Thr in glycan residues of proteins with mucin-type O-linked glycans. O-linked glycopeptides are generated, allowing for O-linked glycan profiling, peptide mapping, determination of site occupancy, and intermediate-level approaches through MS analysis. 【Features】 ■ Specifically cleaves proteins with O-linked glycans ■ Generates O-linked glycopeptides ■ Enables O-linked glycan profiling, peptide mapping, determination of site occupancy, and intermediate-level approaches through MS analysis ■ Does not digest glycoproteins at N-linked glycan sites *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

"GingisREX (RgpB)" is an arginine-specific protease that cleaves proteins at the C-terminal of arginine residues. It is capable of cleaving arginine-proline sequences, which are difficult to cleave with other enzymes. This enzyme is useful for peptide mapping, de novo peptide sequencing, and the analysis of post-translational modifications. 【Features】 - Cleavage is possible even when the adjacent amino acid is proline. - Compared to cleavage by trypsin, longer peptides are generated, allowing for separation and identification using high-resolution MS. - Increases options for sample preparation for bottom-up approaches, improving degradation profiles and sequence coverage. - Shows activity over a wide pH range of 5.0-9.0, requires cysteine, but is inhibited by guanidine hydrochloride. *For more details, please refer to the PDF document or feel free to contact us.*

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

TransGLYCIT is a platform technology for efficiently transglycosylating native human IgG within 3 hours. Using enzymatic remodeling, it enables the transglycosylation of N-linked glycans in the Fc region of antibodies, resulting in a robust workflow that allows for the preparation of antibody products with specific glycoforms. This technology is available in kit form for producing antibodies with G0, G1, G2, or G2S2 glycan profiles (± fucose), and there is also an option to remove fucose from the core GlcNAc using the TransGLYCIT Afucosylated kit. 【Features】 ■ Efficiently transglycosylate native human IgG within 3 hours ■ Allows for the preparation of antibody products with specific glycoforms ■ Available in kit form for producing antibodies with G0, G1, G2, or G2S2 glycan profiles (± fucose) ■ Option to remove fucose from the core GlcNAc is also available *For more details, please refer to the PDF document or feel free to contact us.

• Research Antibodies
• Other protein analysis

"GingisKHAN (Kgp)" is a cysteine protease that cleaves human IgG1 at a specific site upstream of the hinge region, producing intact and homogeneous Fab and Fc fragments. This enzyme is used for the characterization of antibody-based biological therapies using LC-MS, Fc glycan analysis, studies on the effects of bispecific antibodies, affinity and binding strength, as well as the identification of post-translational modifications. [Features] - Cleaves human IgG1 at a specific site upstream of the hinge region - Produces intact and homogeneous Fab and Fc fragments - Used for the characterization of antibody-based biological therapies using LC-MS, Fc glycan analysis, studies on the effects of bispecific antibodies, affinity and binding strength, and the identification of post-translational modifications *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

"FabULOUS(SpeB)" is a cysteine protease that digests the hinge regions of various species and subclasses of IgG, generating a pool of uniform Fab fragments. The prepared Fab fragments can be used for affinity studies, Fab glycosylation studies, structural studies, and more. This enzyme requires reducing conditions to show activity against IgG, and under strong reducing conditions, disulfide bonds may be reduced. 【Features】 ■ Digests the hinge regions of various species and subclasses of IgG ■ Generates a pool of uniform Fab fragments ■ The prepared Fab fragments can be used for affinity studies, Fab glycosylation studies, structural studies, and more ■ Cleaves the upper part of the IgG1 hinge region *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

"FabRICATOR Z (IdeZ)" is a cysteine protease that cleaves specific sites downstream of the hinge region of mouse IgG2a and IgG3, generating a homogeneous pool of F(ab')2 and Fc fragments after 2 hours of incubation. Some mouse IgG2a that cannot be digested by FabRICATOR can be easily digested with this product, although a longer incubation time may be required. Additionally, due to the high specificity of the enzyme, there is no risk of over-digestion. 【Features】 ■ Cleaves specific sites downstream of the hinge region of mouse IgG2a and IgG3 ■ Generates a homogeneous pool of F(ab')2 and Fc fragments after 2 hours of incubation ■ Some mouse IgG2a can be easily digested ■ No risk of over-digestion due to the high specificity of the enzyme *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

"FabALACTICA(IgdE)" is a cysteine protease that digests specific sites in the upper hinge region of human IgG1, producing intact and homogeneous Fab and Fc fragments. This enzyme facilitates the characterization of bispecific and multispecific antibodies and the analysis of intact Fc glycosylation. Additionally, it makes research on monovalent binding, higher-order structures, disulfide scrambling, and antibodies with mutations in the hinge region easier. 【Features】 ■ Digests specific sites in the upper hinge region of human IgG1 ■ Produces intact and homogeneous Fab and Fc fragments ■ Facilitates the characterization of bispecific and multispecific antibodies and the analysis of intact Fc glycosylation ■ Makes research on monovalent binding, higher-order structures, disulfide scrambling, and antibodies with mutations in the hinge region easier *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

"FabRICATOR(IdeS)" is an IgG-specific cysteine protease that digests antibodies at a single amino acid site just below the hinge region. It is capable of generating homogeneous F(ab')2 and Fc fragments. This enzyme is widely used for the characterization, quality control, stability testing, production monitoring, and clone selection of antibody-based therapeutics such as mAbs, ADCs (antibody-drug conjugates), biosimilars, and Fc fusion proteins. 【Features】 ■ Digests antibodies at a single amino acid site just below the hinge region ■ Capable of generating homogeneous F(ab')2 and Fc fragments ■ Pre-treatment for LC-MS analysis workflow at an intermediate level - Reduces subunits to generate fragments of 23–25 kDa - Enhances mass resolution to accurately determine important quality attributes *For more details, please refer to the PDF document or feel free to contact us.

• Other restriction enzymes
• Research Antibodies
• Other protein analysis

The "Assay Genie Hamster ELISA Kit" can be used as an analytical tool to quantitatively measure cytokine production in hamster samples. This small animal model is useful for studying the etiology of human infectious diseases, and furthermore, using the hamster model allows for the confirmation of the efficacy and interactions of treatments and vaccines against pathogens. This kit serves as an excellent research tool for elucidating the fundamental immune responses to infectious diseases. 【Features】 ■ Detection sensitivity - capable of detecting at the (sub)picogram level ■ Ready-to-use, pre-coated 96-well ELISA kit ■ Specificity - tested for cross-reactivity *For more details, please refer to the related links or feel free to contact us.

• Ingredient analysis
• Other Analysis

Immobilized PNGase F is a product in which the enzyme PNGase F (Peptide N-glycosidase F) is covalently bonded to agarose beads in a spin column format, allowing for the easy removal of N-glycans from antibodies, fusion proteins, and other N-glycosylated proteins. This enzyme is produced by expressing a gene derived from Elizabethkingia meningoseptica in E. coli through recombinant methods. Samples of glycoproteins are incubated with Immobilized PNGase F under standard reaction conditions for 1 hour to overnight, or under denaturing reaction conditions (using RapiGest SF Surfactant) for 15 to 60 minutes. The deglycosylated glycoproteins can then be easily collected by centrifugation. The activity of PNGase F on some glycoproteins may be reduced or inhibited due to steric hindrance. In such cases, longer incubation times or denaturation of the glycoproteins may be necessary.

• Other bio-related products
• Other protein analysis

Introducing Genovis enzymes useful for the evaluation and analysis of antibody-drug conjugates. ◎FabRICATOR (IdeS) An enzyme that digests specific sites just below the hinge region of antibodies. It generates a uniform pool of F(ab')2 and Fc/2 with a 30-minute incubation. Typically, IgG is digested within 30 minutes, but there is no risk of excessive digestion even with longer incubation times. The enzyme activity is maximized at 37°C, but it can also be used at room temperature by extending the reaction time. ◎IgGZERO (EndoS) An enzyme that hydrolyzes the N-linked glycans in the Fc region of IgG. It is useful for reducing complexity through rapid deglycosylation of IgG and inactivating the effector functions of the Fc region. ◎GlycINATOR (EndoS2) An enzyme that hydrolyzes the glycans in the Fc region of IgG. It has been demonstrated to remove glycan structures on IgG, including high-mannose, hybrid, complex, and bisecting type glycans. *You can view the product information (in English) by downloading the PDF. Feel free to contact us with any inquiries.

• Other analysis and evaluation services

Basic amines contained in drug discovery molecules are prone to ionization at physiological pH, leading to reduced lipophilicity, which is believed to affect membrane permeability and oral absorption. Furthermore, basic molecules can cause hERG inhibition and strongly bind to α-acidic glycoproteins, resulting in a decrease in the free drug concentration in plasma. "SpiroKit1" consists of derivatives of nitrogen-containing heterocyclic compounds such as azetidine, and by replacing these derivatives with parts of drug discovery molecules, it is possible to freely adjust the pKa. This adjustment can optimize issues related to hERG inhibition and cellular permeability. *For more details, please refer to the PDF materials or feel free to contact us.*

• Other analytical and testing equipment

Aryl amines are commonly used structures in screening libraries, but they tend to generate highly reactive metabolites, which can become problematic in the later stages of drug development. Additionally, many sp2-rich molecules fail to achieve excellent pharmacokinetic properties. To address these specific issues associated with sp2 carbons, "SpiroKit2" has been developed. This kit consists of sp3-rich linkers that can mimic benzene ring structures and includes bicyclo[1.1.1]pentane derivatives and cubane derivatives. By introducing these structures into drug discovery molecules, the proportion of sp3 carbons within the molecule increases, allowing for improved solubility and the adjustment of lipophilicity. Moreover, compared to sp2-rich structures that adopt planar conformations, sp3-rich structures possess three-dimensional chemical space, enabling the adjustment of the stereochemical shape of drug discovery molecules. These changes in physical properties yield positive results for pharmacokinetic characteristics. *For more details, please refer to the PDF document or feel free to contact us.*

• Other analytical and testing equipment

Stereochemically restricted amino acids have become one of the fundamental building blocks in modern drug discovery chemistry, allowing for the expression of important structural features in drug design by controlling the conformation of side chains in these amino acids. Specifically, by combining amines and carboxylic acids functionalized at chiral centers with side chains that have restricted stereoconformation, it is possible to achieve unique three-dimensional structures with functionality. In this way, restricted amino acids provide diverse information for investigating structure-activity relationships and are essential components in peptide mimetics. Additionally, due to their unique three-dimensional structures, these amino acids serve as special motifs to enhance pharmacological activity, selectivity, and ADME, and are expected to improve membrane permeability, oral bioavailability, and metabolic stability. 【SpiroKit3 Features】 ■ Composed of stereochemically controlled amino acids ■ In addition to α,α-disubstituted amino acids, special amino acids with β-amino acids and spiro rings as their framework are also included. *For more details, please refer to the PDF document or feel free to contact us.

• Other analytical and testing equipment

In general, building blocks in drug discovery chemistry include scaffolds such as piperidine, piperazine, morpholine, and thiomorpholine. "SpiroKit4" employs azaspiro[3.3]heptane derivatives as alternatives to these scaffolds. By replacing the monocyclic heterocyclic portions contained in drug discovery molecules with spiro[3.3]heptane derivatives, it is possible to uniquely adjust the physicochemical and biochemical properties of the drug discovery molecules. These adjustments enable the exploration of new chemical spaces, and there are reports of improvements in metabolic stability and ADME using this method. *For more details, please refer to the PDF materials or feel free to contact us.*

• Other analytical and testing equipment

"Mastermix 16S/18S" guarantees powerful amplification activity and accuracy, ensuring high-sensitivity detection of bacterial and fungal DNA. It is compatible with commercially available PCR or real-time PCR equipment, including thermal cyclers. It is suitable for PCR/real-time PCR. 【Features】 ■ High-activity Taq polymerase ■ Microbial DNA-free ■ High amplification activity within 40 cycles ■ Ultra-high sensitivity detection of fungal DNA and bacterial DNA ■ Well-suited for PCR/real-time PCR *For more details, please refer to the PDF document or feel free to contact us.

• reagent
• Other research reagents
• Staining Reagents

Lipotype's shotgun lipidomics is a cutting-edge lipid analysis service. Their mass spectrometry-based technology is highly useful for many researchers in the biotech, pharmaceutical, food, and cosmetics industries. It is possible to receive analysis data shortly after ordering lipidomics analysis. <Capable of measuring over 3100 types of lipids> Lipotype's shotgun lipidomics covers an extremely wide range of lipids. This service identifies 57 different lipid classes (such as phosphatidylcholine [PC]) at the level of lipid species (e.g., PC 34:0) or subtypes (e.g., PC 18:0_16:0 + fatty acid information). In total, it is capable of measuring over 3100 types of lipids. [Please refer to the attached PDF for the types of lipids that can be measured.]

• Other Analysis
• Other analytical and testing equipment
• Other bio-related products and services

GlycINATOR (EndoS2) is an endoglycosidase derived from Streptococcus pyogenes that hydrolyzes the glycan chains in the Fc region of IgG. This enzyme has been shown to remove all glycan structures (glycoforms) on IgG, including high-mannose, hybrid, complex, and bisecting type glycans (Sjögren et al. 2015). It deglycosylates human IgG (all subclasses) as well as IgG from many different animal species, including mice, rats, monkeys, sheep, goats, cows, and horses. However, its activity against glycans derived from alpha-1-acid glycoprotein has been reported to be limited (Sjögren et al. 2013). This enzyme is expressed and produced in Escherichia coli, contains a His tag, and has a molecular weight of 92 kDa. This enzyme is useful for reducing the complexity of antibody-based therapies and for studying fucose modifications and the occupancy of N-linked glycans. Rapid and mild reaction conditions minimize the risk of modifications during sample pretreatment (Sjögren et al. 2015).

• Research Antibodies
• Other protein analysis
• Other analytical and testing equipment

<Introduction> Antibodies are challenging molecules to characterize due to their size and complexity. A compelling approach to combat diseases such as cancer is to conjugate drugs (payloads) to antibodies, but this further increases the risks of complexity and heterogeneity. Antibody-drug conjugates (ADCs), like other IgG-based biopharmaceuticals, require careful and detailed characterization and appropriate analytical workflows. The "FabRICATOR" product from Genovis allows for the digestion of ADCs into subunits, enabling detailed characterization of this complex class of drugs. Additionally, the endoglycosidases "IgGZERO" and "GlycINATOR" help reduce complexity and improve resolution, making intact ADC studies possible. [Genovis actively hosts web meetings and seminars. Please feel free to contact us for adjustments according to your needs.]

• Research Antibodies
• Other protein analysis
• Other analytical and testing equipment

IgGZERO (EndoS) is an endoglycosidase derived from Streptococcus pyogenes that hydrolyzes the N-linked glycans in the Fc region of IgG. It is useful for reducing complexity through rapid deglycosylation of IgG and inactivating the effector functions of the Fc region. This enzyme deglycosylates IgG from various animal species, including human IgG (all subclasses), as well as IgG from mice, rats, monkeys, sheep, goats, cows, and horses. The enzyme specifically hydrolyzes only the glycans in the Fc region of IgG, even in the presence of other glycosylated proteins in solution. It is expressed and produced in E. coli, contains a His tag, and has a molecular weight of 110 kDa. Genovis actively holds web meetings and seminars. Please feel free to contact us for adjustments according to your requests.

• Other protein analysis
• Other analytical and testing equipment
• Research Antibodies

FabRICATOR (IdeS) is a unique enzyme that digests specific sites just below the hinge region of antibodies. It generates a uniform pool of F(ab')2 and Fc/2 with a 30-minute incubation. No substrates other than IgG are known. Typically, IgG is digested within 30 minutes, but there is no risk of excessive digestion even with longer incubation times. FabRICATOR digests IgG under physiological conditions, maintaining its immunoreactivity. The enzyme activity is maximized at 37°C, but it can also be used at room temperature by extending the reaction time. FabRICATOR digests all subclasses of IgG from humans, monkeys, rabbits, and sheep. However, its activity against mouse IgG2a and IgG3 is limited. For the digestion of these antibodies, the use of FabRICATORZ is recommended. ● Genovis actively holds web meetings and seminars. Please feel free to contact us for adjustments according to your requests.

• Research Antibodies
• Other protein analysis
• Other analytical and testing equipment

"MolYsis" is a tool that removes human DNA and concentrates bacterial and fungal DNA from liquid samples. Technically, it is effective in a short series of steps for the selective lysis of blood cells and the quantitative degradation of released human DNA (>99%). After the lysis solution is concentrated by centrifugation, the microorganisms are treated with reagents that break down the cell walls of gram-positive bacteria, gram-negative bacteria, and fungi. It has been clinically evaluated for a wide range of microbial lysis, demonstrating effectiveness against over 200 species of bacteria and 65 species of fungi. From December 1, 2021, to March 31, 2022, Jumatsu Trading will offer a trial kit of "MolYsis Complete5" from this series at a special price. For more details, please check our website's news section (December 1, 2021: Announcement). [Features] - Removes human DNA - Selectively concentrates bacterial and fungal DNA - Removes PCR inhibitors - Dissolves a wide range of bacteria and fungi *For more details, please refer to the PDF materials or feel free to contact us.

• Other Nucleic Acid/DNA Research
• Real-time PCR
• Other Amplification/PCR

Lipotype offers unique lipid analysis services ranging from organelles, microorganisms, and cultured cells to tissues and organs. The advantages include absolute quantification of over 2,300 types of lipids, small sample volumes (100,000 cells), and delivery of analysis results within two weeks. Services include delivery, comprehensive statistical analysis, and graphical presentation of data. 【Features】 ■ Analysis of an ultra-wide range of lipids ■ Fast and high-throughput analysis ■ Absolute quantification ■ High quality ■ Use of dedicated software LipotypeXplorer for lipid identification *For more details, please refer to the external link page or feel free to contact us.

• Other contract services
• Other analysis and evaluation services

At Levena Biopharma, we have experienced scientists involved in the modification of ADCs, capable of providing rapid PoC regardless of scale. By combining linker payloads and modification methods, we offer high-quality custom ADCs at competitive prices. Our services include comprehensive reports that contain characteristic specifications. We also have a proven track record of supplying over a hundred types of ADCs made from human, mouse, or rat IgG1 or IgG2, at scales ranging from 1mg to 200mg. 【ADC Characterization Methods, etc.】 ■ Analytical Tools: HPLC (HIC, SEC, RP), iCIEF, LC-MS ■ Quality: Drug-to-Antibody Ratio (DAR), purity via SDS-PAGE, aggregation, endotoxins, residual drugs ■ In vitro Pharmacology: Over 100 common tumor cell lines for cytotoxicity studies ■ ADC reference standards are also available for comparative characterization ■ Development of analytical methods and stability studies ■ Scale-up and process development services to commercial scale *For more details, please refer to the external link page or feel free to contact us.

• Custom reactions and synthesis
• Other contract services

The product is a glass plate coated with fluorescent indicator F254 silica gel. It is a 320 glass plate measuring 2.5×7.5 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 GF254 ■ Number: CS-E0009 ■ Material: Glass support, silica gel matrix ■ Features: Binder high molecular fluorescent indicator ■ Packaging: 320 units in a fiber case ■ L×W: 2.5×7.5 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.25 mm *You can download the English version of the catalog. *For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
• others

The product is a glass plate coated with fluorescent indicator F254 silica gel. It is a 640 glass plate measuring 2.5×5.0 cm. 【Data Sheet】 ■Name: HPTLC Silica Gel 60 GF254 ■Number: CS-E0010 ■Material: Glass support, silica gel matrix ■Features: Binder high molecular fluorescent indicator ■Packaging: 640 units in a fiber case ■L×W: 2.5×5.0 cm ■Shipping: Ambient ■Storage Temperature: Room temperature, caution with humidity ■Layer Thickness: 0.25 mm *You can download the English version of the catalog. *For more details, please refer to the PDF document or feel free to contact us.

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The product is a glass plate coated with fluorescent indicator F254 silica gel. It is an 80 glass plate measuring 5.0×20 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 GF254 ■ Number: CS-E0011 ■ Material: Glass support, silica gel matrix ■ Features: Binder polymer fluorescent indicator ■ Packaging: 80 units in a fiber case ■ L×W: 5.0×20 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.25 mm * You can download the English version of the catalog. * For more details, please refer to the PDF document or feel free to contact us.

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The product is a glass plate coated with fluorescent indicator F254 silica gel. It is a 20 glass plate measuring 20×20 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 GF254 ■ Number: CS-E0013 ■ Material: Glass support, silica gel matrix ■ Features: Binder high polymer fluorescent indicator ■ Packaging: 20 units in a fiber case ■ L×W: 20×20 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.25 mm * You can download the English version of the catalog. * For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
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The product is a glass plate coated with fluorescent indicator F254 silica gel. It is an 800 glass plate measuring 2.0×5.0 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 GF254 ■ Number: CS-E0020 ■ Material: Glass support, silica gel matrix ■ Features: Binder polymer fluorescent indicator ■ Packaging: 800 units in a fiber case ■ L×W: 2.0×5.0 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.25 mm * You can download the English version of the catalog. * For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
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