Cytiva List of Products and Services

We have prepared a "Selection Guide (Japanese version)" that summarizes 13 key points to keep in mind when choosing a filter integrity testing device. If you thoroughly consider and define what the important evaluation criteria are and which items can be compromised before making an actual selection, you will only need to gather information and compare it based on the defined evaluation criteria. It also includes points that are often overlooked during device selection, so please make use of it when considering your options!

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Paul has contributed to the establishment of many current standards regarding filter validation of critical processes and the use of single-use systems, based on over 40 years of experience in validation support. Moving forward, we will continue to be at the forefront of development to support the adoption of new technologies such as continuous production. We provide professional consulting and testing services while safeguarding our clients' highly confidential information. 【General Testing】 ■ Bacterial Challenge Testing ■ Compatibility Testing ■ Consulting on Extractables ■ Extractables and Leachables Testing ■ Leachables Reduction (Flushing) Testing ■ Integrity Testing Factor Setting with Pharmaceutical Solutions *For more details, please refer to the PDF materials or feel free to contact us.

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The "Enfron® HTPFR Filter Cartridge" is designed for the filtration sterilization of high-temperature gases used in the fields of pharmaceutical manufacturing and biopharmaceutical manufacturing, as well as for tank venting of vented and ozone-treated water, and for filtration sterilization of high-concentration oxygen air. It includes a dual-layer hydrophobic polytetrafluoroethylene (PTFE) membrane manufactured by Paul, which possesses antioxidant properties, and the materials used in the cartridge can be utilized for long-term gas filtration applications up to 100°C. 【Features】 ■ Water intrusion testing is possible ■ Uses PTFE membrane uniquely manufactured by Paul ■ Made with materials that have excellent oxidation resistance ■ Challenges B. diminuta at >10^7 cfu/cm2 and obtains validation data *For more details, please refer to the PDF document or feel free to contact us.

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The Supor(R) EX ECV filter combines a unique membrane configuration with a laid-over pleat structure and narrow core design, offering both high processing capacity and flow characteristics. With excellent pH compatibility and high permeability for the active ingredient, protein, it is an optimal filtration sterilization grade filter (0.2 μm) for liquids that are difficult to filter. 【Features】 - Composed of a two-layer hydrophilic polyethersulfone (PES) membrane *For more details, please refer to the PDF document or feel free to contact us.

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The Fluorodyne® II DFL filter is widely used for final filtration sterilization of process liquids with relatively low clogging. It is a filtration sterilization grade filter (0.2 μm) characterized by low extractables and low adsorption, and has a proven track record in many process-specific validation tests. *For more details, please refer to the PDF materials or feel free to contact us.*

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The Fluorodyne® II DJL filter with a filtration precision of 0.1 μm is an optimal mycoplasma control filter for processing fluids with good flow characteristics that are relatively resistant to clogging, under low differential pressure or for short periods of time. 【Features】 - Constructed with a dual-layer target membrane - Filter packing structure optimized to exhibit good flow characteristics until reaching filtration capacity *For more details, please refer to the PDF document or feel free to contact us.

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Supor(R) EBV is a sterilizing filter with a pore size of 0.2 μm. It features a special two-layer structure to enhance protective effects, allowing for efficient and economical filtration. Additionally, the use of hydrophilic polyethersulfone (PES) membranes results in very low adsorption of proteins and preservatives, which is also characterized by a high recovery rate of the target substances. 【Features】 - Excellent flow characteristics with a wide membrane area due to the ultra-pleated structure [U.S. Patent No. 5543047]. - Adoption of a two-layer structure combined with an asymmetric pre-layer to maximize protective effects. - Low adsorption performance and broad chemical resistance. - Improved differential pressure during SIP compared to conventional products. - Enhanced cumulative sterilization time by autoclaving compared to conventional products. *For more details, please refer to the PDF document or feel free to contact us.

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The Fluorodyne® EX EDT filter has a nominal filtration accuracy of 0.1 μm and is a mycoplasma control filter that has enhanced compatibility with biologics that are prone to clogging. 【Features】 - Raid-over pleat structure and narrow core 10-inch module cartridge design - The effective filtration area per 10 inches is 0.95 m², achieving a larger filtration area than conventional filters - Asymmetric membrane adopted *For more details, please refer to the PDF document or feel free to contact us.

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The Fluorodyne® EX EDF filter features a unique hybrid membrane structure that demonstrates excellent filtration and sterilization performance even for fluids that are prone to clogging in conventional filtration sterilization filters. This filter can be steam sterilized whether the cartridge is dry or wet. It has a laid-over pleat structure and incorporates cutting-edge technologies such as asymmetric PES membranes, making it suitable for purification processes after clarification and for filtering formulations that include liposomes and emulsions. **Features** - Excellent flow characteristics due to ultra-pleat structure technology and narrow core design, providing a large membrane area. - High particle capture capacity and long life due to a two-layer structure combining mach V technology's polyethersulfone (PES) pre-layer and hydrophilic PVDF final layer. - Low adsorption characteristics and broad chemical resistance. - Low extractables. - Design allows for SIP (Steam-In-Place) whether the cartridge is dry or wet, among others. *For more details, please refer to the PDF documentation or feel free to contact us.*

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Supor(R) EKV is a 0.2 μm filter sterilization filter ideal for cost-effective filtration sterilization, such as for filtering buffers and media. It features a special two-layer structure to enhance protective effects, allowing for efficient and economical filtration. Additionally, the use of hydrophilic polyethersulfone (PES) membranes results in very low adsorption of proteins and preservatives, which contributes to a high recovery rate of target substances. 【Features】 - Excellent flow characteristics with a wide membrane area due to the ultra-pleated structure [U.S. Patent No. 5543047] - Two-layer structure combined with an asymmetric pre-layer to maximize protective effects - Low adsorption performance and broad chemical resistance - Improved differential pressure during SIP compared to conventional products *For more details, please refer to the PDF document or feel free to contact us.

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The Supor(R) EAV filter ensures high processing capacity and flow rate in the filtration of buffers and bioprocess fluids. 【Features】 - Achieves a more compact and economical filtration system through a narrow core design with a smaller core diameter and the adoption of asymmetric membrane technology in a laid-over pleat structure. - Guarantees excellent microbial filtration efficiency in processes where the bioburden can fluctuate, with a removal efficiency of Brevundimonas diminuta exceeding 6 LRV. *For more details, please refer to the PDF document or feel free to contact us.

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By combining a novel and gentle massage-style process with customizable solutions for temperature and time, we achieve the extraction of single cells from solid tissues such as tumors with minimal damage and a high survival rate. This can be utilized in single-cell RNA sequencing and various omics applications (genomics, proteomics, metabolomics), as well as flow cytometry. If you are struggling with noise after sequence analysis, the number of detected cells, or the number of genes, this is a must-see! *For more details, please contact us or download the PDF materials. *If you would like a demo, please get in touch.

• Other cells

The Acro 500 is a filter capsule equipped with a Supor EKV membrane and a polycarbonate housing, featuring an effective filtration area of 500 cm², allowing for the filtration and sterilization of large volumes of solutions. This capsule incorporates a dual-layer membrane made of polyethersulfone (PES), enabling high-flow filtration. This membrane has low binding characteristics for proteins and preservatives, allowing for maximum permeability of the target components. Additionally, it is compatible with a wide range of solvents, making it suitable for filtration in various applications such as buffers and culture media. The polycarbonate outer housing has improved optical clarity, facilitating easy venting of the capsule during use and maximizing membrane area and flow rate.

• Culture medium

The Acrodisc WBC syringe filter uses unique filter technology to separate white blood cells from 10 mL of whole blood in less than 10 minutes. This syringe filter contains Leukosorb media, which has two properties: size exclusion and adsorption. It captures and collects white blood cells from whole blood samples while allowing red blood cells and platelets to pass through the membrane with its fibrous matrix.

• Filtration Filter

Exosome purification utilizes various ultracentrifugation methods with established size fractionation protocols. However, due to the nature of ultracentrifugation, there is a challenge in increasing the amount of sample that can be processed. Cytiva offers a "TFF system" that combines flow systems and tangential flow filtration, which is introduced as one solution to this challenge. Additionally, there are examples of its use for the purification and concentration of exosomes from cultured cells. To perform exosome purification from large-volume samples derived from cultured cell lines, we provide products suitable for each step, including the removal of cells and debris, the removal of microvesicles and other cellular vesicles, and the purification of exosomes. 1. Debris removal from cell culture media: Supracap 50, 100 depth filter capsules 2. Removal of microvesicles and other cellular vesicles: VacuCap bottle-top filters 3. Exosome purification: Minimate EVO TFF system [1] Jong et al., Nat Commun. 2020. 11. 1113.

• Other cell research

Cytiva offers a product lineup suitable for the small-scale "exosome purification" process. We provide the "AcroPrep 24-well filter plate," which is suitable for the removal of cells and debris, as well as the "Acrodisc syringe filter" with pore sizes of 0.1 and 0.2 µm, which is suitable for the removal of microvesicles. Additionally, we have a wide range of centrifugal filtration devices for exosome purification, including "Nanosep" and "Microsep." 【Product Lineup】 ■ AcroPrep 24-well filter plate ■ Acrodisc syringe filter ■ Centrifugal filtration devices for ultrafiltration - Nanosep (<0.5 mL) - Microsep (0.5-5 mL) - Macrosep (5-20 mL) - Jumbosep (20-60 mL) *For more details, please refer to the PDF document or feel free to contact us.

• Other cell research

We offer membrane disc filters that are optimal for filtering mobile phase solvents in HPLC. - wwPTFE (highly hydrophilic PTFE) membrane: A highly versatile filter that can be used for aqueous and organic solvents. It has excellent chemical resistance and can handle strong organic solvents, making it ideal for filtering mobile phase solvents in HPLC. - Nylaflo (nylon) membrane: A hydrophilic membrane with excellent chemical compatibility for esters, alkalis, and alcohols (however, it cannot be used with solvents containing acids of 1N or higher, or halogenated compounds). - PTFE membrane: Exhibits outstanding chemical compatibility for filtering strong organic solvents. These membranes can be used in combination with Solback filter holders suitable for filtering mobile phase solvents.

• Filter paper/filter

This is a manifold ideal for suction filtration with the AcroPrep filter plate series. It is compatible with 24, 96, and 384 well filter plates. This manifold is made of durable anodized aluminum and comes with the necessary O-rings and gaskets. The control block includes a vacuum pressure gauge, a vacuum metering valve, a vacuum release valve, and a 1/4 inch hose barb for vacuum line attachment. The suction manifold unit comes with a spacer block that accommodates standard 350 μL receiver plates. Additionally, a spacer block for 1 mL receiver plates is also available separately.

• Filtration Equipment

The NanoSep MF centrifugal filtration device is a 1.5 mL tube-style filter equipped with wwPTFE (highly hydrophilic PTFE). It is useful for the pretreatment of small amounts of analytical samples, capable of high-speed rotation at 14,000xg, allowing for rapid sample filtration. Features: ● Rapid sample processing: Designed for use in centrifuges, it can simultaneously centrifuge multiple samples. ● Versatile membrane filter: Built with a wwPTFE (highly hydrophilic PTFE) membrane, it has chemical resistance to aqueous solutions, organic solvents, and corrosive organic solvents. ● High recovery rate: The wwPTFE membrane has low protein adsorption, effectively removing unwanted particles from samples while achieving high recovery rates of valuable proteins. ● Low leachables: HPLC-grade centrifuges have been proven to have low levels of leachables that absorb UV. ● Leak-free structure: With a unique sealing technology, it guarantees no sample leakage by avoiding the use of potentially contaminating materials such as O-rings or adhesives.

• Filtration Filter

The Solvback Filter Holder is used for the removal of contaminating particles from the mobile phase and for degassing. It can filter up to 4 liters of mobile phase solvent at once, eliminating the need to top up the filter funnel. After installing the Solvback Filter Holder in a vacuum container and connecting it to a vacuum source, filtration begins by placing the inlet tube into the solvent to be filtered. Made of durable polypropylene, it is compatible with common HPLC mobile phase solvents such as methanol, acetonitrile, and tetrahydrofuran. The surfaces of the filter holder that come into direct contact with the mobile phase are all made of polypropylene. Features ● Highly versatile design that fits most HPLC bottles, flasks, and containers ● Direct suction from HPLC solvent bottles ● Made of shatter-resistant plastic ● Patented magnetic sealing

• Other filtration equipment and instruments

NanoSep is a centrifugal device for ultrafiltration that incorporates a membrane (Omega membrane) in a 1.5 mL tube size. It is suitable for sample volumes of 50 - 500 µL and is effective for the purification and desalting of small-scale proteins and nucleic acids. For example, it can be used for sample preparation and SDS removal in protein or peptide analysis using LC/MS. Additionally, recent studies have utilized NanoSep with a 300K MWCO (molecular weight cut-off) for the purification of SARS-CoV-2 virus present in human nasopharyngeal swabs. - Rapid sample processing time - Low protein adsorption Omega (modified PES) membrane - Wide range of molecular weight cut-offs - Leak prevention of concentrated solutions into the receiver using ultrasonic sealing technology

• Other purification and extraction

AcroPrep filter plates can perform high-throughput ultrafiltration processes for protein and nucleic acid samples, viral vectors, and extracellular vesicles. They utilize modified PES as the ultrafiltration membrane and support a wide range of MWCO (molecular weight cut-off) from 1K to 100K. Additionally, they have low protein binding properties, contributing to high recovery rates of samples. The filter plates are available in three formats: 24, 96, and 384 wells. When selecting the MWCO, it is recommended to choose a MWCO that is 1/3 to 1/6 times the molecular weight of the protein to be retained when concentrating proteins. For recovering the filtrate, it is advisable to select a membrane with an MWCO that is 3 to 6 times that of the target protein. We are distributing samples for free, so please indicate your desired number of wells and MWCO value in the inquiry section. In the FASP method, it is used for chemical modifications of purified proteins and washing of reaction reagents on a 96-well ultrafiltration membrane. Reference: Potriquet, J., et al., PLOS ONE 12 e0175967 (2017)

• Ultrafiltration

The AcroPrep 96-well filter plate features a silica-based quartz glass fiber media that efficiently captures DNA and RNA for nucleic acid binding (NAB). This media can be used to purify plasmid DNA from bacteria or genomic DNA and total RNA from cell culture samples. Therefore, it can be utilized for a wide range of applications with a single plate. This filter plate has a structure with longer tips at the bottom of the wells, minimizing sample leakage. This property reduces the risk of cross-contamination when removing the filter plate from the receiver plate. To reduce costs, Cytiva's NAB plates can be used in conjunction with commercially available reagents to prepare genomic DNA or RNA, achieving quality and yield that is equal to or greater than that of commercial kits.

• Other purification and extraction

Cytiva's filter plates can perform pre-filtration of the majority of samples simultaneously using centrifugation or suction manifolds. For precise filtration of common aqueous solutions, we recommend the use of Supor (PES) membranes. Supor has high flow characteristics and is an excellent membrane material that meets the requirements for biological, pharmaceutical research, and sterilizing filtration. It also has low protein binding and broad chemical compatibility. Supor membranes are available in various pore sizes depending on the purpose of sample pre-treatment. ■ 0.1 μm - Reduction of mycoplasma ■ 0.2 μm - Sterilizing filtration ■ 0.45 μm - Clarification, filtration of large viruses ■ 0.8 - 5 μm - Removal of large particles, pre-filtration For the clarification of cells or lysates, filter plates equipped with pre-filters are recommended. By incorporating a pre-filter, clogging of the main filter is less likely to occur.

• Other experimental consumables

The "Fluorotrans PVDF membrane" achieves high sensitivity protein detection with low background and low protein leaching. It is suitable for various protein analysis applications, including sequencing and Western transfer. With a large surface area and strong hydrophobic interactions, it has a higher protein adsorption capacity than nylon or nitrocellulose transfer membranes. 【Features】 ■ Achieves high sensitivity protein detection with low background and low protein leaching ■ Large surface area with strong hydrophobic interactions ■ Higher protein adsorption capacity than nylon or nitrocellulose ■ Suitable for various protein analysis applications, including sequencing and Western transfer *For more details, please refer to the PDF document or feel free to contact us.

• Other purification and extraction

The "Biodine (Nylon) Membrane" is an intrinsic hydrophilic 6,6 nylon membrane that achieves high sensitivity and low background, enhancing resolution. It is suitable for nucleic acid blotting and protein ELISA tests. Multiple rounds of hybridization, stripping, and reprobing are possible. It demonstrates excellent performance in detection systems using radioactive substances (Biodine B Membrane) and non-radioactive substances (Biodine A Membrane). 【Features】 ■ Improved detection and resolution due to high sensitivity and low background ■ Multiple rounds of hybridization, stripping, and reprobing are possible ■ Achieves diverse adsorption characteristics with three types of nylon membranes with different charges ■ Suitable for nucleic acid detection ■ Hydrophilic *For more details, please refer to the PDF document or feel free to contact us.

• Other purification and extraction

The integrity test kit includes a pressure gauge, a three-way valve, and a 10 mL syringe. It is possible to test the integrity of filter products after autoclave sterilization. It can be used for water breakthrough tests and bubble point tests. We also offer a variety of filter sizes, materials, and pore sizes to meet your specific applications. 【Features】 ■ It is possible to test the integrity of filter products after autoclave sterilization. ■ Usable for water breakthrough tests and bubble point tests. *For more details, please refer to the PDF document or feel free to contact us.

• Other experimental equipment and supplies

The "Vacushield Vent Device" is a vent filter that incorporates a hydrophobic PTFE membrane. It is used for liquid protection of valves and pumps. This filter can block contaminants from aqueous solutions and aerosols while allowing clean air and gases to pass through. 【Features】 ■ Uses a hydrophobic PTFE membrane ■ Blocks contaminants from aqueous solutions and aerosols ■ Allows clean air and gases to pass through ■ Provides liquid protection for valves and pumps *For more details, please refer to the PDF document or feel free to contact us.

• Filter paper/filter

This product is designed for filtration of bioreactors and chemicals or solvents that require a large effective filtration area (280 cm²) and high airflow. It is possible to perform autoclave sterilization and integrity testing before and after use. It features a high level of hydrophobicity and guarantees excellent performance as an aseptic barrier, with membranes made of PTFE or PVDF available. The bacteria air vent uses a laminated membrane made of fiberglass that can be used at high temperatures, high pressures, and high flow rates. 【Features】 ■ Large effective filtration area (280 cm²) ■ Autoclave sterilization capability ■ Integrity testing before and after use ■ Designed for filtration of bioreactors and chemicals or solvents *For more details, please refer to the PDF document or feel free to contact us.

• Other experimental equipment and supplies

The "Acro 50 Vent Filter" is designed as a bacterial air vent for the sterilization of air and gases, as well as for pharmaceutical research and experimental processes. The filter's pore sizes are available in three options: 0.2, 0.45, and 1 μm. Additionally, we offer the "Acro 50 Bend Device (Enflon II PVDF Membrane)" which has a removal rate of 0.2 μm in liquids and can remove particles smaller than 0.02 μm in air/gas applications. 【Features of PTFE Membrane】 ■ The filter's pore sizes are available in three options: 0.2, 0.45, and 1 μm ■ Non-sterile type that can be sterilized by autoclaving ■ Integrity testing can be performed before and after use ■ Filters are available with hose barb, 1/8 inch MNPT, and 3/8 inch straight pipe options *For more details, please refer to the PDF document or feel free to contact us.

• Filter paper/filter

The "Acro 37 TF Vent Device" is a 37 mm vent filter that uses a PTFE membrane with a pore size of 0.2 μm. It is an unsterilized type that can be autoclaved at 121-123°C for up to 20 minutes. Integrity testing can be performed before and after use, and it is resistant to multiple cleaning cycles. This filter also has the capability to capture bacteria. 【Features】 ■ Uses a PTFE membrane with a pore size of 0.2 μm ■ Unsterilized type ■ Can be autoclaved at 121-123°C for up to 20 minutes ■ Equipped with bacteria capture functionality *For more details, please refer to the PDF document or feel free to contact us.

• Other experimental equipment and supplies

The "37 mm Bacteria Air Vent" is a compact vent filter. It features a hydrophobic glass fiber laminated membrane with a pore size of 1 μm. It reduces the cross-contamination of glass fibers derived from the filter material. Additionally, you can choose between two types: gamma-irradiated sterilized and non-sterilized. 【Features】 ■ Compact ■ Uses a hydrophobic glass fiber laminated membrane ■ Reduces glass fiber cross-contamination ■ Available in two types: gamma-irradiated sterilized and non-sterilized *For more details, please refer to the PDF document or feel free to contact us.

• Filter paper/filter

Legionella bacteria are gram-negative bacteria widely found in soil, rivers, and lakes. When these Legionella bacteria contaminate public bath facilities, hot water systems, or filtration devices, they can infect the human body and potentially cause severe infections such as Legionnaires' disease. Therefore, testing for Legionella bacteria is conducted by various analytical companies worldwide for the purpose of environmental purification management. In May 2017, ISO 11731, which describes methods for counting Legionella in environmental water, was revised, and it proposed a "filtration concentration method using a membrane filter" for the concentration of water samples. Additionally, a direct attachment method for capturing Legionella has also been proposed. Pall handles membrane filters that meet the conditions specified in this ISO 11731.

• Filtration Filter

Industrial waste refers to waste that includes ash, sludge, and dust as defined by the Waste Management Law. The treatment of this industrial waste requires managing the discharge of harmful substances into the environment, and the regulation of the leaching amount of harmful substances is conducted according to the "testing methods for metals contained in industrial waste." Paul's high-water-repellent PTFE (wwPTFE) disk membranes can be used for pre-treatment filtration to analyze heavy metals and pesticides in industrial waste. The pore size is set at 1 μm, as specified in the "testing methods for metals contained in industrial waste." There are two types of membrane diameters available: 47 mm and 90 mm, allowing for selection based on the amount of particles that are prone to clogging.

• Filtration Filter

We would like to introduce the 'Glass Fiber Acrodisc Syringe Filter' for pre-filtration handled by Nippon Paul Co., Ltd. The Multi-Pre-Filter (GxF) offers 2 to 4 times the filtration performance compared to standard glass fiber products, reducing clogging. Since it is made of 100% borosilicate glass fiber without binders, there are no undesirable extracts. 【Features】 ■ Reduces clogging ■ The Multi-Pre-Filter (GxF) has 2 to 4 times the filtration performance compared to standard glass fiber products ■ Polypropylene housing offers broad chemical compatibility ■ The 37 mm size is suitable for pre-filtration of significantly contaminated samples *For more details, please refer to the PDF document or feel free to contact us.

• Filtration Equipment

We would like to introduce the "0.45 μm PSF Acrodisc Syringe Filter" for HPLC and IC handled by Nippon Paul Co., Ltd. The filtration efficiency is improved by the multi-prefilter (GxF), allowing for a filtration volume that is 2 to 4 times greater than that of standard glass fiber products. Additionally, it has high pressure resistance, eliminating concerns about housing breakage during use. 【Features】 ■ Wide range of product lineup - HPLC guaranteed: GHP, PVDF, Nylon, PTFE - IC guaranteed: Supor (PES) ■ Column protection ■ Low drug adsorption and low elution performance *For more details, please refer to the PDF document or feel free to contact us.

• Filtration Equipment

The "Acrodisc Syringe Filter for Ion Chromatography" is a syringe filter developed for sample pretreatment in ion chromatography analysis for HPLC and IC. It has an extremely low background for inorganic compounds, making it suitable for high-sensitivity analysis. There is no need for pre-flushing, and it uses a Supor (polyethersulfone) membrane. 【Features】 ■ Uses Supor (polyethersulfone) membrane ■ No need for pre-flushing ■ Inorganic ion elution amount is below 50 ppb ■ Performance verified by ion chromatography *For more details, please refer to the PDF document or feel free to contact us.

• Filtration Equipment

The "Nylon Acrodisc" is a syringe filter for HPLC and IC with HPLC certification. The 13 mm mini-spike type has a low residual volume and can be used with micro sample vials. It has a wide range of chemical compatibility. 【Features】 ■ The 13 mm mini-spike type has a low residual volume and can be used with micro sample vials. ■ Wide range of chemical compatibility (not suitable for 1N acids and halogenated compounds). ■ HPLC certified. *For more details, please refer to the PDF document or feel free to contact us.

• Filtration Equipment

The "PVDF Acrodisc (Acro LC13・25)" is a syringe filter for HPLC and IC with a wide range of chemical compatibility. The 13 mm mini-spike type has a low residual volume and can be used with micro sample vials. It is suitable for filtering mixed solutions (water/acetonitrile, water/methanol). 【Features】 ■ Wide range of chemical compatibility (not suitable for acetone, DMF, DMSO, or 6N alkali) ■ The 13 mm mini-spike type has a low residual volume and can be used with micro sample vials ■ Ideal for filtering mixed solutions (water/acetonitrile, water/methanol) ■ HPLC guaranteed *For more details, please refer to the PDF document or feel free to contact us.

• Filtration Equipment

We would like to introduce our HPLC syringe filter, 'Ekicrodisc'. The water-based 'Ekicrodisc 3 and 13' reliably filters precious aqueous solution samples with minimal residual volume. Additionally, the 'Ekicrodisc 25' allows for observation of the filtration state due to its acrylic housing. The organic-based 'Ekicrodisc 3CR, 13CR, and 25CR' utilize a hydrophobic and chemically resistant PTFE membrane, making them suitable for filtering organic solvent samples. 【Features】 <Ekicrodisc 3 and 13 (Water-based)> ■ Versapor (acrylic copolymer) membrane provides high flow rates and reliable particle retention. ■ Minimal residual volume reduces sample loss. ■ Proven track record in HPLC for many years. *For more details, please refer to the PDF document or feel free to contact us.

• Filtration Equipment

We would like to introduce our "0.2 μm PSF Acrodisc Syringe Filter." The free-floating pre-filter prevents early clogging. The thermally bonded 0.2 μm final membrane guarantees particle removal without breakthrough. 【Features】 ■ Wide range of product lineup (GHP, PVDF, PES, Nylon, PTFE) ■ Enhanced filtration efficiency with multi-pre-filter (GxF) ■ Compatibility guarantee for SOTAX automatic analyzers for dissolution testing ■ Low drug adsorption and low elution performance ■ Effective filtration area of 3.9 cm² in 25 mm size *For more details, please refer to the PDF document or feel free to contact us.

• Filtration Equipment

The new business fields related to the manufacturing of biopharmaceuticals, such as gene therapy drugs, peptide medicines, and new types of vaccines represented by mRNA vaccines, are on a continuous path of expansion. However, the technology for scaling up from lab-scale to commercial production scale remains a challenge. The equipment and operating methods used in small-scale lab production differ from those used in commercial production scale. Therefore, while leveraging the results of laboratory-level research, it is essential to collect test data that anticipates the transition to GMP manufacturing from the preclinical and clinical trial drug production stages. This will be the first step toward practical application in the future. This seminar will provide an overview of the fundamentals of TFF technology, which is frequently used in manufacturing processes. Date: November 25, 2021 (Thursday) 13:30 ~ 14:30 *An on-demand version is currently available. URL: https://biotech.pall.jp/jp/ja/landing/tff-basics.html?utm_source=e_signature&utm_medium=email&utm_campaign=21-11-121-TFFWB-JP&utm_content=text_link_lab

• Other experimental equipment and supplies

The "37 mm Quality Monitor" is a compact, disposable filtration device. The white grid membrane complies with EPA and ASTM specifications for microbiological testing and is suitable for the examination of colored colonies. The black grid membrane is approved for the MF method and is ideal for measuring transparent and light-colored colonies and particles. 【Features】 ■ Sample processing volume of approximately 10 to 1000 mL ■ White grid membrane - Complies with EPA and ASTM specifications for microbiological testing and is suitable for the examination of colored colonies ■ Black grid membrane - Approved for the MF method and is ideal for measuring transparent and light-colored colonies and particles *For more details, please refer to the PDF document or feel free to contact us.

• Microbiology

The "Microcheck II Beverage Monitor" is a simple disposable filter funnel that meets the needs for microbial analysis of drinking water. It can be taken out of the box and directly attached to the suction manifold. After filtering the sample, a gentle twist will detach the funnel. Additionally, the funnel has an easily readable external scale, eliminating the risk of bacteria adhering to the scale. 【Features】 ■ Can be taken out of the box and directly attached to the suction manifold ■ A gentle twist will detach the funnel after sample filtration ■ Accurate sample volume measurement ■ Membrane pore sizes of 0.45 and 0.8 μm *For more details, please refer to the PDF document or feel free to contact us.

• Microbiology

The "47 mm Magnetic Filter Funnel" has high resistance to disinfectants made from polyphenylsulfone material and many other solvents. The 150 mL type fits into small autoclave sterilizers, while the 500 mL type can filter large volume samples. It features an extraction port for easy retrieval of the filter using tweezers. 【Features】 ■ High resistance to disinfectants and many other solvents due to polyphenylsulfone material ■ The 150 mL type fits into small autoclave sterilizers ■ The 500 mL type can filter large volume samples ■ Easy retrieval of the filter with an extraction port for tweezers ■ Graduated in 50 mL increments for accurate measurement of sample volume *For more details, please refer to the PDF document or feel free to contact us.

• Microbiology