サーモフィッシャーサイエンティフィック株式会社／Thermo Fisher Scientific K.K. Product Lineup

The ARL X900 is a wavelength-dispersive X-ray fluorescence analyzer (WDXRF) optimized for industrial process control. - High-precision elemental analysis using wavelength-dispersive X-ray fluorescence (WDXRF) - High sensitivity and reproducibility for quantifying from major components to trace elements - High-throughput measurement with simultaneous/sequential analysis capability - Elemental analysis plus phase analysis through integrated X-ray diffraction (XRD) functionality - Supports online quality control and production line monitoring - Robust design and long-term stable operation enable continuous analysis for 24 hours - Extensive track record of implementation in the metal, cement, and mining industries

• Other physicochemical equipment
• X-ray fluorescence analyzer

The Thermo Scientific ARL QUANT'X EDXRF analysis device enables rapid and highly accurate quantitative analysis of a wide range of sample forms, from bulk solids, granules, and powders (loose or compressed) to fusion beads, thin films, pastes, and liquids, covering major elements to trace and ultra-trace elements. 【Features】 - Compact and high-performance benchtop design minimizes installation space while providing exceptional analytical accuracy and reliability. - Equipped with standardless software "UniQuant," allowing for accurate quantitative analysis even when unknown samples or reference materials are difficult to obtain. - Versatile sample chamber accommodating 10 to 20 positions, flexible enough to handle large samples. - Features high-performance silicon-lithium (Si(Li)) drift detectors and the latest generation SDD detectors, achieving excellent sensitivity and resolution from light to heavy elements. - Capable of analysis across a wide dynamic range from ppm levels to high concentrations. - Simple sample introduction and operation, ensuring rapid measurement and high throughput.

• Other physicochemical equipment
• X-ray fluorescence analyzer

The Thermo Scientific ARL PERFORM'X sequential fluorescent X-ray analysis system and the ARL X900 WDXRF analysis system are next-generation platforms that enable a multifaceted approach, from elemental analysis of solid and liquid samples to material property evaluation. These devices can analyze almost all elements with high precision, from beryllium (Be) to americium (Am), and are utilized in a wide range of fields, from industrial process management to academic research. **Core Technologies of the ARL PERFORM'X WDXRF Spectrophotometer** - Rapid analysis of unknown samples with integrated analytical functions - Sequential WDXRF analysis covering up to 90 elements - Inclusion analysis using micro spot beams of 0.5mm/1.5mm and elemental mapping with 0.1mm steps - Dual sample loading and a high-speed goniometer at 4800°/min, processing up to 60 samples per hour - Semi-quantitative analysis in three minutes using QuantAS software and standardless analysis up to Am (Z=95) using UniQuant software

• Other physicochemical equipment
• X-ray fluorescence analyzer

The Thermo Scientific ARL OPTIM’X WDXRF spectrometer is a device that enables high-precision elemental analysis of solid and liquid samples using wavelength dispersive X-ray fluorescence (WDXRF) technology. - Equipped with sequential and multi-analysis functions for flexible analysis [Versatility of WDXRF] - Achieves high sensitivity and high reliability analysis through UCCO (Ultra-Coupled Optical System) - Delivers performance equivalent to 200 W / 500 W with 50 W / 200 W output - Compact design for direct sample introduction and space-saving standalone installation - Compatible with quantitative and qualitative analysis software (OXSAS, OptiQuant) to meet diverse analytical requirements It supports a wide range of materials from solids, powders, pellets, to liquids, providing strong support for QC and material evaluation in analytical labs and manufacturing sites [Compliant with ASTM and ISO standards].

• Other physicochemical equipment
• X-ray fluorescence analyzer

The Invitrogen EVOS S1000 Spatial Imaging System efficiently performs multiplex imaging of tissue samples, enabling rapid understanding of the spatial localization of proteins. The EVOS S1000 Spatial Imaging System can simultaneously image up to eight targets and nuclear staining in a single scan, and it separates targets from each other by eliminating crosstalk from adjacent channels using spectral unmixing technology. Please download the catalog to check the details.

• Imaging and image analysis equipment

This document presents guidelines for smoothly integrating the Thermo Scientific Vanquish HPLC/UHPLC system with Waters Corporation's Empower 3 Chromatography Data System (CDS), along with case studies from Contract Development and Manufacturing Organizations (CDMOs). By introducing a new LC system, we were able to significantly reduce system suitability failures (SSF), extend column life, and improve operational efficiency in a cGMP environment. Additionally, we will provide specific examples of the method transfer process between analytical instruments from different manufacturers. 【Features】 ■ Significant reduction in system suitability failures due to equipment upgrades ■ Intelligent features that greatly simplify the method transfer process ■ Achieving reproducible and robust separations with very high stability, precision, and accuracy ■ Thermo Scientific Vanquish Duo UHPLC system: significantly improved throughput and productivity with two independent flow paths

• Analytical Equipment and Devices

We have published the comprehensive catalog of general-purpose equipment required for research laboratories at Thermo Fisher Scientific, 2025 edition. <Product List> ■ Centrifuges / Centrifuge containers ■ Shakers ■ Incubators ■ Safety cabinets ■ Ovens ■ Centrifugal concentrators ■ Sample storage equipment (dispensers / pipettors, sealers, cappers / decappers, scanners) ■ Water quality meters (pH / conductivity / dissolved oxygen / ions) *For more details, please download and view the catalog.

• Other physicochemical equipment

The Purge and Trap GC-MS system is specialized for trace analysis of volatile organic compounds (VOCs) contained in water samples. After collecting VOCs on an adsorption trap, they are rapidly desorbed and injected into the GC-MS system. By automatically pre-treating large volumes of water samples, it achieves detection limits at the ppt level, meeting domestic regulatory requirements for drinking water testing. It is compatible with the Thermo Scientific HeSaver-H2Safer option, which reduces the consumption of helium carrier gas, thus effectively lowering the running costs of analysis. The Thermo Scientific Chromeleon Chromatography Data System (CDS) allows for a series of operations from control to analysis, simplifying daily tasks. System Configuration: • Teledyne LABS Lumin Purge & Trap CONCENTRATOR and AQUATek LVA liquid autosampler • Thermo Scientific ISQ 7610 single quadrupole GC-MS system

• Analytical Equipment and Devices

The Orbitrap mass spectrometer enables direct isotopic ratio analysis of isotopologue species and clumped isotopes. It serves as a new tool for elucidating chemical, physical, and biological processes in the environment. The technical documentation below explains the measurement techniques of the Orbitrap mass spectrometer for isotopologue measurements of nitrates, sulfates, and acetic acid, including measurement conditions and comparisons with conventional magnetic field IRMS. For more details, please download the PDF or feel free to contact us.

• Analytical Equipment and Devices

The "Thermo Scientific KingFisher PlasmidPro Maxi Processor" is a device that automates the purification of Maxi-scale plasmid DNA, eliminating the labor-intensive steps of centrifugation and pipetting. By simply placing 150 mL of E. coli culture (LB medium) into the cartridge, it enables the purification of endotoxin-free plasmid DNA (<0.1 EU/µg) within 75 minutes.

• Refining and Extraction Equipment
• Other purification and extraction

This is a sterilized single-use membrane filter suitable for microbiological testing in water quality testing and quality control (QA/QC) of food and beverages. Thermo Scientific Nalgene analytical filterware does not require a set of membranes or cleaning and sterilization, allowing for direct use and disposal. It reduces contamination risks and enhances the reproducibility and safety of tests. Depending on the application, we offer two types: a filter unit with an integrated filter funnel and receiver, and a funnel for vacuum manifolds. This supports smooth and highly reproducible testing. 【Product Lineup】 Thermo Scientific Nalgene analytical filter unit (CN) sterilized Thermo Scientific Nalgene analytical filter funnel (CN) sterilized

• Filter paper/filter

Glow Discharge Mass Spectrometry (GD-MS) is a system that samples and analyzes elements on the surface of solid samples using argon plasma. The ELEMENT GD Plus GD-MS employs a high-pressure glow discharge ion source that allows for switching between continuous and pulsed discharge, achieving both speed and flexibility in analysis. ■ Rapid analysis of elemental composition in solid materials - Simultaneous analysis of over 70 elements - A 12-digit dynamic range covering from sub-ppb levels, which are difficult to detect with XRF or OES, to major components - Semi-quantitative analysis without the need for standard samples. Precise quantification is also possible with the use of standard samples - High throughput: Rapid sampling and vacuum evacuation of high-pressure glow discharge allow for analysis in about 10 minutes per sample, including sample exchange ■ Compatibility with a wide range of materials and elements - Rapid analysis of metals and semiconductor materials. Non-conductive ceramics can also be analyzed using pulsed discharge and secondary electrodes - High-sensitivity analysis of C, N, and O with a newly developed ion source option - High-sensitivity analysis of low melting point elements Ga, In, and Te using pulsed discharge and cooling mechanisms ■ Multi-element simultaneous analysis with a wide dynamic range for depth profiling Supports rapid analysis from nm-order thin films using pulsed discharge to depth profiling up to 100 µm, which would take a long time with SIMS.

• Analytical Equipment and Devices

This technical document introduces a method for efficiently analyzing ten types of ultraviolet filter components contained in five types of sunscreen using a UHPLC system under a single analytical condition. The results of the validation of the method's accuracy and precision showed that the peak area RSD was below 1.10%, and the retention time RSD was below 0.50%, indicating high precision. Additionally, by transitioning the existing analytical method to the UHPLC method, we reduced solvent consumption and waste generation, and replaced tetrahydrofuran (THF) used in the sample solution with a more environmentally friendly solvent, thereby reducing the environmental impact. 【Features】 ■ Efficient analysis of ten types of ultraviolet filter components under a single analytical condition ■ High precision with peak area RSD below 1.10% and retention time RSD below 0.50% ■ Reduction of solvent consumption and waste generation through the UHPLC method ■ Thorough evaluation of accuracy, linearity, and precision ■ Use of environmentally friendly solvents to reduce environmental impact *For more details, please download the PDF or feel free to contact us.

• Other measurement, recording and measuring instruments

This content explains the benefits of combining a Charged Aerosol Detector (CAD) and a Single Quadrupole Mass Spectrometer for impurity analysis of topiramate. The HPLC-UV system is a common analytical method used in many laboratories. By combining CAD and a mass spectrometer with this system, comprehensive impurity detection becomes possible. CAD detects non-volatile and semi-volatile compounds with high sensitivity. The mass spectrometer not only confirms molecular weight but also eliminates the possibility of co-elution by verifying peak purity. Additionally, the in-source Collision-Induced Dissociation (CID) function allows for the confirmation of known impurities and the structural estimation of unknown impurities. 【Features】 ■ Identification of known impurities and molecular weight prediction and structural estimation of unknown impurities ■ High-precision impurity profiling through combination with a Single Quadrupole Mass Spectrometer ■ Peak identification based on m/z and elimination of co-elution possibilities ■ CAD has high sensitivity and a wide dynamic range, accommodating gradient analysis *For more details, please download the PDF or feel free to contact us.

• Other measurement, recording and measuring instruments

This technical document explains an HPLC method suitable for the fingerprinting of Polysorbate 80 and proposes a simple approach to detect variations between different suppliers, grades, and manufacturing lots, as well as to identify quality issues. The Thermo Scientific ISQ EM single quadrupole mass spectrometer, with a mass range up to m/z 2,000, allows for the easy identification of a wide range of key components of polysorbates from low to high molecular weights. Additionally, the consistent response of the CAD and the reverse gradient method enable semi-quantification without standard substances, allowing for a substantial understanding of the mass balance between components with varying degrees of esterification. Please take a look at the optimal HPLC-CAD-MS method for fingerprinting Polysorbate 80. *For more details, please download the PDF or feel free to contact us.*

• Other measurement, recording and measuring instruments

We introduce a rapid and cost-effective method for measuring the titer of adeno-associated virus (AAV) products after downstream processing, combining size exclusion chromatography (SEC) with a highly sensitive fluorescence detector. By using the Thermo Scientific MAbPac SEC-1 column, efficient separation of AAV capsids and low molecular weight impurities is achieved, allowing for detailed monitoring of product quality attributes (PQA). This method enables rapid determination of AAV product titer after a single step of affinity purification, contributing to the evaluation of product characteristics. 【Features】 ■ Rapid and cost-effective titer measurement method ■ Measurement possible with small sample sizes due to high-sensitivity fluorescence detection ■ Efficient separation using the MAbPac SEC-1 column ■ Detailed monitoring of PQA is possible ■ Improved reproducibility with low-adsorption glass vials (RSD less than 5%) *For more details, please download the PDF or feel free to contact us.

• Other measurement, recording and measuring instruments

● Compatible with standalone and automation systems ● Compatible with Thermo Scientific Matrix and Nunc tube racks, in both 48-tube and 96-tube formats ● Universal cap driver eliminates the need for adapter or part replacement ● Completes the capping cycle in under 60 seconds ● User-friendly interface with a 7-inch touchscreen, operable while wearing gloves ● Drip tray acts as a barrier between the cap and tube after the cap is removed, preventing cross-contamination

• Other storage and equipment

We offer the 'Invitrogen PureLink RNA Mini Kit', which is suitable for high-quality, high-purity RNA extraction. It features a spin column format that eliminates the need for phenol-chloroform extraction. Despite its mini column size, it achieves yields comparable to midi kits. It can accommodate a wide range of sample volumes and types. 【Features】 ■ Purifies high-quality total RNA in about 20 minutes ■ Can obtain purified RNA up to 1,000 μg in a single extraction ■ Does not use harmful organic solvents (phenol/chloroform) in the dissolution step *For more details, please download the PDF or feel free to contact us.

• RNA Purification Kit

The Invitrogen EVOS Onstage Incubator (OSI-2) is an incubator that can control temperature, humidity, and gas with high precision. It operates as a fully integrated unit with the Invitrogen EVOS M7000 Imaging System, enabling seamless live cell experiments, imaging, and analysis. It allows for the setting and saving of protocols along with microscope parameters on the same software as the EVOS M7000 Imaging System. Please contact us if you have any inquiries. 【Features】 ■ Fully integrated environmental chamber for live cell time-lapse imaging ■ High environmental control capability that can accurately maintain physiological or hypoxic conditions

• incubator
• Other Analysis

Invitrogen Celleste 6 Image Analysis Software is an image analysis software equipped with machine learning algorithms for advanced image analysis and quantification, including segmentation, counting, sizing, classification, and analysis. The MCA (Multi Class Analysis) tool, based on algorithms and analysis templates, allows for various analysis results such as heat maps, image montages, and histograms to be obtained in just a few steps. This powerful analysis software enables you to maximize the use of image data for processes such as neurite formation, angiogenesis, cell viability, and cell cycle. 【Examples of MCA Protocols】 ■Angiogenesis ■Autophagy ■Cell count ■Cell morphology ■Colocalization

• Image analysis software
• Cell Analysis Software
• Other analysis software

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are currently one of the most concerning emerging contaminants. The detection and quantification of known PFAS, as well as the discovery of unknown PFAS substances, are becoming increasingly important. This catalog introduces the following: - PFAS transport pathways - Target analysis and screening of unknown compounds - PFAS sampling - PFAS analytical methods - PFAS analysis in drinking water and wastewater - Target analysis of PFAS by direct injection - AOF using combustion ion chromatography - Extraction and analysis of PFAS in soil

• Analytical Equipment and Devices

The "Thermo Scientific KingFisher Apex Nucleic Acid, Protein, and Cell Automated Extraction and Purification System" is a device that rapidly processes purification applications using magnetic beads for DNA, RNA, proteins, and cells, providing highly reproducible results. With a touch screen and intuitive interface, it simplifies operation and reduces errors. It can be operated without a computer. Additionally, the software in the main unit allows for easy creation and editing of protocols, enabling customization of each step of the protocol, including the binding of magnetic beads to the purification target, washing, and elution. 【Features】 ■ Enhanced performance ■ Easy operation via touch screen ■ Customizable protocols ■ Capability to connect to cloud and network ■ Can simultaneously incorporate up to two types of magnetic heads and heat blocks, allowing selection from multiple formats based on the number of samples *For more details, please refer to the PDF document or feel free to contact us.

• Refining and Extraction Equipment
• Other Nucleic Acid/DNA Research
• Protein Purification Equipment

Automating antibody reactions for Western blotting! Achieving an automated process with hands-free operation. The Invitrogen iBind/iBind Flex Western System is a system that automates the process from blocking in Western blotting to washing after the secondary antibody reaction. It uses Sequential Lateral Flow (SLF) technology to control the release of antibody solutions and wash solutions in sequence. Additionally, it operates silently without the need for an external power source, making it usable anywhere in the laboratory. In addition to the convenience of hands-free operation, it provides data with superior sensitivity and reproducibility compared to manual methods. 【Features】 ■ Saves time ■ Reproducibility ■ Flexibility ■ Reliable results with a small amount of primary antibody ■ Superior performance compared to manual methods *For more details, please refer to the PDF document or feel free to contact us.

• others

The Invitrogen Neon NxT Electroporation System is an electroporation platform with an innovative design that streamlines the transfection workflow for mammalian cells. The electrodes placed in biologically compatible pipette tips and buffer tubes create a more uniform electric field than previous electroporation devices, significantly improving transfection efficiency and cell viability. Additionally, the electroporation workflow is simple, allowing for safe transfection even with challenging cell lines. 【Features】 ■ Proven performance and excellent cell viability ■ Sample protection ■ Time reduction ■ Flexibility *For more details, please refer to the PDF document or feel free to contact us.

• others

The Invitrogen E-Gel Power Snap electrophoresis system is an integrated system that combines an electrophoresis device with a high-resolution imaging system using precast agarose gels. It supports the acceleration of research in scenarios that require high-throughput processing, such as quality verification of cultured cells, screening of clones after genome editing, and NGS library preparation, all achieved through a simple workflow for high-throughput electrophoresis. Please feel free to contact us when you need assistance. 【Features】 ■ Simple operability ■ Space-saving imaging system ■ Faster analysis

• others

The "Applied Biosystems MagMAX Pure Bind Beads" is a product that serves as a high-performance option for DNA cleanup and size selection in NGS library preparation and PCR applications. It supports both manual and automated protocols, allowing for direct replacement in established workflows. Additionally, it can be stored at room temperature, eliminating the need to bring the beads back to room temperature before use, thus reducing waiting time. 【Features】 ■ Recovers >90% of DNA fragments over 90 bp ■ Flexibility in starting sample amounts and scalability ■ High cost-effectiveness ■ Compatible with both manual and automated processes ■ Room temperature storage *For more details, please refer to the PDF document or feel free to contact us.

• Other purification and extraction

The development and quality control of LNP formulations require rapid and accurate identification of lipid components and evaluation of molar ratios. This technical document introduces a method for efficiently quantifying the concentration and molar ratio of each lipid in LNP formulations. The Charged Aerosol Detector (CAD) is a versatile detector for liquid chromatography that can detect all non-volatile and semi-volatile compounds. It is particularly sensitive for detecting compounds that do not absorb UV light, such as LNPs. Furthermore, by leveraging the CAD's high sensitivity, consistent responsiveness, and wide dynamic range, we aim to simplify sample preparation and facilitate method development. Additionally, by using the Thermo Scientific Accucore C30 LC column, we can effectively separate lipid components and other excipients in LNP formulations in a short time. This has also confirmed that the measurement results align well with the theoretical molar ratio%. 【Features】 ■ Rapid and accurate identification of lipid components and evaluation of molar ratios ■ Compliance support with Thermo Scientific Chromeleon CDS software ■ Effective separation with Accucore C30 LC column ■ Measurement results that align well with theoretical molar ratio%

• Analytical Equipment and Devices

The Thermo Scientific Varioskan LUX Multi-Mode Microplate Reader is a device designed for bioscience research that requires support for a wide range of assays. Its automatic dynamic range selection feature simplifies measurement setup, and its smart safety controls help avoid experimental errors. Reliable results can be obtained quickly, even for applications that are difficult to measure. Features: ■ Five detection modes: absorbance, fluorescence, luminescence, TRF, and AlphaScreen ■ Equipped with a quad monochromator, it can accommodate a wide wavelength range ■ Optional gas module for controlling CO2 and O2 gases ■ Thermo Scientific SkanIt software for control and analysis supports nine languages, including Japanese and English ■ Capable of performing rapid dispensing and measurement simultaneously right after the start (when equipped with a dispenser) *For more details, please refer to the PDF document or feel free to contact us.

• Other physicochemical equipment

The Thermo Scientific Multiskan FC absorbance microplate reader is a robust and reliable filter-based device suitable for a variety of research and routine applications. Features: ■ Supports a wide range of applications across wavelengths from 340 to 850 nm ■ Wide reading range of 0 to 6.0 Abs, with linearity up to 3.0 Abs ■ Measures 96-well plates in under 7 seconds ■ Large color LCD display and intuitive user interface ■ Stable performance with self-diagnostic capabilities ■ Can accommodate up to 8 filters (comes standard with 3 filters at 405 nm, 450 nm, and 620 nm) ■ Operable and analyzable from the device itself or standard software ■ Multi-language operation including Japanese and English ■ Ideal for ELISA and protein quantification

• Other physicochemical equipment

The Thermo Scientific Multiskan SkyHigh absorbance microplate reader is equipped with a robust and reliable monochromator, making it suitable for a variety of research and routine applications. Features: - Capable of measuring a wide wavelength range from 200 to 1,000 nm in 1 nm increments (for both endpoint and spectral measurements) - Supports a diverse range of applications including quantification of nucleic acids such as DNA and RNA, various protein quantifications, and ELISA - Compatible with 6/12/24/48/96/384 well plates (supports lids up to a height of 19.5 mm) - Built-in shaking function and incubator function with a temperature range of +2 to 45 °C - Supports 9 languages including Japanese and English, accessible via touch screen or PC

• Other physicochemical equipment

This is a twin-screw extruder that has evolved for battery electrode development, inheriting the features of Process 11 and Pharma 11, which brought revolutionary productivity to material development. It not only improves the quality of electrode slurries at the R&D scale but also accommodates low-solvent mixing, dry mixing, granulation, and the creation of sheet-like samples. The design allows for easy cleaning and part replacement to prevent batch-to-batch contamination. It is a versatile extruder that balances safety features with compactness.

• Secondary Cells/Batteries

Consistent data acquisition across various matrices, from industrial materials to environmental samples, eliminates analytical errors and improves throughput. We offer a single quadrupole model and a triple quadrupole model with enhanced interference removal capabilities. ■ New technology achieving reliability independent of matrix - Improved chamber and gas dilution system - Voltage-variable skimmer cone: no need for differentiation, one unit accommodates diverse analyses - New feature Intelligent Matrix Handling: optimizes sample intake volume for each step of aspiration/analysis/rinsing ■ Supports a variety of accessories that expand analytical capabilities - Automatic dilution and high-speed analysis valve system - Laser ablation system: direct qualitative, quantitative, and imaging analysis of solid samples - Chromatography: analysis by chemical form, etc. ■ User-friendly operation requiring no advanced skills - Vacuum section requiring no user maintenance, simple introduction system that can be replaced in minutes - Unique feature that automatically removes low-mass ions that cause interference - Complex method creation for the triple quadrupole, data monitoring, and equipment operation are handled by software.

• Analytical Equipment and Devices

This technical document introduces an analytical method for sugar alcohols based on official methods. We measured six types of commercially available foods using the Thermo Scientific Syncronis Amino LC column in HILIC mode and the Thermo Scientific HyperREZ XP CarbohydrateCa2+ LC column in ligand exchange mode. Furthermore, the Thermo Scientific Chromeleon Chromatography Data System (CDS) report designer automatically calculates the sugar alcohol content in the food by inputting the sample volume, fixed volume, and dilution ratio during measurement. This helps prevent human errors and allows for the rapid and accurate creation of the final report. 【Features】 ■ High-precision measurement of sugar alcohols based on official methods ■ Use of specific columns in HILIC mode and ligand exchange mode ■ Automatic calculation and accurate result verification by the Chromeleon CDS report designer ■ High-reliability custom report function to prevent transcription errors and rounding errors *For more details, please download the PDF or feel free to contact us.

• Analytical Equipment and Devices

This application introduces a method for the highly sensitive and robust analysis of L-aspartic acid and glycine impurities using the HPLC-UV-CAD method. The conventional derivatization methods used in amino acid analysis have faced challenges such as human error and variability in derivatization efficiency; however, this method provides a more reliable approach by detecting without derivatization. Additionally, it allows for the simultaneous analysis of amino acids and their impurities (especially organic acids) in a single chromatography run, significantly reducing analysis time and contributing to cost savings. Furthermore, the selectivity and limit of quantification (LOQ) of the new analytical method are equivalent to established official methods, making it useful for amino acid quality control. 【Features】 ■ Fewer errors compared to derivatization methods, offering greater robustness and reliability ■ Simultaneous detection of amino acids and organic acids using a single method, reducing analysis time and costs ■ Highly sensitive detection of amino acids through the combination of CAD and UV ■ The selectivity and limit of quantification (LOQ) of the new analytical method are equivalent to official methods *For more details, please download the PDF or feel free to contact us.

• Analytical Equipment and Devices

TD-GC-MS/MS is a system suitable for the analysis of volatile PFAS in the air. TD concentrates the target substances from hundreds of liters of air and connects to a high-sensitivity triple quadrupole GC-MS/MS to detect concentrations in pg/m3. Since PFAS exist in low concentrations in the air, the system requires a low detection limit. Additionally, because PFAS are widely used in various products, it is crucial to ensure there is no contamination from the system or components. Evaluating background levels is essential for obtaining reliable analytical results. The technical documentation for PFAS analysis in indoor air presents examples of screening analysis using full scan and high-sensitivity analysis using target SRM for 19 PFAS components emitted from indoor air and everyday products. It evaluates the emissions from indoor air in diverse workplace spaces and everyday items. Methods for measuring PFAS released from solid samples, such as everyday products, without pre-treatment are also introduced. The technical documentation for PFAS analysis in the atmosphere introduces high-throughput analysis of neutral and ionic PFAS. It also shares know-how for improving analytical accuracy using samples collected from three locations in an industrial park.

• Analytical Equipment and Devices

The HPLC-CAD system analyzes choline and its counterions, as well as impurities of choline, with high precision without the need for derivatization. The analysis conditions using mixed-mode with hydrophilic interaction chromatography (HILIC) accommodate both charged particle detection and mass spectrometry, enabling the simultaneous analysis of anions and cations, which allows for rapid and reliable detection of choline content and impurities. In this application note, we successfully detected the content of choline derivatives such as choline chloride, choline bitartrate, and choline citrate, along with their impurities, with high precision. Choline chloride, which had poor responsiveness with conventional UV detectors, can also be directly detected without the use of derivatization methods. Furthermore, the mixed-mode using HILIC accurately identifies impurities while avoiding interference from counterions. This serves as a powerful tool for ensuring safety and efficacy in quality control for dietary supplements and other products.

• Analytical Equipment and Devices

The Charged Aerosol Detector (CAD) is a highly versatile liquid chromatography detector capable of detecting all non-volatile and semi-volatile compounds. In particular, it can sensitively detect compounds that do not absorb UV light, such as lipid nanoparticles (LNPs). Additionally, the consistent responsiveness of the CAD allows for accurate assessment of the relative amounts of each lipid component. Furthermore, it is suitable for monitoring impurities and degradation products, in addition to evaluating the composition of LNPs. This application note presents examples of constructing a fast and robust UHPLC method using the Thermo Scientific Accucore C30 LC column to separate and evaluate lipid components contained in two different formulations, as well as an example using the Thermo Scientific Hypersil GOLD C8 column to effectively profile lipid components and their impurities present in raw materials. For this analysis, we used the bio-compatible Thermo Scientific Vanquish Flex and Thermo Scientific Vanquish Horizon UHPLC systems.

• Analytical Equipment and Devices

Do you know how the choice of tubes for cryopreservation affects the quality of samples? In the cryopreservation of valuable specimens handled in clinical research, cell culture, biopharmaceutical research, and biobanks, it is considered important to select appropriate cryopreservation tubes to prevent contamination and sample degradation, thereby maintaining their quality over the long term. This white paper compares the characteristics of various tubes and explains how to choose them based on the type of sample and storage conditions. It also discusses tubes suitable for sample preservation in harsh environments, such as liquid nitrogen storage, providing content that researchers can refer to for sample management. Please use this as a resource to aid in the success of your sample preservation efforts.

• Plastic utensils and containers

The Thermo Scientific Varioskan ALF Multi-Mode Microplate Reader features an optical system for absorbance measurement based on a xenon flash lamp and monochromator, allowing for continuous wavelength selection in the range of 200 nm to 1,000 nm. Its wide wavelength range enables many common assays, including quantification of nucleic acids and proteins, bacterial growth curves, ELISA, and cell viability. Fluorescence and luminescence measurements utilize a filter-based optical system, achieving suitable specificity and sensitivity. Three pre-installed excitation and emission filter sets are suitable for many common fluorescence applications, such as Thermo Scientific Quant-iT DNA quantification assays, PrestoBlue, and AlamarBlue cell viability assays. Additionally, five open filter positions allow for customization of fluorescence and luminescence measurements. The automatic dynamic range selection feature chooses the appropriate dynamic range for fluorescence or luminescence based on the signal intensity in the well, eliminating the need for manual adjustments.

• Analytical Equipment and Devices

Introducing the ultrapure water system "Aquanex." 【Main Features】 Aquanex System User Interface - The large full-color display allows for clear visibility of water quality and tank levels from a distance. - Sampling data can be downloaded from a USB memory stick. Aquanex Touch Smart Dispenser - Easy-to-use pipette-style dispenser. - Intuitive operation with a user-friendly touchscreen. - Can be removed from the stand for flexible sampling operations. Easy Maintenance, Self-Service Design - Ion exchange cartridges can be attached and detached with the push of a button, and new cartridges automatically recognize and record the replacement date. - Not only the ion exchange cartridges but also the RO membrane and UV lamp can be replaced without screws or complex tools, reducing service costs. *For detailed specifications, please download the PDF. Feel free to contact us for more information.

• Pure water production equipment

The Invitrogen EVOS M3000 Imaging System is an all-in-one microscope capable of capturing brightfield, phase contrast, color, and fluorescence images. It simplifies cell culture workflows using an innovative machine learning model and provides real-time notifications of cell confluency values. Additionally, the built-in CMOS camera ensures the acquisition of remarkably high-quality images and videos of cells. Features: ◆ Obtain cell confluency data in seconds: Built-in real-time image analysis tool ◆ No training required: Simple user interface with a touchscreen display ◆ Space-saving design: The smallest footprint among the Invitrogen EVOS imaging system series (can be installed in clean benches or safety cabinets) *For more details, please refer to the PDF document or feel free to contact us.

• Other microscopes

Since 1994, the Thermo Scientific Niton handheld X-ray fluorescence (XRF) analyzer has been chosen as a reliable instrument for conducting lab-quality elemental analysis in the field. Designed for use in harsh conditions, this user-friendly handheld XRF analyzer offers excellent detection limits and very fast measurement times, enabling confident decision-making on-site.

• X-ray fluorescence analyzer

This is a dual convergence high-resolution gas chromatography mass spectrometer (GC-HRMS) for ultra-trace quantitative analysis of dioxins and persistent organic pollutants (POPs). It complies with all official methods and regulations for dioxin analysis and is used worldwide due to its excellent performance. ■ Flexible Equipment Configuration - Unique Dual GC configuration (2 GCs for 1 MS, up to 4 columns) allows for expanded flexibility (optional) - Sophisticated space-saving design - Environmentally friendly low power consumption design ■ Excellent Sensitivity and Reliability of Dual Convergence HRMS - Reliable analysis of trace samples: Guaranteed specification value of S/N ≧ 200 for 20 fg TCDD - High ion transmission rate and reproducibility achieved through optical system design - Cleaning and replacement of filaments and ionization chambers do not require vacuum release ■ GC that Enhances Productivity - Modular inlet to maximize uptime - Helium saver module: Reduces helium consumption while maintaining analysis conditions (estimated example: approximately 84% reduction) - Multifunctional auto-sampler For more details, please download the PDF or feel free to contact us.

• Analytical Equipment and Devices

The Thermo Scientific LInspector Edge inline mass profilometer is a next-generation process measurement tool for battery manufacturing, establishing a new standard in the quality assurance of electrode coatings. This device measures 100% of the area of the coated electrodes in real-time. By simultaneously collecting spatial information and coating weight data, it provides full-width areal density analysis and profile uniformity analysis.

• Other inspection equipment and devices

At Thermo Fisher Scientific, we are promoting the use of non-fluorinated equipment with cooling functions that are environmentally friendly. We offer devices that use non-fluorinated refrigerants that do not deplete the ozone layer or contribute to global warming, as well as general-purpose products equipped with Peltier cooling functions, which are safer non-compressor models. Please consider these options when updating your equipment. *For detailed specifications, please download the PDF. Feel free to contact us for more information.*

• Refrigerators and freezers