enzyme Product List and Ranking from 26 Manufacturers, Suppliers and Companies

Mass Spectrometry (MS) Grade Trypsin RapiZyme

Fast! Clean! And complete! MS-grade trypsin to solve the challenges of protein digestion.

With RapiZyme trypsin, it is possible to achieve uncompromising speed and clean digestion due to extremely high self-digestion resistance, high purity, and improved activity. It solves issues such as long pre-treatment times, noise from impurities (self-digestion, incompatibility, non-specific cleavage, cleavage errors), and poor reproducibility, resulting in highly reproducible and efficient digestion with minimal artifacts and high coverage. 【Features】 - High self-digestion resistance allows for the use of a high ratio (1:5) of enzyme, enabling efficient digestion in a short time. - Clean baseline without peaks of noise or artifacts. - High sequencing coverage rate. - Achieves reproducibility and predictability with chemically optimized recombinant expressed porcine trypsin. - Improved stability, recovery rate from vials, and activity upon re-dissolution. - Excellent robustness and flexibility to accommodate various protocols.

Company：日本ウォーターズ（米国本社 Waters Corporation）　
Price：Other

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Environmental Enzyme "Ecozyme Series"

Effective in removing bad odors caused by the decay of organic matter, purifying wastewater, and reducing soil diseases!

"Ecozyme" is a concentrated enzyme complex. It contains no bacteria and promotes the decomposition of organic matter while enhancing the proliferation of beneficial bacteria. This action is expected to have significant effects such as the removal of unpleasant odors caused by the decay of organic matter, purification of wastewater, reduction of soil diseases, improvement of plant health, shortening the fermentation period for compost, and purification of lake water and suppression of algal blooms. We also offer "Ecozyme GX" for fat decomposition and "Ecozyme EZ." 【Features】 ■ A concentrated oxygen complex in a biological catalyst system that contains no bacteria ■ Promotes the decomposition of organic matter and measures the proliferation activity of beneficial bacteria ■ Non-irritating ■ Non-flammable ■ Easy to add and use *For more details, please refer to the PDF materials or feel free to contact us.

Company：カクタニ
Price：Other

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Plant and seafood extract enzyme "Universal Enzyme"

Improved crop yield, quality, color, and taste! Fermentation materials that create healthy crops and fertile soil.

"Universal Enzyme" is a revolutionary enzyme material that combines the power of enzymes extracted from a variety of sources such as grains, fruits, root vegetables, seaweed, mushrooms, and shellfish, along with the strength of aerobic microorganisms. It improves crop yield, quality, coloration, and taste. The effects are further enhanced when used in conjunction with the aerobic microbial activator "High Power Dream." 【Features】 - Enzymes mediate and promote chemical reactions within the plant, activating its metabolism. - Small particles are easily absorbed through the plant's leaves and root tips. - Promotes root development and growth, strengthens cells, and exhibits excellent effects on fruit coloration and enlargement. *For more details, please refer to the PDF materials or feel free to contact us.

Company：CRTワールド
Price：Other

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Biofertilizer for Agriculture
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Genovis AB FabRICATOR (IdeS)

Proteases useful for the analysis and evaluation of antibody drugs and ADCs (antibody-drug conjugates) including biosimilars.

FabRICATOR (IdeS) is a unique enzyme that digests specific sites just below the hinge region of antibodies. It generates a uniform pool of F(ab')2 and Fc/2 with a 30-minute incubation. No substrates other than IgG are known. Typically, IgG is digested within 30 minutes, but there is no risk of excessive digestion even with longer incubation times. FabRICATOR digests IgG under physiological conditions, maintaining its immunoreactivity. The enzyme activity is maximized at 37°C, but it can also be used at room temperature by extending the reaction time. FabRICATOR digests all subclasses of IgG from humans, monkeys, rabbits, and sheep. However, its activity against mouse IgG2a and IgG3 is limited. For the digestion of these antibodies, the use of FabRICATORZ is recommended. ● Genovis actively holds web meetings and seminars. Please feel free to contact us for adjustments according to your requests.

Company：重松貿易大阪本社
Price：Other

Research Antibodies
Other protein analysis
Other analytical and testing equipment
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Cysteine protease 'FabALACTICA (IgdE)'

Cutting the upper part of the human IgG1 hinge region! Research on antibodies with mutated hinge regions will also become easier!

"FabALACTICA(IgdE)" is a cysteine protease that digests specific sites in the upper hinge region of human IgG1, producing intact and homogeneous Fab and Fc fragments. This enzyme facilitates the characterization of bispecific and multispecific antibodies and the analysis of intact Fc glycosylation. Additionally, it makes research on monovalent binding, higher-order structures, disulfide scrambling, and antibodies with mutations in the hinge region easier. 【Features】 ■ Digests specific sites in the upper hinge region of human IgG1 ■ Produces intact and homogeneous Fab and Fc fragments ■ Facilitates the characterization of bispecific and multispecific antibodies and the analysis of intact Fc glycosylation ■ Makes research on monovalent binding, higher-order structures, disulfide scrambling, and antibodies with mutations in the hinge region easier *For more details, please refer to the PDF document or feel free to contact us.

Company：重松貿易大阪本社
Price：Other

Other restriction enzymes
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Cysteine protease 'FabRICATOR Z (IdeZ)'

Cutting just below the hinge region of mouse IgG! There is no risk of over-digestion due to the high specificity of the enzyme!

"FabRICATOR Z (IdeZ)" is a cysteine protease that cleaves specific sites downstream of the hinge region of mouse IgG2a and IgG3, generating a homogeneous pool of F(ab')2 and Fc fragments after 2 hours of incubation. Some mouse IgG2a that cannot be digested by FabRICATOR can be easily digested with this product, although a longer incubation time may be required. Additionally, due to the high specificity of the enzyme, there is no risk of over-digestion. 【Features】 ■ Cleaves specific sites downstream of the hinge region of mouse IgG2a and IgG3 ■ Generates a homogeneous pool of F(ab')2 and Fc fragments after 2 hours of incubation ■ Some mouse IgG2a can be easily digested ■ No risk of over-digestion due to the high specificity of the enzyme *For more details, please refer to the PDF document or feel free to contact us.

Company：重松貿易大阪本社
Price：Other

Other restriction enzymes
Research Antibodies
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Sialidase "SialEXO"

Hydrolyze sialic acid! By removing sialic acid, research on the variants inherent in proteins becomes easier!

The enzyme 'SialEXO' is a sialidase useful for the removal and analysis of sialic acid. This enzyme shows activity on both N- and O-linked glycans present in native glycoproteins and free glycans. It is used for the processing of O-glycosylated proteins before digestion with OpeRATOR or OglyZOR, and other applications include reducing sample complexity, charge variant analysis, and exoglycosidase arrays. 【Features】 ■ Useful for the removal and analysis of sialic acid ■ Shows activity on both N- and O-linked glycans present in native glycoproteins and free glycans ■ Used for the processing of O-glycosylated proteins before digestion with OpeRATOR or OglyZOR ■ Hydrolyzes glycoproteins under native conditions, demonstrating high activity over a wide pH range of 6.5 to 9 *For more details, please refer to the PDF document or feel free to contact us.

Company：重松貿易大阪本社
Price：Other

Other restriction enzymes
Research Antibodies
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Beta-galactosidase "GalactEXO"

Hydrolyze β1-3,4-linked galactose! Usable for both intact glycoproteins and free oligosaccharides!

"GalactEXO" is a mixture of β-galactosidases that hydrolyze terminal galactose linked by β1-3,4 bonds in N- and O-glycosylated proteins. This enzyme is useful for trimming galactose on free glycan structures in exoglycosidase arrays and for producing antibodies with a homogeneous G0/G0F glycan profile. 【Features】 ■ Mixture of β-galactosidases ■ Efficiently promotes the hydrolysis of β1-3,4-linked galactose on glycoproteins ■ Acts on both N- and O-glycosylated structures ■ Completes the hydrolysis of terminal galactose within 2 hours ■ Applicable for glycan sequencing and trimming of glycans in the antibody Fc region *For more details, please refer to the PDF document or feel free to contact us.

Company：重松貿易大阪本社
Price：Other

Other restriction enzymes
Research Antibodies
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α-N-acetylgalactosaminidase "GalNAcEXO"

Hydrolysis of α-linked GalNAc! Introducing a valuable tool to reduce sample heterogeneity!

The enzyme 'GalNAcEXO' is an α-N-acetylgalactosaminidase that efficiently hydrolyzes terminal GalNAc on glycoproteins. GalNAc, which is bound to serine or threonine and referred to as the Tn antigen, is rapidly and efficiently hydrolyzed by GalNAcEXO, and it also shows activity against α1-3 linked GalNAc. This enzyme serves as a valuable tool in the analysis of complex O-glycosylated proteins that have α-linked GalNAc as a core 1 with a sugar chain that has stopped elongating, reducing sample heterogeneity. 【Features】 ■ Hydrolyzes GalNAc on glycoproteins under native conditions ■ Shows activity in the pH range of 6.0 to 7.6 ■ No cofactors or special buffers are required ■ Reactions on glycoproteins are completed in 2 hours (depending on the nature of the substrate) ■ Complex samples may require overnight incubation *For more details, please refer to the PDF document or feel free to contact us.

Company：重松貿易大阪本社
Price：Other

Other restriction enzymes
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SmartEnzymes for antibody pharmaceuticals and protein glycan analysis

To facilitate the rapid and easy removal of enzymes, we offer a wide range of products that immobilize enzymes in spin columns.

Genovis provides rapid and user-friendly proprietary enzyme tools primarily for the biopharmaceutical industry. These tools, available worldwide, are called SmartEnzymes and are highly useful for the following applications: ● Analysis and characterization of antibody drugs and antibody-drug conjugates (ADCs) ● Conversion of antibody glycosylation ● Automation of antibody subunit analysis ● Antibody modification (fluorescent labeling, biotinylation, azidation, etc.) ● Research and development of antibody-drug conjugates (ADCs) ● De-fucosylation of glycoproteins ● Removal of glycans from proteins You can check the features and usage examples of various enzymes by downloading the PDF. Please feel free to take a look.

Company：重松貿易大阪本社
Price：Other

Other bio-related products
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Enzyme "F Enzyme"

3.5 years aged fermented plant-based lactic acid bacteria paste!

"F Enzyme" is a plant-based lactic acid bacteria fermented paste that has been fermented and aged for three and a half years using over 80 types of raw materials. Vegetables and fruits grown using enzyme farming methods by contracted farmers are used whole, including skins and stems. Brown sugar from the Amami Islands is used for extraction and fermentation. Additionally, carefully selected lactic acid bacteria and yeast are used for long-term aging fermentation. 【Features】 ■ Uses over 80 types of raw materials ■ Uses brown sugar from the Amami Islands for extraction and fermentation ■ Comprehensive analysis data from third-party organizations *For more details, please refer to the catalog or feel free to contact us.

Company：グローリー・インターナショナル
Price：Other

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Proteins and Enzymes: Innovation and Development through Precision Fermentation

Recombinant bovine serum albumin (rBSA), bovine-derived DNase 1 and thermolabile dsDNase 1, Taq DNA polymerase, and Brucine.

The current protein portfolio and technology of LEVPROT BIOSCIENCE, a Spanish company, are used in three major industries: food, IVD, and biopharmaceuticals. 【Brazain】 - A protein with 1600 times the sweetness of sugar - Provides the same sweetness with fewer calories consumed - Heat stability: withstands low-temperature pasteurization 【Recombinant Bovine Serum Albumin (rBSA)】 - Contains no E. coli DNA - An ideal blocking solution for various immunoassays such as ELISA - Improved sensitivity with minimized non-specific binding - 20 to 100 times higher blocking efficiency than BSA 【Bovine-derived DNase 1 and Thermolabile dsDNase1】 - DNase I derived from Bos taurus (bovine) fermented in yeast: widely used for DNA removal and nucleic acid analysis in laboratories. - Thermolabile dsDNase1 is inactivated by heat treatment (55°C) 【Taq DNA Polymerase】 - Contains no E. coli DNA - Contains no glycerol *For more details, please refer to the PDF document or feel free to contact us.

Company：河口・サポート名古屋事務所
Price：Other

Yeast and fungi
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Concentrated complex enzyme "Biso Enzyme"

Exhibits excellent effects in organic matter decomposition, fat decomposition, beneficial microorganism activity, deodorization, and more!

"Biso Enzyme" is an enzyme solution that contains multiple enzyme activities extracted through a unique fermentation system, and it is a product that is friendly to both humans and the natural environment, containing coenzymes such as vitamins and minerals, as well as amino acids and trace elements. It demonstrates significant effects in improving quality in fields such as environmental purification utilizing the power of nature, livestock, aquaculture, and agriculture. 【Features】 ■ The product itself exhibits the function of a biocatalyst (organic catalyst) towards organic matter (organic carbon). ■ It promotes and accelerates the decomposition and digestion of organic matter and oils through a catalytic chain reaction of multiple enzymes. ■ As a non-bacterial product that contains no microorganisms (bacteria), there is no concern about causing ecological abnormalities (this product is not a microbial preparation). ■ It quickly activates useful microorganisms (bacteria) and promotes their proliferation. ■ It removes and suppresses odor components caused by the decay of organic matter through enzymatic oxidation deodorization reactions. ■ Compared to chemical agents, it is a safer product that is also easy to handle.

Company：美創技研
Price：Other

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Standard PCR enzyme "Gene Taq"

Possessing terminal transferase activity! Introducing the research reagents we handle.

"Gene Taq" is a heat-stable DNA polymerase that has been modified from the DNA polymerase gene of Thermus aquaticus YT1, expressed in and purified from E. coli, making it suitable for PCR methods. It possesses terminal transferase activity, allowing the resulting PCR products to be used for TA cloning. Since part of the N-terminal of Taq DNA polymerase has been deleted, it does not have 5' → 3' exonuclease activity. Additionally, it shows particularly high amplification efficiency for DNA fragments under 1 kbp. 【Features】 ■ Particularly high amplification efficiency for DNA fragments under 1 kbp ■ PCR products can be used for TA cloning ■ Part of the N-terminal of Taq DNA polymerase has been deleted *For more details, please refer to the related links or feel free to contact us.

Company：ニッポンジーン
Price：Other

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PCR enzyme "Hot-Start Gene Taq NT"

Introducing a research reagent with terminal transferase activity! It has high specificity.

"Hot-Start Gene Taq NT" is a heat-resistant DNA polymerase for hot-start PCR, which undergoes an activation process at 95°C for 5 minutes before entering the PCR cycle. It has the same functionality as natural Taq DNA polymerase, with chemical modifications applied to "Gene Taq NT," possessing 5'→ 3' exonuclease activity but lacking 3'→ 5' exonuclease activity. Additionally, it has terminal transferase activity, allowing the resulting PCR products to be used for TA cloning. 【Features】 ■ High specificity ■ Hot-Start functionality ■ PCR products can be used for TA cloning *For more details, please refer to the related links or feel free to contact us.

Company：ニッポンジーン
Price：Other

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PCR enzyme "Hot-Start Gene Taq"

The obtained PCR products can be used for TA cloning! A reagent for experimental research characterized by high DNA yield.

The "Hot-Start Gene Taq" we handle is a heat-resistant DNA polymerase for hot start PCR, which undergoes enzyme activation treatment at 95°C for 5 minutes before entering the PCR cycle. It is a modified Taq DNA polymerase called "Gene Taq FP," which minimizes contamination from host bacterial DNA and has been chemically modified. The resulting PCR products can be used for TA cloning. Additionally, this product comes with two types of reaction buffers: the conventional 10 x Gene Taq Universal Buffer and the 10 x Brilliant Buffer. 【Features】 ■ High specificity and high DNA yield ■ Hot-Start function allows for reaction mixture preparation at room temperature ■ Suitable for multiplex PCR ■ Comes with two types of buffers that can be used according to experimental conditions *For more details, please refer to the related links or feel free to contact us.

Company：ニッポンジーン
Price：Other

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High-accuracy enzyme 'Pho DNA Polymerase'

Capable of amplifying long-chain DNA and DNA with high GC content! A research reagent for testing that is less affected by SDS.

"Pho DNA Polymerase" is a heat-stable DNA polymerase derived from the hyperthermophilic archaeon Pyrococcus horikoshii OT3. It possesses 3’→ 5’ exonuclease activity (proofreading activity), so the resulting PCR products have blunt ends. If necessary, they can be ligated to blunt-ended vectors after phosphorylation. Additionally, the mutation frequency is approximately 10 times lower than that of Pol I type, and due to its high fidelity of synthesis, it is suitable for PCR where accurate amplification is required. 【Features】 ■ Has 3’→ 5’ exonuclease activity (proofreading activity), resulting in blunt-ended PCR products ■ High fidelity of synthesis allows for accurate PCR ■ Capable of amplifying long-chain DNA and DNA with high GC content ■ Less affected by PCR inhibitors such as SDS ■ No enzyme inactivation observed at PCR denaturation temperatures of 92℃ to 98℃ *For more details, please refer to the related links or feel free to contact us.

Company：ニッポンジーン
Price：Other

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High-purity HRV-3C protease suitable for protein tag cleavage.

High-purity array-specific protease is optimal for tag cleavage of tag-fused proteins!

Human rhinovirus type 14-derived 3C protease (HRV-3C Protease) recognizes the specific 8 amino acid sequence Leu-Glu-Val-Leu-Phe-Gln-Gly-Pro and cleaves between Gln and Gly. This product is a high-purity protein fused with a GST tag at the N-terminus and an 8×His tag at the C-terminus. 【Features】 - Cleaves tags from target proteins with the recognition sequence - After the reaction, removal of this enzyme is easy using the GST tag - Minimal buffer composition without additives such as surfactants - Ideal for sample preparation in protein science research

Company：ニッポンジーン
Price：10,000 yen-100,000 yen

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Decomposing enzyme "Bacillus molasses liquid"

Reduce pesticide usage and increase yield! Spore-forming bacteria that create high-quality soil with excellent nutrient retention.

"Bacillus Molasses Liquid" is a decomposition enzyme primarily consisting of Bacillus subtilis (Bacillus subtilis), which metabolizes and breaks down various organic substances such as proteins and fats, producing metabolic byproducts. Due to its bacteriostatic action, it supports plant growth. Additionally, the molasses and amino acids contained in the liquid serve as food for beneficial bacteria, activating the activity of indigenous bacteria, creating a granular structure, and improving soil fertility. This allows for the creation of high-quality soil. [Features] - Bacillus bacteria form a coating on leaves, preventing diseases. - Amino acids and peptides serve as food for microorganisms in the soil, activating them. - Molasses enhances sweetness and flavor. *For more details, please download the PDF or feel free to contact us.*

Company：三和メック
Price：Other

Biofertilizer for Agriculture
Biofertilizer for Horticulture
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Catalase

Effective for high concentration, strong acid, and strong alkali hydrogen peroxide wastewater from semiconductor factories!

★Performance Advantage: Usable with high-concentration hydrogen peroxide solutions (30,000ppm) and strong acids/strong alkalis (pH 2.0 - pH 10.0) 　* High activity not found in conventional catalase 　* Particularly effective with high-concentration, strong acid, and strong alkali hydrogen peroxide waste in semiconductor factories, showing a trend of increasing results ★Economical: Cost per enzyme activity is overwhelmingly cheaper compared to other companies' enzymes ★No hassle, just add the specified amount regardless of waste concentration 　* As a substitute for reducing agents that require quantity adjustment, such as sodium thiosulfate ★Custom-made products and packaging can be supplied

Company：リンカ産業
Price：Other

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Sensiscript RT Kit

Reverse transcriptase | Reverse transcription reaction using less than 50 ng of RNA per reaction

■Reverse transcription reaction using less than 50 ng of RNA per reaction ■Efficient reverse transcription from small amounts of transcription products due to high affinity for RNA ■Compatible with GC-rich RNA and RNA with secondary structures *For more details, please download the PDF or feel free to contact us.*

Company：キアゲン
Price：Other

Real-time PCR
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Soy peptone

High in carbohydrates and vitamins! Obtained from papain digestion of soybean flour.

We would like to introduce "Soy Peptone," which is handled by the estuary support. It is characterized by a particularly wide nutritional spectrum and a high content of carbohydrates and vitamins. It is obtained from the papain digestion of soybean flour and is used in media, fermentation, and vaccine production. Please feel free to consult us when you need it. 【Product Overview】 ■ Density (D): 1.41g/cm3 ■ Storage Temperature: +15 to +25°C ■ Transport Temperature: Ambient Temperature ■ WGK1 ■ CAS Number: 91079-46-8 ■ EG-Nr. 293-434-7 *For more details, please refer to the PDF document or feel free to contact us.

Company：河口・サポート
Price：Other

Culture medium
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Tsurumi-style® enzyme

A enzyme supplement developed by a doctor who first introduced enzyme nutrition in Japan.

This is the Tsurumi-style® enzyme supervised by a leading expert in enzyme nutrition. "I want to consume vegetables and fruits for my health." However, busy modern people tend to rely on cooked foods and processed products. The "Tsurumi-style® enzyme" can be easily consumed even on hectic days. Made from about 80 types of vegetables, fruits, mushrooms, and other ingredients without heating, it supports the intake of live enzymes. It is a product that can be confidently recommended to those who feel they are lacking in dietary enzymes. Additionally, it includes various other ingredients that work in conjunction with the enzymes.

Company：イムノカーサ
Price：10,000 yen-100,000 yen

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Enzymes for the production of antibodies with uniform glycosylation.

Please make use of TCI's "Endo-M," "Glycosynthase," and "synthetic oligosaccharides" in the research and development of biopharmaceuticals.

The issue of the heterogeneity of glycan structures in antibody drugs for disease treatment has not been resolved for a long time. We have successfully transferred uniform glycans to antibody drugs using our enzymes "Endo-M" and "Glycosynthase," which we have commercialized. We can provide this in quantities suitable for practical scale. *For more details, please refer to the PDF document or feel free to contact us.*

Company：東京化成工業
Price：Other

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Hydrolytic enzymes β-glucuronidase/sulfatase

Analysis of urine samples, research on steroid conjugates, for doping tests!

We would like to introduce the 'β-glucuronidase/sulfatase' from KURA biotech, which we handle. 'β-glucuronidase' is an enzyme that hydrolyzes glucuronide conjugates. 'Sulfatase' is an enzyme that hydrolyzes sulfate conjugates. The company's products include uniquely purified recombinant enzymes and enzymes derived from abalone. We offer a range from highly active types to those with both glucuronidase and sulfatase activities.

Company：中部科学機器本社/名古屋営業所、東京支社、大阪営業所、埼玉営業所
Price：Other

Physicochemical testing
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Tohoku Univ. Technology ：Amyloid‑β–Degrading Enzymes Derived from Habu Snake Venom：T23-051

A Highly Selective Amyloid‑β Degrader as a Seed for Alzheimer’s Disease Therapeutics

Current Alzheimer’s disease therapies provide only limited cognitive benefit, and there is an unmet need for disease‑modifying drugs that directly reduce amyloid‑β (Aβ) accumulation. The inventors identified habu snake (Protobothrops flavoviridis) venom metalloproteinases (SVMPs), evolutionarily related to non‑amyloidogenic APP‑processing ADAM proteases, as potent Aβ‑degrading enzymes. In vitro, an SVMP cocktail cleaved secreted Aβ at the APP α‑cleavage–equivalent site, converted it to non‑toxic p3 fragments, and reduced Aβ levels in culture medium by about 90%. Among these, the flavoridin‑precursor–derived SVMP targets both monomeric and aggregated Aβ and shows higher substrate selectivity than neprilysin with minimal neuropeptide degradation, supporting its potential as a low‑toxicity, disease‑modifying AD drug lead.

Company：Tohoku Techno Arch Co., Ltd.
Price：Other

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Universal enzyme "Krinase 5000SS"

It demonstrates high cleaning power for mixed stains containing proteins such as milk, meat juice, and blood at room temperature (25°C).

"Cleanerase 5000SS" is a versatile enzyme that neutralizes the liquid properties to minimize fabric damage and efficiently removes protein stains through the power of protein-decomposing enzymes. This product contains a high-activity, low-temperature active protein-decomposing enzyme, which demonstrates strong cleaning power against mixed stains containing proteins such as milk, meat juice, and blood at room temperature (25°C). Additionally, it exhibits high effectiveness not only when used alone but also when mixed with other detergents. 【Features】 ■ Neutral liquid properties ■ Minimal fabric damage ■ Efficient removal of protein stains through the power of protein-decomposing enzymes ■ Contains high-activity, low-temperature active protein-decomposing enzymes ■ High effectiveness even when mixed with other detergents *For more details, please refer to the PDF document or feel free to contact us.

Company：日本酵研本社
Price：Other

enzyme
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Genovis AB IgGZERO (EndoS)

Endoglycosidases useful for the analysis and evaluation of antibody drugs and ADCs (antibody-drug conjugates) including biosimilars.

IgGZERO (EndoS) is an endoglycosidase derived from Streptococcus pyogenes that hydrolyzes the N-linked glycans in the Fc region of IgG. It is useful for reducing complexity through rapid deglycosylation of IgG and inactivating the effector functions of the Fc region. This enzyme deglycosylates IgG from various animal species, including human IgG (all subclasses), as well as IgG from mice, rats, monkeys, sheep, goats, cows, and horses. The enzyme specifically hydrolyzes only the glycans in the Fc region of IgG, even in the presence of other glycosylated proteins in solution. It is expressed and produced in E. coli, contains a His tag, and has a molecular weight of 110 kDa. Genovis actively holds web meetings and seminars. Please feel free to contact us for adjustments according to your requests.

Company：重松貿易大阪本社
Price：Other

Other protein analysis
Other analytical and testing equipment
Research Antibodies
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Enzymes useful for the characterization and analysis of antibody-drug conjugates (ADCs).

Useful for the evaluation and analysis of important quality characteristics such as drug-antibody ratio (DAR), site occupancy, and in vivo changes of antibody-drug conjugates (ADCs).

<Introduction> Antibodies are challenging molecules to characterize due to their size and complexity. A compelling approach to combat diseases such as cancer is to conjugate drugs (payloads) to antibodies, but this further increases the risks of complexity and heterogeneity. Antibody-drug conjugates (ADCs), like other IgG-based biopharmaceuticals, require careful and detailed characterization and appropriate analytical workflows. The "FabRICATOR" product from Genovis allows for the digestion of ADCs into subunits, enabling detailed characterization of this complex class of drugs. Additionally, the endoglycosidases "IgGZERO" and "GlycINATOR" help reduce complexity and improve resolution, making intact ADC studies possible. [Genovis actively hosts web meetings and seminars. Please feel free to contact us for adjustments according to your needs.]

Company：重松貿易大阪本社
Price：Other

Research Antibodies
Other protein analysis
Other analytical and testing equipment
enzyme

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Genovis enzyme for the evaluation and analysis of antibody-drug conjugates (ADC)

Line up proteases that digest specific sites just below the antibody hinge region. This enables detailed characterization of ADCs.

Introducing Genovis enzymes useful for the evaluation and analysis of antibody-drug conjugates. ◎FabRICATOR (IdeS) An enzyme that digests specific sites just below the hinge region of antibodies. It generates a uniform pool of F(ab')2 and Fc/2 with a 30-minute incubation. Typically, IgG is digested within 30 minutes, but there is no risk of excessive digestion even with longer incubation times. The enzyme activity is maximized at 37°C, but it can also be used at room temperature by extending the reaction time. ◎IgGZERO (EndoS) An enzyme that hydrolyzes the N-linked glycans in the Fc region of IgG. It is useful for reducing complexity through rapid deglycosylation of IgG and inactivating the effector functions of the Fc region. ◎GlycINATOR (EndoS2) An enzyme that hydrolyzes the glycans in the Fc region of IgG. It has been demonstrated to remove glycan structures on IgG, including high-mannose, hybrid, complex, and bisecting type glycans. *You can view the product information (in English) by downloading the PDF. Feel free to contact us with any inquiries.

Company：重松貿易大阪本社
Price：Other

Other analysis and evaluation services
enzyme

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enzyme Product List and Ranking from 26 Manufacturers, Suppliers and Companies | IPROS GMS

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