HIGUCHI INC. List of Products and Services

Sulfuric acid is widely produced in Japan and is used in various applications across different industries. However, since it falls under specific chemical substances, special precautions are required during sampling. → A simple and safe sampling system is necessary. Additionally, sulfuric acid can have harmful effects on the human body not only in liquid form but also as gas (vapor), and inhaling the vapor may cause airway inflammation or bronchitis. → A sampling system equipped with appropriate exhaust and ventilation mechanisms is necessary. Furthermore, sulfuric acid is corrosive, and depending on its concentration and temperature, it can corrode even stainless steel (SUS), leading to the possibility of sulfuric acid leaking from the corroded areas. → Each component must be made from materials resistant to sulfuric acid. By using Biar's sampling valve (PFA lining), it becomes easy to construct a sampling system that meets the above requirements!

• Other physicochemical equipment
• valve
• Other safety and hygiene products

It is said that 20 kilograms of CO2 are needed to produce 1 kilogram of coffee. However, only 1% of the coffee beans are used in production, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. KAFFIBRE is a natural scrub expected to be a substitute for microplastics. It features a particle size of less than 150μm, making it easy to incorporate into formulations.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

It is said that 20 kilograms of CO2 are needed to produce 1 kilogram of coffee. However, only 1% of the coffee beans are used in production, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. KLEANSTANT is a natural anionic surfactant that contains potassium salts of palmitic acid and linoleic acid, polyphenols, tocopherols, and diterpene esters. It has cleansing, emulsifying, foaming, antioxidant, and moisturizing effects.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

It is said that 20 kilograms of CO2 are needed to produce 1 kilogram of coffee. However, only 1% of the beans are used in coffee production, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. KAFFEAGE is a powdered extract product that has turned water-soluble active ingredients into powder. Efficacy: UV Protection: Confirmed absorption in the UV range, suppressing the production of weekend glycation substances due to UV. Wrinkle suppression effect. Moisturizing effect: +16.37%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

It is said that 20 kilograms of CO2 are needed to produce 1 kilogram of coffee. However, only 1% of the coffee beans are used in production, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. KAFFEOIL is an oil product that utilizes the aroma and color of coffee. If you are concerned about the scent and color, refined products are recommended. Effectiveness: Nrf2 production: 7 times Repair effect: repairs in 48 hours Hair shine, protection (brushing): equivalent to argan oil.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Jover Scientech was established in 1991 in Terrassa, Spain, and is a company that operates primarily in the cosmetics and pharmaceuticals industries. The company utilizes over 30 years of extensive experience and advanced product development technology to develop a variety of additives, including naturally derived emollients, multifunctional preservatives, antioxidants, and thickening agents that serve as alternatives to carbomers. Vercatech Penty C is a 100% plant-derived pentylene glycol sourced from corn cobs and sugarcane bagasse. It has been confirmed to have antibacterial effects against bacteria (both gram-positive and gram-negative) and fungi (yeasts and molds), regardless of pH. COSMOS

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Mechanical stimulation of cultured tissues such as 3D cardiac microtissues using actuators to mimic heartbeats and knee joint movements. Evaluation of changes in electrical activity after drug administration allows for in vitro safety assessment of drugs. *Measurement of heart rate, electrical activity, contractility, etc.

• Cell culture contract service

This product can be used as a feel-enhancing agent, an adsorbent, and a thickening agent. It achieves a low bacterial count through heat treatment. It is also gaining attention as an alternative to microplastics. ISO 16128 Ino = 1 COSMOS certification obtained Particle size: 14μm (peak) (max. 1.0% > 45μm) It has a sharp particle size distribution. For organic certified products, please inquire separately.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

This product is a delicate zone care ingredient made from soapberry fruit and fermented aloe vera. Soapberry is rich in saponins, which destroy the cell walls of Candida and have a sterilizing effect. The fermentation of aloe vera enhances its powerful soothing components. Effectiveness: - Inhibition of Candida - Promotion of Lactobacillus - Suppression of IL-8 production - Immediate moisturizing effect (15 minutes): +33%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

This is an oil extract made from ginger roots sourced from Madagascar, extracted with triheptanoin. LUMILYS suppresses lipofuscin and melanin, the root causes of age-related spots, through both traditional and new mechanisms of action. Old mechanism: It suppresses the production of lipofuscin and melanin through antioxidant and anti-inflammatory effects. New mechanism: By inhibiting growth factor SCF and nerve factor RGMB, it directly acts on melanocytes to fundamentally control melanin production. *RGMB is a factor secreted from nerves when they interact with melanocytes (LUMILYS acts on the nerves). Active ingredients: • Gingerol: >32%/dry weight *A component that possesses whitening effects, longevity effects, stress resistance, antioxidant effects, and calming effects (6-gingerol: >20%, 8-gingerol: >4%, 10-gingerol: >4%) Efficacy: Antioxidant: EC50: 0.25% IL8: -46% Reactive oxygen species: -46.5% Growth factor SCF: -27% Nerve factor RGMB: -12% Lipofuscin accumulation: -26% Melanin production: -46% Currently conducting In Vivo studies.

• Cosmetic materials and raw materials
• Other medical supplies and cosmetic manufacturing materials
• Other pharmaceutical intermediates and cosmetic ingredients

To produce 1 kilogram of coffee, 20 kilograms of CO2 are required. However, only 1% of the coffee beans are used in the production process, while 99% is discarded. Cafe Bueno has achieved zero waste by utilizing this residue as a cosmetic ingredient. KLEANSTANT is a natural anionic surfactant upcycled from coffee by-products, containing potassium palmitate, linoleic acid, polyphenols, tocopherols, and diterpene esters. In addition to its cleansing properties, foaming ability, and antioxidant effects, it also has moisturizing benefits. KLEANSTANT exhibits high foaming performance when the original pH is lowered through neutralization treatment. It shows the best performance at a pH of 5 to 6, and citric acid also contributes to the removal of residues and improvement of emulsification. However, at a pH of 4, foaming ability may decrease.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

To produce 1 kilogram of coffee, 20 kilograms of CO2 are required. However, only 1% of the coffee beans are used in production, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. KAFFEAGE is a powdered extract product that has powdered the water-soluble active ingredients contained in coffee residue. It contains polyphenols and melanoidins. Efficacy: UV Protection: Confirmed absorption in the UV range, suppresses the production of glycation substances caused by UV. SPF Boost: +73.9% (1.8% added) Crow's Feet Wrinkles: -12% Elasticity Improvement: +12.2% Moisturizing Effect: +16.37%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

To produce 1 kilogram of coffee, 20 kilograms of CO2 are required. However, only 1% of the coffee production uses the beans, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. This product is available in two grades: unrefined KAFFEOIL and refined KAFFEOIL-R. If you are considering a formulation that emphasizes not only efficacy but also the color and aroma of coffee, we recommend the unrefined KAFFEOIL. For those concerned about odor and color, we recommend the refined KAFFEOIL-R. Efficacy: Nrf2 production: 7 times Repair effect: repairs in 48 hours Hair shine: equivalent to argan oil Protection (prevention and improvement of breakage due to brushing): equivalent to argan.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Winemakers may consider alternative technologies to reduce or completely eliminate the use of additives such as sulfur dioxide (SO2), which acts as a preservative against wine oxidation. As a result, the evaluation of the oxidation stability of must and wine is becoming increasingly important. In wine science, methods for measuring antioxidant capacity such as DPPH, FRAP, and ABTS are well known, but the complexity and time required for these methods pose challenges. We have collaborated with the University of Florence to focus on PAT (Plasma Antioxidant Test) as an alternative method and have developed a measurement kit. The measurement kit can quantitatively measure the antioxidant capacity due to polyphenols and tannins in terms of ascorbic acid equivalent (mg/L). The amount of SO2 is not considered. This allows for research on: 1) raw materials, 2) the effects of treatments such as clarification, 3) the influence of containers used for purification (wood, steel, etc.), 4) changes in color as an index of antioxidant capacity, 5) stress from storage and transportation in warehouses, and 6) parameters when placing on shelves (temperature, light), types of closures (cork, synthetic), and types of bottles (clear, dark glass, etc.). The measurement time is 30 minutes.

• Spectroscopic Analysis Equipment

Zinnerine is a hexapeptide-2 conjugated with zinc. It has efficacy similar to retinol and is characterized by having equal or greater activity than retinol. In vitro: - Inhibition of hyperkeratosis - Sebum suppression (5α-reductase): over -60% - Inhibition of acne bacteria: approximately -50% - Anti-inflammatory effects - IL1α: -35% - IL-6: over -20% - IL-8: over -20% - Promotion of collagen production (COL1A1 gene expression): +40% In vivo: - Suppression of acne papules: -20% (2 weeks) - Pore contraction: -20% - Improvement of wrinkles: over -30%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Elaself is a pentapeptide (valine-serine-glycine-isoleucine-arginine) synthesized to mimic a fragment of MFAP4. MFAP4 is necessary for binding fibrillin chains to form microfibrils. These microfibrils are then further modified to become mature elastic fibers (elastin). <In Vitro> MFAP4 gene expression (+30%) Collagen type I gene expression (+30%) Increased intracellular collagen levels in NHDF cells (20-60%) Increased elastin levels <In Vivo> Improvement in skin elasticity (R2: 20%, R5: 25%) Reduction in wrinkle depth (-40%)

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Maintaining skin homeostasis relies heavily on intercellular communication. CellCon promotes the production of the intercellular adhesion protein desmoglein-1, actively enhancing the communication necessary for maintaining skin homeostasis. <In Vitro> Promotion of desmoglein-1 gene expression: +150% or more Suppression of sebum production: -15% Increase in skin moisture levels: +13% Suppression of moisture evaporation: -6%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

SOMITINE is an acidic mannosyl polyglucan derived from purified glucuronic acid obtained through fermentation and mannose. SOMITINE promotes energy metabolism by stimulating ATP levels and recharges the energy readiness of cells. It stimulates cellular activity, basal metabolism, and mitochondrial respiration. SOMITINE enhances cell regeneration and activates the skin to restore its glow. Cellular basal respiration stimulation: +27% Mitochondrial respiration stimulation: +22% ATP: +14%, ADP: +39%, AMP: +18% Skin glow: 205% increase Shine: 50% suppression

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Monocyte activation test kit, an alternative method to the rabbit pyrogen test and LAL test. It uses human monocytic THP-1 cells to detect the inflammatory cytokine TNF-α. Capable of detecting gram-negative bacteria, gram-positive bacteria, fungi, and viruses.

• Other analytical and testing equipment

Microchannel technology enables compartmentalization and co-culture. Compatibility with other companies' MEAs allows for the recording of electrical activity. Determination of toxicity and efficacy through the creation of digital signatures of compounds tested on innervated target organs. Prediction of toxicity and efficacy by comparing digital signatures of compounds using a digital library.

• Culture vessel

It is an extract of the natural ruby-colored Chosen Gomi, a symbol of beauty and longevity, with a wide range of health benefits. It works on the skin longevity mechanism, leading to vibrant, radiant, and smooth skin. <Active Ingredients> Lignans: ≥10%/DM Longevity extension mechanism Schisandrin: 6-8%/DM Autophagy induction & improvement of skin health lifespan Organic Acids: Citric Acid: 10-15% Malic Acid: 10-15% Tartaric Acid ≥2% Cellular energy production <Efficacy> Unit: % Vitro SIRT6: +181 FOXO3: +104 Anti-inflammatory (NfkB: -14, IL6: -66, PGE2: -87) Antioxidant (ROS: -16, SOD2: +50, Catalase: +104) Mitochondrial activity: +55 Autophagy (LAMP2A: +80, LC3A: +44) Skin barrier (Cornifin A, Occludin: +32, Filaggrin: +160, MDA: -22, Epidermal thickness: +63) Dermis (Elastin: +16, MMP1: -72) Vivo TEWL: -24 Moisture content: +34 Microcirculation: +33 Radiance: +47

• Cosmetic materials and raw materials

We assemble various single-use parts such as tubes, bags, filters, filling needles, and RTP ports according to your requirements. After assembly, they can be sterilized and delivered. The parts undergo various tests and validations based on guidelines.

• Bio-related product packaging machine

The combination of deep filtration and alluvial filtration allows for the removal of CHO cells, bacteria, etc., in a single step without the need for a centrifugation step. This reduces the cost and downtime of the bioprocess.

• Protein Extraction Kit

The sterile sampling system can be customized to meet user requirements for tube size, sampling ports, and sampling containers.

• Other bio products

Single-use mixing bags are designed for quick and uniform mixing. An impeller is attached to the bottom of the bag and rotates via a magnetic drive. It can accommodate bag capacities of up to 1000L. A 4-inch or 8-inch port can be installed on the top. It is also compatible with sanitary flanges. The bags are customizable.

• Culture vessel

The disposable sampling port cartridge eliminates the need for time-consuming assembly of multi-port adapters. This allows for direct attachment to the container's port, creating a simple, fast, and immediately usable sampling system. It is a gamma-irradiated disposable system for aseptic liquid sampling at various stages of pharmaceutical and biopharmaceutical processing. These systems minimize the potential for false positives compared to traditional sampling systems and reduce the need for cleaning. A sealed system that maximizes operator safety and eliminates contamination. A simpler, faster, and completely disposable ready-to-use solution for sampling applications. There is no need for the cumbersome and time-consuming assembly of sampling system ports and multi-port adapters within the cartridge.

• Animal cells

<About Contipro> It is a biotechnology company and a global manufacturer that has been producing active ingredients used in the pharmaceutical and cosmetic industries for nearly 30 years. We offer a range of products including sodium hyaluronate and its derivatives produced by fermentation, as well as distinctive peptides and natural polysaccharides. <Product Introduction> This is an oil-soluble sodium hyaluronate derivative with caprylic acid. It can be used in oil phases for lip products, balms, hair oils, nail care, and more. <Efficacy> - Stimulates hair growth - Improves cuticles - Increases lip volume - Improves elasticity - Reduces wrinkles: 35% - Shrinks pores: 30% - Smoothing effect - Reduces erythema: over 10% and more.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Odesia is a French cosmetic ingredient manufacturer that offers a range of products centered around extracts from algae native to the Brittany region of France. The company's products apply the unique defensive properties that allow algae to survive in various harsh natural environments to cosmetics. Jade AlgaTM is a patented active ingredient rich in native ulvan (sulfated polysaccharide) derived from the green seaweed Ulva Lactuca Variety Armoricana, which inhabits the Brittany coast. It is the only algae with "shape memory capability." The Brittany seaweed is significantly affected by the tides that occur every six hours. Its shape memory capability allows it to withstand repeated cellular deformation (contraction and expansion) caused by the tides without damage. <Efficacy> - Maintenance and recovery of normal stratum corneum arrangement (shape memory technology) - Soft peeling effect - Improved skin and plasticity flexibility - Photoprotection effect - Antioxidant effect

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Hawthorn Cosmelean is an extract from the flowers of the Western Hawthorn. It contains active ingredients such as vitexin-2-O-rhamnoside: 0.07-0.11%. <Mechanism of Action> - The flavonoids contained in Cosmelean Hawthorn reduce congestion in capillaries and alleviate erythema. - By promoting blood flow, it improves the oxygen levels in the skin. This activates a constant process. <Efficacy> Reduces redness in the skin and brightens it. Unifies skin tone and enhances transparency. Reduces skin discomfort/unpleasant sensations (tightness due to dryness, inflammation). In Vivo: Redness reduction (IR-induced): -6% Redness reduction (UV-induced): -7%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

This product is a low-melting semi-solid avocado oil that has been upcycled using a unique patented method, utilizing the manufacturing residue of avocado oil. The texture is silky and resembles silicone. It is odorless, has a calm color, and excellent oxidative stability, making it a promising alternative to silicone and paraffin. The fatty acid composition is quantified as standard values, and various efficacy can be expected. - Oleic acid: Promotes skin repair and healing - Linolenic acid (5-15%): Improves skin elasticity, suppleness, and moisturizing performance; alleviates symptoms of atopic dermatitis - Palmitic acid (35-45%): Cell regeneration, protective effects on skin and hair - Palmitoleic acid (3-10%): Selective antibacterial, maintains bacterial flora, anti-inflammatory, and repair properties.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

As society's development accelerates, our bodies are constantly confronted with various environments and stressors to which we have not adapted (e.g., night shifts, social obligations, lack of sleep). Furthermore, this stress disrupts the body's natural rhythms (circadian rhythms). This product promotes improvements in autophagy, melatonin production, antioxidant enzyme production, and stimulation of anti-aging genes by regulating the body clock-related genes (CLOCK, CRY1, PER), addressing tired appearance and stress care. = in Vitro ex Vivo = Regulation of CLOCK, CRY1, PER (adjustment of circadian rhythms) Autophagy LC3(2): +93% Cell stress P53: -20% Melatonin receptor MT1: +24% NFR-2: +85% SIRTUIN1: +56% - Promotion of happiness hormones Oxytocin: +82% Endorphin receptor: +20% Endocannabinoid receptor: +21% = in Vivo = - Improvement of tired appearance Dark circles: -13% Eye bags: -28% Fine wrinkles: -21% Dullness - Yoga-like effects on mood Sense of happiness: +8% Negative emotions: -17%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

AsptiBag Gold uses an inactive multilayer polyethylene film that is physically robust and inert to many chemicals and solvents, while also possessing excellent gas barrier properties. The contact surface is made of 130μm ultra-low-density polyethylene without any additives. It meets various regulatory and functional requirements, providing consistently high-quality products.

• Other bio-related products

The beer analysis device "Smart Analysis" is provided by DNAPhone (Italy) and is a spectrophotometric analysis device that allows for the easy analysis of various parameters of wort, beer, and brewing water. The measurement time is approximately 10 minutes, and the required sample volume is less than 1cc. Thanks to patented optical technology, it can measure the entire spectrum in the ultraviolet-visible range, enabling color analysis based on the standard CIELab method, as well as color analysis based on the EBC and ASBC methods. 【Features】 The compact device with a built-in battery can be easily transported for measurements. With temperature control, it allows for highly reproducible measurements (coefficient of variation CV value of 2-5%). This low-cost beer analysis device is adopted by many manufacturers. * A promotional video for the beer analysis device is currently available for free! Please watch it from the middle of the page. For detailed specifications, please download the PDF. For tests or demonstrations, feel free to consult us through the contact information below.

• Analytical Equipment and Devices

Vanilla, belonging to the orchid family, is originally a climbing plant native to tropical America. It grows in Mexico, Guatemala, Venezuela, Guyana, and islands such as Réunion, Comoros, Tahiti, and Madagascar. In the past, in its original habitat of Mexico, vanilla flowers were pollinated by insects. In regions outside of Mexico where vanilla is planted, pollination is done by human hands because insect pollination is not possible. The extract from vanilla fruit is rich in amino acids, polysaccharides, free sugars, minerals, and phenolic compounds, which not only provide fragrance but also offer moisturizing effects, skin quality improvement, antioxidant properties, and antibacterial effects. This product is an extract obtained from organically grown vanilla fruit in Madagascar and has received COSMOS/ECOCERT/HALAL certification.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

This product is rich in isoflavones, such as daidzein, genistein, and glycitein, which have estrogen-like effects and are derived from dry extracts of soybeans. The estrogen levels in the body decrease due to aging and menopause. The decline in estrogen levels not only increases the risk of osteoporosis but also affects changes in the skin and appearance. <Efficacy of Soy Extract> Regeneration Promotion Effects - Promotion of type I and type III collagen production (genistein, glycitein) - Promotion of fibronectin production (glycitein) - Inhibition of elastase (glycitein) Photoprotection Effects - Inhibition of sunburn cells (UVB) Astringent Effects and more.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

The products are manufactured in a controlled environment compliant with ISO 7 by specially trained personnel. Some of the products adhere to strict quality control protocols, including particle count, microscopic observation, and individual bag pressure tests.

• Culture vessel

The SafeCell series is made of fluorinated ethylene propylene (FEP) and meets the demands of in vitro cell culture. FEP is chemically and biologically inert, making it perfectly suitable for cell suspension culture. Its anti-adhesion properties allow cells to freely float and proliferate in the medium. SafeCell bags are permeable to gases (oxygen, carbon dioxide, nitrogen), enabling the necessary exchanges for proper cell development, while also possessing another important characteristic: water impermeability. The low evaporation rate of SafeCell bags prevents issues even in humid incubators that increase the risk of bacterial and microbial growth.

• Culture vessel

EVA-based high-frequency welded tubes and connectors ensure the integrity of a completely sealed system once filling is complete. This process is already used in Technoflex's sterilization bags, preventing the risk of contamination and issues related to the transfer between the container and its contents, while also controlling the assembly costs of the fillers. EVA bags manufactured in an ISO 8 cleanroom undergo numerous tests in accordance with good manufacturing practices, including endotoxin level assessments and airtightness tests. The capacity of the bags ranges from 5 to 500 ml. Sterilization using beta or gamma rays is also available upon request. Technoflex provides global "all-in-one" sterilization for bags, tubes, and connectors.

• Human cells

This product is an extract fermented with rare cold-resistant bacteria that inhabit the air in France, using the roots of wild gentian organically grown in the high mountains of France. This bacteria is resistant to cold and dry environments, and the holobiosis fermented with it demonstrates effectiveness for dehydrated (water-deficient) and dry (lipid-deficient) skin, showing various efficacy data such as promoting hyaluronic acid synthesis in the epidermis and dermis, antioxidant effects, strengthening barrier functions, and promoting beneficial skin bacteria. Main components: polar lipids, amino acids, loganin acid, swertia amarin. Standardized. In Vitro: Hyaluronic acid synthesis: +62% (keratinocytes), +32% (fibroblasts) CD44 synthesis: +42% (keratinocytes) Lipid synthesis: +147% (keratinocytes) Increase in tight junction-related proteins Increase in basement membrane structural proteins (2 types) Increase in collagen-binding proteins (2 types) Increased expression of antioxidant-related genes (8 types) In Vivo: Skin surface moisture content: +7.3% (all subjects), +12.5% (seborrheic deficiency) Promotion of sebum production: +27% (all), +43% (deficiency) Wrinkle length: -5% Epidermal Staphylococcus: +39% Ralstonia species: +45%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Over 100 extracts and oil extracts from 17 regions of France Introduction of 16 data-rich raw materials BIOTILYS: Regulation of skin microbiota, protection booster, skin repair CARICILINE: Moisture content booster for the skin CERNILYS: Improvement of dark circles, brightness enhancement, care around the eyes EPICA: Extracellular matrix protection, improvement of crow's feet EPSILINE: Tanning agent, three types of natural protection HEBELYS: Improvement of skin and mood, anti-aging care for the silver generation HYDRALYS M: Hydration for dry skin, long-lasting moisture retention IAA 50: Slimming, fat breakdown LACTOPHYT: Long-lasting odor control, selective sterilization of odor-causing bacteria LIPACTIF CAMELINE: Nutritional supplementation for the skin, soft-touch oil MYRALYS: Rejuvenation around the eyes, eyelid lifting RAYOLYS: Booster for skin radiance and evenness REVERSKIN: Firming and regeneration booster for the skin SIDILINE: Redness improvement, blood vessel tightening, swelling reduction SILYPUR OC: Oral care, selective sterilization TILICINE: Moisture protection for fragile hair and scalp

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

"Smart Analysis" is a patented spectrophotometric analysis device provided by DNAPhone (Italy) that allows for the easy analysis of various parameters of wort, beer, and brewing water. The measurement time is approximately 10 minutes, and the required sample volume is less than 1cc. Thanks to patented optical technology, it can measure the entire spectrum in the ultraviolet-visible range, enabling color analysis based on the standard CIELab method, as well as color analysis based on the EBC and ASBC methods. The compact device with a built-in battery is portable for on-the-go measurements. With temperature control, it allows for highly reproducible measurements (coefficient of variation CV value of 2-5%). Analysis is conducted using a tablet device with a dedicated app, where users scan the QR code displayed on the reagent box and follow the instructions on the tablet for measurement. The measurement procedure is displayed graphically, making it intuitive to operate. Glassware is not required. The reagents come in a single-use reagent set (20 pieces), and by scanning the QR code, the unique data of the reagents is automatically reflected, eliminating the need for cumbersome tasks such as calibrating the device before measurement. (For more details, please feel free to contact us.)

• Analytical Equipment and Devices

The waste liquid is collected into a single tank through a pipe system fixed to the wall and the laboratory bench. There is no need to prepare a waste tank for each piece of equipment, reducing the installation space required for tanks. The tanks and piping are made of conductive plastic, which effectively prevents the risk of ignition through proper grounding. The tank's level sensor manages the liquid level in the tank using optical and auditory signals, preventing overflow. Symline is a modular solvent handling system that connects multiple HPLCs in the simplest way possible.

• Other bio-related products and services
• Other Chromatograph
• Other storage and equipment

SETILINE is an extract from fenugreek (koroha) seeds. It contains galactomannan oligosaccharides as its main component, standardized to contain 80% or more of mannose and galactose. Galactomannan oligosaccharides are said to have effects such as suppressing glycation reactions, promoting keratinocyte differentiation, and exhibiting antioxidant properties. This raw material is an extract of koroha seeds that possesses various effects attributed to galactomannan oligosaccharides. <DNA Transcriptome Analysis> - Suppression of ISM1 and HK3 gene expression - Promotion of SOD2 gene expression - Stimulation of SAA1 gene expression - Promotion of hyaluronic acid production - Suppression of MAL gene expression - Suppression of KRT16 gene expression and more. <In Vitro> - Suppression of glycation substance production: -26% - Promotion of keratinocyte differentiation - Epidermal densification: +14% <In Vivo> Improvement in elasticity: +45% (maximum: +214%) Improvement in firmness: +11% (maximum: +93%) Anti-wrinkle: maximum: -37% Smoothing: -30.5% and more.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

This is an extract derived from three types of leaves: green tea, white tea, and red tea. This product contains an extract that suppresses damage caused by external oxidation and helps to reduce wrinkles and spots, thanks to the antioxidant power of the three types of black tea leaves. <Source Ingredients> - Green Tea: Rich in epigallocatechin gallate (EGCG), a major type of catechin, which is a kind of polyphenol with antioxidant properties. - White Tea: A precious tea made from buds that were only used by Chinese emperors. It is rich in antioxidants such as epicatechin gallate, epigallocatechin (EPC), and catechins/epicatechins. - Red Tea (Rooibos Tea): Contains a wealth of polyphenols and flavonoids. <Efficacy Component Specification Values> Polyphenols: 60-90% Flavonoids: 1-5% <Effects> It suppresses oxidation reactions caused by free radicals and inhibits lipid peroxidation and MMP at the molecular and cellular levels. It protects tissues from external attacks such as light, pollution, and smoke. In vitro [Suppression of MDA production due to UVB irradiation] - Vitamin E: -46% - TEALINE 0.5%: -40%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Manufactured in an ISO Class 7 cleanroom Compliant with USP Class 6, various certifications BPA, phthalate, latex, and animal-free Operating temperature: -45℃ to 135℃ Low gas permeability Thermal bonding possible Please inquire about delivery time.

• Other bio products