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"Ion Pair Reagent" is a reagent for HPLC. In chromatographic analysis of samples containing ionic compounds, issues may arise with solute retention and peak shape. In such cases, it is known that adding an ion pair reagent to the mobile phase can improve separation, and it is particularly useful in reverse phase chromatography. When this reagent is added to the mobile phase, ions of opposite charges attract each other to form neutral ion pairs, which suppresses the dissociation of the sample in the mobile phase. Additionally, since the ion pair reagents are bonded with various alkyl groups, the formed ion pairs become more lipophilic, resulting in increased retention on ODS packing materials. We offer a lineup for both basic and acidic samples. If you require more guarantee items for use in pharmaceutical testing, we can provide a quote. Please feel free to consult us. In addition, we handle other HPLC reagents: ◇ Solvent for High-Performance Liquid Chromatography HLC-SOL ◇ For LC/MS ◇ For pharmaceutical testing ◇ Pre-prepared mobile phases (custom orders available) …etc. For more details, please download the catalog or feel free to contact us.
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Free membership registration"Prepsol" is a solvent for large-scale preparative liquid chromatography. This product is packaged in an 18L container, designed for preparative use, minimizing UV absorption and non-volatile components while considering large-scale applications. Large-scale preparative liquid chromatography using high-speed liquid chromatography is an effective method for the separation and purification of pharmaceuticals and bioactive substances, and industrial applications are also anticipated. Such large-scale HPLC requires inexpensive yet high-quality solvents. We offer "Prepsol" to meet these demands. 【Features】 ■ Minimizes non-volatile components in the solvent ■ Keeps UV absorption blanks low ■ By lowering acidity, it enables the separation of unstable substances that are prone to decomposition by acids 【Product Lineup】 ◇ Acetonitrile ◇ Chloroform ◇ Distilled water ◇ Ethanol (99.5) ◇ Ethyl acetate ◇ Hexane ◇ Methanol Additionally, we have a lineup for HLC-SOL (for HPLC), LC/MS, and pharmaceutical testing. For more details, please download the catalog or feel free to contact us.
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Free membership registrationThe product "For HPLC (Pharmaceutical Testing)" is based on our unique standards derived from the Japanese Pharmacopoeia (JP) reagent standards, and guarantees compliance with the United States Pharmacopeia (USP) reagent standards and the European Pharmacopoeia (EP) reagent standards. Additionally, we have added JIS special grade specifications. This allows for use in both JIS special grade and liquid chromatography applications, reducing the burden of reagent management and waste reagents. 【Features】 ■ Complies with reagent standards listed in the Japanese Pharmacopoeia, United States Pharmacopeia, and European Pharmacopoeia. ■ Expiration date (year, month, day) is displayed on the label. ■ Test date (year, month, day) is displayed on the certificate of analysis. 【Product Lineup】 ◇ Acetonitrile (compliant with JP, JIS, USP, EP) ◇ Methanol (compliant with JP, JIS, USP, EP) ◇ Tetrahydrofuran (compliant with JP, USP) 【Related Products】 Prepared mobile phases minimize the hassle of reagent management and issues related to contamination. ◇ Acetonitrile/water mixture (4:1) ◇ Acetonitrile/water mixture (3:2) For more details, please download the catalog or feel free to contact us.
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Free membership registrationWe offer solvents specifically designed for "LC/MS" analysis, which is becoming increasingly sensitive. With the proliferation of high-sensitivity mass spectrometers, we have added even more guarantee items compared to the conventional "HLC-SOL" (for HPLC). We also provide high-purity products in ampoules for acids such as formic acid. Additionally, we propose products that contribute to the reliability and workability of LC/MS analysis, such as acetonitrile mixed with formic acid. 【Features】 ■ Conducted LC/MS compatibility tests ■ Followed the conventional HLC-SOL standards ■ Packaging designed to minimize contamination ■ Additional guarantees for organic fluorine compounds (PFOS, PFOA, PFHxS) (acetonitrile, distilled water, methanol) We have added tetrahydrofuran for LC/MS. With relative fluorescence intensity and LC/MS compatibility tests included, we ensure the strictest quality control, allowing you to use it with confidence during GPC/MS analysis. We also have solvents available for HPLC. For more details, please download the catalog or feel free to contact us.
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Free membership registrationThe residual solvent test measures the amount of organic solvents present in pharmaceuticals using methods such as gas chromatography, confirming that organic solvents do not exceed the limit values in the pharmaceuticals. Most commercially available general reagents have not had low boiling point impurities removed, making them unusable as the impurity peaks from the reagents overlap with the peaks of the substances being measured on the GC chart. This product reduces the content of low boiling point compounds such as methanol and guarantees quality through a unique residual solvent compatibility test. The expiration date is displayed on the label, and a certificate of analysis can also be issued. Additionally, we offer single-use reagents packaged in 100mL. Please make use of these for recording and managing reagents.
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Free membership registrationWe have prepared convenient pre-made test solutions suitable for drug dissolution and disintegration tests. 【New Product】 -NEW- ◆ Disodium hydrogen phosphate-citrate buffer, pH 6.0 This buffer is prepared according to the methods described in the Japanese Pharmacopoeia for reagents and test solutions. It is used diluted four times in the dissolution test of "Rebamipide Tablets." ◆ Pioglitazone hydrochloride tablet dissolution test solution This dissolution test solution is prepared according to the preparation method described in the dissolution test for the pharmaceutical "Pioglitazone Hydrochloride Tablets" in the Japanese Pharmacopoeia. These tests aim to ensure a certain level of quality for oral solid preparations by testing the dissolution of the main component or the disintegration or resistance of the test solution for oral solid preparations. The dissolution test also aims to prevent significant biological non-equivalence. We offer test solutions prepared at various pH levels in a variety of containers and packaging. They are prepared in accordance with the Japanese Pharmacopoeia, and we can also issue test reports. Please make use of this to reduce the burden of preparation work and improve the efficiency of preparation record management. We also accept requests for test solutions at pH levels not listed, so please feel free to contact us.
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Free membership registrationOur company offers a series of single-use reagents for pharmaceutical testing in 100 mL packaging. The PIC/S GMP Guidelines Part 1, Chapter 6 states: "Special attention must be paid to the quality of laboratory reagents, test solutions, glassware, reference materials, and culture media. They must be prepared and managed according to the procedures. The level of management should be appropriate to their intended use and the available stability data." It is expected that the management of reagents once opened will be based on stability data after opening. This product is available in small, single-use packaging, which allows for reduced waste and effective use of storage space, and eliminates the need for stability confirmation after opening. There is no concern about cross-contamination, allowing for safe use.
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Free membership registration【New Coronavirus S Gene Mutation Detection Real-time PCR Kit】 The "PowerChek SARS-CoV-2 S-gene Mutation Detection Kit series" is a product that allows for the simultaneous screening of multiple mutations in the S protein of the novel coronavirus from RNA extracts. Positive controls and internal controls are included. 【New Product: PowerChek SARS-CoV-2 S-gene Mutation Detection Kit Ver.3.0】 We are now launching a product that enables the simultaneous screening of seven mutations in the S protein, including those possessed by the Omicron variant (K417N, L452R, E484A/K, N501Y, T547K, P681R). ★ Compatible Models ■ BioRad / CFX96 System ■ ThermoFisher / Applied Biosystems 7500, 7500 Fast, QuantStudio 5 ★ This kit is for research and testing use only. It has not received approval or certification as an in vitro diagnostic medical device.
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Free membership registrationKanto Chemical Co., Ltd. has decided to construct a new building at the Isehara Research Institute (Isehara City, Kanagawa Prefecture) to strengthen its research and development capabilities in the life and bio fields. We will significantly expand laboratories equipped to handle bio clean rooms and microbial containment, and in addition to our traditional research areas such as clinical diagnostic reagents, we will install facilities that also cater to new fields such as regenerative medicine. Furthermore, we are advancing the introduction of equipment for updating culture media for bacterial testing in part of the new building, and we are also planning to strengthen the Isehara Factory, which serves as our manufacturing base in the bio and life fields, by transferring inspection equipment from the current research building. [Overview of Isehara Research Institute] ■ Location: 21 Suzukawa, Isehara City, Kanagawa Prefecture ■ Research and Development Fields: Clinical diagnostic reagents, culture media for microbial testing, simple analytical reagents (such as immunochromatography), reagents for genetic analysis, regenerative medicine, alternative methods for animal testing, and basic technology development (such as antibody development). *For more details, please refer to the external link page or feel free to contact us.
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Free membership registrationThe "ciKIC iPS medium" is a feeder-free medium suitable for the culture of iPS cells. Typically, frequent medium changes are necessary when culturing iPS cells, but using this medium eliminates the need for medium changes on weekends (or during three-day holidays). Since a certain number of cells can be seeded, it allows for simple and highly reproducible passaging work. 【Features】 ■ Low-protein medium without albumin ■ Reduced burden of medium changes ■ Passaging work possible with single cells ■ High proliferation support capability ■ Good ability to maintain undifferentiated state ■ Free from components of animal origin (Xeno-free) ★ For applications (cell morphology, proliferation, karyotype analysis, undifferentiated state, pluripotency, etc.), please refer to the brochure.
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Free membership registrationThe "ciKIC IEC Maturation Medium" is a culture medium that allows for the maturation of intestinal epithelial cells derived from human iPS cells, enabling the creation of a human intestinal epithelial model. In oral drug pharmacokinetic testing, the Caco-2 cells derived from human colon cancer have traditionally been used as a model for gastrointestinal absorption and metabolism tests; however, there has been a challenge in adequately replicating the functions of the living small intestine. This product allows for the maturation of intestinal epithelial cells derived from human iPS cells, making it possible to create a human intestinal epithelial model that is similar to the living small intestine. 【Features】 ■ Capable of producing high-performance human intestinal epithelial models ■ Wide range of applications *For more details, please refer to the PDF materials or feel free to contact us. 【Keywords】 Drug discovery support, non-clinical trials, pharmacokinetics, gastrointestinal absorption tests, Caco-2, iPS-small intestine model, drug metabolism enzymes, transporters, barrier function, drug-drug interactions, functional foods, health foods, nutrient absorption, intestinal immunity, gut microbiota.
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Free membership registrationBioConcept is a manufacturer of cell culture media based in Basel, Switzerland. The company specializes in the production of animal-free (ACF) media, with its manufacturing facility equipped with ACF-specific containers and production equipment. To maintain high product quality, it utilizes a very high standard of water purification systems and air conditioning control systems. Additionally, to meet various customer needs, the equipment and control mechanisms in the manufacturing facility are regularly upgraded. Custom media and other flexible solutions are available. 【About Custom Media】 The following items can be customized: ● Changes to the composition of existing products (addition or removal of components), concentration changes ● Contract manufacturing of original formulation media ● Changes in batch size (liquid: 20 L to 5,000 L, powder: 2 kg to 800 kg) ● Changes in container size and type ● Changes in testing content Standard tests: pH, osmotic pressure, concentration, sterility test (liquid products only), cell culture performance test Additional possible items: conductivity, endotoxin, mycoplasma, bioburden (powder products only), etc. *For more details, please refer to the PDF document or feel free to contact us.
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Free membership registrationThe "MAM-PF Medium Series" is a culture medium for CHO cells and BHK cells that meets the standards of being serum-free, protein-free, and free from animal-derived components (ACF). The liquid medium uses high-quality water for injection (WFI) and the particle size of the powdered medium is crushed to approximately 20 µm, enabling rapid dissolution. Additionally, it allows for high-density cell culture and facilitates high expression of recombinant proteins. 【Features】 ■ Chemically defined and free from animal-derived components ■ Compliant with European Medicines Agency EMA/410/01 ■ High cell density and high yield ■ High-quality liquid and powdered media ■ High adaptability *For more details, please refer to the PDF document or feel free to contact us.
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Free membership registrationHuman mesenchymal stem cells (hMSC), one type of somatic stem cell, possess the ability to differentiate or transdifferentiate into cartilage, bone, ligaments, fat, muscle, and blood vessels, and can be isolated from living tissues such as bone marrow with minimal discomfort. Therefore, they are attracting attention as transplantable stem cells for regenerative medicine. Traditionally, the in vitro amplification and differentiation induction of MSCs required fetal bovine serum (FBS) or autologous human serum (derived from the patient's own blood), but the STK series allows for serum-free culture of MSCs and is composed of chemically defined media, making it a useful tool for future MSC research. *For more details, please refer to the PDF document or feel free to contact us.*
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Free membership registration"ad-MED Vitrigel" is a cell culture insert that uses a collagen Vitrigel membrane useful for tissue reconstruction. It has superior cell adhesion and spreading activity compared to conventional plastic membranes, enabling effective cell culture for various cell types. In addition to liquid-phase to liquid-phase culture, it is also possible to culture under conditions that mimic the in vivo environment, such as liquid-phase to gas-phase culture. Furthermore, the membrane has excellent permeability, making it useful for interaction analysis through co-culture of different cell types. 【Features】 ■ High cell adhesion, allowing for uniform culture seeding ■ Rapid formation of adhesion spots and high cell spreading activity ■ Bidirectional culture through the Vitrigel membrane ■ High-density collagen fiber structure comparable to biological connective tissue ■ Capable of culturing under conditions that mimic the in vivo environment * "Vitrigel" is a registered trademark of the National Agriculture and Food Research Organization. * For more details, please refer to the PDF document or feel free to contact us.
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Free membership registrationThe "Trans-epithelial Electrical Resistance (TEER) Measurement Device" is a TEER measurement device for ad-MED Vitrogel. 【Features】 ■ Stable measurements possible with ad-MED Vitrogel dedicated electrodes ■ Compatible with data storage and analysis via PC ■ Electrode structure that supports temperature measurement with a temperature sensor (sold separately) ■ Allows access to the insert while measuring TEER values
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Free membership registrationThe "Vitrigel-Eye Irritancy Test (Vitrigel-EIT method)" is a testing method used to evaluate the severity of damage caused by the attachment of chemical substances to the eyes. By dropping a chemical substance onto a corneal epithelial model and measuring the change in its TEER value with a specialized measuring device, it is possible to determine the presence or absence of eye irritation from the chemical substance in just 3 minutes. This testing method was included in June 2019 as OECD Test Guideline No. 494, an international standard method, and it is expected to be widely used for safety testing of cosmetics and other products around the world. [Test Method] ■ Drop the test substance onto the corneal model ■ Measure the change in TEER value for 3 minutes ■ Analyze the change in TEER value to determine the presence or absence of eye irritation *For more details, please refer to the external link page or feel free to contact us.
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Free membership registrationThe PCR-based ORF Typing (POT method) developed by Dr. Masahiro Suzuki at Fujita Medical University is a method for comparing the homology between bacterial strains by simultaneously amplifying multiple specific genes using multiplex PCR and analyzing the amplified band patterns. Features: - All necessary reagents are included in the PCR kit. - Molecular epidemiological analysis can be completed in about 4 hours. - Comparable analytical capability to PFGE, MLST, etc. - The analysis results are quantified (POT value), making it easy to compare and manage the homology between bacterial strains.
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Free membership registrationThe "Kogene Biotech Gene Detection Kit Series" includes over 500 real-time PCR/conventional PCR kits for detecting pathogens such as monkeypox, novel coronavirus variants, and pathogenic bacteria. 【Product Lineup】 - Pathogenic Bacteria Salmonella, Shigella, Vibrio parahaemolyticus, Legionella, etc. - Enteric Viruses Adenovirus, Norovirus, Hepatitis A/C viruses, etc. - Respiratory Viruses and Bacteria Measles virus, Coronavirus, Chlamydia pneumoniae, etc. - Influenza Viruses Influenza A/B viruses, Avian influenza, etc. - Protozoa Entamoeba histolytica, Giardia lamblia, etc. - Tropical Disease Viruses Dengue virus, Zika virus, etc. - Tick-borne Infection Pathogens Rickettsia, Bartonella, etc. - Veterinary Medicine BVDV, PEDV, Mycobacterium avium, etc. - Animal Species Chickens, sheep, ducks, etc. - Food Allergens Shrimp & crab, soybeans, peanuts, etc. - Halal For detecting gelatin-derived DNA - Genetically Modified Organisms (GMO) - Plant Pathogenic Viruses ToMV, RSV, etc.
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Free membership registrationKogeneBiotech, established in 2000, is the top manufacturer of gene detection kits in South Korea and currently manufactures and sells over 500 items of real-time PCR and conventional PCR kits. In February 2020, KogeneBiotech received the first approval in South Korea for the "PowerChek 2019-nCoV Real-time PCR Kit" as an in vitro diagnostic medical device (IVD), and since then, it has developed and sold various real-time PCR reagents related to the novel coronavirus (SARS-CoV-2). Each kit includes all the necessary reagents for measurement, such as enzymes and positive controls, enabling rapid and accurate detection of the novel coronavirus genes. ★ This kit series is for research and testing purposes only. It has not received approval or certification as an in vitro diagnostic medical device.
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Free membership registrationWe offer Shikajinius nucleic acid extraction reagents and nucleic acid purification kits according to the purpose of extracting nucleic acids (DNA/RNA) from samples. The nucleic acid extraction reagent is a simple purification reagent that allows for PCR preprocessing in as little as 10 minutes. The nucleic acid purification kit is a silica membrane-type purification kit that can be selected from various types depending on the sample type. *Please check the selection guide for choosing the appropriate kit based on the sample. If it is difficult to determine the suitable kit for your sample, please feel free to contact us. *Samples of each product are also available. You can apply through the application form in the selection guide or contact us directly from this site.
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Free membership registration● Easy operation allows for the purification of high-purity nucleic acids (DNA/RNA) in about 20 minutes. ● Can be used for samples in various applications such as PCR.
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Free membership registration"Protease K solution" is a reagent that efficiently breaks down proteins due to its broad cleavage activity as a type of endopeptidase. 【Features】 ■ Optimal for nucleic acid purification with DNase and RNase below detection limits ■ Recombinant enzyme with minimal lot-to-lot variation ■ Solution type that is easy to dilute ■ Guaranteed enzyme activity of ≧600 U/mL (37 °C, hemoglobin) ■ Long-term storage possible even in refrigeration (2–8 °C) *For more details, please refer to the catalog or feel free to contact us.
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Free membership registration"Agarose KANTO" is a purified agarose for the electrophoresis of nucleic acids such as DNA. You can adjust the agarose concentration according to the DNA size for the separation and recovery of nucleic acids. You can choose from seven types of agarose suitable for electrophoresis, and we offer high-quality materials at an affordable price. [Features] ■ Easy-to-handle solubility and gel strength ■ High cost performance ■ A range of products tailored for various applications *For more details, please refer to the catalog or feel free to contact us.
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Free membership registrationThe 'Agar for Dryness Prevention' is an agar that is highly resistant to drying and has excellent water retention, making it ideal for algae, plants, and microorganisms. By using this agar, it is possible to prevent cracking of the medium and drying of samples that can occur during long-term cultivation due to dryness. *For more details, please refer to the catalog or feel free to contact us.
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Free membership registration"LB Medium (Miller), Granulated Type" is a premix type of LB medium. It is ideal for the cultivation of competent cells and others. 【Features】 ■ Granulated type that minimizes powder scattering *For more details, please refer to the catalog or feel free to contact us.*
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Free membership registrationThe "QIAxcel Connect" is a capillary electrophoresis device from QIAGEN that serves as an alternative to DNA/RNA gel analysis. It allows for safe and easy analysis using ready-to-use gel cartridges. The electrophoresis results can be output as digital data, which is convenient for analysis. Additionally, related products include the Sicagenius Molecular Epidemiology Analysis POT Kit series and Sicagenius PCR kits, among others. 【Features】 ● High-speed analysis of up to 96 samples without manual operation ● Accurate results even at nucleic acid concentrations of 5 pg/μL ※1 ● Analysis of DNA fragments from 12 samples (one run) in 9-25 minutes ※2 ● Accurate analysis with high resolution of 3-5 bp (for fragments under 500 bp) ※2 ● Safe and easy system with ready-to-use gel cartridges ● Output of convenient digital data for analysis ※1 High-sensitivity detection reagents are scheduled to be released soon. ※2 When using the QIAxcel DNA High Resolution Kit. ※For more details, please refer to the catalog or feel free to contact us.
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Free membership registrationThe "Mupid Series" is an electrophoresis device manufactured and sold by Mupid Co., Ltd., which specializes in submarine-type electrophoresis equipment. We offer a range of models including the standard model Mupid-2plus, the multifunctional Mupid-exU, and the top-of-the-line Mupid-One. 【Features of Mupid-ONE】 ■ Multi-pipette & multi-sample compatible ■ Heat-resistant gel maker set included as standard ■ Safety compliant with European electrical safety standards (CE) ■ Built-in timer ■ Seven variations of output voltage *For more details, please refer to the catalog or feel free to contact us.
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Free membership registration"SCOPE 21" is a desktop imaging device manufactured by OPTIMA Corporation. It comes with a variety of accessories, including a digital camera (requires an SDHC card) and filters for different staining solutions. Additionally, the digital camera is pre-configured for gel imaging.
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Free membership registrationThe "phi29 DNA Polymerase Set" is a DNA synthesis enzyme derived from the Bacillus subtilis phage phi29. It is active around 30°C, possesses high strand displacement activity, and has excellent proofreading activity due to its 3'→5' exonuclease activity, making it suitable for applications such as whole genome amplification. Our unique manufacturing technology allows for the extreme removal of residual DNA. 【Features】 ■ Mesophilic enzyme ■ High strand displacement activity ■ Fast synthesis speed ■ High elongation capability ■ Low replication error rate For more details, please refer to the catalog or feel free to contact us.
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Free membership registration"ImmunoAssist MG-PP Re" is a ceramic-type separation and purification agent primarily composed of magnesium pyrophosphate. It allows for the easy purification of IgM and IgG with high purity from serum, ascitic fluid, and culture supernatants through simple procedures.
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Free membership registrationThe "Deer Allergy Test - Cedar Pollen Allergen Cry j 1" is an immunochromatographic reagent that qualitatively detects Cry j 1, the major allergen of cedar pollen. The "Deer Allergy Test - Dust Mite Allergen Der f 1" is an immunochromatographic reagent that qualitatively detects Der f 1, an allergen derived from the feces of the house dust mite. It allows for the identification of areas contaminated with pollen or dust mites and the verification of cleaning conditions based on objective data.
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Free membership registrationThe "Dust Mite Allergen Measurement ELISA Kit" is a kit designed to measure the concentrations of the major allergens Der p 1 and Der f 1 or Der 2 from house dust mites and storage mites. By using this kit, you can sensitively detect allergens derived from dust mite bodies or feces, which serve as indicators when assessing contamination levels of dust mite allergens in indoor environments. <NEW> By using the dilution solution (flour) for the dust mite allergen kit, it has become possible to efficiently extract and measure dust mite allergens (Der p 1, Der f 1, Der 2) contained in flour, which was difficult to extract with conventional dilution solutions. 【Features】 - Detection of allergens from dust mite bodies or feces - High-sensitivity quantification using ELISA - High reproducibility with an average C.V. value of less than 5% - All necessary reagents included - Uses a separate plate that can be used in multiple sessions *For more details, please refer to the catalog or feel free to contact us.
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Free membership registrationThe 'Sugi Pollen Antigen Measurement ELISA Kit' handled by Kanto Chemical is a kit for measuring the concentrations of Cry j 1 and Cry j 2, which are the main pollen allergens of Sugi (Cryptomeria japonica). This kit is based on the ELISA method, allowing for the measurement of pollen levels even in samples that contain contaminants like indoor dust. It can detect pollen levels equivalent to about 50 samples and achieves high reproducibility with an average C.V. value of less than 5%. 【Features】 ■ High sensitivity quantification using ELISA ■ High reproducibility with an average C.V. value of less than 5% ■ All necessary reagents included ■ Uses a separate plate design, allowing for usage in multiple sessions For more details, please refer to the catalog or feel free to contact us.
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Free membership registrationThe "Cat Allergen Measurement ELISA Kit" is a kit for measuring the concentration of Fel d 1, the cat allergen. It is known that cat allergens can be detected even in environments without cats, indicating that people who have no contact with cats may still be at risk of developing allergies. It is important to understand the amount of cat allergens in the environment and to take measures to remove them. 【Features】 ■ Detects cat skin allergens ■ High sensitivity quantification using ELISA ■ High reproducibility with an average C.V. value of less than 5% ■ All necessary reagents included ■ Uses a separate plate design, allowing for multiple uses *For more details, please refer to the catalog or feel free to contact us.
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Free membership registration■Labeling reagent for nucleic acid oligomers Nucleic acid oligomers with an ethynyl group introduced at any position on either the terminal or non-terminal ends can be easily synthesized. By performing a click reaction with organic azide compounds, efficient and easy post-modification is possible. ■3' terminal modification reagent for nucleic acid oligomers Nucleic acid oligomers with a modified 3' terminal can be easily synthesized. This product allows the dangling end nucleoside portion to have a highly hydrophobic benzene skeleton, resulting in synthesized nucleic acid oligomers with excellent nuclease resistance.
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